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  1. Article ; Online: Cancer Telerehabilitation.

    Chang, Philip / Asher, Arash

    Physical medicine and rehabilitation clinics of North America

    2021  Volume 32, Issue 2, Page(s) 277–289

    Abstract: Telemedicine has clear benefits to the cancer population, including reducing the risk of contracting communicable disease, reaching remote populations, and added convenience. With adequate preparation, cancer rehabilitation telemedicine can serve as a ... ...

    Abstract Telemedicine has clear benefits to the cancer population, including reducing the risk of contracting communicable disease, reaching remote populations, and added convenience. With adequate preparation, cancer rehabilitation telemedicine can serve as a suitable substitute for in-person encounters in several situations. There are limits with technologic deficits, reimbursement questions, and the inability to conduct hands-on physical examinations. It is important to appropriately triage patients to the most suitable visit type, whether telemedicine or in person, with aims of reducing unnecessary risks, monitoring for potential complications, and having productive encounters.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Health Services Accessibility ; Humans ; Immunocompromised Host ; Neoplasms/complications ; Neoplasms/rehabilitation ; Pandemics ; SARS-CoV-2 ; Telerehabilitation/methods
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196791-2
    ISSN 1558-1381 ; 1047-9651
    ISSN (online) 1558-1381
    ISSN 1047-9651
    DOI 10.1016/j.pmr.2020.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can high-intensity interval training impact tumor suppression and inflammatory response in prostate cancer survivors?

    Gresham, Gillian / Raines, Carolina / Asher, Arash / Freedland, Stephen J / Shirazipour, Celina H / Sleight, Alix G

    Prostate cancer and prostatic diseases

    2023  Volume 26, Issue 4, Page(s) 643–645

    MeSH term(s) Male ; Humans ; Cancer Survivors ; Prostate ; Prostatic Neoplasms/therapy ; High-Intensity Interval Training ; Exercise Therapy
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Editorial
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-023-00661-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Targeted Approach to Post-Mastectomy Pain and Persistent Pain following Breast Cancer Treatment.

    Chang, Philip J / Asher, Arash / Smith, Sean R

    Cancers

    2021  Volume 13, Issue 20

    Abstract: Persistent pain following treatment for breast cancer is common and often imprecisely labeled as post-mastectomy pain syndrome (PMPS). PMPS is a disorder with multiple potential underlying causes including intercostobrachial nerve injury, intercostal ... ...

    Abstract Persistent pain following treatment for breast cancer is common and often imprecisely labeled as post-mastectomy pain syndrome (PMPS). PMPS is a disorder with multiple potential underlying causes including intercostobrachial nerve injury, intercostal neuromas, phantom breast pain, and pectoralis minor syndrome. Adding further complexity to the issue are various musculoskeletal pain syndromes including cervical radiculopathy, shoulder impingement syndrome, frozen shoulder, and myofascial pain that may occur concurrently and at times overlap with PMPS. These overlapping pain syndromes may be difficult to separate from one another, but precise diagnosis is essential, as treatment for each pain generator may be distinct. The purpose of this review is to clearly outline different pain sources based on anatomic location that commonly occur following treatment for breast cancer, and to provide tailored and evidence-based recommendations for the evaluation and treatment of each disorder.
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13205191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer.

    Bower, Julienne E / Ganz, Patricia A / Irwin, Michael R / Crespi, Catherine M / Petersen, Laura / Asher, Arash / Hurvitz, Sara A / Cole, Steve W

    Brain, behavior, and immunity

    2024  Volume 118, Page(s) 312–317

    Abstract: Background: Fatigue is a common side effect of cancer and its treatment and is thought to be driven in part by activation of the proinflammatory cytokine network. However, the cellular and molecular underpinnings of cancer-related fatigue (CRF) have not ...

    Abstract Background: Fatigue is a common side effect of cancer and its treatment and is thought to be driven in part by activation of the proinflammatory cytokine network. However, the cellular and molecular underpinnings of cancer-related fatigue (CRF) have not been determined, nor have immune pathways beyond inflammation been carefully investigated. The goal of this study was to examine the association between CRF and activation of canonical proinflammatory gene regulation pathways and Type I interferon (IFN) signaling pathways in breast cancer patients during and after treatment.
    Methods: Women diagnosed with early-stage breast cancer (n = 181) completed assessments before and after treatment with radiation and/or chemotherapy and at 6, 12, and 18-month post-treatment follow-ups. Assessments included self-reported fatigue (Multidimensional Fatigue Symptom Inventory - Short Form) and expression of pre-specified sets of Type I IFN and pro-inflammatory immune response genes determined from mRNA sequencing of PBMCs. Mixed effect linear models examined changes in fatigue and immune gene expression over time and tested the hypothesis that fatigue would be associated with increased expression of Type I IFN and inflammatory response genes.
    Results: There were significant changes in fatigue and immune gene expression across the assessment period; all measures increased from pre- to post-treatment but showed diverging patterns over the follow-up, with declines in fatigue and persistent elevations in Type I IFN and proinflammatory gene expression. In mixed effect linear models, expression of Type I IFN response genes was elevated in association with fatigue across the assessment period, from pre-treatment to 18-month follow-up. In contrast, pro-inflammatory gene expression was associated with fatigue only at 6, 12, and 18-month follow-ups. Analyses controlling for changes in leukocyte subsets continued to show a significant association between fatigue and Type I IFN gene expression but reduced the time-dependent association with pro-inflammatory gene expression to non-significant.
    Conclusions: Results revealed unexpected complexity in the immune underpinnings of CRF and identify a novel role for IFN signaling as a robust contributor to this symptom before, during, and after treatment. Pro-inflammatory gene expression emerged as a predictor of fatigue later in the cancer trajectory, and that effect was primarily accounted for by a concurrent increase in monocyte prevalence.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/complications ; Interferon Type I ; RNA ; Fatigue/genetics ; Inflammation/complications
    Chemical Substances Interferon Type I ; RNA (63231-63-0)
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Feasibility Pilot Study of a Virtual Intervention for Survivors With Decreased Perceived Cognitive Function After Cancer Treatment.

