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  1. Article ; Online: Suprachoroidal steroids for uveitic macular oedema: Teaching an old drug new tricks?

    Campbell, Thomas Gordon / Lin, Ming-Lee

    Clinical & experimental ophthalmology

    2022  Volume 50, Issue 1, Page(s) 14–16

    MeSH term(s) Glucocorticoids/therapeutic use ; Humans ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Macular Edema/etiology ; Triamcinolone Acetonide/therapeutic use ; Uveitis/complications ; Uveitis/diagnosis ; Uveitis/drug therapy
    Chemical Substances Glucocorticoids ; Triamcinolone Acetonide (F446C597KA)
    Language English
    Publishing date 2022-02-14
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1064: Show issues Location:
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  2. Article: Acute Macular Neuroretinopathy Related to Alcoholic Hepatitis.

    Mc Cabe, Grace Anne / Campbell, William Gordon / Campbell, Thomas Gordon

    Case reports in ophthalmology

    2021  Volume 12, Issue 1, Page(s) 293–298

    Abstract: A 33-year-old woman admitted for acute alcoholic hepatitis was referred to the ophthalmology department with an acute onset paracentral scotoma of the left eye. On examination, best-corrected visual acuity was Snellen 6/4 in the right eye and 6/9 in the ... ...

    Abstract A 33-year-old woman admitted for acute alcoholic hepatitis was referred to the ophthalmology department with an acute onset paracentral scotoma of the left eye. On examination, best-corrected visual acuity was Snellen 6/4 in the right eye and 6/9 in the left eye. Dilated left fundus examination revealed wedge-shaped changes at the macula. Spectral-domain ocular coherence tomography (SD-OCT) initially revealed a small cuff of subfoveal fluid and band-like hyperreflectivity extending outwards from the outer plexiform layer consistent with acute macular neuroretinopathy (AMN). Four days later, repeat SD-OCT was performed and it demonstrated resolution of the subfoveal fluid and disruption of the outer retinal layers. At the 6-week follow-up, the patient had no improvement in her symptoms and OCT angiography demonstrated coarsening and microvascular changes in both the deep vascular plexus and the choriocapillaris. To our knowledge, this is the first case of AMN in association with acute hepatitis. Although the exact pathophysiology of AMN remains obscure, this case highlights the benefits of multimodal retinal imaging and aims to bring attention to the possible association of AMN with alcoholic hepatitis.
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000513186
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  3. Article ; Online: Bilateral periorbital necrotising fasciitis associated with invasive group: a

    McCabe, Grace Anne / Hardy, Thomas / Campbell, Thomas Gordon

    BMJ case reports

    2020  Volume 13, Issue 12

    Abstract: A previously independent 56-year-old immunocompetent woman presented with septic shock in the setting of periorbital swelling and diffuse infiltrates on chest imaging. Blood cultures were positive for growth of group ... ...

    Abstract A previously independent 56-year-old immunocompetent woman presented with septic shock in the setting of periorbital swelling and diffuse infiltrates on chest imaging. Blood cultures were positive for growth of group A
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Debridement ; Drug Therapy, Combination ; Eyelids/microbiology ; Eyelids/surgery ; Fasciitis, Necrotizing/complications ; Fasciitis, Necrotizing/diagnosis ; Fasciitis, Necrotizing/microbiology ; Fasciitis, Necrotizing/therapy ; Female ; Humans ; Middle Aged ; Severity of Illness Index ; Shock, Septic/diagnosis ; Shock, Septic/microbiology ; Shock, Septic/therapy ; Skin Transplantation ; Streptococcal Infections/complications ; Streptococcal Infections/diagnosis ; Streptococcal Infections/microbiology ; Streptococcal Infections/therapy ; Streptococcus pyogenes/isolation & purification ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-12-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A radical treatment for surfer's eye.

    Campbell, Thomas Gordon

    BMJ case reports

    2014  Volume 2014

    MeSH term(s) Corneal Injuries ; Humans ; Male ; Middle Aged ; Pterygium/etiology ; Remission Induction ; Sports
    Language English
    Publishing date 2014-03-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2014-203896
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  5. Article ; Online: Development of an intracellular quantitative assay to measure compound binding kinetics.

    Lay, Charles S / Thomas, Daniel A / Evans, John P / Campbell, Matthew / McCombe, Kristopher / Phillipou, Alexander N / Gordon, Laurie J / Jones, Emma J / Riching, Kristin / Mahmood, Mahnoor / Messenger, Cassie / Carver, Charlotte E / Gatfield, Kelly M / Craggs, Peter D

    Cell chemical biology

    2023  Volume 30, Issue 12, Page(s) 1692

    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Published Erratum
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genomics reveals the novel species placement of industrial contaminant isolates incorrectly identified as

    Cunningham-Oakes, Edward / Pointon, Tom / Murphy, Barry / Campbell-Lee, Stuart / Webster, Gordon / Connor, Thomas R / Mahenthiralingam, Eshwar

    Microbial genomics

    2021  Volume 7, Issue 4

    Abstract: ... ...

