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Article ; Online: Impaired Glymphatic Flow on Diffusion Tensor MRI as a Marker of Neurodegeneration in Alzheimer's Disease: Correlation with Gray Matter Volume Loss and Cognitive Decline Independent of Cerebral Amyloid Deposition.

Kim, Minjae / Song, Yoo Sung / Han, Kyunghwa / Bae, Yun Jung / Han, Ji Won / Kim, Ki Woong

2024

Abstract: Background: Impaired glymphatic flow on the Alzheimer's disease (AD) spectrum may be evaluated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).: Objective: We aimed to validate impaired glymphatic flow and explore its ... ...

Abstract	Background: Impaired glymphatic flow on the Alzheimer's disease (AD) spectrum may be evaluated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Objective: We aimed to validate impaired glymphatic flow and explore its association with gray matter volume, cognitive status, and cerebral amyloid deposition on the AD spectrum. Methods: 80 participants (mean age, 76.9±8.5 years; 57 women) with AD (n = 65) and cognitively normal (CN) (n = 15) who underwent 3T brain MRI including DTI and/or amyloid PET were included. After adjusting for age, sex, apolipoprotein E status, and burden of white matter hyperintensities, the ALPS-index was compared according to the AD spectrum. The association between the ALPS-index and gray matter volume, cognitive status, and quantitative amyloid from PET was assessed. Results: The ALPS-index in the AD was significantly lower (mean, 1.476; 95% CI, 1.395-1.556) than in the CN (1.784;1.615-1.952; p = 0.026). Volumes of the entorhinal cortex, hippocampus, temporal pole, and primary motor cortex showed significant associations with the ALPS-index (all, p < 0.05). There was a positive correlation between the ALPS-index and MMSE score (partial r = 0.435; p < 0.001), but there was no significant correlation between the ALPS-index and amyloid SUVRs (all, p > 0.05). Conclusions: Decreased glymphatic flow measured by DTI-ALPS in AD may serve as a marker of neurodegeneration correlating with structural atrophy and cognitive decline.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231131
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Zs.A 6084: Show issues

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Article ; Online: Rejuvenation of the Lower Eyelid and Midface with Deep Nasolabial Fat Lift in East Asians.

Lee, Tae-Yul / Cha, Ji-Hwan / Ko, Han-Woong

Plastic and reconstructive surgery

2023 Volume 151, Issue 6, Page(s) 931e–940e

Abstract: Background: Correcting infraorbital hollowness is an important procedure for midface rejuvenation. Sub-orbicularis oculi fat lift is a commonly used method. However, adipose tissue, which has been thought of as sub-orbicularis oculi fat, has recently ... ...

Abstract	Background: Correcting infraorbital hollowness is an important procedure for midface rejuvenation. Sub-orbicularis oculi fat lift is a commonly used method. However, adipose tissue, which has been thought of as sub-orbicularis oculi fat, has recently been controversial. The objective of this study was to introduce a method of midface rejuvenation using deep nasolabial fat lift (MRDN) by means of lower blepharoplasty and to compare surgical outcomes between MRDN and lower blepharoplasty with fat transposition (LBF). Methods: The medical records of patients who had undergone midface rejuvenation with lower blepharoplasty between 2013 and 2020 were retrospectively reviewed. Questionnaires, digital photographs, and charts were used to evaluate the surgical outcomes and complications. The degree of aging was graded as mild, moderate, or severe. LBF and MRDN were used for mild and severe grades, respectively. For the moderate grade, the preferred surgical method of the two methods was selected and surgical outcomes were compared. The MRDN technique included LBF. Results: Postoperative satisfaction was significantly higher ( P < 0.001), recurrence rate for tear trough ( P = 0.046) and fat bulging ( P = 0.005) was significantly lower, duration of swelling ( P < 0.001) was significantly longer, and incidence of chemosis ( P = 0.024) was significantly higher in the MRDN group than in the LBF group. Regarding lid malposition, transient retraction was higher in the LBF group, whereas cicatricial ectropion was higher in the MRDN group; however, these differences were not significant. Conclusion: MRDN is associated with higher patient satisfaction and surgical longevity without serious complications than LBF. Clinical question/level of evidence: Therapeutic, III.
MeSH term(s)	Humans ; Adipose Tissue/transplantation ; Blepharoplasty/methods ; East Asian People ; Eyelids/surgery ; Rejuvenation ; Retrospective Studies ; Rhytidoplasty/methods
Language	English
Publishing date	2023-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010130
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Article ; Online: Direct Observation of Room-Temperature Magnetic Skyrmion Motion Driven by Ultra-Low Current Density in Van Der Waals Ferromagnets.

