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Article ; Online: Regulation of the methylome in differentiation from adult stem cells may underpin vitamin D risk in MS.

Ong, Lawrence T C / Parnell, Grant P / Veale, Kelly / Stewart, Graeme J / Liddle, Christopher / Booth, David R

2020 Volume 21, Issue 5, Page(s) 335–347

Abstract: Multiple lines of evidence indicate Multiple Sclerosis (MS) is affected by vitamin D. This effect ... the interaction of methylation with the vitamin D receptor binding sites. We interrogated genomic methylation ... methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using ...

Abstract	Multiple lines of evidence indicate Multiple Sclerosis (MS) is affected by vitamin D. This effect may be mediated by methylation in immune cell progenitors. We aimed to determine (1) if haematopoietic stem cell methylation constrains methylation in daughter cells and is variable between individuals, and (2) the interaction of methylation with the vitamin D receptor binding sites. We interrogated genomic methylation levels from matching purified CD34+ haematopoietic stem cells and progeny CD14+ monocytes and CD56+ NK cells from 11 individuals using modified reduced representation bisulfite sequencing. Differential methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using pyrosequencing for the vitamin D regulated MS risk gene ZMIZ1. Although DNA methylation states at CpG islands and other sites are almost entirely recapitulated between progenitor and progeny immune cells, significant variation was detected at some regions between cell subsets and individuals; including around the MS risk genes HLA DRB1 and the vitamin D repressor NCOR2. Methylation of the vitamin D responsive MS risk gene ZMIZ1 was associated with risk SNP and disease. We conclude that DNA methylation settings in adult haematopoietic stem cells may contribute to individual variation in vitamin D responses in immune cells.
MeSH term(s)	Adult ; CpG Islands ; DNA Methylation ; Epigenome ; Female ; HLA-DRB1 Chains/genetics ; Hematopoiesis ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Male ; Middle Aged ; Monocytes/cytology ; Monocytes/metabolism ; Multiple Sclerosis/genetics ; Multiple Sclerosis/metabolism ; Nuclear Receptor Co-Repressor 2/genetics ; Protein Binding ; Receptors, Calcitriol/metabolism ; Transcription Factors/genetics ; Vitamin D/metabolism
Chemical Substances	HLA-DRB1 Chains ; NCOR2 protein, human ; Nuclear Receptor Co-Repressor 2 ; Receptors, Calcitriol ; Transcription Factors ; ZMIZ1 protein, human ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2060566-3
ISSN	1476-5470 ; 1466-4879
ISSN (online)	1476-5470
ISSN	1466-4879
DOI	10.1038/s41435-020-00114-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5592: Show issues

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Article ; Online: Effects of Gadolinium Depositions in Vivo.

Bruno, Drew / Vealé, Beth L

Radiologic technology

2021 Volume 93, Issue 1, Page(s) 46–54

Abstract: Purpose: To explain the kinetics of gadolinium-based contrast agents (GBCAs), where they leave deposits, and whether they ever leave the body.: Methods: A literature search was conducted using databases such as Academic Search Premier, EBSCO Host, ... ...

Abstract	Purpose: To explain the kinetics of gadolinium-based contrast agents (GBCAs), where they leave deposits, and whether they ever leave the body. Methods: A literature search was conducted using databases such as Academic Search Premier, EBSCO Host, PubMed, Radiological Society of North America, and Google Scholar. Studies pertaining to various GBCAs, their depositions, and their adverse effects were reported. Results: GBCAs were deposited in the skin, brain, dentate nucleus, globus pallidus, and thalamus. Common adverse effects of GBCAs included headache, joint pain, torso pain, weakness and fatigue, and cloudy mentation. Discussion: GBCAs should be avoided when not necessary, and the physician ordering the contrast should understand the benefits vs the risks for each patient. Although there is evidence of depositions of GBCA, it remains clinically acceptable to administer this contrast when there is an indication. The clinical indication for the GBCA, the type of agent, the dose, and other important information should be documented in the patient's medical record after administration. Conclusion: The effects of gadolinium retention are still not understood fully and require future investigation. This literature review helped to show that all GBCAs-linear, nonionic, ionic, and macrocyclic contrast agents-leave deposits in the brain that show up on medical images. Further research should be conducted to assess possible links between depositions in the body and adverse effects.
MeSH term(s)	Brain/diagnostic imaging ; Contrast Media/adverse effects ; Gadolinium/adverse effects ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Skin
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	414079-5
ISSN	1943-5657 ; 0033-8397
ISSN (online)	1943-5657
ISSN	0033-8397
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Article: Against the stream: intermittent nurse observations of in-patients at night serve no purpose and cause sleep deprivation.

