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Article ; Online: Bolstering the surgical response to COVID-19: how virtual technology will save lives and safeguard surgical practice.

Karim, Jamila S / Hachach-Haram, Nadine / Dasgupta, Prokar

2020 Volume 125, Issue 6, Page(s) E18–E19

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Elective Surgical Procedures ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Telemedicine ; Urologic Surgical Procedures
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	England
Document type	Letter
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15080
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Article: Bolstering the surgical response to COVID-19: how virtual technology will save lives and safeguard surgical practice

Karim, Jamila S / Hachach-Haram, Nadine / Dasgupta, Prokar

BJU Int

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #47059
Database	COVID19

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Article ; Online: Bolstering the surgical response to COVID-19

Karim, Jamila S. / Hachach-Haram, Nadine / Dasgupta, Prokar

BJU International ; ISSN 1464-4096

how virtual technology will save lives and safeguard surgical practice

2020

Keywords	Urology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/bju.15080
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Applying augmented reality to treat Fournier's gangrene in COVID-19 positive patients whilst safeguarding the multi-disciplinary surgical team: A case series.

Alyaqout, Khaled / AlQinai, Shamlan / Almazeedi, Sulaiman / Karim, Jamila S / Al-Youha, Sarah / Al-Sabah, Salman

International journal of surgery case reports

2021 Volume 79, Page(s) 335–338

Abstract: Introduction: COVID-19 has presented the surgical community with a multitude of challenges. Patients requiring surgical intervention who are positive for COVID-19 are not only more likely to develop complications post-operatively, but also pose an ... ...

Abstract	Introduction: COVID-19 has presented the surgical community with a multitude of challenges. Patients requiring surgical intervention who are positive for COVID-19 are not only more likely to develop complications post-operatively, but also pose an increased infection risk to the surgical team involved in their care. The infection control concerns raised at the peak of the pandemic persist in the post-pandemic era as patients continue to test positive for COVID-19 and the risk of a 'second wave' looms. Methods: We present a case series (compliant with SCARE [4] and PROCESS [5] criteria) to demonstrate the effective use of an AR technology platform during the intraoperative treatment of two complex COVID positive patients diagnosed with Fournier's gangrene.Retrospective review of prospectively collected data of all patients that required surgery involving multiple specialties during the COVID-19 pandemic at Jaber AlAhmad hospital in Kuwait between March 2020 to October 2020. Presentation of case: We present two cases to highlight the use of an augmented reality (AR) platform during the treatment of COVID-19 positive patients with Fournier's gangrene in order to safeguard surgical teams whilst simultaneously enabling these complex cases to benefit from multi-specialty input intraoperatively. Outcome: Augmented reality is a feasible option to minimize surgeons' exposure during surgery without compromising the patients safety. Discussion: This case series demonstrates how AR solutions can be employed to bolster infection control measures and may be useful in the treatment of surgical patients who test positive for COVID-19. Conclusion: AR solutions could be considered as an infection control strategy to safeguard surgical teams operating on COVID-19 positive patients.
Language	English
Publishing date	2021-01-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2021.01.055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Needs assessment for curricular reform of a post graduate paediatric training programme at a private university hospital in Karachi, Pakistan.

Saeed, Sana / Humayun, Khadija Nuzhat / Qamar, Farah Naz / Rahman, Arshalooz Jamila / Karim, Kashif

JPMA. The Journal of the Pakistan Medical Association

2018 Volume 68, Issue 9, Page(s) 1381–1382

Abstract: In order to make and sustain changes in the curriculum, needs assessment is the key. We conducted a need assessment survey using a questionnaire based on a 7 point Likert Scale by residents and alumni. Over all response rate in the study was 77.5%. Fifty ...

