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  1. Article ; Online: FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 M

    Tan, Haozhou / Hu, Yanmei / Wang, Jun

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102323

    Abstract: FlipGFP assay characterizes the intracellular drug target engagement to ... ...

    Abstract FlipGFP assay characterizes the intracellular drug target engagement to M
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death.

    Hu, Ning / Tian, Yanhua / Song, Yanmei / Zang, Leilei

    Genetics and molecular biology

    2024  Volume 47, Issue 1, Page(s) e20220170

    Abstract: ABT737 is used as a specific BCL2 inhibitor, which can treat papillary thyroid carcinoma (PTC). However, the effect of ABT737 on PTC cell apoptosis is limited. Moreover, BCL2 inhibition causes the activation of Beclin1-dependent autophagy. Our study ... ...

    Abstract ABT737 is used as a specific BCL2 inhibitor, which can treat papillary thyroid carcinoma (PTC). However, the effect of ABT737 on PTC cell apoptosis is limited. Moreover, BCL2 inhibition causes the activation of Beclin1-dependent autophagy. Our study aimed to explore the effects of autophagy and Beclin1 on ABT737 efficacy in PTC. The experimental data showed that ABT737 synchronously enhanced autophagic activity and apoptosis level in PTC cells. ABT737 also promoted the dissociation of BCL2-Beclin1 and BCL2-Bax complexes. Autophagy inhibitors, Bafilomycin A1 and 3-MA, enhanced the inhibitory effect of ABT737 on the survival and function in PTC cells. Consistently, autophagy inhibition with Beclin1 pharmacological inhibitor (spautin-1) also enhanced the efficacy of ABT737. Additionally, ABT737 at low-dose promoted LC3 conversion in PTC cells, and did not affect PTC cell apoptosis and survival. However, The efficacy of low-dose of ABT737 in PTC cell apoptosis and survival was displayed with the addition of Bafilomycin A1, 3-MA or spautin-1. In conclusion, the limited role of ABT737 in PTC cell apoptosis is attributed to its promoting effect on Beclin1-dependent autophagy. Therefore, autophagy inhibition based on Beclin1 downregulation can enhance the sensitivity of PTC cells to ABT737-induced death.
    Language English
    Publishing date 2024-03-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1445712-x
    ISSN 1678-4685 ; 1415-4757
    ISSN (online) 1678-4685
    ISSN 1415-4757
    DOI 10.1590/1678-4685-GMB-2022-0170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3079: Show issues Location:
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  3. Article ; Online: Ultrafast restricted intramolecular rotation in molecules with aggregation induced emission.

    Hu, Xiao / Wang, Dongdong / Wang, Yanmei / Wang, Ye / Zhang, Song

    The Journal of chemical physics

    2024  Volume 160, Issue 15

    Abstract: In this work, the ultrafast intramolecular rotation behavior of 1,1,2,3,4,5-hexaphenylsilole has been investigated in several solutions with different viscosities using femtosecond transient absorption spectroscopy combined with density functional theory ...

    Abstract In this work, the ultrafast intramolecular rotation behavior of 1,1,2,3,4,5-hexaphenylsilole has been investigated in several solutions with different viscosities using femtosecond transient absorption spectroscopy combined with density functional theory and time-dependent density functional theory calculations. It is demonstrated that the nonradiative process, which competes with radiative decay, involves two main stages, namely the restricted intramolecular rotation and internal conversion processes. The intramolecular rotation depends on viscosity and presents a significant restriction. The restricted rotational rate is determined to be dozens of picoseconds. The following nonradiative process is strongly dominated by intramolecular rotation. The nonradiative decay rate will decrease with the increase in viscosity, leading to a rise in the radiative probability and photoluminous yield. These results have borne out the mechanism of ultrafast restricted intramolecular rotation of aggregation induced emission and provided a detailed photophysical picture of nonradiative processes.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0200622
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  4. Article: Isolation and molecular characteristics of a recombinant feline calicivirus from Qingdao, China.

    Liu, Yongxiang / Qin, Lide / Hu, Xiaoliang / Jiang, Yanmei

    Veterinary research forum : an international quarterly journal

    2023  Volume 14, Issue 11, Page(s) 583–588

    Abstract: Feline calicivirus (FCV) is a highly contagious pathogen seriously affecting the upper respiratory tract and producing oral diseases in the feline. Despite widespread vaccination, the prevalence of FCV remains high. In this study, the FCV qingdao (qd)/ ... ...