Veale, David

BJPsych bulletin

2019 Volume 43, Issue 4, Page(s) 174–176

Abstract: This paper argues that intermittent nursing observations of in-patients at night do not reduce the risk of suicide or severe self-harm. Suicides between 23.00 h and 07.00 h are rare, and these overwhelmingly occur under intermittent observations. Such ... ...

Abstract	This paper argues that intermittent nursing observations of in-patients at night do not reduce the risk of suicide or severe self-harm. Suicides between 23.00 h and 07.00 h are rare, and these overwhelmingly occur under intermittent observations. Such observation is purely a defensive intervention to document that a patient is safe at a particular time, as there is no engagement. For the large majority of in-patients, it has the unintended consequence of causing sleep deprivation. The intervention may cause harm to in-patients by making their disorder worse and increase their risk during the day. If patients are judged to be at immediate risk, then they should be placed on constant observation. If they are not, then optimising sleep is important for treating a psychiatric disorder and they should be placed on general observations.Declaration of interestNone.
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2816886-0
ISSN	2056-4708 ; 2056-4694
ISSN (online)	2056-4708
ISSN	2056-4694
DOI	10.1192/bjb.2018.116
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Article: Choice of provider for out-patient treatment is not working.

Veale, David

BJPsych bulletin

2018 Volume 42, Issue 2, Page(s) 82–85

Abstract: In 2012, the coalition government introduced the legal right for National Health Service (NHS) patients in England to choose their mental healthcare provider for out-patient treatment. This was a significant step towards parity of care between mental and ...

Abstract	In 2012, the coalition government introduced the legal right for National Health Service (NHS) patients in England to choose their mental healthcare provider for out-patient treatment. This was a significant step towards parity of care between mental and physical ill health, and NHS Improvement and NHS England have provided sensible guidance on its implementation. However, several factors prevent the system from working as it was intended: lack of awareness of the principle of patient choice for out-patient treatment; complacency from some trusts and commissioners; mental health trusts operating outside the e-referrals system; misuse of care pathways; lack of direct access by many general practitioners for out-of-area referrals; and delays in authorisation for funding. I describe how I have come to this conclusion and suggest some solutions. Declaration of interest The author is employed by a trust that potentially benefits from 'patient choice'.
Language	English
Publishing date	2018-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2816886-0
ISSN	2056-4708 ; 2056-4694
ISSN (online)	2056-4708
ISSN	2056-4694
DOI	10.1192/bjb.2017.25
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Article ; Online: Salto Talaris Fixed-Bearing Total Ankle Arthroplasty: Long-Term Results at a Mean of 10.7 Years.

Veale, Matthew / Endo, Atsushi / Veale, Nicholas / Swanson, Daniel / Mahendraraj, Kuhan / Brzezinski, Andrzej / Hofmann, Kurt / Slovenkai, Mark

Foot & ankle orthopaedics

2024 Volume 9, Issue 1, Page(s) 24730114231225458

Abstract: Background: Total ankle arthroplasty (TAA) has become increasingly popular in the treatment for end-stage ankle arthritis in recent decades. However, there is limited evidence regarding the long-term clinical outcomes and complication rates of modern ... ...

Abstract	Background: Total ankle arthroplasty (TAA) has become increasingly popular in the treatment for end-stage ankle arthritis in recent decades. However, there is limited evidence regarding the long-term clinical outcomes and complication rates of modern TAA implants. Methods: This study presents a follow-up on a previous cohort involving 78 patients (81 ankles) who underwent Salto Talaris fixed-bearing TAA to treat end-stage arthritis, with a mean postoperative follow-up of 5.2 years. The aim of this follow-up study was to assess the radiographic (33 patients, 35 ankles) and clinical (48 patients, 50 ankles) results from the original cohort at a mean of 10.7 years (range, 7.8-14 years). Results: At a mean of 10.7 years, the Kaplan-Meier estimated survivorship was 84.2% (95% CI, 71.9%-98.6%). For the patients reviewed, we did not find any change in patient-reported outcomes between an average 5- and 11-year follow-up. Measured total range of motion and plantarflexion did not change between 1 and 11 years, but dorsiflexion was measured as decreasing by an average of 4 degrees ( Conclusion: In this longer-term follow-up of a limited cohort, we found that Salto Talaris fixed-bearing TAA demonstrated good long-term survival with relatively low rates of revision or other complications. Patient-reported outcome and range of motion measures revealed good stability. Level of evidence: Level III, therapeutic.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ISSN	2473-0114
ISSN (online)	2473-0114
DOI	10.1177/24730114231225458
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Article ; Online: Targeted Therapies in Psoriatic Arthritis-An Update.

