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  1. Article: Assessing the Value of a Pre-operative CT Sinus Anatomy Review Tool.

    Luu, Kimberly / Ospina, Javier / Gurberg, Joshua / Janjua, Arif

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 75, Issue Suppl 1, Page(s) 860–866

    Abstract: Performing endoscopic sinus surgery requires an intricate understanding of the anatomy of the paranasal sinuses, orbits and skull base. Avoidance of adverse events requires careful review of pre-operative computed tomography (CT) images to recognize ... ...

    Abstract Performing endoscopic sinus surgery requires an intricate understanding of the anatomy of the paranasal sinuses, orbits and skull base. Avoidance of adverse events requires careful review of pre-operative computed tomography (CT) images to recognize potential areas of safety concern. Using a preoperative checklist may aid surgeons in identifying these features. The objective of this study is to determine the educational value of a pre-operative CT sinus review tool and to determine if its use improves identification of important anatomical features. Otolaryngologists from varying practice levels reviewed 2 preoperative sinus CTs, with and without the tool. A 6-item Likert scale questionnaire assessed the operator experience with the tool. The number of high-risk features identified, determination of overall safety risk and difficulty, and time needed for review were compared between the two groups. A total of 18 participants reviewed 36 CT scans. The use of the CT review tool improved identification of important anatomical feature from 47% to 74% on average. All participants agreed that the tool was useful in capturing important anatomical variations in an organized manner and enabled overall assessment of surgical risk and difficulty. The checklist required significantly more time to complete. A preoperative CT sinus tool is perceived to be a useful tool by surgeons who perform endoscopic sinus surgery. The tool requires more time, but increases the number and consistency of high-risk features identified.
    Language English
    Publishing date 2023-01-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-022-03359-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of influenza and COVID-19 hospitalisations in British Columbia, Canada: a population-based study.

    Setayeshgar, Solmaz / Wilton, James / Sbihi, Hind / Zandy, Moe / Janjua, Naveed / Choi, Alexandra / Smolina, Kate

    BMJ open respiratory research

    2023  Volume 10, Issue 1

    Abstract: ... rates by age group were 'J' shaped. The population rate of COVID-19 hospital admissions in the annual ...

    Abstract Introduction: We compared the population rate of COVID-19 and influenza hospitalisations by age, COVID-19 vaccine status and pandemic phase, which was lacking in other studies.
    Method: We conducted a population-based study using hospital data from the province of British Columbia (population 5.3 million) in Canada with universal healthcare coverage. We created two cohorts of COVID-19 hospitalisations based on date of admission: annual cohort (March 2020 to February 2021) and peak cohort (Omicron era; first 10 weeks of 2022). For comparison, we created influenza annual and peak cohorts using three historical periods years to capture varying severity and circulating strains: 2009/2010, 2015/2016 and 2016/2017. We estimated hospitalisation rates per 100 000 population.
    Results: COVID-19 and influenza hospitalisation rates by age group were 'J' shaped. The population rate of COVID-19 hospital admissions in the annual cohort (mostly unvaccinated; public health restrictions in place) was significantly higher than influenza among individuals aged 30-69 years, and comparable to the severe influenza year (2016/2017) among 70+. In the peak COVID-19 cohort (mostly vaccinated; few restrictions in place), the hospitalisation rate was comparable with influenza 2016/2017 in all age groups, although rates among the unvaccinated population were still higher than influenza among 18+. Among people aged 5-17 years, COVID-19 hospitalisation rates were lower than/comparable to influenza years in both cohorts. The COVID-19 hospitalisation rate among 0-4 years old, during Omicron, was higher than influenza 2015/2016 and 2016/2017 and lower than 2009/2010 pandemic.
    Conclusions: During first Omicron wave, COVID-19 hospitalisation rates were significantly higher than historical influenza hospitalisation rates for unvaccinated adults but were comparable to influenza for vaccinated adults. For children, in the context of high infection levels, hospitalisation rates for COVID-19 were lower than 2009/2010 H1N1 influenza and comparable (higher for 0-4) to non-pandemic years, regardless of the vaccine status.
    MeSH term(s) Adult ; Child ; Humans ; Infant, Newborn ; Infant ; Child, Preschool ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; British Columbia/epidemiology ; Influenza A Virus, H1N1 Subtype ; COVID-19 Vaccines ; COVID-19/epidemiology ; Influenza Vaccines ; Hospitalization
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2022-001567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bupropion-Associated Neurotoxicity in Adolescent With Autism Spectrum Disorder on Stable Dose of Amantadine.