    Myers, Jamie S / Shirazipour, Celina H / Wertheimer, Jeffrey C / Asher, Arash

    Oncology nursing forum

    2022  Volume 49, Issue 1, Page(s) 90–95

    Abstract: Objectives: Many cancer survivors report issues with cognitive function following diagnosis and treatment. The purpose of this single-arm pilot study was to test the feasibility and acceptability of virtual delivery of a cognitive rehabilitation ... ...

    Abstract Objectives: Many cancer survivors report issues with cognitive function following diagnosis and treatment. The purpose of this single-arm pilot study was to test the feasibility and acceptability of virtual delivery of a cognitive rehabilitation intervention for participants in virtual groups.
    Sample & setting: 37 adult cancer survivors reporting impaired cognitive function following primary treatment were enrolled from Cedars-Sinai Medical Center and affiliates, the University of Kansas Cancer Center, and the Masonic Cancer Alliance.
    Methods & variables: Two cohorts attended six weekly virtual sessions and completed pre- and postintervention patient-reported outcome questionnaires designed to measure perceived cognitive function, loneliness, and determinants of behavior change for exercise, sleep, and mindfulness.
    Results: Postintervention scores for perceived cognitive function, determinants of behavior change, and loneliness ratings significantly improved.
    Implications for nursing: Evidence continues to build in support of cognitive rehabilitation interventions for cancer survivors. Nurses play an important role in terms of patient identification, participation, and facilitation.
    MeSH term(s) Adenosine Monophosphate ; Adult ; Cognition ; Feasibility Studies ; Humans ; Neoplasms/therapy ; Pilot Projects ; Survivors
    Chemical Substances Adenosine Monophosphate (415SHH325A)
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/22.ONF.90-95
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Palliative Care Education in US Physical Medicine and Rehabilitation Residency Programs: Current Practices, Perceived Needs, and Barriers.

    Yeh, Jonathan C / Ambady, Leena / Lewis, Ryan / Mehta, Ambereen K / Asher, Arash / Raj, Vishwa S / Engle, Jessica P

    Journal of palliative medicine

    2023  Volume 26, Issue 8, Page(s) 1128–1132

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Internship and Residency ; Palliative Care ; Cross-Sectional Studies ; Physical and Rehabilitation Medicine ; Education, Medical, Graduate ; Surveys and Questionnaires ; Curriculum
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2022.0606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A perspective on a precision approach to pain in cancer; moving beyond opioid therapy.

    Chang, Philip / Amaral, Lauren Julia / Asher, Arash / Clauw, Daniel / Jones, Bronwen / Thompson, Patricia / Warner, Alix Sleight

    Disability and rehabilitation

    2023  , Page(s) 1–10

    Abstract: Purpose: Cancer-related pain is primarily treated with opioids which while effective can add significant patient burden due to side effects, associated stigma, and timely access. The purpose of this perspective discussion is to argue for a precision ... ...

    Abstract Purpose: Cancer-related pain is primarily treated with opioids which while effective can add significant patient burden due to side effects, associated stigma, and timely access. The purpose of this perspective discussion is to argue for a precision approach to pain in cancer based on a biopsychosocial and spiritual model which we argue can offer a higher quality of life while limiting opioid use.
    Conclusions: Pain in cancer represents a heterogenous process with multiple contributing and modulating factors. Specific characterization of pain as either nociceptive, neuropathic, nociplastic, or mixed can allow for targeted treatments. Additional assessment of biopsychosocial and spiritual issues can elucidate further points of targeted intervention which can lead to overall greater pain control.Implications for Rehabilitation
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2023.2212916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Palliative Care and Rehabilitative Medicine: A Call for Greater Collaboration.

