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Article ; Online: Re: Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging: P. A. Pinto, P. H. Chung, A. R. Rastinehad, A. A. Baccala, Jr., J. Kruecker, C. J. Benjamin, S. Xu, P. Yan, S. Kadoury, C. Chua, J. K. Locklin, B. Turkbey, J. H. Shih, S. P. Gates, C. Buckner, G. Bratslavsky, W. M. Linehan, N. D. Glossop, P. L. Choyke and B. J. Wood J Urol 2011; 186: 1281-1285.

Robertson, Nicola L / Moore, Caroline M / Emberton, Mark

2012 Volume 187, Issue 4, Page(s) 1511–1512

MeSH term(s)	Biopsy, Needle ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Interventional ; Male ; Prostate/pathology ; Prostatic Neoplasms/diagnosis ; Ultrasonography, Interventional
Language	English
Publishing date	2012-02-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2011.12.007
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Article: N.m.r., e.p.r. and magnetic-c.d. studies of cytochrome f. Identity of the haem axial ligands.

Rigby, S E / Moore, G R / Gray, J C / Gadsby, P M / George, S J / Thomson, A J

The Biochemical journal

1988 Volume 256, Issue 2, Page(s) 571–577

Abstract: N.m.r.-, magnetic-c.d.- and e.p.r.-spectroscopic studies of oxidized and reduced cytochrome f ... 101-107] that lysine is the sixth ligand of native cytochrome f. Detailed analysis of the e.p.r ... 203, 101-107]. The observation of a one-proton intensity resonance at -3.27 p.p.m. in the 1H-n.m.r ...

Abstract	N.m.r.-, magnetic-c.d.- and e.p.r.-spectroscopic studies of oxidized and reduced cytochrome f from charlock, rape and woad are reported. Comparison of the spectra with corresponding spectra of other haem proteins, including horse and yeast cytochromes c, bovine cytochrome b5 and n-butylamine adduct of soya-bean leghaemoglobin support the hypothesis [Siedow, Vickery & Palmer (1980) Arch. Biochem. Biophys. 203, 101-107] that lysine is the sixth ligand of native cytochrome f. Detailed analysis of the e.p.r. spectrum of ferricytochrome f indicates that its principle g-values are 3.51, 1.70 and less than 1.3, and not 3.48, 2.07 and 1.6 as previously suggested [Siedow, Vickery & Palmer (1980) Arch. Biochem. Biophys. 203, 101-107]. The observation of a one-proton intensity resonance at -3.27 p.p.m. in the 1H-n.m.r. spectrum of ferrocytochrome f, coupled with the absence of a methionine methyl resonance from the spectral region to low frequency of -2 p.p.m., is suggested to be a general indicator of lysine co-ordination.
MeSH term(s)	Animals ; Cattle ; Circular Dichroism ; Cytochromes ; Cytochromes f ; Heme ; Horses ; Ligands ; Magnetic Resonance Spectroscopy ; Oxidation-Reduction ; Plants/enzymology ; Protein Conformation ; Yeasts
Chemical Substances	Cytochromes ; Ligands ; Heme (42VZT0U6YR) ; Cytochromes f (9035-46-5)
Language	English
Publishing date	1988-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/bj2560571
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Article ; Online: Re: A critical analysis of the tumor volume threshold for clinically insignificant prostate cancer using a data set of a randomized screening trial. T. Wolters, M. J. Roobol, P. J. van Leeuwen, R. C. van den Bergh, R. F. Hoedemaeker, G. J. van Leenders, F. H. Schröder and T. H. van der Kwast. J Urol 2011;185: 121-125.

Moore, Caroline M / Klotz, Laurence / Emberton, Mark

The Journal of urology

2011 Volume 186, Issue 3, Page(s) 1158–9; author reply 1159

MeSH term(s)	Humans ; Male ; Prostatic Neoplasms/pathology
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2011.04.100
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Article ; Online: Preventing disease through opportunistic, r apid e ngag em ent by p rimary c are t eams using b ehaviour c hange c ounselling (PRE-EMPT)

Smith Christine / Pickles Timothy / Randell Elizabeth / Moore Laurence / McCambridge Jim / Carter Ben / Rollnick Stephen / Cohen David / Edwards Adrian / Hood Kerry / Simpson Sharon A / Spanou Clio / Lane Claire / Wood Fiona / Thornton Hazel / Butler Chris C

BMC Family Practice, Vol 11, Iss 1, p

protocol for a general practice-based cluster randomised trial

2010 Volume 69

Abstract: Abstract Background Smoking, excessive alcohol consumption, lack of exercise and an unhealthy diet are the key modifiable factors contributing to premature morbidity and mortality in the developed world. Brief interventions in health care consultations ... ...