    Janjua, Khurram / Hillwig-Garcia, Jolene / Baweja, Raman

    Journal of clinical psychopharmacology

    2021  Volume 41, Issue 4, Page(s) 493–495

    MeSH term(s) Adolescent ; Amantadine/therapeutic use ; Antidepressive Agents, Second-Generation/adverse effects ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/psychology ; Bupropion/adverse effects ; Dopamine Agents/therapeutic use ; Female ; Humans ; Neurotoxicity Syndromes/diagnosis ; Neurotoxicity Syndromes/etiology
    Chemical Substances Antidepressive Agents, Second-Generation ; Dopamine Agents ; Bupropion (01ZG3TPX31) ; Amantadine (BF4C9Z1J53)
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001422
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  4. Article ; Online: Sudden perceived absence of foetal movement - a unique presentation of a vertebral haemangioma in pregnancy.

    Devaraj, Ankitha / Raoof, Jamaal / Janjua, Osman / Tsang, Kevin / Zamir, Muhammad

    BJR case reports

    2021  Volume 8, Issue 1, Page(s) 20200199

    Abstract: Objective: Symptomatic vertebral haemangiomas that present during pregnancy are extremely uncommon with few cases reported in literature. Epidural haemangiomas are rarer still with few documented.: Methods: In this report, we describe the case of a ... ...

    Abstract Objective: Symptomatic vertebral haemangiomas that present during pregnancy are extremely uncommon with few cases reported in literature. Epidural haemangiomas are rarer still with few documented.
    Methods: In this report, we describe the case of a 22-year-old pregnant patient who presented with apparent loss of foetal movement at 38 weeks' gestation. Clinical review demonstrated the foetus was well but neurological examination revealed lower limb paresthesia, paresis and evident uterine hypoesthesia. An MRI scan illustrated a haemangioma in the T1 vertebral body with an epidural component causing cord compression.
    Results: The management of spinal haemangiomas that present during pregnancy is a complex clinical scenario, which requires careful multidisciplinary consideration to determine if surgical intervention is appropriate. In this case, the patient had an emergency caesarean section followed by posterior decompression and laminectomy of the T1 vertebra with excellent post-operative recovery.
    Conclusion: Gestational increase in the size of vertebral haemangiomas is well documented. We discuss a rare case in which a young pregnant patient presents with an atypical symptom of a vertebral haemangioma (uterine hypoesthesia). This case highlights the importance of prompt imaging in these scenarios and a cohesive multidisciplinary approach in order to provide optimal treatment for the patient.
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1259/bjrcr.20200199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ongoing Gaps in the Hepatitis C Care Cascade during the Direct-Acting Antiviral Era in a Large Retrospective Cohort in Canada: A Population-Based Study.

    Passos-Castilho, Ana Maria / Murphy, Donald G / Blouin, Karine / Benedetti, Andrea / Panagiotoglou, Dimitra / Bruneau, Julie / Klein, Marina B / Kwong, Jeffrey C / Sander, Beate / Janjua, Naveed Z / Greenaway, Christina

    Viruses

    2024  Volume 16, Issue 3

    Abstract: To achieve hepatitis C virus (HCV) elimination, high uptake along the care cascade steps for all will be necessary. We mapped engagement with the care cascade overall and among priority groups in the post-direct-acting antivirals (DAAs) period and ... ...

