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  1. Article ; Online: Greetings from the endoplasmic reticulum (ER): escaping ER thiol isomerases regulate thrombosis.

    Kehrel, B E / Fender, A C

    Journal of thrombosis and haemostasis : JTH

    2018  Volume 16, Issue 2, Page(s) 364–366

    MeSH term(s) Animals ; Endoplasmic Reticulum ; Isomerases ; Membrane Glycoproteins ; Sulfhydryl Compounds ; Thrombosis
    Chemical Substances Membrane Glycoproteins ; Sulfhydryl Compounds ; endoplasmic reticulum glycoprotein p72 ; Isomerases (EC 5.-)
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.13916
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  2. Article ; Conference proceedings: Some Plasma Derived FVIII Concentrates Activated FXII Leading to Kallikrein and Bradykinin Formation In vitro, while Recombinant FVIII Concentrates did not

    Brodde, M. / Oenning, S. / Kehrel, B.E.

    Hämostaseologie

    2019  Volume 39, Issue S 01

    Event/congress 63rd Annual Meeting of the Society of Thrombosis and Haemostasis Research, Berlin, Germany, 2019-02-27
    Language English
    Publishing date 2019-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0039-1680230
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  3. Article: Blutplättchen: Biochemie und Physiologie.

    Kehrel, B E

    Hamostaseologie

    2008  Volume 28, Issue 5, Page(s) 289–298

    Abstract: This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, ... ...

    Title translation Platelets: biochemistry and physiology.
    Abstract This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is presented. The different signal transduction pathways in platelets are a main focus of this review.
    MeSH term(s) Blood Platelets/cytology ; Blood Platelets/metabolism ; Blood Platelets/physiology ; Endothelium, Vascular/physiology ; Fibrin/physiology ; Fibrinogen/physiology ; Hemostasis/physiology ; Humans ; Platelet Adhesiveness ; Platelet Aggregation ; Signal Transduction ; Thrombin/metabolism ; Thromboembolism/blood ; von Willebrand Factor/physiology
    Chemical Substances von Willebrand Factor ; Fibrin (9001-31-4) ; Fibrinogen (9001-32-5) ; Thrombin (EC 3.4.21.5)
    Language German
    Publishing date 2008-12
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 0720-9355
    ISSN 0720-9355
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  4. Article ; Online: Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow.

    Schönichen, Claudia / Montague, Samantha J / Brouns, Sanne L N / Burston, James J / Cosemans, Judith M E M / Jurk, Kerstin / Kehrel, Beate E / Koenen, Rory R / Ní Áinle, Fionnuala / O'Donnell, Valerie B / Soehnlein, Oliver / Watson, Steve P / Kuijpers, Marijke J E / Heemskerk, Johan W M / Nagy, Magdolna

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 9, Page(s) 1700–1712

    Abstract: Background: Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of thrombotic events. We aimed to identify key interaction mechanisms between these ... ...

    Abstract Background: Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of thrombotic events. We aimed to identify key interaction mechanisms between these cells using microfluidic approaches.
    Methods: Whole-blood perfusion was performed over a collagen surface at arterial shear rate. Platelet and leukocyte (in majority neutrophil) activation were microscopically visualized using fluorescent markers. The contributions of platelet-adhesive receptors (integrin, P-selectin, CD40L) and chemokines were studied by using inhibitors or antibodies and using blood from patients with GT (Glanzmann thrombasthenia) lacking platelet-expressed αIIbβ3.
    Results: We observed (1) an unknown role of activated platelet integrin αIIbß3 preventing leukocyte adhesion, which was overcome by short-term flow disturbance provoking massive adhesion; (2) that platelet-expressed CD40L controls the crawling pattern and thrombus fidelity of the cells on a thrombus; (3) that continued secretion of platelet substances promotes activation of identified neutrophils, as assessed by (fMLP [
    Conclusions: Together, these findings reveal a multifaceted regulation of adhesion and activation of neutrophils by platelets in a thrombus, with a balanced role of several platelet-adhesive receptors and a promoting role of platelet-released substances. This multivalent nature of neutrophil-thrombus interactions offers novel prospects for pharmacological intervention.
    MeSH term(s) Blood Platelets/immunology ; Blood Platelets/metabolism ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; Chemokines/metabolism ; Thrombosis/immunology ; Neutrophil Activation ; CD40 Ligand ; Neutrophils/immunology ; Neutrophils/metabolism ; Cell Adhesion ; Humans ; Arteries
    Chemical Substances Platelet Glycoprotein GPIIb-IIIa Complex ; Chemokines ; CD40 Ligand (147205-72-9)
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318767
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  5. Article: Blutplättchen: biochemie und physiologie.