Abstract	Abstract Background Smoking, excessive alcohol consumption, lack of exercise and an unhealthy diet are the key modifiable factors contributing to premature morbidity and mortality in the developed world. Brief interventions in health care consultations can be effective in changing single health behaviours. General Practice holds considerable potential for primary prevention through modifying patients' multiple risk behaviours, but feasible, acceptable and effective interventions are poorly developed, and uptake by practitioners is low. Through a process of theoretical development, modeling and exploratory trials, we have developed an intervention called Behaviour Change Counselling (BCC) derived from Motivational Interviewing (MI). This paper describes the protocol for an evaluation of a training intervention (the Talking Lifestyles Programme) which will enable practitioners to routinely use BCC during consultations for the above four risk behaviours. Methods/Design This cluster randomised controlled efficacy trial (RCT) will evaluate the outcomes and costs of this training intervention for General Practitioners (GPs) and nurses. Training methods will include: a practice-based seminar, online self-directed learning, and reflecting on video recorded and simulated consultations. The intervention will be evaluated in 29 practices in Wales, UK; two clinicians will take part (one GP and one nurse) from each practice. In intervention practices both clinicians will receive training. The aim is to recruit 2000 patients into the study with an expected 30% drop out. The primary outcome will be the proportion of patients making changes in one or more of the four behaviours at three months. Results will be compared for patients seeing clinicians trained in BCC with patients seeing non-BCC trained clinicians. Economic and process evaluations will also be conducted. Discussion Opportunistic engagement by health professionals potentially represents a cost effective medical intervention. This study integrates an existing, ...
Keywords	Medicine (General) ; R5-920
Subject code	796
Language	English
Publishing date	2010-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: E.p.r. and magnetic circular dichroism spectroscopic characterization of bacterioferritin from Pseudomonas aeruginosa and Azotobacter vinelandii.

Cheesman, M R / Kadir, F H / al-Basseet, J / al-Massad, F / Farrar, J / Greenwood, C / Thomson, A J / Moore, G R

The Biochemical journal

1992 Volume 286 Pt 2, Page(s) 361–367

Abstract: The e.p.r. and magnetic circular dichroism (m.c.d.) spectra of bacterioferritin (BFR) extracted ... temperature. The e.p.r. spectra show the presence of low-spin Fe3+ haem with g values of 2.86, 2.32, 1.48 (P ... group in A. vinelandii BFR shifts from -475 mV to -225 mV on removal of the core. The e.p.r. spectra ...

Abstract	The e.p.r. and magnetic circular dichroism (m.c.d.) spectra of bacterioferritin (BFR) extracted from Pseudomonas aeruginosa and Azotobacter vinelandii have been studied over a wide temperature range down to liquid-helium temperature. The e.p.r. spectra show the presence of low-spin Fe3+ haem with g values of 2.86, 2.32, 1.48 (P. aeruginosa) and 2.88, 2.31, 1.46 (A. vinelandii), in both the presence and absence of the BFR core. Together with evidence from the porphyrin-to-Fe3+ charge-transfer band at 2240 and 2270 nm the axial haem ligands are identified as two methionines. The low-temperature m.c.d. spectra in the region 300-1000 nm of P. aeruginosa and A. vinelandii BFR are identical with one another and unaffected by removal of the iron core. Hence it can be concluded that the presence of the iron core has no detectable effect on the electronic states and on the stereochemistry of the haem group. This was unexpected, in view of the observations by Watt, Frankel, Papaefthymiou, Spartalian & Stiefel [(1986) Biochemistry 25, 4330-4336] that the redox potential of the haem group in A. vinelandii BFR shifts from -475 mV to -225 mV on removal of the core. The e.p.r. spectra of holoBFR show a broad symmetrical derivative-shaped band centred at g = 2.0 which decreases in bandwidth as the temperature is raised. This signal is assigned to the uncompensated electron spins of the iron core.
MeSH term(s)	Azotobacter vinelandii/chemistry ; Bacterial Proteins ; Circular Dichroism ; Cytochrome b Group/chemistry ; Electron Spin Resonance Spectroscopy ; Ferritins/chemistry ; Magnetics ; Pseudomonas aeruginosa/chemistry ; Spectrophotometry, Ultraviolet
Chemical Substances	Bacterial Proteins ; Cytochrome b Group ; Ferritins (9007-73-2) ; bacterioferritin (9035-38-5)
Language	English
Publishing date	1992-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/bj2860361
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Article: Whole-body net protein balance plateaus in response to increasing protein intakes during post-exercise recovery in adults and adolescents

Moore, Daniel

Nutrition & metabolism, 15:62

2018

Abstract: ... zero) in adolescents vs. adults. Urea/creatinine excretion increased linearly (all, r ≥ 0.76; P < 0.01 ... than linear regression (all, r2 ≥ 0.56; P < 0.01), indicating an anabolic plateau. Net balance was maximized at ~ 0.15, 0 ... across the range of protein intakes. At plateau, net balance was greater (P < 0.05) in AM vs. M ...