    Abstract Feline calicivirus (FCV) is a highly contagious pathogen seriously affecting the upper respiratory tract and producing oral diseases in the feline. Despite widespread vaccination, the prevalence of FCV remains high. In this study, the FCV qingdao (qd)/2019/china was isolated from a domestic feline oropharyngeal swab collected from Qingdao, China. The virus was purified using the plaque assay and identified using the Polymerase chain reaction and indirect immunofluorescence assay methods, the capsid amino acid,
    Language English
    Publishing date 2023-11-15
    Publishing country Iran
    Document type Journal Article
    ISSN 2008-8140
    ISSN 2008-8140
    DOI 10.30466/vrf.2023.1975795.3701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing F-actin formation

    Leilei Zang / Yanmei Song / Yanhua Tian / Ning Hu

    Heliyon, Vol 9, Iss 10, Pp e20461- (2023)

    2023  

    Abstract: Papillary thyroid carcinoma (PTC) limits effective biomarkers for predicting prognosis and targeted therapy. Phosphatase and actin regulator 1 (PHACTR1) is a mobility-promoting molecule due to its regulation on F-actin formation, which is valuable for ... ...

    Abstract Papillary thyroid carcinoma (PTC) limits effective biomarkers for predicting prognosis and targeted therapy. Phosphatase and actin regulator 1 (PHACTR1) is a mobility-promoting molecule due to its regulation on F-actin formation, which is valuable for the investigation of PTC. Our study aimed to investigate the relationship between PHACTR1 and PTC carcinogenesis, especially mobility. Our results displayed that PHACTR1 expression was elevated in metastatic or larger PTC tissues. In addition, PTC cells K1 with more obvious mobility had higher PHACTR1 expression whereas weakly mobile cells TPC-1 was contrary. Moreover, PHACTR1 silencing inhibited the invasion, migration and tumorigenicity of K1 cells, while PHACTR1 overexpression promoted the invasion, migration and tumorigenicity in TPC-1 cells. Furthermore, PHACTR1 overexpression increased the fluorescent intensity of F-actin in TPC-1 cells. Importantly, the enhanced invasion and migration in TPC-1 cells caused by PHACTR1 overexpression were significantly reversed by the disruption of F-actin assembly with swinholide A. In conclusion, PHACTR1 can promote the mobility of PTC cells, which results in the carcinogenesis of PTC. PHACTR1-regulated F-actin formation determines the mobility of PTC cells. Therefore, PHACTR1 can function as a potential biomarker for predicting prognosis and targeting therapy in PTC.
    Keywords PHACTR1 ; PTC ; Invasion ; Migration ; F-actin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing F-actin formation.

    Zang, Leilei / Song, Yanmei / Tian, Yanhua / Hu, Ning

    Heliyon

    2023  Volume 9, Issue 10, Page(s) e20461

    Abstract: Papillary thyroid carcinoma (PTC) limits effective biomarkers for predicting prognosis and targeted therapy. Phosphatase and actin regulator 1 (PHACTR1) is a mobility-promoting molecule due to its regulation on F-actin formation, which is valuable for ... ...

    Abstract Papillary thyroid carcinoma (PTC) limits effective biomarkers for predicting prognosis and targeted therapy. Phosphatase and actin regulator 1 (PHACTR1) is a mobility-promoting molecule due to its regulation on F-actin formation, which is valuable for the investigation of PTC. Our study aimed to investigate the relationship between PHACTR1 and PTC carcinogenesis, especially mobility. Our results displayed that PHACTR1 expression was elevated in metastatic or larger PTC tissues. In addition, PTC cells K1 with more obvious mobility had higher PHACTR1 expression whereas weakly mobile cells TPC-1 was contrary. Moreover, PHACTR1 silencing inhibited the invasion, migration and tumorigenicity of K1 cells, while PHACTR1 overexpression promoted the invasion, migration and tumorigenicity in TPC-1 cells. Furthermore, PHACTR1 overexpression increased the fluorescent intensity of F-actin in TPC-1 cells. Importantly, the enhanced invasion and migration in TPC-1 cells caused by PHACTR1 overexpression were significantly reversed by the disruption of F-actin assembly with swinholide A. In conclusion, PHACTR1 can promote the mobility of PTC cells, which results in the carcinogenesis of PTC. PHACTR1-regulated F-actin formation determines the mobility of PTC cells. Therefore, PHACTR1 can function as a potential biomarker for predicting prognosis and targeting therapy in PTC.
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e20461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical experience of professor

    Zhou, Jingying / Cao, Lianying / Hu, Yanmei / Yu, Liqing / Ye, Wencheng / Zhang, Ren

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2023  Volume 44, Issue 3, Page(s) 318–322

    Abstract: The paper summarizes the clinical experience of ... ...

