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Article ; Online: Intracystic Papillary Neoplasm of Gallbladder Mimicking Metastatic Malignancy on PET/CT.

Ismail, Rasha / Saeed Bamashmos, Anas / Cohen, Paul J / Pucar, Darko

2020 Volume 46, Issue 7, Page(s) e363–e364

Abstract: Abstract: Intracystic papillary neoplasm of the gallbladder is a rare preinvasive neoplastic lesion with similar characteristics as intraductal papillary mucinous neoplasm and other papillary neoplasms of pancreaticobiliary system. We report a case of ... ...

Abstract	Abstract: Intracystic papillary neoplasm of the gallbladder is a rare preinvasive neoplastic lesion with similar characteristics as intraductal papillary mucinous neoplasm and other papillary neoplasms of pancreaticobiliary system. We report a case of 48-year-old woman with a history of recurrent right flank chondrosarcoma and gallbladder lesion on MRI and PET/CT interpreted as indeterminate for metastatic disease. Subsequent cholecystectomy showed intracystic papillary neoplasm. With gallbladder lesions being rare on PET/CT, this case illustrates the importance of considering both primary and secondary tumors in the differential diagnosis.
MeSH term(s)	Diagnosis, Differential ; Female ; Gallbladder Neoplasms/diagnostic imaging ; Gallbladder Neoplasms/pathology ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm Metastasis ; Positron Emission Tomography Computed Tomography
Language	English
Publishing date	2020-11-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003442
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Article: Investigating Potential Cancer Therapeutics: Insight into Histone Deacetylases (HDACs) Inhibitions.

Ahmad, Basharat / Saeed, Aamir / Al-Amery, Ahmed / Celik, Ismail / Ahmed, Iraj / Yaseen, Muhammad / Khan, Imran Ahmad / Al-Fahad, Dhurgham / Bhat, Mashooq Ahmad

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: Histone deacetylases (HDACs) are enzymes that remove acetyl groups from ɛ-amino of histone, and their involvement in the development and progression of cancer disorders makes them an interesting therapeutic target. This study seeks to discover new ... ...

Abstract	Histone deacetylases (HDACs) are enzymes that remove acetyl groups from ɛ-amino of histone, and their involvement in the development and progression of cancer disorders makes them an interesting therapeutic target. This study seeks to discover new inhibitors that selectively inhibit HDAC enzymes which are linked to deadly disorders like T-cell lymphoma, childhood neuroblastoma, and colon cancer. MOE was used to dock libraries of ZINC database molecules within the catalytic active pocket of target HDACs. The top three hits were submitted to MD simulations ranked on binding affinities and well-occupied interaction mechanisms determined from molecular docking studies. Inside the catalytic active site of HDACs, the two stable inhibitors LIG1 and LIG2 affect the protein flexibility, as evidenced by RMSD, RMSF, Rg, and PCA. MD simulations of HDACs complexes revealed an alteration from extended to bent motional changes within loop regions. The structural deviation following superimposition shows flexibility via a visual inspection of movable loops at different timeframes. According to PCA, the activity of HDACs inhibitors induces structural dynamics that might potentially be utilized to define the nature of protein inhibition. The findings suggest that this study offers solid proof to investigate LIG1 and LIG2 as potential HDAC inhibitors.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040444
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Article ; Online: Blue rubber bleb naevus syndrome: a rare cause of iron deficiency anaemia.

Saeed, Ismail D / Kheroo, Khalid N / Abdullah, Thamer Jaber / Salih, Khalaf Ali

BMJ case reports

2014 Volume 2014

Abstract: We report a case in an adolescent male patient with a history of chronic fatigue, headache and unexplained iron deficiency anaemia since 2007. Numerous bluish-black lesions were found over his body surface. A surgical scar from a previous lumpectomy with ...

Abstract	We report a case in an adolescent male patient with a history of chronic fatigue, headache and unexplained iron deficiency anaemia since 2007. Numerous bluish-black lesions were found over his body surface. A surgical scar from a previous lumpectomy with a small lump were noted at the left submandibular region and another smaller lesion on the left lobe of the thyroid was also palpated. His most recent blood indices displayed the presence of moderately severe iron deficiency anaemia. Endoscopic evaluation exhibited multiple vascular lesions throughout the gastrointestinal tract. MRI of the brain revealed an irregular intracranial vascular lesion at the cerebellopontine angle. Further work-up with abdominal CT demonstrated the absence of similar lesions in the extraintestinal abdominal organs. Putting these together with histological findings, the diagnosis of blue rubber bleb naevus syndrome was confirmed. The patient was treated conservatively at this point and future management planning was discussed with him.
MeSH term(s)	Adolescent ; Anemia, Iron-Deficiency/etiology ; Endoscopy, Gastrointestinal ; Gastrointestinal Neoplasms/diagnosis ; Humans ; Male ; Nevus, Blue/diagnosis ; Skin Neoplasms/diagnosis
Language	English
Publishing date	2014-11-11
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2014-205144
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Article ; Online: Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review.