Ji, Yubin / Yang, Seungmo / Ahn, Hyo-Bin / Moon, Kyoung-Woong / Ju, Tae-Seong / Im, Mi-Young / Han, Hee-Sung / Lee, Jisung / Park, Seung-Young / Lee, Changgu / Kim, Kab-Jin / Hwang, Chanyong

Advanced materials (Deerfield Beach, Fla.)

2024 , Page(s) e2312013

Abstract: The recent discovery of room-temperature ferromagnetism in 2D van der Waals (vdW) materials, such as ... ...

Abstract	The recent discovery of room-temperature ferromagnetism in 2D van der Waals (vdW) materials, such as Fe
Language	English
Publishing date	2024-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202312013
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Article ; Online: Persistent Primitive Olfactory Artery Type 4 with Fusiform Aneurysm: A Case Report.

Park, Heecheol / Baek, Jin Wook / Jeong, Hae Woong / Heo, Young Jin / Yun, Suyoung / Han, Ji-Yeon

Journal of the Korean Society of Radiology

2023 Volume 84, Issue 6, Page(s) 1361–1366

Abstract: The persistent primitive olfactory artery (PPOA) is a rare variant of the anterior cerebral artery, first reported in 1979. It reportedly has a high correlation with the development of aneurysms, owing to the hemodynamic stress induced by the structural ... ...

Abstract	The persistent primitive olfactory artery (PPOA) is a rare variant of the anterior cerebral artery, first reported in 1979. It reportedly has a high correlation with the development of aneurysms, owing to the hemodynamic stress induced by the structural characteristics of the hairpin turn. Herein, we present a rare case of PPOA type 4 with a fusiform aneurysm at the hairpin turn segment in a 46-year-old female with occasional headaches. Time-of-flight MR angiography and transfemoral cerebral angiography revealed an unusual branch arising from the left A1 segment, running anteromedially along the ipsilateral olfactory tract, and turning the hairpin posterior to the olfactory bulb. This branch continued into the left accessory middle cerebral artery, and a fusiform aneurysm was observed at the hairpin segment. No further treatment was performed, and follow-up imaging was recommended. Nevertheless, it is essential to recognize and diagnose these rare variations.
Language	English
Publishing date	2023-09-01
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2951-0805
ISSN (online)	2951-0805
DOI	10.3348/jksr.2022.0139
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Article: Exploring age-related changes in saccades during cognitive tasks in healthy adults.

Yang, Hee Won / Choe, Jin Yeong / Noh, Soo Rim / Kim, Jeong Lan / Han, Ji Won / Kim, Ki Woong

Frontiers in behavioral neuroscience

2024 Volume 17, Page(s) 1301318

Abstract: Introduction: Although eye movements such as saccades are related to internal cognitive processes and are independent of visual processing, few studies have investigated whether non-visual cognitive tasks simultaneously affect horizontal and vertical ... ...

