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  1. Article ; Online: Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful?

    Chu, Po-Chun / Yu, Hsiang-Yu / Fisher, Robert S / Liu, Hao-Li

    ACS chemical neuroscience

    2024  Volume 15, Issue 9, Page(s) 1728–1731

    Abstract: Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In ... ...

    Abstract Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In this Viewpoint, we highlight the valuable guidance of preclinical validation methods for choosing the optimal FUS parameters, thus ensuring consistency with the outcomes of clinical trials and leading human trials to the safest and most effective approaches.
    MeSH term(s) Animals ; Humans ; Disease Models, Animal ; Epilepsy/therapy ; Ultrasonic Therapy/methods ; Epilepsy, Temporal Lobe/therapy
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.4c00198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Radical Cation Salts of Hetera-Buckybowls: Polar Crystals, Negative Thermal Expansion and Phase Transition.

    Wu, Lingxi / Li, Yecheng / Hua, Xinqiang / Ye, Lei / Yuan, Chengshan / Liu, Zitong / Zhang, Hao-Li / Shao, Xiangfeng

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 12, Page(s) e202319587

    Abstract: Radical cation salts of π-conjugated polycycles are rich in physical properties. Herein, two kinds of hetera-buckybowls, ethoxy-substituted trithiasumanene (3SEt) and triselenasumanene (3SeEt), are synthesized as electron donors. Galvanostatic oxidation ... ...

    Abstract Radical cation salts of π-conjugated polycycles are rich in physical properties. Herein, two kinds of hetera-buckybowls, ethoxy-substituted trithiasumanene (3SEt) and triselenasumanene (3SeEt), are synthesized as electron donors. Galvanostatic oxidation of them affords radical cation salts (3SEt)
    Language English
    Publishing date 2024-02-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202319587
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  3. Article: Evaluation the Effect of Sonodynamic Therapy with 5-Aminolevulinic Acid and Sodium Fluorescein by Preclinical Animal Study.

    Huang, Chiung-Yin / Li, Jui-Chin / Chen, Ko-Ting / Lin, Ya-Jui / Feng, Li-Ying / Liu, Hao-Li / Wei, Kuo-Chen

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Sonodynamic therapy (SDT) is a novel tumor treatment that combines biosafe sonosensitizers and noninvasive focused ultrasound to eradicate solid tumors. Sonosensitizers such as 5-aminolevulinic acid and fluorescein have great potential in tumor treatment. ...

    Abstract Sonodynamic therapy (SDT) is a novel tumor treatment that combines biosafe sonosensitizers and noninvasive focused ultrasound to eradicate solid tumors. Sonosensitizers such as 5-aminolevulinic acid and fluorescein have great potential in tumor treatment. Here, rodent subcutaneous and brain tumor models were used to evaluate the treatment effect of both 5-ALA- and fluorescein-mediated SDT. The subcutaneous tumor growth rates of both SDT groups were significantly inhibited compared with that of the control groups. For intracranial tumors, 5-ALA-SDT treatment significantly inhibited brain tumor growth, while fluorescein-SDT exerted no therapeutic effect in animals. The distribution of fluorescein in the brain tumor region underwent further assessment. Seven days post tumor implantation, experimental animals received fluorescein and were sacrificed for brain specimen collection. Analysis of the dissected brains revealed no fluorescence signals, indicating an absence of fluorescein accumulation in the early-stage glioma tissue. These data suggest that the fluorescein-SDT treatment response is closely related to the amount of accumulated fluorescein. This study reports the equivalent effects of 5-ALA and fluorescein on the treatment of somatic tumors. For orthotopic brain tumor models, tumor vascular permeability should be considered when choosing fluorescein as a sonosensitizer. In conclusion, both fluorescein and 5-ALA are safe and effective SDT sonosensitizers, and the tumor microenvironment and pathologic type should be considered in the selection of adequate sonosensitizers.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020253
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  4. Article ; Online: Dual-frequency ultrasound enhances functional neuron differentiation from neural stem cells by modulating Ca

    Lee, I-Chi / Lin, Yu-Chieh / Liu, Hao-Li / Liu, Nien-Che

    Journal of cellular physiology

    2022  Volume 238, Issue 1, Page(s) 137–150

    Abstract: Our previous study demonstrated that ultrasound is able to promote differentiation on neural stem cells (NSCs), and dual-frequency ultrasound promotes this effect due to enhanced acoustic cavitation compared with single-frequency ultrasound. However, the ...