Communications medicine

2024 Volume 4, Issue 1, Page(s) 66

Abstract: Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D ... ...

Abstract	Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Results: Here we show that 152 studies that met extraction criteria most commonly characterized heterogeneity before diagnosis (91/152). Autoantibody type/target was most frequently examined, followed by autoantibody number. Recurring themes included correlations of autoantibody number, type, and titers with progression, differing phenotypes based on order of autoantibody seroconversion, and interactions with age and genetics. Only 44% specifically described autoantibody assay standardization program participation. Conclusions: Current evidence most strongly supports the application of autoantibody features to more precisely define T1D before diagnosis. Our findings support continued use of pre-clinical staging paradigms based on autoantibody number and suggest that additional autoantibody features, particularly in relation to age and genetic risk, could offer more precise stratification. To improve reproducibility and applicability of autoantibody-based precision medicine in T1D, we propose a methods checklist for islet autoantibody-based manuscripts which includes use of precision medicine MeSH terms and participation in autoantibody standardization workshops.
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-024-00478-y
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Article: Myco-Synthesis of Silver Nanoparticles and Their Bioactive Role against Pathogenic Microbes.

Abdel-Hadi, Ahmed / Iqbal, Danish / Alharbi, Raed / Jahan, Sadaf / Darwish, Omar / Alshehri, Bader / Banawas, Saeed / Palanisamy, Manikanadan / Ismail, Ahmed / Aldosari, Sahar / Alsaweed, Mohammed / Madkhali, Yahya / Kamal, Mehnaz / Fatima, Faria

Biology

2023 Volume 12, Issue 5

Abstract: Nanotechnology based on nanoscale materials is rapidly being used in clinical settings, particularly as a new approach for infectious illnesses. Recently, many physical/chemical approaches utilized to produce nanoparticles are expensive and highly unsafe ...

Abstract	Nanotechnology based on nanoscale materials is rapidly being used in clinical settings, particularly as a new approach for infectious illnesses. Recently, many physical/chemical approaches utilized to produce nanoparticles are expensive and highly unsafe to biological species and ecosystems. This study demonstrated an environmentally friendly mode of producing nanoparticles (NPs) where
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12050661
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Article: Facile synthesis, crystal structure, biological evaluation, and molecular modeling studies of

Saeed, Aamer / Ejaz, Syeda Abida / Khalid, Aqsa / Channar, Pervaiz Ali / Aziz, Mubashir / Wani, Tanveer A / Zargar, Seema / Hassan, Sidra / Ismail, Hammad / Khalid, Dania / Hashmi, Muhammad Zaffar / Hökelek, Tuncer / Aborode, Abdullahi Tunde

Frontiers in chemistry

2022 Volume 10, Page(s) 992701

Abstract: The crystal structure ... ...

Abstract	The crystal structure of
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.992701
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Article: As simple as it sounds? The treatment of simple bone cysts in the proximal femur in children and adolescents: Retrospective multicenter EPOS study of 74 patients.

van Geloven, Thomas Pg / van der Heijden, Lizz / Laitinen, Minna K / Campanacci, Domenico A / Döring, Kevin / Dammerer, Dietmar / Badr, Ismail T / Haara, Mikko / Beltrami, Giovanni / Hobusch, Gerhard M / Kraus, Tanja / Scheider, Philipp / Soto-Montoya, Camilo / Umer, Masood / Saeed, Javeria / Funovics, Phillipp T / Fiocco, Marta / van de Sande, Michiel Aj / de Witte, Pieter Bas

Journal of children's orthopaedics

2024 Volume 18, Issue 1, Page(s) 85–95

Abstract: Purpose: Simple bone cysts are among the most prevalent benign cystic tumor-like lesions in children. Proximal femoral simple bone cysts may require specific treatment because of increased fracture risk. With limited literature available on this ... ...

