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Article: Changes in Plasma TPH2, GDNF, Trk-b, BDNF, and proBDNF in People Who Died by Suicide.

Liu, Xiaoyu / Li, Shangda / Yu, Yueran / Hu, Jianbo / Xu, Yi

2023 Volume 13, Issue 7

Abstract: Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient. Our study aimed to explore the biological patterns ... ...

Abstract	Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient. Our study aimed to explore the biological patterns of suicide deaths, including levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2. The researchers selected 25 normal control patients matched by age with 30 suicide deaths. We used enzyme-linked immunosorbent assays to detect the levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 in the plasma of suicide and control subjects. proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 levels are shown as the median (25th-75th percentile). BDNF levels are shown as the mean (standard error of the mean). (1) The levels of plasma TPH2 and proBDNF in people who died by suicide were significantly higher than those in the control group. (2) The plasma levels of GDNF and BDNF/proBDNF in the suicide group were obviously lower than those in the control group. (3) There was no significant difference in plasma BDNF or Trk-b concentrations between the suicide group and the control group.Plasma TPH2, GDNF, and proBDNF levels are related to suicide. Plasma neurotrophic factor markers may predict suicide risk.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13071096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fabrication of hollow microtube arrays based on a femtosecond laser double-pulse multiphoton polymerization.

Gao, Lixiang / Sun, Lina / Qiu, Ye / Jiang, Yueran / Luo, Hao / Wang, Xiaoduo / Yu, Haibo

Optics letters

2023 Volume 48, Issue 21, Page(s) 5495–5498

Abstract: Microtubes with widely varied dimensions and materials have great prospects in functional devices applied in microoptics, microrobot, and biomedicine. However, the fabrication of vertically protruding hollow microtubes with high diameter-to-thickness ... ...

Abstract	Microtubes with widely varied dimensions and materials have great prospects in functional devices applied in microoptics, microrobot, and biomedicine. However, the fabrication of vertically protruding hollow microtubes with high diameter-to-thickness ratio is challenging and few reported. Femtosecond laser two-photon polymerization can solve this problem via point-by-point scanning or SLM-based parallel processing, but the low efficiency limits its high throughput fabrication. Here, we report a novel, to the best of our knowledge, femtosecond laser double-pulse multiphoton polymerization approach for high efficiency fabrication of hollow microtube arrays. We established a two-aperture laser beam reshaping system to generate a circular beam via two rounds of Fresnel diffraction. Based on the unique laser energy distribution, hollow microtubes with high diameter-to-thickness ratio can be generated by two successively laser pulses exposure, which can improve the fabrication efficiency significantly. With the optimized parameters, we can achieve repeatable and uniform microtube array fabrication in large scale, and the yield can be 94.9%. Defocus testing showed that the proposed approach has a high range of focusing tolerance. The proposed microtube fabrication approach is meaningful in providing some enlightenment for researchers in the field of microfabrication.
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.502919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dietary Restriction against Parkinson's Disease: What We Know So Far.

Wang, Zhonglei / Cui, Yueran / Wen, Lulu / Yu, Haiyang / Feng, Juan / Yuan, Wei / He, Xin

Nutrients

2022 Volume 14, Issue 19

Abstract: Dietary restriction (DR) is defined as a moderate reduction in food intake while avoiding malnutrition. The beneficial effects of DR are being increasingly acknowledged in aging and in a series of age-related neurodegenerative disorders, for example, ... ...

