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  1. Article ; Online: The ideal drug dosage adaptation through estimated glomerular filtration rate in obese patients? Measuring GFR is the key.

    Delanaye, Pierre / Cavalier, Etienne / Bouquegneau, Antoine

    British journal of clinical pharmacology

    2022  Volume 88, Issue 6, Page(s) 2588–2590

    MeSH term(s) Creatinine ; Glomerular Filtration Rate ; Humans ; Iohexol ; Obesity
    Chemical Substances Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15255
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    Zs.A 1118: Show issues Location:
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  2. Article ; Online: Piège diagnostique : neurotoxicité au lithium avec lithémie normale.

    Tiv, Hugo / Vandelaer, Antoine / Delanaye, Pierre / Forte, Florence / Bouquegneau, Antoine

    Nephrologie & therapeutique

    2022  Volume 18, Issue 7, Page(s) 650–654

    Abstract: We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness ... ...

    Title translation Diagnostic trap: Lithium neurotoxicity with normal lithemia.
    Abstract We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness caused by a supposed mismanagement of her treatment. Lithium poisoning was suggested based on neurological clinical features, but the blood test brought out a lithium concentration within the therapeutic values at 1,2 mmol/L (N: 0,6-1,2 mmol/L). The classic biological complications related to lithium poisoning (hypercalcemia, diabetes insipidus) confirmed the diagnosis. The patient has been transferred to our nephrology department where she got two hemodialysis sessions conducting to clinical and biological improvement, confirming the diagnosis of lithium poisoning despite the normal blood levels. Later, she was transferred to the psychiatry department for follow-up and for treatment adjustment.
    Language French
    Publishing date 2022-09-23
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2022.07.398
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  3. Article ; Online: Long-term effects of COVID-19 on kidney function.

    Delanaye, Pierre / Huart, Justine / Bouquegneau, Antoine / Jouret, François

    Lancet (London, England)

    2021  Volume 397, Issue 10287, Page(s) 1807

    MeSH term(s) COVID-19 ; Cohort Studies ; Hospitals ; Humans ; Kidney ; Patient Discharge ; SARS-CoV-2
    Language English
    Publishing date 2021-05-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00881-3
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  4. Article: Comment estimer la filtration glomérulaire dans le contexte de l’adaptation posologique de médicaments ?

    Delanaye, Pierre / Bouquegneau, Antoine / Moranne, Olivier / Cavalier, Étienne

    Revue medicale suisse

    2020  Volume 16, Issue 703, Page(s) 1489–1493

    Abstract: In chronic kidney disease (CKD) patients, the dosage of many medications should be adapted according to the glomerular filtration rate (GFR). GFR estimation is obtained by using creatinine-based equations. Many different equations have been proposed in ... ...

    Title translation How to estimate glomerular filtration rate in the context of drug dosage adaptation ?
    Abstract In chronic kidney disease (CKD) patients, the dosage of many medications should be adapted according to the glomerular filtration rate (GFR). GFR estimation is obtained by using creatinine-based equations. Many different equations have been proposed in the literature, and they don't systematically lead to the same result in terms of drug dosage. There is an ongoing debate to determine which equations should be recommended, with the Cockcroft equation on one side and the MDRD (« Modified Diet in Renal Diseases ») or CKD-EPI (« Chronic Kidney Disease Epidemiology ») on the other side. The last two equations are especially used by nephrologists whereas the Cockcroft is still considered by geriatrists and pharmacologists. In the current article, we discuss the pro/cons from both sides, and propose recommendation for the clinical practice.
    MeSH term(s) Creatinine ; Glomerular Filtration Rate ; Humans ; Renal Insufficiency, Chronic/diagnosis
    Chemical Substances Creatinine (AYI8EX34EU)
    Language French
    Publishing date 2020-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
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  5. Article ; Online: A call for promoting living kidney donation in France in 2023

    Mariat, Christophe / Gaillard, François / Fournier, Thomas / Rabate, Clémentine / Pincon, Émilie / Bacchetta, Justine / Aurelle, Manon / Bouquegneau, Antoine

    Nephrologie & therapeutique

    2023  Volume 19, Issue 2, Page(s) 83–88

    Abstract: Kidney transplantation from living donors is particularly under-developed in France in comparison with the US and most European countries. Among others, the lack of a proactive and evidence-based communication from French health providers is a potential ... ...

    Title translation Pourquoi développer la greffe de rein à partir de donneurs vivants en France en 2023 ?
    Abstract Kidney transplantation from living donors is particularly under-developed in France in comparison with the US and most European countries. Among others, the lack of a proactive and evidence-based communication from French health providers is a potential cause that has been overlooked thus far. With this as a backdrop, the SFNDT Commission of transplantation has elaborated a 10 points-call for promoting living kidney transplantation in France in 2023 with the aims at (1) providing the entire nephrology community with a scientific rationale and (2) strenghtening the conviction of health providers, patients, and their relatives regarding the relevance of this modality of kidney transplantation.
    MeSH term(s) Humans ; Kidney ; Kidney Transplantation ; Tissue and Organ Harvesting ; France ; Living Donors
    Language French
    Publishing date 2023-03-14
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1684/ndt.2023.20
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  6. Article ; Online: Monitoring 25-OH and 1,25-OH vitamin D levels in hemodialysis patients after starting therapy: Does it make sense?