    Title translation 张仁教授特色针法分期治疗动眼神经麻痹临床经验撷要.
    Abstract The paper summarizes the clinical experience of professor
    MeSH term(s) Humans ; Acupuncture Therapy/methods ; Acupuncture ; Acupuncture Points ; Electroacupuncture ; Ophthalmoplegia
    Language Chinese
    Publishing date 2023-10-20
    Publishing country China
    Document type Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20230608-k0001
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  8. Article ; Online: Dual biomarkers-activatable hollow MnO

    Ning, Juan / Hu, Guizhen / Wu, Tian / Zhao, Yijun / Nie, Yamin / Zhou, Yanmei

    Analytica chimica acta

    2024  Volume 1303, Page(s) 342521

    Abstract: Background: Theranostic nanoplatforms with integrated diagnostic imaging and multiple therapeutic functions play a vital role in precise diagnosis and efficient treatment for breast cancer, but unfortunately, these nanoplatforms are usually stuck in ... ...

    Abstract Background: Theranostic nanoplatforms with integrated diagnostic imaging and multiple therapeutic functions play a vital role in precise diagnosis and efficient treatment for breast cancer, but unfortunately, these nanoplatforms are usually stuck in single-site imaging and single mode of treatment, causing unsatisfactory diagnostic and therapeutic efficiency. Herein, a dual biomarkers-activatable facile hollow mesoporous MnO
    Results: The DHMM acted as an integrated diagnostic and therapeutic nanoplatform that realizes multi-site fluorescence imaging-guided high-efficient photothermal/chemodynamic/gene synergistic therapy (PTT/CDT/GT) for breast cancer. The H-MnO
    Significance: This dual biomarker-activatable multiple therapeutic nanoplatform was realized multi-site fluorescence imaging-guided PTT/CDT/GT combination therapy for breast cancer with higher specificity and efficiency, which provides a promising theranostic nanoplatform for the precision and efficiency of breast cancer treatment.
    MeSH term(s) Precision Medicine ; DNA, Catalytic ; Manganese Compounds ; Oxides ; Optical Imaging ; Biomarkers ; Neoplasms ; Carbocyanines
    Chemical Substances cyanine dye 5 ; DNA, Catalytic ; Manganese Compounds ; Oxides ; Biomarkers ; Carbocyanines
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Portable Detection of Lysine Acetyltransferase Activity in Lung Cancer Cells Based on a Miniature Electrochemical Sensor.

    Liu, Jiayue / Lu, Yanmei / Hu, Yufang / Zhang, Qingqing / Wang, Sui / Guo, Zhiyong / Qing, Zhihe

    Analytical chemistry

    2024  Volume 96, Issue 14, Page(s) 5546–5553

    Abstract: The detection of lysine acetyltransferases is crucial for diagnosing and treating lung cancer, highlighting the necessity for highly efficient detection methods. We developed a portable, highly accurate, and sensitive technique using fast-scan cyclic ... ...

    Abstract The detection of lysine acetyltransferases is crucial for diagnosing and treating lung cancer, highlighting the necessity for highly efficient detection methods. We developed a portable, highly accurate, and sensitive technique using fast-scan cyclic voltammetry (FSCV) to determine the activity of the lysine acetyltransferase TIP60, employing a novel miniature electrochemical sensor. This approach involves a compact electrochemical cell, merely 3 mm in diameter, that holds solutions up to 50 μL, equipped with a conductive indium tin oxide working electrode. Uniquely, this system operates on a two-electrode model compatible with the FSCV, obviating the traditional requirement for a reference electrode. The system detects TIP60 activity through the continuous generation of CoA molecules that engage in reactions with Cu(II), thereby significantly improving the accuracy of the acetylation analysis. Remarkably, the detection limit achieved for TIP60 is notably low at 3.3 pg/mL (
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lysine Acetyltransferases ; Electrochemical Techniques
    Chemical Substances Lysine Acetyltransferases (EC 2.3.1.32)
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
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  10. Article ; Online: Glucans from

    Liu, Yan / Li, Yanmei / Sun, Bo / Kang, Ji / Hu, Xinzhong / Zou, Liang / Cui, Steve W / Guo, Qingbin

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 11, Page(s) 6006–6018

    Abstract: Polysaccharides ... ...

    Abstract Polysaccharides from
    MeSH term(s) Animals ; Mice ; Glucans ; Armillaria ; Polysaccharides ; beta-Glucans ; Cyclophosphamide
    Chemical Substances Glucans ; Polysaccharides ; beta-Glucans ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.4c00071
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    Zs.A 1172: Show issues Location:
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