Abstract	Dietary restriction (DR) is defined as a moderate reduction in food intake while avoiding malnutrition. The beneficial effects of DR are being increasingly acknowledged in aging and in a series of age-related neurodegenerative disorders, for example, Parkinson's disease (PD). To date, the pathogenesis of PD remains elusive and there is no cure for it in spite of intensive research over decades. In this review, we summarize the current knowledge on the efficacy of DR on PD, focusing on the underlying mechanisms involving general metabolism, neuroendocrinolgy, neuroinflammation, gut microbiome, and so on. We anticipate that this review will provide future perspectives for PD prevention and treatment.
MeSH term(s)	Aging ; Gastrointestinal Microbiome ; Humans ; Neurodegenerative Diseases ; Parkinson Disease/pathology ; Parkinson Disease/prevention & control
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14194108
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Article ; Online: IFN-α armed gE elicits superior immunogenicity compared to unmodified antigens and flagellin armed gE in mice.

Zhang, Jiangang / Peng, Shaodan / Xu, Fang / Qiao, Ying / Ye, Xiaoke / Guan, Yu / Zhao, Xiaolong / Wang, Yueran / Shao, Zhongqi / Zhu, Tao / Si, Weixue

Vaccine: X

2024 Volume 17, Page(s) 100432

Abstract: Herpes zoster (HZ) induces significant pain and discomfort, which can seriously affect the quality of life of patients. At present, there is no specific treatment for HZ, and the mosteffective HZ control is vaccination. The main obstacle to developing an ...

Abstract	Herpes zoster (HZ) induces significant pain and discomfort, which can seriously affect the quality of life of patients. At present, there is no specific treatment for HZ, and the mosteffective HZ control is vaccination. The main obstacle to developing an effective HZ vaccine is poorly induced cellular immune response. In this study, the IFN-α-gE-Fc fusion protein induced higher levels of humoral and cellular immunity compared to the unengineered gE antigen and higher levels of cellular immunity compared to the flagellin-gE-Fc fusion protein in a murine model. Compared with the marketed recombinant herpes zoster vaccine (Shingrix), IFN-α-gE-Fc can replace current used MPL adjuvant. At the same time, the immunogenicity of the IFN-α-gE-Fc + AQ was not weaker than that of the marketed recombinant zoster vaccine. The novel fusion protein provides a candidate entity for the development of a safe and effective novel HZ vaccine.
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2024.100432
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Article: Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics.

Cui, Yueran / Yu, Haiyang / Bu, Zhongqi / Wen, Lulu / Yan, Lili / Feng, Juan

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 894298

Abstract: Neuroinflammation is initiated with an aberrant innate immune response in the central nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are intracellular multiprotein complexes that can be used as platforms to induce the ... ...

Abstract	Neuroinflammation is initiated with an aberrant innate immune response in the central nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are intracellular multiprotein complexes that can be used as platforms to induce the maturation and secretion of proinflammatory cytokines and pyroptosis, thus playing a pivotal role in neuroinflammation. Among the inflammasomes, the nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome is well-characterized and contributes to many neurological diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), and ischemic stroke. MS is a chronic autoimmune disease of the CNS, and its hallmarks include chronic inflammation, demyelination, and neurodegeneration. Studies have demonstrated a relationship between MS and the NLRP3 inflammasome. To date, the pathogenesis of MS is not fully understood, and clinical studies on novel therapies are still underway. Here, we review the activation mechanism of the NLRP3 inflammasome, its role in MS, and therapies targeting related molecules, which may be beneficial in MS.
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.894298
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Article ; Online: Sustainable Recognition Methods of Modeling Design Features of Light and Micro Vehicle-Mounted UAV

Hao Yang / Yunxiang Huo / Ruoyu Jia / Feng Sha / Naiqi Hu / Linglan Yu / Yueran Wang

Sustainability, Vol 14, Iss 8210, p

Based on Support Vector Regression and Kano Model

2022 Volume 8210

Abstract: In the era of Industry 4.0, intelligent algorithms provide an effective way to make design methods more sustainable through mining people’s demands continuously, especially in the field of evaluating and predicting the user preferences of phasic or ... ...