    Delanaye, Pierre / Lanot, Antoine / Bouquegneau, Antoine / Warling, Xavier / Radermacher, Luc / Masset, Catherine / Krzesinski, Jean-Marie / Moranne, Olivier / Cavalier, Etienne

    Clinica chimica acta; international journal of clinical chemistry

    2022  Volume 539, Page(s) 50–54

    Abstract: Background and aims: In hemodialysis patients, monitoring 25-hydroxyvitamin D (25(OH)D) levels is recommended. It is however unclear if monitoring 1,25-dihydroxyvitamin D (1,25(OH): Materials and methods: We repeatedly measured 1,25(OH): Results: ... ...

    Abstract Background and aims: In hemodialysis patients, monitoring 25-hydroxyvitamin D (25(OH)D) levels is recommended. It is however unclear if monitoring 1,25-dihydroxyvitamin D (1,25(OH)
    Materials and methods: We repeatedly measured 1,25(OH)
    Results: Ten patients were included in the native and 12 in the active vitamin D group. In the native group, a significant increase was observed between the baseline and the last 25(OH)D concentrations available (21.65[17.39;25.26] versus 33.49[28.60;40.30] ng/mL, p = 0.0059). The baseline and last available 1,25(OH)
    Conclusion: Measuring 1,25(OH)2D levels in patients newly treated by active vitamin D does not seem useful in monitoring active vitamin D therapy.
    MeSH term(s) Humans ; Cholecalciferol ; Vitamin D ; Calcifediol ; Renal Dialysis ; Vitamin D Deficiency/drug therapy
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2022-12-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2022.11.032
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  7. Article ; Online: Complement-activating donor-specific anti-HLA antibodies in solid organ transplantation: systematic review, meta-analysis, and critical appraisal.

    Al-Awadhi, Solaf / Raynaud, Marc / Louis, Kevin / Bouquegneau, Antoine / Taupin, Jean-Luc / Aubert, Olivier / Loupy, Alexandre / Lefaucheur, Carmen

    Frontiers in immunology

    2023  Volume 14, Page(s) 1265796

    Abstract: Introduction: Several studies have investigated the impact of circulating complement-activating anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) on organ transplant outcomes. However, a critical appraisal of these studies and a ... ...

    Abstract Introduction: Several studies have investigated the impact of circulating complement-activating anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) on organ transplant outcomes. However, a critical appraisal of these studies and a demonstration of the prognostic value of complement-activating status over anti-HLA DSA mean fluorescence intensity (MFI) level are lacking.
    Methods: We conducted a systematic review, meta-analysis and critical appraisal evaluating the role of complement-activating anti-HLA DSAs on allograft outcomes in different solid organ transplants. We included studies through Medline, Cochrane, Scopus, and Embase since inception of databases till May 05, 2023. We evaluated allograft loss as the primary outcome, and allograft rejection as the secondary outcome. We used the Newcastle-Ottawa Scale and funnel plots to assess risk of bias and used bias adjustment methods when appropriate. We performed multiple subgroup analyses to account for sources of heterogeneity and studied the added value of complement assays over anti-HLA DSA MFI level.
    Results: In total, 52 studies were included in the final meta-analysis (11,035 patients). Complement-activating anti-HLA DSAs were associated with an increased risk of allograft loss (HR 2.77; 95% CI 2.33-3.29, p<0.001; I²=46.2%), and allograft rejection (HR 4.98; 95% CI 2.96-8.36, p<0.01; I²=70.9%). These results remained significant after adjustment for potential sources of bias and across multiple subgroup analyses. After adjusting on pan-IgG anti-HLA DSA defined by the MFI levels, complement-activating anti-HLA DSAs were significantly and independently associated with an increased risk of allograft loss.
    Discussion: We demonstrated in this systematic review, meta-analysis and critical appraisal the significant deleterious impact and the independent prognostic value of circulating complement-activating anti-HLA DSAs on solid organ transplant risk of allograft loss and rejection.
    MeSH term(s) Humans ; Graft Rejection ; Organ Transplantation/adverse effects ; Complement System Proteins ; Transplantation, Homologous ; HLA Antigens
    Chemical Substances Complement System Proteins (9007-36-7) ; HLA Antigens
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1265796
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  8. Article ; Online: The Case | An unusual cause of renal vascular thrombi after kidney transplantation.

    Erpicum, Pauline / Grosch, Stéphanie / Bonvoisin, Catherine / Bouquegneau, Antoine / Weekers, Laurent / Radermacher, Luc / Jouret, François / Lejeune, Marie / Hougrand, Olivier / Bovy, Christophe

    Kidney international

    2022  Volume 101, Issue 2, Page(s) 427–428

    MeSH term(s) Humans ; Kidney ; Kidney Transplantation/adverse effects ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.08.008
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  9. Article ; Online: The Effect of Elective Ligation of the Arteriovenous Fistula on Cardiac and Renal Functions in Kidney Transplant Recipients.

    Masson, Grégoire / Viva, Tommaso / Huart, Justine / Weekers, Laurent / Bonvoisin, Catherine / Bouquegneau, Antoine / Maweja, Sylvie / Hamoir, Etienne / Seidel, Laurence / Pottel, Hans / Lancellotti, Patrizio / Jouret, François

    Kidney360

    2023  Volume 4, Issue 8, Page(s) 1130–1138

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Heart ; Renal Dialysis ; Kidney/physiology ; Arteriovenous Fistula/surgery
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000198
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  10. Article ; Online: Clinical outcomes after ABO-incompatible renal transplantation.

    Loupy, Alexandre / Bouquegneau, Antoine / Stegall, Mark D / Montgomery, Robert A

    Lancet (London, England)

    2019  Volume 394, Issue 10213, Page(s) 1988–1989

    MeSH term(s) Blood Group Incompatibility ; Graft Survival ; Kidney Transplantation
    Language English
    Publishing date 2019-12-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)32490-0
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