Abstract	Purpose: Simple bone cysts are among the most prevalent benign cystic tumor-like lesions in children. Proximal femoral simple bone cysts may require specific treatment because of increased fracture risk. With limited literature available on this specific localization, consensus regarding optimal treatment is lacking. We present a large international multicenter retrospective cohort study on proximal femoral simple bone cysts. Methods: All consecutive pediatric patients with proximal femoral simple bone cyst from 10 tertiary referral centers for musculoskeletal oncology were included (2000-2021). Demographics, primary treatment, complications, and re-operations were evaluated. Primary outcomes were time until full weight-bearing and failure-free survival. Results: Overall, 74 simple bone cyst patients were included (median age 9 years (range = 2-16), 56 (76%) male). Median follow-up was 2.9 years (range = 0.5-21). Index procedure was watchful waiting (n = 6), percutaneous procedure (n = 12), open procedure (n = 50), or osteosynthesis alone (n = 6). Median time until full weight-bearing was 8 weeks (95% confidence interval = 0.1-15.9) for watchful waiting, 9.5 (95% confidence interval = 3.7-15.3) for percutaneous procedure, 11 (95% confidence interval = -0.7 to 13.7) for open procedure, and 6.5 (95% confidence interval = 5.9-16.1) for osteosynthesis alone (p = 0.58). Failure rates were 33%, 58%, 29%, and 0%, respectively (p = 0.069). Overall failure-free survival at 1, 2, and 5 years was 77.8% (95% confidence interval = 68.2-87.4), 69.5% (95% confidence interval = 58.5-80.5), and 62.0% (95% confidence interval = 47.9-76.1), respectively. Conclusion: A preferred treatment for proximal femoral simple bone cysts remains unclear, with comparable failure rates and times until full weight-bearing. Watchful waiting may be successful in certain cases. If not feasible, osteosynthesis alone can be considered. Treatment goals should be cyst control, minimizing complications and swift return to normal activities. Therefore, an individualized balance should be made between undertreatment, with potentially higher complication risks versus overtreatment, resulting in possible larger interventions and accompanying complications. Level of evidence: Level IV, retrospective multicentre study.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2279410-4
ISSN	1863-2548 ; 1863-2521
ISSN (online)	1863-2548
ISSN	1863-2521
DOI	10.1177/18632521231221553
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Zs.A 6613: Show issues

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Article ; Online: Nutritional perspectives for the prevention and mitigation of COVID-19.

Akhtar, Saeed / Das, Jai K / Ismail, Tariq / Wahid, Muqeet / Saeed, Wisha / Bhutta, Zulfiqar A

Nutrition reviews

2021 Volume 79, Issue 3, Page(s) 289–300

Abstract: ... D, zinc, iron, and selenium, are common among vulnerable populations in general and among COVID-19 ...

Abstract	Worldwide, there is an array of clinical trials under way to evaluate treatment options against coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2. Concurrently, several nutritional therapies and alternative supportive treatments are also being used and tested to reduce the mortality associated with acute respiratory distress in patients with COVID-19. In the context of COVID-19, improved nutrition that includes micronutrient supplementation to augment the immune system has been recognized as a viable approach to both prevent and alleviate the severity of the infection. The potential role of micronutrients as immune-boosting agents is particularly relevant for low- and middle-income countries, which already have an existing high burden of undernutrition and micronutrient deficiencies. A systematic literature review was performed to identify nutritional interventions that might prevent or aid in the recovery from COVID-19. The PubMed, ScienceDirect, Cochrane, Scopus, Web of Science, and Google Scholar databases were searched electronically from February to April 2020. All abstracts and full-text articles were examined for their relevance to this review. The information gathered was collated under various categories. Deficiencies of micronutrients, especially vitamins A, B complex, C, and D, zinc, iron, and selenium, are common among vulnerable populations in general and among COVID-19 patients in particular and could plausibly increase the risk of mortality. Judicious use of need-based micronutrient supplementation, alongside existing micronutrient fortification programs, is warranted in the current global pandemic, especially in low- and middle-income economies.
MeSH term(s)	COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/therapy ; Diet ; Dietary Supplements ; Humans ; Immune System ; Iron ; Micronutrients ; Nutrition Therapy/methods ; Nutritional Status ; Selenium ; Trace Elements ; Vitamin A ; Zinc
Chemical Substances	Micronutrients ; Trace Elements ; Vitamin A (11103-57-4) ; Iron (E1UOL152H7) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	82067-2
ISSN	1753-4887 ; 0029-6643
ISSN (online)	1753-4887
ISSN	0029-6643
DOI	10.1093/nutrit/nuaa063
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Zs.A 3388: Show issues

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Article ; Online: Compartmental approach for modelling twin-screw granulation using population balances.

