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  1. Article ; Online: Persistent hypoxaemia and a headache in a previously healthy 11-year-old girl.

    Sadras, Ido / Mei-Zahav, Meir / Breuer, Oded

    Thorax

    2022  Volume 77, Issue 6, Page(s) 631–632

    MeSH term(s) Child ; Female ; Headache/etiology ; Humans ; Hypoxia/etiology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2022-218723
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    Ui III Zs.83: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Aerosol treatments for childhood asthma in the era of COVID-19.

    Mei-Zahav, Meir / Amirav, Israel

    Pediatric pulmonology

    2020  Volume 55, Issue 8, Page(s) 1871–1872

    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24849
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    Zs.A 2143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Pregnancy-associated ruptured splenic arteriovenous malformation: A rare but fatal complication in hereditary hemorrhagic telangiectasia.

    Kabiri, Doron / Gavra, Hadar / Keidar Haran, Tal / Goldschmidt, Neta / Elazary, Ram / Mei-Zahav, Meir

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 283, Page(s) 158–159

    MeSH term(s) Female ; Pregnancy ; Humans ; Telangiectasia, Hereditary Hemorrhagic/complications ; Arteriovenous Malformations/complications ; Arteriovenous Malformations/diagnostic imaging
    Language English
    Publishing date 2023-02-11
    Publishing country Ireland
    Document type Letter
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.02.004
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    Zs.A 837: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Wearing face masks while climbing stairs influences respiratory physiology.

    Bar-On, Ophir / Goldberg, Ori / Stafler, Patrick / Levine, Hagit / Jacobi, Eyal / Shmueli, Einat / Rothschild, Benjamin / Prais, Dario / Mei-Zahav, Meir

    Journal of breath research

    2024  

    Abstract: Background: During the COVID-19 pandemic wearing face masks was mandatory. Nowadays, face masks are still encouraged indoors, especially in hospitals. People climbing stairs with masks describe unpredictable dyspnea.: Methods: Healthy adults climbed ... ...

    Abstract Background: During the COVID-19 pandemic wearing face masks was mandatory. Nowadays, face masks are still encouraged indoors, especially in hospitals. People climbing stairs with masks describe unpredictable dyspnea.
    Methods: Healthy adults climbed 5 floors with and without a mask. Various cardio-respiratory parameters were measured, including O2-Saturation (O2-Sat) and End-tidal CO2 (EtCO2), at baseline and on the top floor. Subjective indexes, such as Borg's scale, were evaluated.
    Results: Thirty-two volunteers (16 males), median age 39 years (IQR 32.5-43), median BMI=23.6 (IQR 21.5-25.1), with good fitness levels, participated. Comparing baseline to end-activity, median (IQR): O2-Sat change was -1.0% (-2-0) without mask, versus -3.0% (-4-0) with mask, p=0.003; EtCO2 +7.0 (+3.3-+9) without mask, versus +8.0 (+6 -+12) with mask, p=0.0001. Hypercarbia was seen in 5 (15.6%) participants without mask, median=48mmHg (IQR 47.5-51), and in 11 (34%) participants with mask, median=50mmHg (IQR 47-54), p<0.001. Desaturation (O2-Sat<95%) was seen in 5 (15.6%) participants without mask, median=94% (IQR 93-94%), and in 10 (31%) participants with mask, median=91.5% (IQR 90-93%), p=0.06. Regression analysis demonstrated that only male sex was significantly associated with abnormal EtCO2 (OR=26.4, 95%CI=1.9-366.4, p=0.005). Ascent duration increased from median (IQR) of 94 seconds (86-100) without mask to 98 seconds (89-107) with mask, p<0.001. Borg's scale of perceived exertion (range 0-10) increased from median (IQR) of 3.0 (2.5-3.87) without mask to 4.0 (3.0-4.37) with mask, p<0.001.
    Conclusions: During routine daily activities, such as stair-climbing, face masks cause dyspnea, and have measurable influences on ventilation, including true desaturation and hypercapnia, especially in males.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ad3fde
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  6. Article ; Online: Aerosol treatments for childhood asthma in the era of COVID‐19