    Yeh, Jonathan C / Lewis, Ryan / Mehta, Ambereen K / Asher, Arash / Raj, Vishwa S / Engle, Jessica P

    Journal of palliative medicine

    2021  Volume 24, Issue 10, Page(s) 1422–1423

    MeSH term(s) Hospice and Palliative Care Nursing ; Humans ; Palliative Care
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Letter
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2021.0345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Post-traumatic stress symptoms, post-traumatic stress disorder, and post-traumatic growth among cancer survivors: a systematic scoping review of interventions.

    Capaldi, Jessica M / Shabanian, Julia / Finster, Laurel B / Asher, Arash / Wertheimer, Jeffrey C / Zebrack, Bradley J / Shirazipour, Celina H

    Health psychology review

    2023  Volume 18, Issue 1, Page(s) 41–74

    Abstract: The detrimental effects of Post-Traumatic Stress Symptoms (PTSS) and Post-Traumatic Stress Disorder (PTSD) and the benefits of Post-Traumatic Growth (PTG) are well established for cancer survivors. Increased cancer survival rates necessitate an ... ...

    Abstract The detrimental effects of Post-Traumatic Stress Symptoms (PTSS) and Post-Traumatic Stress Disorder (PTSD) and the benefits of Post-Traumatic Growth (PTG) are well established for cancer survivors. Increased cancer survival rates necessitate an understanding of how these two paradoxical outcomes, PTSS/PTSD and PTG, are targeted through interventions. This systematic scoping review aims to (a) examine existing evidence on interventions targeting PTSS/PTSD and/or PTG among cancer survivors and (b) identify knowledge gaps to inform future research. Following the six steps of a scoping review, 76 articles met the inclusion criteria. Quantitative articles were examined using descriptive analysis. Frequency counts of the collated data were tabulated into summary tables. Qualitative articles were reviewed using meta-synthesis. Most articles were quantitative (n = 52) and targeted PTG (n = 68) through promising intervention approaches such as psychotherapy, mindfulness, physical activity, and psilocybin-assisted therapy. Three key implications for future research and practice were synthesized: (1) mechanistic considerations for intervention design that provide a roadmap for rigorous and theoretically-grounded research; (2) the need for improved representation of cancer survivors in trials; and (3) potential facilitators of intervention efficacy. Together, these findings can direct future research to optimize interventions to reduce PTSS/PTSD and promote PTG achievement among cancer survivors.
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/therapy ; Posttraumatic Growth, Psychological ; Cancer Survivors ; Adaptation, Psychological ; Mindfulness ; Neoplasms/complications
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2364161-7
    ISSN 1743-7202 ; 1743-7199
    ISSN (online) 1743-7202
    ISSN 1743-7199
    DOI 10.1080/17437199.2022.2162947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging From the Haze™: Pilot Feasibility Study Comparing Two Virtual Formats of a Cognitive Rehabilitation Intervention.

    Myers, Jamie S / Wertheimer, Jeffrey C / Kim, Jaromme Geebum / He, Jianghua / Shirazipour, Celina H / Hooper, Dedrick / Penne Mays, Mary / Klemp, Jennifer R / Zegers, Carli / Asher, Arash

    Oncology nursing forum

    2024  Volume 51, Issue 3, Page(s) 223–242

    Abstract: Objectives: To gather feasibility and preliminary data comparing two virtual delivery methods for providing Emerging From the Haze™ (Haze) to cancer survivors compared to waitlist control (WLC).: Sample & setting: Eligible participants (N = 93) ... ...

    Abstract Objectives: To gather feasibility and preliminary data comparing two virtual delivery methods for providing Emerging From the Haze™ (Haze) to cancer survivors compared to waitlist control (WLC).
    Sample & setting: Eligible participants (N = 93) reported cancer-related cognitive impairment following chemotherapy for stage I-III solid tumors, Hodgkin lymphoma, or non-Hodgkin lymphoma.
    Methods & variables: A three-arm randomized design was used to compare virtual live group presentation of Haze sessions, virtual prerecorded Haze group sessions, and WLC. Data were collected at baseline, week 10, and week 14.
    Results: Feasibility was demonstrated. Significant cognitive function improvement at week 10 versus WLC was reported for the live group, and clinical improvement was reported for the prerecorded group. The prerecorded group reported significant improvement at week 14 versus WLC in physical activity, sleep, and health-related quality of life.
    Implications for nursing: Additional pilot and feasibility evidence for cognitive rehabilitation interventions was demonstrated. Prerecorded Haze delivery shows potential for clinical effectiveness and scalability. Future multisite research is warranted.
    MeSH term(s) Humans ; Pilot Projects ; Feasibility Studies ; Female ; Male ; Middle Aged ; Aged ; Cancer Survivors/psychology ; Adult ; Cognitive Dysfunction/rehabilitation ; Cognitive Dysfunction/etiology ; Neoplasms/psychology ; Neoplasms/complications ; Quality of Life/psychology ; Aged, 80 and over ; Cognitive Training
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Comparative Study ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Randomized Controlled Trial
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/24.ONF.223-242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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