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  1. Article ; Online: Oral health, hypertension and cardiovascular diseases.

    Carasol, M / Muñoz Aguilera, E / Ruilope, L M

    Hipertension y riesgo vascular

    2023  Volume 40, Issue 4, Page(s) 167–170

    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Oral Health ; Hypertension/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-05-10
    Publishing country Spain
    Document type Journal Article
    ISSN 1989-4805
    ISSN (online) 1989-4805
    DOI 10.1016/j.hipert.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Counteracting aldosterone in cardiorenal disease in type 2 diabetes through finerenone administration.

    Ruilope, L M / Ruiz-Hurtado, G

    Hipertension y riesgo vascular

    2022  Volume 40, Issue 2, Page(s) 55–57

    MeSH term(s) Humans ; Aldosterone ; Diabetes Mellitus, Type 2/complications ; Naphthyridines ; Heart Diseases
    Chemical Substances Aldosterone (4964P6T9RB) ; finerenone ; Naphthyridines
    Language English
    Publishing date 2022-12-16
    Publishing country Spain
    Document type Journal Article
    ISSN 1989-4805
    ISSN (online) 1989-4805
    DOI 10.1016/j.hipert.2022.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digital therapeutics and lifestyle: the start of a new era in the management of arterial hypertension?

    Ruilope, Luis M / Valenzuela, Pedro L / Lucia, Alejandro

    European heart journal

    2021  Volume 42, Issue 40, Page(s) 4123–4125

    MeSH term(s) Humans ; Hypertension/drug therapy ; Hypertension, Pulmonary ; Life Style
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab694
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  4. Article: Physical Exercise in Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Saco-Ledo, Gonzalo / Valenzuela, Pedro L / Ruilope, Luis M / Lucia, Alejandro

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 893811

    Abstract: Physical exercise reduces blood pressure (BP) in patients with hypertension in general but more evidence is needed specifically for a high-risk phenotype associated with intensive medication, resistant hypertension (RH). In this systematic review and ... ...

    Abstract Physical exercise reduces blood pressure (BP) in patients with hypertension in general but more evidence is needed specifically for a high-risk phenotype associated with intensive medication, resistant hypertension (RH). In this systematic review and meta-analysis, we aimed to summarize current evidence of the exercise effects on BP in patients with RH. A systematic search was conducted in PubMed, Web of Science and Cochrane Library (from inception to 3rd November, 2021). A random effects meta-analysis was performed when at least two trials assessed the effect of either acute or regular exercise (vs. a control condition) on the same outcome. Ten studies (
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.893811
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  5. Article ; Online: Physical activity, chronic kidney disease, and cardiovascular risk: A study in half a million adults.

    Castillo-García, Adrián / Valenzuela, Pedro L / Saco-Ledo, Gonzalo / Morales, Javier S / Ruilope, Luis M / Santos-Lozano, Alejandro / Lucia, Alejandro

    Scandinavian journal of medicine & science in sports

    2024  Volume 34, Issue 1, Page(s) e14557

    Abstract: ... estimated glomerular filtration rate <60 mL/min/1.73 m: Results: 517 917 participants (44 ± 9 years, 67 ...

    Abstract Objective: There is a growing prevalence of chronic kidney disease (CKD), a condition associated with a higher cardiovascular disease (CVD) risk. We assessed the association between self-reported physical activity (PA) and CKD and also studied whether PA attenuates CKD-associated CVD risk.
    Methods: A cohort of Spanish adults (18-64 years) participated in this nationwide study. Participants were categorized at baseline as being either inactive (performing no PA), regularly, or insufficiently active (meeting or not, respectively, international PA recommendations) and were followed for up to 5 years. The presence of CKD (estimated glomerular filtration rate <60 mL/min/1.73 m
    Results: 517 917 participants (44 ± 9 years, 67% male, CKD prevalence = 7%) were studied at baseline, with prospective analyses (median follow-up = 2 years, range = 2-5) in a subcohort of 264 581 individuals. Compared to physical inactivity, cross-sectional analyses at baseline showed that regular PA (odds ratio = 0.80; 95% confidence interval = 0.79-0.81), but not insufficient PA (1.02; 0.99-1.04) was associated with lower CKD prevalence. However, prospective analyses failed to confirm this association (p > 0.1). In turn, CKD was associated with a higher prevalence of hypertension (+3%) and diabetes (+5%) at baseline and with a greater incidence of hypertension at follow-up (+37%). Among those participants with CKD, regular PA was associated with a lower prevalence (-45% to -7%) and incidence (-38% to -4%) of all CVD risk factors.
    Conclusion: Although PA might not reduce incident CKD in the middle term (~2 years), it can attenuate the CVD risk linked to this condition.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Cardiovascular Diseases/epidemiology ; Cross-Sectional Studies ; Prospective Studies ; Risk Factors ; Heart Disease Risk Factors ; Exercise ; Hypertension/epidemiology ; Renal Insufficiency, Chronic/epidemiology ; Diabetes Mellitus
    Language English
    Publishing date 2024-01-24
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1077418-x
    ISSN 1600-0838 ; 0905-7188
    ISSN (online) 1600-0838
    ISSN 0905-7188
    DOI 10.1111/sms.14557
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    Zs.A 3247: Show issues Location:
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  6. Article ; Online: Lifestyle and cardiovascular risk in working young adults: insights from a nationwide Spanish cohort.