Abstract	BACKGROUND: Muscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net balance to dietary protein. Moreover, limited research has addressed the anabolic response to dietary protein in adolescents. The present study determined whether whole-body net balance plateaued in response to increasing protein intakes during post-exercise recovery and whether there were age- and/or sex-related dimorphisms in the anabolic response. METHODS: Thirteen adults [7 males (M), 6 females (F)] and 14 adolescents [7 males (AM), 7 females (AF) within ~ 0.4 y from peak height velocity] performed ~ 1 h variable intensity exercise (i.e., Loughborough Intermittent Shuttle Test) prior to ingesting hourly mixed meals that provided a variable amount of protein (0.02–0.25 g·kg− 1·h− 1) as crystalline amino acids modeled after egg protein. Steady-state protein kinetics were modeled noninvasively with oral L-[1-13C]phenylalanine. Breath and urine samples were taken at plateau to determine phenylalanine oxidation and flux (estimate of protein breakdown), respectively. Whole-body net balance was determined by the difference between protein synthesis (flux – oxidation) and protein breakdown. Total amino acid oxidation was estimated from the ratio of urinary urea/creatinine. RESULTS: Mixed model biphasic linear regression explained a greater proportion of net balance variance than linear regression (all, r2 ≥ 0.56; P < 0.01), indicating an anabolic plateau. Net balance was maximized at ~ 0.15, 0.12, 0.12, and 0.11 g protein·kg− 1·h− 1 in M, F, AM, and AF, respectively. When collapsed across age, the y-intercept (net balance at very low protein intake) was greater (overlapping CI did not contain zero) in adolescents vs. adults. Urea/creatinine excretion increased linearly (all, r ≥ 0.76; P < 0.01) across the range of protein intakes. At plateau, net balance was greater (P < 0.05) in AM vs. M. CONCLUSIONS: Our data suggest there is a practical limit to the anabolic response to protein ingestion within a mixed meal and that higher intakes lead to deamination and oxidation of excess amino acids. Consistent with a need to support lean mass growth, adolescents appear to have greater anabolic sensitivity and a greater capacity to assimilate dietary amino acids than adults.
Keywords	Amino acids ; Athlete ; Growth ; Lean body mass ; Maximal anabolic response ; Muscle protein synthesis ; Postprandial ; Youth
Language	English
Document type	Article
Database	Repository for Life Sciences

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Book ; Conference proceedings ; Online: Physical properties and color of sediment core Site 199-1218 from the equatorial Pacific, supplementary data to: P?like, Heiko; Moore, Theodore C; Backman, Jan; Raffi, Isabella; Lanci, Luca; Par?s, Josep M; Janecek, Thomas R (2005): Integrated stratigraphic correlation and improved composite depth scales for ODP Sites 1218 and 1219. In: Wilson, PA; Lyle, M; Firth, JV (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 199, 1-41

P?like, Heiko / Backman, Jan / Janecek, Thomas R / Lanci, Luca / Moore, Theodore C / Par?s, Josep M / Raffi, Isabella

2006

Abstract: During Ocean Drilling Program Leg 199 a high-resolution (ab. 1-2 cm/k.y.) biogenic sediment record from the late Paleocene to the early Miocene was recovered, containing an uninterrupted set of geomagnetic chrons as well as a detailed record of ... ...