Abstract	Introduction: Although eye movements such as saccades are related to internal cognitive processes and are independent of visual processing, few studies have investigated whether non-visual cognitive tasks simultaneously affect horizontal and vertical saccades in younger and older adults. Methods: We recruited 28 younger adults aged 20-29 years and 26 older adults aged >60 years through advertisements in community settings. All participants were free of major psychiatric, neurological, or ocular diseases. All participants performed the mental arithmetic task (MAT) and verbal fluency task (VFT). The primary measures were saccade parameters, including frequency, mean amplitude, and mean velocity. Results: During MAT and VFT, the frequencies of horizontal and vertical saccades increased ( Discussion: Saccade parameters can change during non-visual cognitive tasks with differences between age groups and saccade directions. This study significantly contributes to our understanding of the distinct dynamics of horizontal and vertical saccades across various age group in cognitive aging, despite its restricted focus on specific saccade parameters and cognitive tasks, and inclusion solely of cognitively normal individuals. This study highlights the importance of saccade analysis in elucidating age-related cognitive changes. In conclusion, saccades should be examined in future studies as a potential non-invasive biomarker for early detection of cognitive decline and neurodegenerative diseases.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2023.1301318
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Article ; Online: The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.

Suh, Seung Wan / Lim, Eunji / Burm, Suh-Yuhn / Lee, Hyungji / Bae, Jong Bin / Han, Ji Won / Kim, Ki Woong

BMC medicine

2024 Volume 22, Issue 1, Page(s) 109

Abstract: Background: Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been suggested as a cognitive enhancing agent, though their effect is doubtful. We aimed to examine the effect of n-3 PUFA on the cognitive function of middle-aged or older adults without ... ...

Abstract	Background: Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been suggested as a cognitive enhancing agent, though their effect is doubtful. We aimed to examine the effect of n-3 PUFA on the cognitive function of middle-aged or older adults without dementia. Methods: We reviewed randomized controlled trials of individuals aged 40 years or older. We systematically searched PubMed/MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Library databases. We used the restricted cubic splines model for non-linear dose-response meta-analysis in terms of the standardized mean difference with 95% confidence intervals. Results: The current meta-analysis on 24 studies (n 9660; follow-up 3 to 36 months) found that the beneficial effect on executive function demonstrates an upward trend within the initial 12 months of intervention. This effect is prominently observed with a daily intake surpassing 500 mg of n-3 PUFA and up to 420 mg of eicosapentaenoic acid (EPA). Furthermore, these trends exhibit heightened significance in regions where the levels of blood docosahexaenoic acid (DHA) + EPA are not very low. Conclusions: Supplementation of n-3 PUFA may confer potential benefits to executive function among the middle-aged and elderly demographic, particularly in individuals whose dietary DHA + EPA level is not substantially diminished.
MeSH term(s)	Aged ; Middle Aged ; Humans ; Fatty Acids, Omega-3 ; Docosahexaenoic Acids/pharmacology ; Eicosapentaenoic Acid/pharmacology ; Cognition ; Dementia ; Dietary Supplements
Chemical Substances	Fatty Acids, Omega-3 ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-024-03296-0
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Article: Assessing Radiation Exposure and Contrast Agent Utilization: A Comparative Analysis of the Woven EndoBridge Device and Stent-Assisted Coil Embolization for Managing Unruptured Wide-Neck Bifurcation Aneurysms.

Baek, Jinwook / Jeong, Hae Woong / Han, Ji-Yeon / Heo, Young Jin / Yun, Sooyoung / Lee, Won Hee / Kim, Sung Tae

Neurointervention

2024

Abstract: Purpose: In this study, we determined whether there were significant differences in procedure time, radiation dose, fluoroscopy time, and total contrast media dose when unruptured wideneck bifurcation aneurysms (WNBAs) were treated with the Woven ... ...