Abstract	In order to make and sustain changes in the curriculum, needs assessment is the key. We conducted a need assessment survey using a questionnaire based on a 7 point Likert Scale by residents and alumni. Over all response rate in the study was 77.5%. Fifty eight percent participants were females. Highest level of agreement (mean score 5.7) was found between the alumni and residents regarding the need to revise the content, teaching and assessment strategies in the programme. Twenty seven alumni (n= 38, 71%) had cleared their FCPS exams. The alumni thought that the existing teaching and assessment strategies do not facilitate in passing professional certificate exams (mean score 3.6). The mean attempts required by the alumni for clearing this exam was 3.3, and 84.2% considered their weak clinical skills as the reason for their recurrent failure.
MeSH term(s)	Academic Success ; Adult ; Clinical Competence ; Curriculum/standards ; Education, Medical, Continuing/methods ; Education, Medical, Continuing/standards ; Female ; Hospitals, University ; Humans ; Male ; Needs Assessment ; Pakistan ; Pediatrics/education ; Quality Improvement
Language	English
Publishing date	2018-10-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article: Unplanned Clinic Attendance, Readmission, and Reoperation in the First 12 Months Postoperatively Following Hip Hemiarthroplasty for Acute Hip Fractures: Who Is At Risk?

Ghani, Rafia / Usman, Muhammad / Salar, Omer / Khan, Abdul M / Karim, Jamila / Davis, Edward T / Quraishi, Sohail / Ahmed, Mushtaq

Cureus

2019 Volume 11, Issue 11, Page(s) e6128

Abstract: Introduction Up to 19% of patients who undergo surgery for an acute hip fracture are readmitted to the hospital within three months of the index operation. We aimed to identify risk factors for unplanned clinic attendance, readmission, and mortality ... ...

Abstract	Introduction Up to 19% of patients who undergo surgery for an acute hip fracture are readmitted to the hospital within three months of the index operation. We aimed to identify risk factors for unplanned clinic attendance, readmission, and mortality within the first 12 months postoperatively and subsequently determine if there is a role for routine follow-up. Method Patients greater than 65 years old who underwent hip hemiarthroplasty using an uncemented Thompson implant for treatment of a traumatic non-pathological hip fracture were identified from a prospectively maintained database at a single institution between August 2007 and February 2011. Patient demographics, comorbidities, place of residence, mobility status, unplanned attendance to an orthopaedic clinic with symptoms relating to the respective limb, readmission, and mortality were recorded. Regression analysis was performed using the IBM Statistical Package for Social Sciences (SPSS), version 24 (IBM SPSS Statistics, Armonk, NY) with P < 0.05 considered significant. Results Five hundred and fifty-four consecutive patients were identified. Unplanned clinic attendance was correlated to age (p = 0.000, B = -0.0159, 95% confidence interval (CI): -0.200 to -0.65), with patients between the ages of 65 - 70 years most likely to require unplanned clinic review postoperatively. The American Society of Anesthesiologists (ASA) grade (p = 0.019, 95% CI: 0.014 to 0.163) and frequency of unplanned outpatient attendance (p = 0.000, 95% CI: 0.120 to 0.284) were significantly associated with increased readmission within 12 months of the index procedure with patients who were regarded as ASA > 2 most likely to require readmission within the first postoperative year. Conclusion To our knowledge, this is the first piece of research that identifies causative factors for unplanned clinic attendance and acute readmission during the first postoperative year in acute hip fracture patients treated by hemiarthroplasty. Routine scheduled follow-up of patients based on risk stratification may be effective in reducing the financial burden of unplanned clinic attendance.
Language	English
Publishing date	2019-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.6128
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Article: Potential Transmission Cycles of Leishmania tropica in a Historic Disease Focus of Cutaneous Leishmaniasis in Southeast Tunisia

Tabbabi, Ahmed / Bousslimi, Nadia / Rhim, Adel / Sghaier, Ines Ben / Ghrab, Jamila / Ben-Abda, Imene / Aoun, Karim / Bouratbine, Aïda

Journal of entomological science. 2020 Jan. 3, v. 55, no. 1

2020

Abstract: ... the most abundant Phlebotomus species found in homes. Phlebotomus chabaudi s.l. (Croset) was ... sergenti transmitting L. tropica among humans inside and in peridomestic habitats and P. chabaudi s.l ... transmitting the disease agent among gundi in their natural habitats. Phlebotomus chabaudi s.l. also ...