Sundanum, Sonia / Orr, Carl / Veale, Douglas

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Psoriatic arthritis (PsA) is a systemic inflammatory condition characterised by multiple clinical manifestations. Over the last decade, significant progress has been made in understanding the pathobiology of the disease. An expanded set of targeted ... ...

Abstract	Psoriatic arthritis (PsA) is a systemic inflammatory condition characterised by multiple clinical manifestations. Over the last decade, significant progress has been made in understanding the pathobiology of the disease. An expanded set of targeted therapies have emerged and have shown efficacy in PsA. Nevertheless, there is still a substantial subset of patients who experience no response or only a partial response to currently licensed therapies. The heterogeneous nature of the disease, together with a varying level of severity at presentation and disease activity during follow-up, brings tremendous challenges to devising management strategies. While there are certain pathophysiological similarities between PsA and rheumatoid arthritis (RA), it has become clear that there are discriminating features between these two conditions at the clinical, cellular, and molecular levels. However, there is a degree of overlap in the clinical approach when treating both PsA and RA, given that many biological and targeted therapies have proven efficacy for both pathologies. With an increasing understanding of the relevance of the IL-23/IL-17 axis in PsA, pharmacological agents blocking this pathway have provided promising possibilities for patients with PsA.
MeSH term(s)	Humans ; Arthritis, Psoriatic/drug therapy ; Arthritis, Rheumatoid/drug therapy
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076384
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Book: Body dysmorphic disorder

Veale, David / Neziroglu, Fugen A.

a treatment manual

2010

Author's details	David Veale and Fugen Neziroglu
Keywords	Somatoform Disorders / therapy ; Obsessive-Compulsive Disorder / therapy ; Body Image ; Self Concept
Language	English
Size	X, 476 S. : graph. Darst.
Publisher	Wiley-Blackwell
Publishing place	Chichester
Publishing country	Great Britain
Document type	Book
Note	Formerly CIP Uk. - Includes bibliographical references and index
HBZ-ID	HT016452814
ISBN	978-0-470-85120-3 ; 0-470-85120-1 ; 978-0-470-85121-0 ; 0-470-85121-X
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Redefining Beauty: A Qualitative Study Exploring Adult Women's Motivations for Lip Filler Resulting in Anatomical Distortion.

Love, Madeleine / Saunders, Chloe / Harris, Steven / Moon, Zoe / Veale, David

Aesthetic surgery journal

2023 Volume 43, Issue 8, Page(s) 907–916

Abstract: Background: Lip filler enhancement has fast become one of the most popular minimally invasive cosmetic procedures. Motivations for "overtreatment" with lip fillers are poorly understood.: Objectives: The aim of this study was to explore female ... ...

Abstract	Background: Lip filler enhancement has fast become one of the most popular minimally invasive cosmetic procedures. Motivations for "overtreatment" with lip fillers are poorly understood. Objectives: The aim of this study was to explore female motivations for and experiences of procedures that achieve an aesthetic of distorted lip anatomy. Methods: Twenty-four females who had undergone lip filler procedures resulting in strikingly distorted lip anatomy, determined by the Harris classification of filler spread, took part in semistructured interviews about their motivations, experiences, and perceptions related to lip fillers. A qualitative thematic analysis was carried out. Results: Four major themes are discussed: (1) the normalization of lip fillers, (2) perceptual drift which is mediated by exposure to repetitive images of larger lips on social media, (3) perceived financial and social benefits of larger lips, and (4) the relation between mental health and seeking repeated lip filler procedures. Conclusions: Motivations for seeking lip fillers vary, but most subjects described social media impacting perceived aesthetic norms. A process of perceptual drift occurs whereby mental schema encoding expectations of "natural" facial anatomy can adapt through repeated exposure to enhanced images. The results can inform aesthetic practitioners and policymakers seeking to understand and support those seeking minimally invasive cosmetic procedures.
MeSH term(s)	Adult ; Humans ; Female ; Motivation ; Beauty ; Cosmetic Techniques/psychology ; Lip ; Face ; Dermal Fillers ; Hyaluronic Acid
Chemical Substances	Dermal Fillers ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad050
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 570: Show issues

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Article: Trophoblastic giant cells of the mouse placenta contain calbindin-D9k but not the vitamin D receptor.

