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  1. Article: Microbiology of Meropenem-Vaborbactam: A Novel Carbapenem Beta-Lactamase Inhibitor Combination for Carbapenem-Resistant Enterobacterales Infections.

    Bhowmick, Tanaya / Weinstein, Melvin P

    Infectious diseases and therapy

    2020  Volume 9, Issue 4, Page(s) 757–767

    Abstract: Vaborbactam is a novel boron-based beta-lactamase inhibitor developed to be effective against Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria. This enzyme is a key driver in the global spread of β-lactam resistance among carbapenem-resistant ...

    Abstract Vaborbactam is a novel boron-based beta-lactamase inhibitor developed to be effective against Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria. This enzyme is a key driver in the global spread of β-lactam resistance among carbapenem-resistant Enterobacterales. Alone, vaborbactam has no antibacterial activity; however, the combination of meropenem-vaborbactam has enhanced activity against gram-negative organisms, particularly Enterobacterales with class A and C carbapenemases. Multiple in vitro studies evaluating isolates from various geographic regions, and over different time periods, have demonstrated the high potency of meropenem-vaborbactam against organisms containing KPC2 and KPC3. However, meropenem-vaborbactam does not have activity against OXA-48 or metallo-beta lactamases. This review covers the in vitro studies of meropenem-vaborbactam performed to date, which evaluated both large cohorts of clinical isolates and engineered isolates, to determine efficacy in various settings, including the presence of porin mutations and efflux pump upregulation.
    Language English
    Publishing date 2020-10-05
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-020-00350-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Clinical and Laboratory Standards Institute Subcommittee on Antimicrobial Susceptibility Testing: Background, Organization, Functions, and Processes.

    Weinstein, Melvin P / Lewis, James S

    Journal of clinical microbiology

    2020  Volume 58, Issue 3

    Abstract: The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing (AST SC) is a volunteer-led, multidisciplinary consensus body that develops and publishes standards and guidelines (among other products) for ... ...

    Abstract The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing (AST SC) is a volunteer-led, multidisciplinary consensus body that develops and publishes standards and guidelines (among other products) for antimicrobial susceptibility testing (AST) methods and results interpretation in the United States and internationally. The Subcommittee (SC) meets face-to-face twice yearly, and its working groups (WGs) are active throughout the year via teleconferences. All meetings are open to the public. Participants include clinical microbiologists, infectious disease (ID) pharmacists, and infectious disease physicians representing the health care professions, government, and industry. Individuals who work for a company with a primary financial dependency on drug sales cannot serve as voting members, and well-defined conflict of interest polices are in place. In addition to developing and updating susceptibility breakpoints, the SC develops and validates new testing methods, provides guidance on how results should be interpreted and applied, sets quality control ranges, and educates users through seminars, symposia, and webinars. Based on its work, the SC publishes print and electronic standards and guidelines, including an annual update, the Performance Standards for Antimicrobial Susceptibility Testing (M100). This commentary will describe the background, organization, functions, and operational processes of the AST SC.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Clinical Laboratory Services ; Humans ; Laboratories ; Microbial Sensitivity Tests ; Reference Standards ; United States
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01864-19
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    Zs.A 1188: Show issues Location:
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  3. Article ; Online: Potential of Inaccurate Cefiderocol Susceptibility Results: a CLSI AST Subcommittee Advisory.

    Simner, Patricia J / Palavecino, Elizabeth L / Satlin, Michael J / Mathers, Amy J / Weinstein, Melvin P / Lewis, James S / Humphries, Romney

    Journal of clinical microbiology

    2023  Volume 61, Issue 4, Page(s) e0160022

    MeSH term(s) Humans ; Cephalosporins/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; Cefiderocol
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01600-22
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  4. Article ; Online: Systematic Evaluation of the Accelerate Pheno System for Susceptibility Testing of Gram-Negative Bacteria Isolated from Blood Cultures.

    Patel, Yera A / Kirn, Thomas J / Weinstein, Melvin P / Uprety, Priyanka

    Microbiology spectrum

    2021  Volume 9, Issue 3, Page(s) e0183621

    Abstract: Bacteremia is a major cause of morbidity and mortality. Rapid identification of pathogens for early targeted antimicrobial therapy is crucial for detecting emergence of antibiotic resistance and improving outcomes. However, there are limited data ... ...