    Abstract Our previous study demonstrated that ultrasound is able to promote differentiation on neural stem cells (NSCs), and dual-frequency ultrasound promotes this effect due to enhanced acoustic cavitation compared with single-frequency ultrasound. However, the underlying biological reasons have not been well disclosed. The purpose of this study was to investigate the underlying bioeffects, mechanisms and signaling pathways of dual-frequency ultrasound on NSC differentiation. The morphology, neurite outgrowth, and differentiation percentages were investigated under various dual-frequency simulation parameters with exposure periods varying from 5 to 15 min. Morphological observations identified that dual-frequency ultrasound stimulation promoted ultrasound dose-dependent neurite outgrowth. In particular, cells exposed for 10 min/2 days showed optimal neurite outgrowth and neuron differentiation percentages. In addition, live cell calcium images showed that dual-frequency ultrasound enhanced the internal calcium content of the cells, and calcium ions entering cells from the extracellular environment could be observed. Dual frequency ultrasound exposure enhanced extracellular calcium influx and upregulated extracellular signal-regulated kinases 1/2 (ERK1/2) expression. Observations from immunostaining and protein expression examinations also identified that dual-frequency ultrasound promoted brain-derived neurotrophic factor (BDNF) secretion from astrocytes derived from NSCs. In summary, evidence supports that dual-frequency ultrasound effectively enhances functional neuron differentiation via calcium channel regulation via the downstream ERK1/2 pathway and promotes BDNF secretion to serve as feedback to cascade neuron differentiation. The results may provide an alternative for cell-based therapy in brain injury.
    MeSH term(s) Brain-Derived Neurotrophic Factor/metabolism ; Calcium/metabolism ; Cell Differentiation ; Cells, Cultured ; MAP Kinase Signaling System ; Neural Stem Cells/cytology ; Neurons/cytology ; Signal Transduction ; Ultrasonic Waves
    Chemical Substances Brain-Derived Neurotrophic Factor ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30911
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  5. Article ; Online: Hyperbranched Polymers for Organic Semiconductors.

    Zhou, Zhaoqiong / Luo, Nan / Shao, Xiangfeng / Zhang, Hao-Li / Liu, Zitong

    ChemPlusChem

    2023  Volume 88, Issue 7, Page(s) e202300261

    Abstract: Hyperbranched polymers (HBPs) have attracted increasing attention owing to their distinct highly branched topological structures, resulting in unique properties and wide applications in organic semiconductors (OSCs). In this Review, recent progress in ... ...

    Abstract Hyperbranched polymers (HBPs) have attracted increasing attention owing to their distinct highly branched topological structures, resulting in unique properties and wide applications in organic semiconductors (OSCs). In this Review, recent progress in functional HBPs is outlined in the field of OSCs, including organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), dye-sensitized solar cells (DSSCs), and organic field effect transistors (OFETs), among others. Prospects of HBPs-based materials in OSCs are examined. The results revealed that multi-dimensional topologies not only regulate the electron (hole) transport but also adjust the film morphology, thereby affecting the efficiency and long life of organic electronic devices. Many studies showed the usefulness of HBPs as hole transport materials but reports dealing with n-type and ambipolar materials are still lacking. In addition, the interchain covalent bond in hyperbranched polymers could mitigate the damage caused by stretching, conducive to building stable flexible stretchable devices with long-term durability and good safety under harsh environmental conditions. Overall, the flexible stretchable design may enrich the applications of HBPs in organic semiconductors and provide new ideas for guiding the future design of functional organic semiconductor materials.
    MeSH term(s) Polymers/chemistry ; Semiconductors
    Chemical Substances Polymers
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202300261
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  6. Article: Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson's Disease.

    Lin, Chung-Yin / Huang, Ching-Yun / Chen, Chiung-Mei / Liu, Hao-Li

    Pharmaceutics

    2022  Volume 14, Issue 2

    Abstract: Parkinson's disease (PD) is characterized by α-synuclein (αSNCA) aggregation in dopaminergic neurons. Gradual accumulation of αSNCA aggregates in substantia nigra (SN) diminishes the normal functioning of soluble αSNCA, leading to a loss of dopamine (DA) ...

    Abstract Parkinson's disease (PD) is characterized by α-synuclein (αSNCA) aggregation in dopaminergic neurons. Gradual accumulation of αSNCA aggregates in substantia nigra (SN) diminishes the normal functioning of soluble αSNCA, leading to a loss of dopamine (DA) neurons. In this study, we developed focused ultrasound-targeted microbubble destruction (UTMD)-mediated PD model that could generate the disease phenotype via αSNCA CNS gene delivery. The formation of neuronal aggregates was analyzed with immunostaining. To evaluate the DA cell loss, we used tyrosine hydroxylase immunostaining and HPLC analysis on DA and its two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This loss of DA was associated with a dose-dependent impairment in motor function, as assessed by the rotarod motor assessment. We demonstrate that UTMD-induced SNCA expression initiates αSNCA aggregation and results in a 50% loss of DA in SN. UTMD-related dose-dependent neuronal loss was identified, and it correlates with the degree of impairment of motor function. In comparison to chemical neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated and conventional intracerebral (IC)-injected animal models of PD, the UTMD-mediated αSNCA-based mouse model offers the advantage of mimicking the rapid development of the PD phenotype. The PD models that we created using UTMD also prove valuable in assessing specific aspects of PD pathogenesis and can serve as a useful PD model for the development of new therapeutic strategies.
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14020444
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  7. Article: Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications.