    Abstract The
    MeSH term(s) Burkholderia/classification ; Burkholderia/genetics ; Burkholderia/isolation & purification ; Genome, Bacterial ; Genomics ; Industrial Microbiology ; Multilocus Sequence Typing ; Phylogeny
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000564
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  7. Article ; Online: A novel clinical entity: the Campbell-Trachter syndrome.

    Campbell, Thomas Gordon / Trachter, Robert

    BMJ (Clinical research ed.)

    2014  Volume 349, Page(s) g7423

    MeSH term(s) Emotions ; Eponyms ; Humans ; Students, Medical/psychology ; Syndrome
    Language English
    Publishing date 2014-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.g7423
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  8. Article ; Online: Author Correction: Inherent mosaicism and extensive mutation of human placentas.

    Coorens, Tim H H / Oliver, Thomas R W / Sanghvi, Rashesh / Sovio, Ulla / Cook, Emma / Vento-Tormo, Roser / Haniffa, Muzlifah / Young, Matthew D / Rahbari, Raheleh / Sebire, Neil / Campbell, Peter J / Charnock-Jones, D Stephen / Smith, Gordon C S / Behjati, Sam

    Nature

    2022  Volume 603, Issue 7901, Page(s) E17

    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-04347-9
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    Zs.MO 244: Show issues

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  9. Article ; Online: Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate.

    Reddell, Paul / De Ridder, Thomas R / Morton, John M / Jones, Pamela D / Campbell, Justine E / Brown, Graham / Johannes, Chad M / Schmidt, Peter F / Gordon, Victoria

    Journal of veterinary internal medicine

    2021  Volume 35, Issue 1, Page(s) 430–441

    Abstract: Background: Tigilanol tiglate (TT) is a novel small molecule for intratumoral treatment of nonmetastatic mast cell tumors (MCTs) in dogs. In a randomized controlled clinical study, 75% of dogs that received a single TT treatment achieved complete ... ...

    Abstract Background: Tigilanol tiglate (TT) is a novel small molecule for intratumoral treatment of nonmetastatic mast cell tumors (MCTs) in dogs. In a randomized controlled clinical study, 75% of dogs that received a single TT treatment achieved complete resolution of the MCT by 28 days, with no recurrence in 93% of dogs at 84 days. Critical to TT's efficacy was the area of the wound (tissue deficit) after slough of the necrotic tumor relative to pretreatment tumor volume.
    Objectives: To analyze data collected during the previous study to (a) describe wounds after slough of treated MCTs and (b) identify determinants of wound area and speed of wound healing.
    Methods: Wound presence, condition, and area were determined from clinical records of 117 dogs over 84 days after a single intratumoral TT treatment.
    Results: Tumor slough occurred 3 to 14 days after treatment, exposing granulation tissue in the wound bed. Wound area after tumor slough in general was related to pretreatment tumor volume, with maximal recorded wound area fully evident in 89% of dogs by day 7. In dogs achieving complete tumor resolution, all wounds were left to heal by secondary intention. Bandaging and other wound management interventions only were required in 5 dogs. Time to healing (ie, full re-epithelialization of treatment site) depended on wound area and location on the body, with most wounds being fully healed between 28 and 42 days after treatment.
    Conclusions: Wound area and healing after slough of TT-treated tumors follow a consistent clinical pattern for most dogs.
    MeSH term(s) Animals ; Dog Diseases/drug therapy ; Dogs ; Mast Cells ; Neoplasm Recurrence, Local/veterinary ; Surgical Wound Infection/veterinary ; Wound Healing
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial, Veterinary
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16009
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    Zs.A 4095: Show issues Location:
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  10. Article ; Online: Development of an intracellular quantitative assay to measure compound binding kinetics.

    Lay, Charles S / Thomas, Daniel A / Evans, John P / Campbell, Matthew / McCombe, Kristopher / Phillipou, Alexander N / Gordon, Laurie J / Jones, Emma J / Riching, Kristin / Mahmood, Mahnoor / Messenger, Cassie / Carver, Charlotte E / Gatfield, Kelly M / Craggs, Peter D

    Cell chemical biology

    2021  Volume 29, Issue 2, Page(s) 287–299.e8

    Abstract: Contemporary drug discovery typically quantifies the effect of a molecule on a biological target using the equilibrium-derived measurements of ... ...

    Abstract Contemporary drug discovery typically quantifies the effect of a molecule on a biological target using the equilibrium-derived measurements of IC
    MeSH term(s) Binding Sites ; Bioluminescence Resonance Energy Transfer Techniques ; Cells, Cultured ; Female ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Luciferases/chemistry ; Luciferases/metabolism ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/metabolism
    Chemical Substances DNER protein, human ; Fluorescent Dyes ; Nerve Tissue Proteins ; Receptors, Cell Surface ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.07.018
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