Abstract	Purpose: In this study, we determined whether there were significant differences in procedure time, radiation dose, fluoroscopy time, and total contrast media dose when unruptured wideneck bifurcation aneurysms (WNBAs) were treated with the Woven EndoBridge (WEB) device and stent-assisted coil (SAC) embolization. Materials and methods: The WEB device and SAC embolization (14:17) were used to treat 31 cases of internal carotid artery bifurcation, anterior communicating artery, middle cerebral artery bifurcation, and basilar bifurcation aneurysms between August 2021 and December 2022. The procedure time, radiation dose, fluoroscopy time, and total contrast medium dose between the 2 treatment groups were compared and analyzed. In the WEB device group, the results between operators were compared, and the follow-up radiologic outcomes were investigated. Results: The procedure and fluoroscopy times were significantly shorter in the WEB device group. Radiation and total contrast media dose were also significantly smaller in the WEB device, but there was no significant difference in results between operators. The follow-up radiological outcome showed adequate occlusion in 83.3% (10/12) of cases. Conclusion: The WEB device can be used as an alternative treatment method among the available endovascular treatment methods for WNBAs to reduce radiation exposure and the dose of contrast media when used adequately with appropriate indications.
Language	English
Publishing date	2024-04-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2639823-0
ISSN	2233-6273 ; 2093-9043
ISSN (online)	2233-6273
ISSN	2093-9043
DOI	10.5469/neuroint.2024.00143
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Article ; Online: Infection-related Hospitalizations During Immune Checkpoint Inhibitor Treatment Without Immunosuppressants.

Jeung, Ye Sul / Chun, June Young / Choi, Beom Kyu / Park, Seog Yun / Lim, Hyun-Ju / Park, Jong Woong / Han, Ji-Youn / Lee, Youngjoo

Journal of immunotherapy (Hagerstown, Md. : 1997)

2024 Volume 47, Issue 4, Page(s) 139–147

Abstract: Immunosuppressants are increasingly being used in the clinic to manage immune-related adverse effects. Consequently, the incidence of secondary infections associated with immunosuppression is increasing. However, little is known about primary infections ... ...

Abstract	Immunosuppressants are increasingly being used in the clinic to manage immune-related adverse effects. Consequently, the incidence of secondary infections associated with immunosuppression is increasing. However, little is known about primary infections during immune checkpoint inhibitor (ICI) treatment without immunosuppressants. We aimed to evaluate primary infectious diseases during antiprogrammed death ligand-1 immunotherapy without immunosuppressants. We retrospectively screened medical records of 233 patients who underwent ICI treatment for advanced non-small cell lung cancer between January 2014 and May 2018 at National Cancer Center, Republic of Korea. Subsequently, we evaluated the clinical characteristics and treatment outcomes of selected patients hospitalized for potential infectious disease without immunosuppressive treatment (n=80). Eight cases (3.4%) were identified as bacterial pneumonia (n=5) and cellulitis, inflamed epidermoid cyst, and wound infection (n=1 each). The bacterial pathogens Streptococcus pneumoniae and Haemophilus influenzae were identified in 4 patients with pneumonia. The period between the start of ICI treatment and infection varied between 3 and 189 days (median, 24.5 days). Five (62.5%) patients were infected within a month after ICI treatment initiation. All patients were treated with empirical antibiotics and discharged without complications. The median progression-free and overall survival for ICI treatment was 11.5 and 25.5 months, respectively. Six patients experienced ICI-associated adverse effects postinfection: Herpes zoster infection (n=4) and pneumonitis (n=2). Infectious disease independent of immunosuppression is a rare, but possible event in patients with lung cancer receiving ICI treatment. Clinical awareness would enable prompt diagnosis of primary infection during immunotherapy.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms/drug therapy ; Immune Checkpoint Inhibitors/adverse effects ; Immunosuppressive Agents/adverse effects ; Retrospective Studies ; Antineoplastic Agents, Immunological/therapeutic use ; Pneumonia/epidemiology ; Pneumonia/etiology ; Communicable Diseases/chemically induced ; Communicable Diseases/drug therapy ; Hospitalization
Chemical Substances	Immune Checkpoint Inhibitors ; Immunosuppressive Agents ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064067-8
ISSN	1537-4513 ; 1053-8550 ; 1524-9557
ISSN (online)	1537-4513
ISSN	1053-8550 ; 1524-9557
DOI	10.1097/CJI.0000000000000504
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Article ; Online: Comprehensive drought risk assessment using structural equation modeling and objective weighting methods

Ji Eun Kim / Jiyoung Yoo / Hyun-Han Kwon / Tae-Woong Kim

Journal of Hydrology: Regional Studies, Vol 50, Iss , Pp 101538- (2023)

2023

Abstract: Study region: Gyeongsang province in Korea Study focus: Drought is a complex phenomenon influencing the natural, physical, and social sectors depending on the occurrence probability, regional characteristics, and the water supply and demand. To reduce ... ...