Abstract	The transmission of Leishmania tropica (Wright) (Protozoa: Sarcomastigophora: Trypanosomatidae) was studied in a historic focus of the cutaneous leishmaniasis disease in southeast Tunisia. The sandfly Phlebotomus sergenti (Parrot) (Diptera: Psychodidae), the confirmed vector of L. tropica in humans, was the most abundant Phlebotomus species found in homes. Phlebotomus chabaudi s.l. (Croset) was the dominant species in the natural rocky habitats favored by the North African gundi, Ctenodactylus gundi (Rothman), which is a known putative rodent reservoir of L. tropica. Leishmania tropica MON-8 (Rioux, Lanotte and Pratlong) was the species isolated and identified from gundi, humans, and P. sergenti in the disease focus area. Based on these results, the North African gundi may serve at least as a maintenance host for L. tropica in this area of southeast Tunisia, even though L. tropica is commonly stated to be anthroponotic. These results also suggest that there may be two transmission cycles of L. tropica in this region, with P. sergenti transmitting L. tropica among humans inside and in peridomestic habitats and P. chabaudi s.l. transmitting the disease agent among gundi in their natural habitats. Phlebotomus chabaudi s.l. also may transmit to humans when humans venture into areas inhabited by gundi host reservoirs.
Keywords	Leishmania tropica ; Phlebotomus sergenti ; cutaneous leishmaniasis ; disease transmission ; dominant species ; habitats ; humans ; rodents ; Tunisia
Language	English
Dates of publication	2020-0103
Size	p. 38-45.
Publishing place	Georgia Entomological Society
Document type	Article
ZDB-ID	12629-9
ISSN	0749-8004
ISSN	0749-8004
DOI	10.18474/0749-8004-55.1.38
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vertical transmission of hepatitis C virus in low to middle socio-economic pregnant population of Karachi.

Aziz, Sina / Hossain, Nazli / Karim, Saadiya Aziz / Rajper, Jamila / Soomro, Nargis / Noorulain, Wajeeha / Qamar, Rana / Khanani, Rafiq

Hepatology international

2010 Volume 5, Issue 2, Page(s) 677–680

Abstract: Purpose: To determine the rate of vertical transmission (transmission from mother to child) of hepatitis C virus in low to middle socio-economic pregnant women.: Methods: This study was conducted at Sarwar Zuberi Liver Centre (SZLC) in collaboration ... ...

Abstract	Purpose: To determine the rate of vertical transmission (transmission from mother to child) of hepatitis C virus in low to middle socio-economic pregnant women. Methods: This study was conducted at Sarwar Zuberi Liver Centre (SZLC) in collaboration with the department of Gynaecology and Obstetrics, Civil Hospital Karachi (CHK) and Abbasi Shaheed Hospital (ASH) for a period of 4 years from September 2005 to December 2009. Total 18,000 women seeking antenatal care were screened for hepatitis C antibodies (Anti-HCV) using 4th generation ELISA technique. Positive 1,043 women were further offered HCV ribonucleic acid (RNA) by polymerase chain reaction (PCR). Six hundred and forty women agreed to have PCR done, and 510 PCR positive women were finally included in the study, followed till delivery and treated if required. Newborns of 510 PCR positive mothers were advised HCV-RNA by PCR from 3 to 12 months of age and Anti-HCV at 18 up to 24 months and followed up to 3 years. Results: 1,043/18,000 (5.79%) mothers were Anti-HCV positive, of which PCR results of 640 mothers are available where 510/640 (79.7%) were PCR positive, 357/510 (70%) delivered by spontaneous vaginal delivery (SVD), 33 (6.4%) by forceps delivery, 70 (13.7%) had elective, and 50 (9.8%) had emergency caesarian section. Premature rupture of membranes (PROM) was present in 81 mothers. Data of 510 babies from 3 months to 3 years of age was available of which only 215 had their laboratory tests done (HCV-RNA-PCR in 86 and Anti-HCV in 129). Mean birth weight (kg), height (cm) and OFC (cm) were 2.74 ± 0.43, 52.4 ± 7.5, and 35 ± 4. Apgar score median at 1 and 5 min was 7 (range 2-10), 8 (range 4-10), respectively. Low birth weight was present in 49 (9.6%), 37 (7.2%) had history of Neonatal Intensive Care Unit (NICU) admission. PCR of none of the 86 babies done at 3-12 months was positive. Five babies out of 129 were Anti-HCV positive at 18 months of age. Of this, 3/5 was HCV-RNA-PCR positive. Rate of vertical transmission of HCV was 1.39. Conclusion: In spite of the high hepatitis C positivity in pregnant population, the rate of vertical transmission to the neonate is low.
Language	English
Publishing date	2010-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2270316-0
ISSN	1936-0541 ; 1936-0533
ISSN (online)	1936-0541
ISSN	1936-0533
DOI	10.1007/s12072-010-9229-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.