    Abstract Bacteremia is a major cause of morbidity and mortality. Rapid identification of pathogens for early targeted antimicrobial therapy is crucial for detecting emergence of antibiotic resistance and improving outcomes. However, there are limited data regarding the analytical performance of a rapid identification (ID) and antimicrobial susceptibility testing (AST) method like Accelerate Pheno blood culture detection system compared with the conventional methods routinely used in microbiology laboratories. We undertook a systematic quality improvement (QI) study to compare AST results obtained with Accelerate Pheno system rapid ID/AST system with a standard reference method in a university hospital microbiology laboratory. This was a single center, retrospective (5/10/19 to 8/1/19) and prospective (8/1/19 to 1/31/20) study that evaluated all blood cultures growing Gram-negative rods (GNR). We compared AST results obtained using the reference disk diffusion (DD) susceptibility method with those obtained by the Accelerate Pheno system. We calculated the error rates and categorical agreement between the Accelerate Pheno system and DD for each organism and specific drug tested. We evaluated 355 blood cultures growing GNR, of which 284 met the inclusion criteria. We grouped all Enterobacterales (
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Blood Culture ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Microbial Sensitivity Tests/methods ; Prospective Studies ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/Spectrum.01836-21
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  5. Article ; Online: Comparison of 4 molecular assays for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    Uprety, Priyanka / Mathew, Jeffrey / Weinstein, Melvin P / Kirn, Thomas J

    Diagnostic microbiology and infectious disease

    2020  Volume 99, Issue 2, Page(s) 115196

    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing/methods ; Humans ; Molecular Diagnostic Techniques/methods ; Nasopharynx/virology ; Oropharynx/virology ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-10-17
    Publishing country United States
    Document type Comparative Study ; Letter
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2020.115196
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  6. Article: Positive blood cultures.

    Weinstein, Melvin P

    Clinical advances in hematology & oncology : H&O

    2010  Volume 8, Issue 12, Page(s) 850–851

    MeSH term(s) Bacteremia/drug therapy ; Bacteremia/mortality ; Bacteriological Techniques ; Fungemia/drug therapy ; Fungemia/mortality ; Humans ; Morbidity
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
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  7. Article ; Online: Erythema migrans spares rash of engraftment syndrome.

    Bhowmick, Tanaya / Rasool, Altaf / Desai, Avani / Weinstein, Melvin P

    Transfusion

    2019  Volume 59, Issue 7, Page(s) 2193–2194

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Aged ; Diagnosis, Differential ; Doxycycline/therapeutic use ; Erythema Chronicum Migrans/complications ; Erythema Chronicum Migrans/diagnosis ; Exanthema/complications ; Exanthema/drug therapy ; Graft vs Host Reaction ; Humans ; Lyme Disease/complications ; Lyme Disease/diagnosis ; Lyme Disease/drug therapy ; Male ; Multiple Myeloma/surgery ; Stem Cell Transplantation/adverse effects ; Transplantation Immunology
    Chemical Substances Adrenal Cortex Hormones ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15290
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  8. Article: Comparison of Four Molecular Assays for Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

    Uprety, Priyanka / Mathew, Jeffrey / Weinstein, Melvin P. / Kirn, Thomas J.

    Diagnostic Microbiology and Infectious Disease

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #866636
    Database COVID19

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  9. Article ; Online: Comparison of Four Molecular Assays for Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

    Uprety, Priyanka / Mathew, Jeffrey / Weinstein, Melvin P / Kirn, Thomas J

    Diagnostic Microbiology and Infectious Disease

    2020  , Page(s) 115196

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604920-5
    ISSN 0732-8893
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2020.115196
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Erratum for Cheruvanky et al., Cost-Effectiveness of 30- Compared to 20-Milliliter Blood Cultures: a Retrospective Study.

    Cheruvanky, Anita / Kirn, Thomas J / Weinstein, Melvin P

    Journal of clinical microbiology

    2016  Volume 54, Issue 3, Page(s) 821

    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00004-16
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