    Mei‐Zahav, Meir / Amirav, Israel

    Pediatric Pulmonology

    2020  Volume 55, Issue 8, Page(s) 1871–1872

    Keywords Pediatrics, Perinatology, and Child Health ; Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24849
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    Zs.A 2143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Prevalence, trends and outcomes of long-term inhaled antibiotic treatment in people with cystic fibrosis without chronic Pseudomonas aeruginosa infection - A European cystic fibrosis patient registry data analysis.

    Orenti, Annalisa / Mei-Zahav, Meir / Boracchi, Patrizia / Lindblad, Anders / Shteinberg, Michal

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 22, Issue 1, Page(s) 103–111

    Abstract: Background: Long-term treatment with inhaled antibiotics is recommended for people with cystic fibrosis (pwCF) chronically infected with Pseudomonas aeruginosa (PA). However, pwCF without chronic PA infection are also commonly treated with inhaled ... ...

    Abstract Background: Long-term treatment with inhaled antibiotics is recommended for people with cystic fibrosis (pwCF) chronically infected with Pseudomonas aeruginosa (PA). However, pwCF without chronic PA infection are also commonly treated with inhaled antibiotics. Using data from the European Cystic Fibrosis Patient Registry (ECFSPR) we aimed to determine the prevalence and factors associated with inhaled antibiotic treatment in pwCF without chronic PA infection, and long-term outcomes with inhaled antibiotics use.
    Methods: The ECFSPR was searched for pwCF 6 years of age and older who were not chronically infected with PA at baseline. Factors associated with inhaled antibiotic use were first assessed through a logistic regression. From this model a propensity score was computed for each individual, providing the likelihood of being treated with inhaled antibiotics. Long-term outcomes with and without inhaled antibiotics were assessed separately for propensity scores tertiles.
    Results: 7210 pwCF without chronic PA infection at baseline were included, with 2722 (37.75%) receiving long-term treatment with inhaled antibiotics. Treatment with inhaled antibiotics was more prevalent with severe genotype, diabetes, pancreatic insufficiency, and past infection with chronic PA (OR 3.8, 95% CI, 2.88-5.04). Treatment with inhaled antibiotics was not associated with a reduced risk for acquisition of PA or other resistant pathogens, or with improved lung function decline, mortality, or transplantation.
    Conclusions: Many pwCF without chronic PA infection are receiving long-term treatment with inhaled antibiotics despite lack of support from clinical trials or practice guidelines. We did not observe improve outcomes with inhaled antibiotics. Our findings suggest controlled studies evaluating specific inhaled antibiotic regimens targeting specific pathogens or indications be performed to determine their effect.
    MeSH term(s) Humans ; Pseudomonas Infections/drug therapy ; Cystic Fibrosis/drug therapy ; Prevalence ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas aeruginosa ; Data Analysis ; Registries
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.08.010
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    Zs.A 6028: Show issues Location:
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    Zs.MO 459: Show issues

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  8. Article: Risk factors for forced expiratory volume in 1 s decline in European patients with cystic fibrosis: data from the European Cystic Fibrosis Society Patient Registry.

    Hatziagorou, Elpis / Fieuws, Steffen / Orenti, Annalisa / Naehrlich, Lutz / Krivec, Uros / Mei-Zahav, Meir / Jung, Andreas / De Boeck, Kris

    ERJ open research

    2023  Volume 9, Issue 3

    Abstract: Aim: To examine the trajectory of forced expiratory volume in 1 s (FEV: Methods: The study population included patients with a confirmed diagnosis of cystic fibrosis recorded in the ECFPR (2008-2016). The evolution of FEV: Results: We used 199 604 ...