    Castillo-García, Adrián / Valenzuela, Pedro L / Saco-Ledo, Gonzalo / Carrera-Bastos, Pedro / Ruilope, Luis M / Santos-Lozano, Alejandro / Lucia, Alejandro

    Revista espanola de cardiologia (English ed.)

    2024  

    Abstract: Introduction and objectives: This study aimed to describe the cardiovascular risk profile of working young adults from Spain and its association with lifestyle.: Methods: Participants (18-30 years) were recruited from a nationwide cohort of ... ...

    Abstract Introduction and objectives: This study aimed to describe the cardiovascular risk profile of working young adults from Spain and its association with lifestyle.
    Methods: Participants (18-30 years) were recruited from a nationwide cohort of economically active adults insured by a large occupational risk prevention company, with data obtained from routine medical assessments. The participants were categorized as having an "unhealthy" cardiovascular risk profile based on the presence of prediabetes/diabetes, prehypertension/hypertension, or hypercholesterolemia, or a "healthy" profile if these conditions were completely absent. The association with lifestyle factors (weight, physical activity, sleeping characteristics, alcohol consumption, smoking) was assessed.
    Results: A total of 78 421 young adults (27±2 years, 36% female) were evaluated at baseline. The "unhealthy" cardiovascular risk profile was prevalent (18%) and inversely associated (OR, 0.64; 95%CI, 0.57-0.80) with an optimal lifestyle (normal weight, regular physical activity, no drinking/smoking, and good sleep). The latter condition was found in only 3.5% of the participants. On the other hand, prospective analyses in 44 776 participants (median follow-up=2 [range 2-5] years) showed that 2.0% transitioned from a "healthy" to an "unhealthy" profile. Being physically active (OR, 0.95; 95%CI, 0.81-0.99) and having a normal weight (OR, 0.61; 95%CI, 0.51-0.70) were associated with a lower likelihood of this transition. No consistent associations were found for other lifestyle factors.
    Conclusions: The prevalence of cardiovascular risk factors is high in economically active young Spanish adults. An unhealthy cardiovascular risk profile is inversely associated with an optimal lifestyle, but the latter is highly infrequent in this population.
    Language Spanish
    Publishing date 2024-02-27
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.02.006
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  7. Article ; Online: Estudio de mortalidad del Registro español de monitorización ambulatoria de la presión arterial. Una llamada a la traslación de la monitorización ambulatoria de la presión arterial a la práctica clínica.

    Banegas, J R / Ruilope, L M

    Hipertension y riesgo vascular

    2018  

    Title translation Mortality study from the Spanish Registry of ABPM. An appeal for the transition of ABPM to clinical practice.
    Language Spanish
    Publishing date 2018-06-13
    Publishing country Spain
    Document type Journal Article
    ISSN 1989-4805
    ISSN (online) 1989-4805
    DOI 10.1016/j.hipert.2018.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Muscling in on Resistant Hypertension.

    Valenzuela, Pedro L / Ruilope, Luis M / Lucia, Alejandro

    Circulation

    2020  Volume 141, Issue 4, Page(s) 240–242

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Drug Resistance ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.044378
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    Ui IV Zs.60: Show issues Location:
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  9. Article ; Online: Management of hypertension in the very old: aggressive reduction of blood pressure is harmful in most patients.

    Ruilope, L M / Ruiz-Hurtado, G

    Journal of human hypertension

    2020  Volume 34, Issue 8, Page(s) 557–559

    Abstract: Arterial hypertension is particularly prevalent in the elderly and treatment is required according to the literature. Treatment in subjects between 65 and 80 years of age resembles by characteristics and results that obtained in younger population. The ... ...

    Abstract Arterial hypertension is particularly prevalent in the elderly and treatment is required according to the literature. Treatment in subjects between 65 and 80 years of age resembles by characteristics and results that obtained in younger population. The treatment of arterial hypertension in the very elderly differs in a relevant percentage of them. It is quite similar in those with a good physical fitness with or without cardiovascular disease. A series of factors as the presence of real sustained hypertension, orthostatic hypotension, frailty and disability, and the boundary of safety recommended by international recent guidelines analysed here are relevant to characterize a clearly elevated risk of complications in the remaining very elderly patients.
    MeSH term(s) Aged ; Blood Pressure ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypotension, Orthostatic
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-020-0346-0
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    Zs.A 2380: Show issues Location:
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  10. Article ; Online: Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation.

    Valenzuela, Pedro L / Ruilope, Luis M / Santos-Lozano, Alejandro / Wilhelm, Matthias / Kränkel, Nicolle / Fiuza-Luces, Carmen / Lucia, Alejandro

    European heart journal

    2023  Volume 44, Issue 21, Page(s) 1874–1889

    Abstract: There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but ... ...

    Abstract There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but also in secondary prevention. This review discusses some of the main cardiovascular effects of PA/exercise and the mechanisms involved, including a healthier metabolic milieu with attenuation of systemic chronic inflammation, as well as adaptations at the vascular (antiatherogenic effects) and heart tissue (myocardial regeneration and cardioprotection) levels. The current evidence for safe implementation of PA and exercise in patients with CVD is also summarized.
    MeSH term(s) Humans ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/epidemiology ; Cardiovascular System ; Exercise ; Heart ; Inflammation ; Risk Factors
    Language English
    Publishing date 2023-04-02
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 640: Show issues

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