    Kehrel, B E

    Hamostaseologie

    2003  Volume 23, Issue 4, Page(s) 149–158

    Abstract: This article reviews the roles of blood platelets in different physiologic and pathologic processes in the human body. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the ... ...

    Title translation Blood platelets: biochemistry and physiology.
    Abstract This article reviews the roles of blood platelets in different physiologic and pathologic processes in the human body. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is presented. The different signal transduction pathways in platelets are a main focus of this review.
    MeSH term(s) Blood Platelets/cytology ; Blood Platelets/metabolism ; Blood Platelets/physiology ; Clot Retraction ; Humans ; Platelet Adhesiveness ; Platelet Aggregation ; Reference Values
    Language German
    Publishing date 2003-11
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 0720-9355
    ISSN 0720-9355
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  6. Article: Blutplättchen: Biochemie und Physiologie. Platelets: Biochemistry und physiology

    Kehrel, B. E.

    Hämostaseologie

    2008  Volume 28, Issue 5, Page(s) 289

    Language German
    Document type Article
    ZDB-ID 801512-0
    ISSN 0720-9355
    Database Current Contents Medicine

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  7. Article ; Online: Pathophysiologie und Biochemie der Thrombozyten.

    Jurk, K / Kehrel, B E

    Der Internist

    2010  Volume 51, Issue 9, Page(s) 1086, 1088–92, 1094

    Abstract: ... However, they are probably involved in early stages of arteriosclerosis, e.g. extravasation of leukocytes at sites ...

    Title translation Pathophysiology and biochemistry of platelets.
    Abstract Although their central role is to control bleeding and to induce thrombosis, platelets are important inflammatory and immune cells as well as modulators of angiogenesis. This review focuses on the different roles of platelets in hemostasis, thrombosis, inflammation, arteriosclerosis, angiogenesis, antimicrobial host defense and hematogenous tumor metastasis. Platelets are the central regulators of hemostasis. On their surface the important thrombin burst takes place. Platelets cause atherothrombotic vascular occlusions. However, they are probably involved in early stages of arteriosclerosis, e.g. extravasation of leukocytes at sites of vascular injury, formation of foam cells and proliferation of smooth muscle cells. These processes are triggered by secretion of proinflammatory substances and growth factors as well as by platelet-cell interactions via specific adhesive axes. During infections platelets kill pathogens through secretion of antimicrobial substances and extracellular traps or nets. Platelets facilitate the revascularisation of ischemic tissue and therefore even promote tumor growth.
    MeSH term(s) Arteriosclerosis/blood ; Blood Platelet Disorders/blood ; Blood Platelets/physiology ; Hemostasis/physiology ; Humans ; Immunity, Cellular/physiology ; Inflammation/blood ; Neoplastic Cells, Circulating ; Neovascularization, Physiologic/physiology ; Thrombosis/blood
    Language German
    Publishing date 2010-08-05
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-010-2595-4
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  8. Article: Blutplättchen

    Kehrel, B. E.