    Abstract To achieve hepatitis C virus (HCV) elimination, high uptake along the care cascade steps for all will be necessary. We mapped engagement with the care cascade overall and among priority groups in the post-direct-acting antivirals (DAAs) period and assessed if this changed relative to pre-DAAs. We created a population-based cohort of all reported HCV diagnoses in Quebec (1990-2018) and constructed the care cascade [antibody diagnosed, RNA tested, RNA positive, genotyped, treated, sustained virologic response (SVR)] in 2013 and 2018. Characteristics associated with RNA testing and treatment initiation were investigated using marginal logistic models via generalized estimating equations. Of the 31,439 individuals HCV-diagnosed in Quebec since 1990 and alive as of 2018, there was significant progress in engagement with the care cascade post- vs. pre-DAAs; 86% vs. 77% were RNA-tested, and 64% vs. 40% initiated treatment. As of 2018, a higher risk of not being RNA-tested or treated was observed among individuals born <1945 vs. >1965 [hazard ratio (HR); 95% CI; 1.35 (1.16-1.57)], those with material and social deprivation [1.21 (1.06-1.38)], and those with alcohol use disorder [1.21 (1.08-1.360]. Overall, non-immigrants had lower rates of RNA testing [0.76 (0.67-0.85)] and treatment initiation [0.63 (0.57-0.70)] than immigrants. As of 2018, PWID had a lower risk of not being RNA tested [0.67 (0.61-0.85)] but a similar risk of not being treated, compared to non-PWID. Engagement in the HCV care cascade have improved in the post-DAA era, but inequities remain. Vulnerable subgroups, including certain older immigrants, were less likely to have received RNA testing or treatment as of 2018 and would benefit from focused interventions to strengthen these steps.
    MeSH term(s) Humans ; Hepacivirus/genetics ; Antiviral Agents/therapeutic use ; Retrospective Studies ; Hepatitis C, Chronic/drug therapy ; Cohort Studies ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Canada/epidemiology ; RNA
    Chemical Substances Antiviral Agents ; RNA (63231-63-0)
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis.

    Janjua, Divya / Thakur, Kulbhushan / Aggarwal, Nikita / Chaudhary, Apoorva / Yadav, Joni / Chhokar, Arun / Tripathi, Tanya / Joshi, Udit / Senrung, Anna / Bharti, Alok Chandra

    Critical reviews in oncology/hematology

    2024  Volume 197, Page(s) 104346

    Abstract: Cervical cancer (CaCx) ranks as the fourth most prevalent cancer among women globally. Persistent infection of high-risk human papillomaviruses (HR-HPVs) is major etiological factor associated with CaCx. Signal Transducer and Activator of Transcription 3 ...

    Abstract Cervical cancer (CaCx) ranks as the fourth most prevalent cancer among women globally. Persistent infection of high-risk human papillomaviruses (HR-HPVs) is major etiological factor associated with CaCx. Signal Transducer and Activator of Transcription 3 (STAT3), a prominent member of the STAT family, has emerged as independent oncogenic driver. It is a target of many oncogenic viruses including HPV. How STAT3 influences HPV viral gene expression or gets affected by HPV is an area of active investigation. A better understanding of host-virus interaction will provide a prognostic and therapeutic window for CaCx control and management. In this comprehensive review, we delve into carcinogenic role of STAT3 in development of HPV-induced CaCx. With an emphasis on fascinating interplay between STAT3 and HPV genome, the review explores the diverse array of opportunities and challenges associated with this field to harness the prognostic and therapeutic potential of STAT3 in CaCx.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2024.104346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals.

    Faksova, K / Walsh, D / Jiang, Y / Griffin, J / Phillips, A / Gentile, A / Kwong, J C / Macartney, K / Naus, M / Grange, Z / Escolano, S / Sepulveda, G / Shetty, A / Pillsbury, A / Sullivan, C / Naveed, Z / Janjua, N Z / Giglio, N / Perälä, J /
    Nasreen, S / Gidding, H / Hovi, P / Vo, T / Cui, F / Deng, L / Cullen, L / Artama, M / Lu, H / Clothier, H J / Batty, K / Paynter, J / Petousis-Harris, H / Buttery, J / Black, S / Hviid, A

    Vaccine

    2024  Volume 42, Issue 9, Page(s) 2200–2211

    Abstract: Background: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse ... ...