Kambhampati, Madhuri / Panditharatna, Eshini / Yadavilli, Sridevi / Saoud, Karim / Lee, Sulgi / Eze, Augustine / Almira-Suarez, M I / Hancock, Lauren / Bonner, Erin R / Gittens, Jamila / Stampar, Mojca / Gaonkar, Krutika / Resnick, Adam C / Kline, Cassie / Ho, Cheng-Ying / Waanders, Angela J / Georgescu, Maria-Magdalena / Rance, Naomi E / Kim, Yong /

Johnson, Courtney / Rood, Brian R / Kilburn, Lindsay B / Hwang, Eugene I / Mueller, Sabine / Packer, Roger J / Bornhorst, Miriam / Nazarian, Javad

Scientific reports

2020 Volume 10, Issue 1, Page(s) 10954

Abstract: Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular ... ...

Abstract	Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular advances, the clinical outcomes of high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor. To address the paucity of tissue for biological studies, we have established a comprehensive protocol for the coordination and processing of donated specimens at postmortem. Since 2010, 60 postmortem pediatric brain tumor donations from 26 institutions were coordinated and collected. Patient derived xenograft models and cell cultures were successfully created (76% and 44% of attempts respectively), irrespective of postmortem processing time. Histological analysis of mid-sagittal whole brain sections revealed evidence of treatment response, immune cell infiltration and the migratory path of infiltrating H3K27M DMG cells into other midline structures and cerebral lobes. Sequencing of primary and disseminated tumors confirmed the presence of oncogenic driver mutations and their obligate partners. Our findings highlight the importance of postmortem tissue donations as an invaluable resource to accelerate research, potentially leading to improved outcomes for children with aggressive brain tumors.
MeSH term(s)	Adolescent ; Adult ; Animals ; Autopsy ; Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/pathology ; Histones/genetics ; Humans ; Infant ; Male ; Mice, Inbred NOD ; Mice, SCID ; Mutation ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Histones
Language	English
Publishing date	2020-07-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-67764-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Intracoronary Infusion of Autologous CD133(+) Cells in Myocardial Infarction and Tracing by Tc99m MIBI Scintigraphy of the Heart Areas Involved in Cell Homing.

Stem cells international

2013 Volume 2013, Page(s) 582527

Abstract: CD133 mesenchymal cells were enriched using magnetic microbead anti-CD133 antibody from bone marrow mononuclear cells (BMMNCs). Flow cytometry and immunocytochemistry analysis using specific antibodies revealed that these cells were essentially 89 ± 4% ... ...

Abstract	CD133 mesenchymal cells were enriched using magnetic microbead anti-CD133 antibody from bone marrow mononuclear cells (BMMNCs). Flow cytometry and immunocytochemistry analysis using specific antibodies revealed that these cells were essentially 89 ± 4% CD133(+) and 8 ± 5% CD34(+). CD133(+)/CD34(+) BMMNCs secrete important bioactive proteins such as cardiotrophin-1, angiogenic and neurogenic factors, morphogenetic proteins, and proinflammatory and remodeling factors in vitro. Single intracoronary infusions of autologous CD133(+)/CD34(+) BMMNCs are effective and reduce infarct size in patients as analyzed by Tc99m MIBI myocardial scintigraphy. The majority of patients were treated via left coronary artery. Nine months after cell therapy, 5 out of 8 patients showed a net positive response to therapy in different regions of the heart. Uptake of Tc99 isotope and revitalization of the heart area in inferoseptal region are more pronounced (P = 0.016) as compared to apex and anterosptal regions after intracoronary injection of the stem cells. The cells chosen here have the properties essential for their potential use in cell therapy and their homing can be followed without major difficulty by the scintigraphy. The cell therapy proposed here is safe and should be practiced, as we found, in conjunction with scintigraphic observation of areas of heart which respond optimally to the infusion of autologous CD133(+)/CD34(+) BMMNCs.
Language	English
Publishing date	2013-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.1155/2013/582527
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