Abstract	In the era of Industry 4.0, intelligent algorithms provide an effective way to make design methods more sustainable through mining people’s demands continuously, especially in the field of evaluating and predicting the user preferences of phasic or interim design schemes. Vehicle-mounted unmanned aerial vehicles (UAVs) are of significance in mobility experience and traffic surveys. However, as a new type of product, UAVs lack general rules in modeling design and the process of development decision making presents some fuzzy characteristics, which make the evolution and iteration of modeling design more complex. Based on the theories of Kansei Engineering, this study utilized support vector regression (SVR) to establish a correlation model between design factors and preference degree. Because the perceptual evaluation knowledge is fuzzy and uncertain, the paper applied cross-validation and grid search methods to find the optimal parameters. The parameters of the SVR model were adjusted to meet the need for stable learning and for endurance of the noise from subjective experience data to improve the prediction effect and generalization ability. In addition, by means of the Kano model, the customers’ cognition of demand types was quantified to obtain the prioritization of UAV modeling design elements, as well as to compare with the preference scores to validate the feasibility of this research. It was found that the SVR model proposed in the study could effectively predict user preference (R 2 = 0.763, RMSE = 0.057). For the UAVs with a higher preference score, the modeling characteristics were consistent with the attractive, one-dimensional or must-be quality elements in the results of the Kano model, which verified the reliability of the study. The conclusion is expected to provide a sustainable design method for vehicle-mounted UAVs commonly used in citizen travel and outdoor activities.
Keywords	sustainable innovation ; UAV ; prediction model ; SVR ; Kano model ; design elements ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ketogenic diet may be a new approach to treatment stress urinary incontinence in obese elderly women: report of five cases.

Sun, Yu / Chen, Haixia / Bai, Yueran / Zhang, Tingyue / Bai, Wenpei / Jiang, Bo

BMC women's health

2022 Volume 22, Issue 1, Page(s) 402

Abstract: Background: Stress urinary incontinence (SUI) as a serious social problem restricted women's daily life and affect their quality of life, especially for obese women. The mechanism of stress urinary incontinence is unclear. Weight loss is the first line ... ...

Abstract	Background: Stress urinary incontinence (SUI) as a serious social problem restricted women's daily life and affect their quality of life, especially for obese women. The mechanism of stress urinary incontinence is unclear. Weight loss is the first line of treatment for stress incontinence in obese women. Ketogenic diet is a special diet with high fat, low carbohydrate and moderate protein, which can reduce body mass faster than the traditional diet. There exist no reports on the therapeutic effect of ketogenic diet on SUI in obese women. Case presentation: Five postmenopausal obese women are diagnosed as mild to moderate stress urinary incontinence, which affected their quality of life for medical treatment. After 4 weeks ketogenic diet, we found that ketogenic diet can significantly improve urine leakage, reduce body weight, decrease visceral fat area, reduce body fat percentage, and reduce BMI. Conclusion: Reports in this case reveal that ketogenic diet may become one of the effective methods for the treatment of stress urinary incontinence in obese women in the future, providing a minimally invasive, highly profitable and highly compliant treatment for stress urinary incontinence in obese women.
MeSH term(s)	Aged ; Carbohydrates ; Diet, Ketogenic ; Female ; Humans ; Obesity/complications ; Quality of Life ; Urinary Incontinence, Stress/therapy
Chemical Substances	Carbohydrates
Language	English
Publishing date	2022-10-04
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-022-01987-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The contribution of macrophages to systemic lupus erythematosus.

Ma, Chunyan / Xia, Yu / Yang, Qingrui / Zhao, Yueran

Clinical immunology (Orlando, Fla.)

2019 Volume 207, Page(s) 1–9

Abstract: As a heterogeneous autoimmune disease associated with severe organ damage, the precise mechanisms of systemic lupus erythematosus (SLE) remain to be clarified. Recent research indicates that innate immunity plays vital roles in SLE. Defects in the ... ...