    Abstract Background: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse events of special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries.
    Methods: Using a common protocol, this observational cohort study compared observed with expected rates of 13 selected AESI across neurological, haematological, and cardiac outcomes. Expected rates were obtained by participating sites using pre-COVID-19 vaccination healthcare data stratified by age and sex. Observed rates were reported from the same healthcare datasets since COVID-19 vaccination program rollout. AESI occurring up to 42 days following vaccination with mRNA (BNT162b2 and mRNA-1273) and adenovirus-vector (ChAdOx1) vaccines were included in the primary analysis. Risks were assessed using observed versus expected (OE) ratios with 95 % confidence intervals. Prioritised potential safety signals were those with lower bound of the 95 % confidence interval (LBCI) greater than 1.5.
    Results: Participants included 99,068,901 vaccinated individuals. In total, 183,559,462 doses of BNT162b2, 36,178,442 doses of mRNA-1273, and 23,093,399 doses of ChAdOx1 were administered across participating sites in the study period. Risk periods following homologous vaccination schedules contributed 23,168,335 person-years of follow-up. OE ratios with LBCI > 1.5 were observed for Guillain-Barré syndrome (2.49, 95 % CI: 2.15, 2.87) and cerebral venous sinus thrombosis (3.23, 95 % CI: 2.51, 4.09) following the first dose of ChAdOx1 vaccine. Acute disseminated encephalomyelitis showed an OE ratio of 3.78 (95 % CI: 1.52, 7.78) following the first dose of mRNA-1273 vaccine. The OE ratios for myocarditis and pericarditis following BNT162b2, mRNA-1273, and ChAdOx1 were significantly increased with LBCIs > 1.5.
    Conclusion: This multi-country analysis confirmed pre-established safety signals for myocarditis, pericarditis, Guillain-Barré syndrome, and cerebral venous sinus thrombosis. Other potential safety signals that require further investigation were identified.
    MeSH term(s) Humans ; 2019-nCoV Vaccine mRNA-1273 ; BNT162 Vaccine ; Cohort Studies ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Guillain-Barre Syndrome/chemically induced ; Guillain-Barre Syndrome/epidemiology ; mRNA Vaccines ; Myocarditis ; Pericarditis ; Sinus Thrombosis, Intracranial ; Vaccination/adverse effects ; Male ; Female
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine ; COVID-19 Vaccines ; mRNA Vaccines
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.01.100
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  8. Article: Duodenal tuberculosis mimicking carcinoma, head of pancreas.

    Janjua, K J

    Annals of Saudi medicine

    2007  Volume 14, Issue 1, Page(s) 53–55

    Language English
    Publishing date 2007-05-24
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 639014-6
    ISSN 0975-4466 ; 0256-4947
    ISSN (online) 0975-4466
    ISSN 0256-4947
    DOI 10.5144/0256-4947.1994.53
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  9. Article ; Online: Comparison of influenza and COVID-19 hospitalizations in British Columbia, Canada: a population-based study

    Setayeshgar, Solmaz / Wilton, James / Sbihi, Hind / Zandy, Moe / Janjua, Naveed / Choi, Alexandra / Smolina, Kate

    medRxiv

    Abstract: ... J shaped. The rates for mostly unvaccinated COVID-19 patients in 2020/21 in the context ...