Abstract	Study region: Gyeongsang province in Korea Study focus: Drought is a complex phenomenon influencing the natural, physical, and social sectors depending on the occurrence probability, regional characteristics, and the water supply and demand. To reduce the damage resulting from drought, it is necessary to assess the drought risk that can identify the impacts, causes, and vulnerability of drought. Previous drought risk assessment has usually been conducted by combining drought hazard and vulnerability, but such assessment is of limited value because the regional response capacity for drought is not considered. Moreover, it contains high uncertainty because indicators and weighting factors are determined by subjective methods. In this study, the comprehensive drought risk was assessed including the drought response capacity and with consideration of the regional water supply system. To remove the uncertainty in the drought risk assessment, this study employed partial least squares – structural equation modeling (PLS-SEM) to select effective indicators including the regional drought response capacity, and also applied objective weighting methods such as entropy, principal component analysis (PCA), Gaussian mixture model (GMM), and Bayesian networks to determine optimal weighting factors. New hydrological insights into the region under study: As a result of application to Gyeongsang province in Korea, PLS-SEM selected 10 indicators for drought risk assessment. Using the selected indicators and the objective weighting methods, this study determined that the drought hazard, vulnerability, response capacity, and risk were highest in GS26 (Ulleung), GS27 (Changwon), GS16 (Cheongsong), and GS28 (Jinju), respectively. The districts with large actual drought damage had high drought risk, indicating that the results of this study were reasonable and useful in the identification of the major impacts and risk of regional drought and may facilitate the decision-making process for selecting drought countermeasures to reduce ...
Keywords	Water supply system ; Drought response capacity ; Drought risk ; Structural equation model ; Bayesian network ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
Subject code	910
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Educational effects of and satisfaction with mixed-reality-based major trauma care simulator: A preliminary evaluation.

Lee, Han-Dong / Huh, Yo / Kim, Sora / Baek, Ji-Woong / Lee, Hojun / Park, Sang-Min / Kim, Jin-Kak

Medicine

2024 Volume 103, Issue 1, Page(s) e36816

Abstract: Mixed reality (MR) is a hybrid system that projects virtual elements into reality. MR technology provides immersive learning using various real-world tools. However, studies on educational programs using MR are scarce. This study aimed to investigate the ...

Abstract	Mixed reality (MR) is a hybrid system that projects virtual elements into reality. MR technology provides immersive learning using various real-world tools. However, studies on educational programs using MR are scarce. This study aimed to investigate the educational effects of and satisfaction with an MR-based trauma decision-making simulator. A total 40 of trainees self-selected to participate in this study. All of them participated in the MR trauma simulator for approximately 30 minutes and conducted voluntary learning without any external help. Declarative knowledge, measured using 20 multiple-choice questions, was assessed before and after MR trauma training. To confirm the educational effect, test scores before and after MR trauma training were compared using a paired t-test. Student satisfaction after training was measured using a ten-item questionnaire rated on a five-point Likert scale. A pretest-posttest comparison yielded a significant increase in declarative knowledge. The percentage of correct answers to multiple choice questions increased (from a mean of 42.3, SD 12.4-54.8, SD 13) after the MR-based trauma assessment and treatment training (P < .001). Of the participants, 79.45% were satisfied with the overall experience of using the MR simulator. This study demonstrated a meaningful educational effect of the MR-based trauma training system even after a short training time.
MeSH term(s)	Humans ; Augmented Reality ; Educational Status ; Learning ; Personal Satisfaction ; Emergency Medical Services
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036816
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