Ismail, Hamza Y / Shirazian, Saeed / Singh, Mehakpreet / Whitaker, Darren / Albadarin, Ahmad B / Walker, Gavin M

International journal of pharmaceutics

2019 Volume 576, Page(s) 118737

Abstract: In this study, a compartmental population balance model (CPBM) is developed as a predictive tool of particle size distribution (PSD) for wet granulation in co-rotating twin-screw granulator (TSG). This model is derived in terms of liquid to solid ratio ( ... ...

Abstract	In this study, a compartmental population balance model (CPBM) is developed as a predictive tool of particle size distribution (PSD) for wet granulation in co-rotating twin-screw granulator (TSG). This model is derived in terms of liquid to solid ratio (L/S) and screw speed representing the main process parameters of the TSG. The mathematical model accounts for aggregation and breakage of the particles occurring in five compartments of the TSG with inhomogeneous screw configurations (3 conveying zones and 2 kneading zones). Kapur's aggregation kernel is implemented in granulation and finite volume numerical method is adapted for solving the mathematical model. The results show a dramatic improvement in solution accuracy compared to the cell average numerical method. Moreover, Kriging interpolation is used to interpolate for new values of empirical parameters at different L/S and screw speeds. Finally, the CPBM model is calibrated and validated using the experimental data.
MeSH term(s)	Bone Screws ; Calibration ; Models, Theoretical ; Particle Size ; Technology, Pharmaceutical/methods
Language	English
Publishing date	2019-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2019.118737
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Zs.A 1409: Show issues

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Article ; Online: Strengthening laboratories in response to outbreaks in humanitarian emergencies and conflict settings: Results, challenges and lessons from expanding PCR diagnostic capacities for COVID-19 testing in Yemen.

Bashir, Ismail Mahat / Al-Waleedi, Ali Ahmed / Al-Shaibani, Saeed Mohamed / Rajamanar, Mohammed / Al-Akbari, Shougi / Al-Harazi, Abdulelah / Salim Aliwah, Layla / Ahmed Salem, Nahed / Al-Ademi, Dina / Barakat, Amal / Sarkis, Nicole / Abubakar, Abdinasir / Senga, Mikiko / Musani, Altaf / Abdel Moneim, Adham Rashad Ismail / Mahmoud, Nuha

PloS one

2024 Volume 19, Issue 2, Page(s) e0298603

Abstract: Background: When the COVID-19 pandemic was declared, Yemen, a country facing years of conflict had only one laboratory with PCR testing capacity. In this article, we describe the outcome of the implementation of molecular based diagnostics platform in ... ...

Abstract	Background: When the COVID-19 pandemic was declared, Yemen, a country facing years of conflict had only one laboratory with PCR testing capacity. In this article, we describe the outcome of the implementation of molecular based diagnostics platform in Yemen and highlight the key milestones the country went through to increase access to testing for its populations residing in a geographically vast and politically divided country. Methods: A retrospective assessment of COVID-19 laboratory response activities was done detailing the needs assessment process, timelines, geographical coverage, and outcomes of the activities. Laboratory data was analyzed to construct the geographical locations of COVID-19 testing laboratories and the numbers of tests performed in each facility to highlight the demands of testing for travelers. Finally, we discuss the impact these activities had in enabling the movement of people across international borders for economic gains and in delivery of critical humanitarian aid. Outcome: PCR testing capacities in Yemen significantly improved, from one laboratory in Sanaa in April 2020 to 18 facilities across the country by June 2022. In addition, the number of functional Real-Time PCR thermocyclers increased from one to 32, the PCR tests output per day improved from 192 to 6144 tests per day. Results from analysis of laboratory data showed there were four peaks of COVID-19 in Yemen as October 2022. The majority of laboratory tests were performed for travelers than for medical or public health reasons. Demand for laboratory testing in Yemen was generally low and waned over time as the perceived risk of COVID-19 declined, in parallel with rollout of the COVID-19 vaccines. Discussion/conclusion: The successful expansion of laboratory testing capacity was instrumental in the control and management of COVID-19 cases and critical in the implementation of public response strategies, including restrictions on gathering. Laboratory testing also facilitated the movement of humanitarian agencies and delivery of aid and enabled hundreds of thousands of Yemeni nationals to travel internationally. By virtue of these outcomes, the impact of laboratory strengthening activities was thus felt in the health sector and beyond.
MeSH term(s)	Humans ; Yemen/epidemiology ; COVID-19 Testing ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Vaccines ; Laboratories ; Emergencies ; Pandemics ; Retrospective Studies ; Disease Outbreaks/prevention & control ; Polymerase Chain Reaction
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298603
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