    Abstract Aim: To examine the trajectory of forced expiratory volume in 1 s (FEV
    Methods: The study population included patients with a confirmed diagnosis of cystic fibrosis recorded in the ECFPR (2008-2016). The evolution of FEV
    Results: We used 199 604 FEV
    Conclusions: These longitudinal FEV
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00449-2022
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  9. Article: Dynamic Hyperinflation While Exercising-A Potential Predictor of Pulmonary Deterioration in Cystic Fibrosis.

    Shmueli, Einat / Gendler, Yulia / Stafler, Patrick / Levine, Hagit / Steuer, Guy / Bar-On, Ophir / Blau, Hannah / Prais, Dario / Mei-Zahav, Meir

    Journal of clinical medicine

    2023  Volume 12, Issue 18

    Abstract: Background: Lung function deterioration in cystic fibrosis (CF) is typically measured by a decline in the forced expiratory volume in one second (FEV: Methods: A retrospective study was conducted of people with CF who performed cardiopulmonary ... ...

    Abstract Background: Lung function deterioration in cystic fibrosis (CF) is typically measured by a decline in the forced expiratory volume in one second (FEV
    Methods: A retrospective study was conducted of people with CF who performed cardiopulmonary exercise tests (CPETs) during 2012-2018. The tests were classified as those demonstrating DH non-DH. Demographic, genetic, and clinical data until 12.2022 were extracted from patient charts.
    Results: A total of 33 patients aged 10-61 years performed 41 valid CPETs with valid DH measurements; sixteen (39%) demonstrated DH. At the time of the CPETs, there was no difference in the FEV
    Conclusions: In our cohort, the DH and peak VO
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12185834
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  10. Article: Thoracoscopic Resection of Pulmonary Lesions in Israel: The Mentorship Approach.

    Seguier-Lipszyc, Emmanuelle / Rothenberg, S / Mei-Zahav, Meir / Stafler, Patrick / Zeitlin, Yelena / Samuk, Inbal / Peysakhovich, Yuri / Kravarusic, Dragan

    Journal of Indian Association of Pediatric Surgeons

    2023  Volume 28, Issue 6, Page(s) 508–513

    Abstract: Background: Most congenital pulmonary airway malformations (CPAMs) are detected antenatally. The majority of newborns are asymptomatic. Patients are prone to subsequent respiratory complications and to a lesser extent malignant transformation remains ... ...

    Abstract Background: Most congenital pulmonary airway malformations (CPAMs) are detected antenatally. The majority of newborns are asymptomatic. Patients are prone to subsequent respiratory complications and to a lesser extent malignant transformation remains concerning. In Israel, until 2013, pediatric surgeries were performed by thoracotomy. To minimize its morbidity, we introduced thoracoscopy using a mentorship approach. We present our experience with thoracoscopic resections coordinated by the mentorship of a pediatric worldwide leader in his field and compare our results with resections performed by thoracotomy.
    Materials and methods: A retrospective review of records of children operated between 2013 and 2020 was conducted. Data were compared using
    Results: Fifty patients were operated by thoracoscopy with a median age of 4 years, a thoracoscopic lobectomy performed in 68%. There was no conversion with a median length of stay (LOS) of 3½ days. Thirty patients were operated by thoracotomy by a thoracic surgeon with a median age of 3.5 years. A lobectomy was performed in 87% with a median LOS of 7 days.
    Conclusions: Thoracoscopic lobectomy is a technically demanding procedure with a long learning curve, strongly related to the low volume of cases. The role of a mentorship program in acquiring those surgical skills is crucial through standardization of the technique applied and supervised by the mentor. Early thoracoscopy for congenital pulmonary lesions at an early age can be achieved with a low conversion rate and minimal complications creating a change in the paradigm of practice when considering surgery for CPAM in Israel.
    Language English
    Publishing date 2023-11-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/jiaps.jiaps_115_23
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