Abstract	As a heterogeneous autoimmune disease associated with severe organ damage, the precise mechanisms of systemic lupus erythematosus (SLE) remain to be clarified. Recent research indicates that innate immunity plays vital roles in SLE. Defects in the phagocytosis of apoptotic cells, aberrant activation and imbalanced polarization of macrophages, have been shown to participate in the pathogenesis of SLE. Treatments targeting these processes may ameliorate the disease activity in lupus models as well as in patients with SLE. Macrophages participate in the initiation of autoimmunity and the development of SLE in multiple levels. Better understanding of this complex disease is the prerequisite for exploring more effective therapies of SLE.
MeSH term(s)	DNA Fragmentation ; Humans ; Interferon Type I ; Lupus Erythematosus, Systemic/physiopathology ; Macrophages/pathology ; Phagocytosis
Chemical Substances	Interferon Type I
Language	English
Publishing date	2019-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2019.06.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association of PM

Pang, Lihong / Jiang, Mingdong / Sui, Xinlei / Dou, Yunde / Yu, Wenhao / Huxley, Rachel / Saldiva, Paulo / Hu, Jingmei / Schikowski, Tamara / Krafft, Thomas / Gao, Panjun / Zhao, Yueran / Zhao, Han / Zhao, Qi / Chen, Zi-Jiang

Journal of hazardous materials

2023 Volume 462, Page(s) 132735

Abstract: Background: A possible role of PM: Objective: To evaluate the association between PM: Methods: We included 15,102 women with serum anti-Müllerian hormone (AMH) measurements from the Center for Reproductive Medicine of Shandong University during ... ...

Abstract	Background: A possible role of PM Objective: To evaluate the association between PM Methods: We included 15,102 women with serum anti-Müllerian hormone (AMH) measurements from the Center for Reproductive Medicine of Shandong University during 2015-2019. Concentrations of PM Results: The strength of association was stronger during the process from primary to small antral follicle compared with other longer windows. For every interquartile range increase in PM Conclusion: Exposure to specific components of air pollution during critical exposure windows is associated with a decline in ovarian reserve. These data add to the growing body of evidence that environmental factors have adverse effects on reproductive health, particularly for vulnerable population subgroups.
MeSH term(s)	Humans ; Female ; Ovarian Reserve ; Air Pollution/analysis ; China ; Particulate Matter/toxicity ; Sulfates ; Environmental Exposure ; Air Pollutants/analysis
Chemical Substances	Particulate Matter ; Sulfates ; Air Pollutants
Language	English
Publishing date	2023-10-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132735
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Article: Dexamethasone Sensitizes Acute Monocytic Leukemia Cells to Ara-C by Upregulating FKBP51.

Sun, Huanxin / Liu, Xiaowen / Wang, Laicheng / Cui, Bin / Mu, Wenli / Xia, Yu / Liu, Shuang / Liu, Xin / Jiao, Yulian / Zhao, Yueran

Frontiers in oncology

2022 Volume 12, Page(s) 888695

Abstract: In this study, we demonstrated that the expression of FK506 binding protein 51 (FKBP51) is upregulated in acute monocytic leukemia (AML-M5) cells by dexamethasone and aimed to investigate the possible effects of FKBP51 on the growth and cytarabine ... ...

Abstract	In this study, we demonstrated that the expression of FK506 binding protein 51 (FKBP51) is upregulated in acute monocytic leukemia (AML-M5) cells by dexamethasone and aimed to investigate the possible effects of FKBP51 on the growth and cytarabine sensitivity of AML-M5 cells. THP-1 and U937cells were used to establish AML-M5 cell models with FKBP51 overexpression and knockdown, respectively. Cell proliferation, apoptosis and response to cytarabine were investigated by cell cycle, CCK-8 and Flow cytometry analyses. The mice experiment was conducted to detect the role of FKBP51 on AML-M5 cells proliferation and antileukemia effect of Ara-C/Dexamethasone co-therapy
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.888695
Database	MEDical Literature Analysis and Retrieval System OnLINE

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