    Chen, Ko-Ting / Wei, Kuo-Chen / Liu, Hao-Li

    Pharmaceutics

    2021  Volume 13, Issue 7

    Abstract: The blood-brain barrier (BBB) protects the central nervous system (CNS) from invasive pathogens and maintains the homeostasis of the brain. Penetrating the BBB has been a major challenge in the delivery of therapeutic agents for treating CNS diseases. ... ...

    Abstract The blood-brain barrier (BBB) protects the central nervous system (CNS) from invasive pathogens and maintains the homeostasis of the brain. Penetrating the BBB has been a major challenge in the delivery of therapeutic agents for treating CNS diseases. Through a physical acoustic cavitation effect, focused ultrasound (FUS) combined with microbubbles achieves the local detachment of tight junctions of capillary endothelial cells without inducing neuronal damage. The bioavailability of therapeutic agents is increased only in the area targeted by FUS energy. FUS with circulating microbubbles is currently the only method for inducing precise, transient, reversible, and noninvasive BBB opening (BBBO). Over the past decade, FUS-induced BBBO (FUS-BBBO) has been preclinically confirmed to not only enhance the penetration of therapeutic agents in the CNS, but also modulate focal immunity and neuronal activity. Several recent clinical human trials have demonstrated both the feasibility and potential advantages of using FUS-BBBO in diseased patients. The promising results support adding FUS-BBBO as a multimodal therapeutic strategy in modern CNS disease management. This review article explores this technology by describing its physical mechanisms and the preclinical findings, including biological effects, therapeutic concepts, and translational design of human medical devices, and summarizes completed and ongoing clinical trials.
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13071084
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  8. Article ; Online: Achieving Strong Circularly Polarized Luminescence through Cascade Cationic Insertion in Lead-free Hybrid Metal Halides.

    Song, Tao / Wang, Cheng-Qiang / Lu, Haolin / Mu, Xi-Jiao / Wang, Bo-Long / Liu, Ji-Zhong / Ma, Bo / Cao, Jing / Sheng, Chuan-Xiang / Long, Guankui / Wang, Qiang / Zhang, Hao-Li

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202400769

    Abstract: Generating circularly polarized luminescence (CPL) with simultaneous high photoluminescence quantum yield (PLQY) and dissymmetry factor ( ... ...

    Abstract Generating circularly polarized luminescence (CPL) with simultaneous high photoluminescence quantum yield (PLQY) and dissymmetry factor (g
    Language English
    Publishing date 2024-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202400769
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  9. Article ; Online: Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex.

    Chu, Po-Chun / Huang, Chen-Syuan / Chang, Pi-Kai / Chen, Rou-Shayn / Chen, Ko-Ting / Hsieh, Tsung-Hsun / Liu, Hao-Li

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Transcranial focused ultrasound (tFUS) is a novel neuromodulating technique. It has been demonstrated that the neuromodulatory effects can be induced by weak ultrasound exposure levels (spatial-peak temporal average intensity, ... ...

    Abstract Transcranial focused ultrasound (tFUS) is a novel neuromodulating technique. It has been demonstrated that the neuromodulatory effects can be induced by weak ultrasound exposure levels (spatial-peak temporal average intensity, I
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Motor Cortex/diagnostic imaging ; Motor Cortex/physiology ; Ultrasonography ; Transcranial Magnetic Stimulation ; GABAergic Neurons ; Evoked Potentials, Motor
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032578
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  10. Article ; Online: Correction to: Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study.

    Chen, Ko-Ting / Huang, Chiung-Yin / Pai, Ping-Ching / Yang, Wen-Chi / Tseng, Chen-Kan / Tsai, Hong-Chieh / Li, Jui-Chin / Chuang, Chi-Cheng / Hsu, Peng-Wei / Lee, Cheng-Chi / Toh, Cheng-Hong / Liu, Hao-Li / Wei, Kuo-Chen

    Journal of neuro-oncology

    2024  Volume 167, Issue 2, Page(s) 371

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-024-04671-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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