    Abstract Objective To compare the population rate of COVID-19 and influenza hospitalizations by age, COVID-19 vaccine status and pandemic phase. Design Observational retrospective study Setting Residents of British Columbia (population 5.3 million), Canada Participants Hospitalized patients due to COVID-19 or historical influenza Main outcome measures This population based study in a setting with universal healthcare coverage, used COVID-19 case and hospital data for COVID-19 and influenza. Admissions were selected from March 2020 to February 2021 for the annual cohort and the first 8 weeks of 2022 for the peak cohort of COVID-19 (Omicron era). Influenza annual and peak cohorts were from three years with varying severity: 2009/10, 2015/16, and 2016/17. We estimated hospitalization rates per 100,000 population by age group. Results Similar to COVID-19 with median age 66 (Q1-Q3 44-80), influenza 2016/17 mostly affected older adults, with median age 78 (64-87). COVID-19 and influenza 2016/17 hospitalization rate by age group were J shaped. The rates for mostly unvaccinated COVID-19 patients in 2020/21 in the context of public health restrictions were significantly higher than influenza among individuals 30 to 69 years of age, and comparable to a severe influenza year (2016/17) among 70+. In early 2022 (Omicron peak), rates primarily due to COVID-19 among vaccinated adults were comparable with influenza 2016/17 in all age groups while rates among unvaccinated COVID-19 patients were still higher than influenza among 18+. In the pediatric population, COVID-19 hospitalization rates were similar to or lower than influenza. Conclusions Our paper highlighted the greater population-level impact of COVID-19 compared with influenza in terms of adult hospitalizations, especially among those unvaccinated. However, influenza had greater impact than COVID-19 among <18 regardless of vaccine status or the circulating variant.
    Keywords covid19
    Language English
    Publishing date 2022-08-30
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.08.26.22279284
    Database COVID19

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  10. Article ; Online: Mapping the geographic migration of United States neurosurgeons across training and current practice regions: associations with academic productivity.

    Pugazenthi, Sangami / Hernandez-Rovira, Miguel A / Fabiano, Alexander S / Rogers, James L / Gajjar, Avi A / Lavadi, Raj Swaroop / Elsayed, Galal A / Greenberg, Jacob K / Hafez, Daniel M / Janjua, M Burhan / Ogunlade, John / Pennicooke, Brenton H / Agarwal, Nitin

    Journal of neurosurgery

    2023  Volume 139, Issue 4, Page(s) 1109–1119

    Abstract: Objective: Characterizing changes in the geographic distribution of neurosurgeons in the United States (US) may inform efforts to provide a more equitable distribution of neurosurgical care. Herein, the authors performed a comprehensive analysis of the ... ...

    Abstract Objective: Characterizing changes in the geographic distribution of neurosurgeons in the United States (US) may inform efforts to provide a more equitable distribution of neurosurgical care. Herein, the authors performed a comprehensive analysis of the geographic movement and distribution of the neurosurgical workforce.
    Methods: A list containing all board-certified neurosurgeons practicing in the US in 2019 was obtained from the American Association of Neurological Surgeons membership database. Chi-square analysis and a post hoc comparison with Bonferroni correction were performed to assess differences in demographics and geographic movement throughout neurosurgeon careers. Three multinomial logistic regression models were performed to further evaluate relationships among training location, current practice location, neurosurgeon characteristics, and academic productivity.
    Results: The study cohort included 4075 (3830 male, 245 female) neurosurgeons practicing in the US. Seven hundred eighty-one neurosurgeons practice in the Northeast, 810 in the Midwest, 1562 in the South, 906 in the West, and 16 in a US territory. States with the lowest density of neurosurgeons included Vermont and Rhode Island in the Northeast; Arkansas, Hawaii, and Wyoming in the West; North Dakota in the Midwest; and Delaware in the South. Overall, the effect size, as measured by Cramér's V statistic, between training stage and training region is relatively modest at 0.27 (1.0 is complete dependence); this finding was reflected in the similarly modest pseudo R2 values of the multinomial logit models, which ranged from 0.197 to 0.246. Multinomial logistic regression with L1 regularization revealed significant associations between current practice region and residency region, medical school region, age, academic status, sex, or race (p < 0.05). On subanalysis of the academic neurosurgeons, the region of residency training correlated with an advanced degree type in the overall neurosurgeon cohort, with more neurosurgeons than expected holding Doctor of Medicine and Doctor of Philosophy degrees in the West (p = 0.021).
    Conclusions: Female neurosurgeons were less likely to practice in the South, and neurosurgeons in the South and West had reduced odds of holding academic rather than private positions. The Northeast was the most likely region to contain neurosurgeons who had completed their training in the same locality, particularly among academic neurosurgeons who did their residency in the Northeast.
    MeSH term(s) United States ; Humans ; Male ; Female ; Neurosurgeons ; Neurosurgery/education ; Internship and Residency ; Schools, Medical ; Efficiency
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.1.JNS222269
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