    Hämostaseologie

    2008  Volume 28, Issue 05, Page(s) 289–298

    Abstract: Der Übersichtsartikel beschäftigt sich mit den verschiedenen Rollen der Blutplättchen in physiologischen und pathologischen Prozessen der Hämostase und der Entstehung thromboembolischer Erkrankungen. Neben Kernprozessen der primären Hämostase, ... ...

    Abstract Der Übersichtsartikel beschäftigt sich mit den verschiedenen Rollen der Blutplättchen in physiologischen und pathologischen Prozessen der Hämostase und der Entstehung thromboembolischer Erkrankungen. Neben Kernprozessen der primären Hämostase, Plättchenadhäsion, Plättchen - sekretion, Plättchenaggregation, Gerinnselretraktion wird die moderne Sicht der Bildung von Thrombin auf der Thrombozytenoberfläche geschildert. Ein Schwerpunkt liegt in der Darstellung der verschiedenen Signaltransduktionswege in den Plättchen.

    This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is presented. The different signal transduction pathways in platelets are a main focus of this review.
    Keywords Plättchenadhäsion ; Plättchenaggregation ; prokoagulanter Zustand ; Plättchen-Leukozyten-Interaktion ; Plättchen- Gefäßwand-Interaktion ; Platelet adhesion ; platelet aggregation ; platelet procoagulant activity ; platelet interaction with cells
    Language German
    Publishing date 2008-05-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0037-1617177
    Database Thieme publisher's database

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  9. Article ; Online: Die Rolle von Thrombozyten bei Hämostase, Thrombose, Immunabwehr und Entzündung.

    Jurk, K / Kehrel, B E

    Deutsche medizinische Wochenschrift (1946)

    2008  Volume 133, Issue 21, Page(s) 1130–1135

    Abstract: The views on the role of platelets in physiology and in pathogenesis have considerably changed in the recent past. While platelets had previously been seen only as contributors in primary haemostasis and as donors of negatively charged phospholipids to ... ...

    Title translation The role of platelets in haemostasis, thrombosis, immune defense and inflammation.
    Abstract The views on the role of platelets in physiology and in pathogenesis have considerably changed in the recent past. While platelets had previously been seen only as contributors in primary haemostasis and as donors of negatively charged phospholipids to support thrombin formation, this view has had to be revised, at least since the discovery of specific receptors for coagulation factors on the platelet surface. Platelets are part of the body's immune defence system. They can interact with bacteria, pathogenic fungi and protozoa. The interaction of platelets with endothelial cells and leukocytes is crucial in innate and adaptive immunity. Platelets participate in the pathogenesis of the initial lesions and in the progression of atherosclerosis by inducing chronic inflammatory processes at the vascular wall, which result in the development of atherosclerotic lesions and atherothrombosis.
    MeSH term(s) Atherosclerosis/physiopathology ; Blood Platelet Disorders/physiopathology ; Blood Platelets/physiology ; Hemorrhage/physiopathology ; Hemostasis/physiology ; Humans ; Inflammation/physiopathology ; Platelet Activation ; Thrombosis/physiopathology
    Language German
    Publishing date 2008-05
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-2008-1077228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: State of the art in platelet function testing.

    E Kehrel, Beate / F Brodde, Martin

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2013  Volume 40, Issue 2, Page(s) 73–86

    Abstract: Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This review ... ...

    Abstract Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This review will summarize the different fields in which platelet function testing is currently in use; diagnostics of patients with bleeding disorders, monitoring patients' response to anti-platelet therapy, monitoring in transfusion medicine (blood donors, platelet concentrates, and after transfusion), and monitoring in perioperative medicine to predict bleeding tendency. The second part of the review outlines different methods for platelet function testing, spanning bleeding time, and platelet counting as well as determining platelet adhesion, platelet secretion, platelet aggregation, platelet morphology, platelet signal transduction, platelet procoagulant activity, platelet apoptosis, platelet proteomics, and molecular biology.
    Language English
    Publishing date 2013-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000350469
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