Shamley, D R / Veale, G / Pettifor, J M / Buffenstein, R

The Journal of endocrinology

1996 Volume 150, Issue 1, Page(s) 25–32

Abstract: The effects of vitamin D deficiency on the ontogeny of calcium-binding proteins (CaBPs) and ... the vitamin D receptor (VDR) in the placenta and yolk sac of the mouse were examined. Maternal vitamin D ... unlikely that CaBP synthesis and/or activity in these cells is controlled by vitamin D. The TGCs ...

Abstract	The effects of vitamin D deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor (VDR) in the placenta and yolk sac of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of CaBP-D9k (9 kDa) in the yolk sac endoderm or trophoblastic giant cells (TGCs) of the placenta. VDRs were undetectable in TGCs and yolk sac endoderm, but were present in the intraplacental yolk sac. Since yolk sac endoderm and TGCs contain CaBP but not VDR, it is unlikely that CaBP synthesis and/or activity in these cells is controlled by vitamin D. The TGCs, therefore, may be involved in vitamin D-independent transplacental transfer of calcium.
MeSH term(s)	Animals ; Calbindins ; Endoderm/chemistry ; Endoderm/metabolism ; Female ; Immunohistochemistry ; Mice ; Mice, Inbred Strains ; Pregnancy ; Receptors, Calcitriol/analysis ; Receptors, Calcitriol/metabolism ; S100 Calcium Binding Protein G/analysis ; S100 Calcium Binding Protein G/metabolism ; Trophoblasts/chemistry ; Trophoblasts/cytology ; Trophoblasts/metabolism ; Vitamin D Deficiency/metabolism ; Yolk Sac/chemistry ; Yolk Sac/metabolism
Chemical Substances	Calbindins ; Receptors, Calcitriol ; S100 Calcium Binding Protein G ; S100G protein, human ; S100g protein, mouse
Language	English
Publishing date	1996-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3028-4
ISSN	1479-6805 ; 0022-0795
ISSN (online)	1479-6805
ISSN	0022-0795
DOI	10.1677/joe.0.1500025
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Uh III Zs.133: Show issues

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Article ; Online: The relationship between symptoms of obsessive compulsive disorder and depression during therapy: A random intercept cross-lagged panel model.

Simkin, Vicky / Hodsoll, John / Veale, David

Journal of behavior therapy and experimental psychiatry

2022 Volume 76, Page(s) 101748

Abstract: Background and objectives: We know little about how symptoms of obsessive-compulsive disorder and depression interact during psychological therapy. Although some previous research suggests that reductions in the severity of depression are driven by ... ...

Abstract	Background and objectives: We know little about how symptoms of obsessive-compulsive disorder and depression interact during psychological therapy. Although some previous research suggests that reductions in the severity of depression are driven by reductions in OCD, support for this conclusion is limited due to the exclusion of individuals with severe depression and limitations of the statistical approaches used. Methods: This study re-examined the interaction between symptoms of OCD and depression during therapy in a sample of 137 adults with a primary diagnosis of OCD and a full range of depression severity. All participants received a 12 to 16-week specialist residential treatment. Participants completed the Florida Obsessive Compulsive Inventory and Patient Health Questionnaire for depression weekly. The relationship between severity of OCD and depression was examined using a random intercept cross-lagged panel model. Results: Both cross-lagged paths were significant, with prior levels of OCD influencing subsequent levels of depression, and prior levels of depression influencing subsequent levels of OCD. Limitations: The present study was conducted in a residential setting, meaning the findings may not generalise to outpatient settings characterised by less severe OCD and depression. Conclusions: Contrary to previous findings, which suggest that the influence of OCD on depression is far greater than the reverse, our findings suggest that OCD and depression influence each other equally. As improvements in mood can help to improve symptoms of OCD, it appears important to target depression concurrently during treatment for OCD. This would be a new treatment target for improvement outcomes in OCD.
MeSH term(s)	Adult ; Depression/psychology ; Depressive Disorder ; Humans ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/therapy
Language	English
Publishing date	2022-06-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280250-8
ISSN	1873-7943 ; 0005-7916
ISSN (online)	1873-7943
ISSN	0005-7916
DOI	10.1016/j.jbtep.2022.101748
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