Abstract	During Ocean Drilling Program Leg 199 a high-resolution (ab. 1-2 cm/k.y.) biogenic sediment record from the late Paleocene to the early Miocene was recovered, containing an uninterrupted set of geomagnetic chrons as well as a detailed record of calcareous and siliceous biostratigraphic datum events. Shipboard lithologic proxy measurements and shore-based determinations of CaCO3 revealed regular cycles that can be attributed to climatic forcing. Discovering drill sites with well defined magneto- and biostratigraphic records that also show clear lithologic cycles is rare and valuable and creates the opportunity to develop a detailed stratigraphic intersite correlation, providing the basis to study paleoceanographic processes and mass accumulation rates at high resolution. Here we present extensive postcruise work that extends the shipboard composite depth stratigraphy by providing a high-resolution revised meters composite depth (rmcd) scale to compensate for depth distortion within individual cores. The depth-aligned data were then used to generate stacked records of lithologic proxy measurements. Making use of the increased signal-to-noise ratio in the stacked records, we then proceeded to generate a detailed site-to-site correlation between Sites 1218 and 1219 in order to decrease the depth uncertainty for magneto- and biostratigraphic datums. Stacked lithologic proxy records in combination with discrete measurements of CaCO3 were then exploited to calculate high-resolution carbonate concentration curves by regression of the multisensor track data with discrete measurements. By matching correlative features between the cores and wireline logging data, we also rescaled our core rmcd back to in situ depths. Our study identifies lithology-dependent core expansion due to unloading as the mechanism of varying stratigraphic thicknesses between cores.
Language	English
Dates of publication	2006-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Conference proceedings ; Online
Note	This dataset is supplement to doi:10.2973/odp.proc.sr.199.213.2005
DOI	10.1594/PANGAEA.547800
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings ; Online: Stratigraphic correlation of ODP Site 199-1218 and 199-1219, supplementary data to: P?like, Heiko; Moore, Theodore C; Backman, Jan; Raffi, Isabella; Lanci, Luca; Par?s, Josep M; Janecek, Thomas R (2005): Integrated stratigraphic correlation and improved composite depth scales for ODP Sites 1218 and 1219. In: Wilson, PA; Lyle, M; Firth, JV (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 199, 1-41

P?like, Heiko / Backman, Jan / Janecek, Thomas R / Lanci, Luca / Moore, Theodore C / Par?s, Josep M / Raffi, Isabella

2005

Abstract: During Ocean Drilling Program Leg 199 a high-resolution (~1-2 cm/k.y.) biogenic sediment record from the late Paleocene to the early Miocene was recovered, containing an uninterrupted set of geomagnetic chrons as well as a detailed record of calcareous ... ...

Abstract	During Ocean Drilling Program Leg 199 a high-resolution (~1-2 cm/k.y.) biogenic sediment record from the late Paleocene to the early Miocene was recovered, containing an uninterrupted set of geomagnetic chrons as well as a detailed record of calcareous and siliceous biostratigraphic datum events. Shipboard lithologic proxy measurements and shore-based determinations of CaCO3 revealed regular cycles that can be attributed to climatic forcing. Discovering drill sites with well defined magneto- and biostratigraphic records that also show clear lithologic cycles is rare and valuable and creates the opportunity to develop a detailed stratigraphic intersite correlation, providing the basis to study paleoceanographic processes and mass accumulation rates at high resolution. Here we present extensive postcruise work that extends the shipboard composite depth stratigraphy by providing a high-resolution revised meters composite depth (rmcd) scale to compensate for depth distortion within individual cores. The depth-aligned data were then used to generate stacked records of lithologic proxy measurements. Making use of the increased signal-to-noise ratio in the stacked records, we then proceeded to generate a detailed site-to-site correlation between Sites 1218 and 1219 in order to decrease the depth uncertainty for magneto- and biostratigraphic datums. Stacked lithologic proxy records in combination with discrete measurements of CaCO3 were then exploited to calculate high-resolution carbonate concentration curves by regression of the multisensor track data with discrete measurements. By matching correlative features between the cores and wireline logging data, we also rescaled our core rmcd back to in situ depths. Our study identifies lithology-dependent core expansion due to unloading as the mechanism of varying stratigraphic thicknesses between cores.
Language	English
Dates of publication	2005-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Conference proceedings ; Online
Note	This dataset is supplement to doi:10.2973/odp.proc.sr.199.213.2005
DOI	10.1594/PANGAEA.771962
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Beta testing the monkey model.

Moore, John P / Gounder, Celine R

Nature immunology

2021 Volume 22, Issue 10, Page(s) 1201–1203

Language	English
Publishing date	2021-09-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-021-01033-w
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Article ; Online: Home-based management on hospital re-admission rates in COPD patients: A systematic review.

Corcoran, Rita / Moore, Zena / Avsar, Pinar / Murray, Bridget

Journal of advanced nursing

2024

Abstract: Aim: To determine the impact of home-based management on hospital re-admission rates in patients with chronic obstructive pulmonary disease (COPD).: Design: Systematic review methodology was utilized, combining meta-analysis, where appropriate, or a ... ...

Abstract	Aim: To determine the impact of home-based management on hospital re-admission rates in patients with chronic obstructive pulmonary disease (COPD). Design: Systematic review methodology was utilized, combining meta-analysis, where appropriate, or a narrative analysis of the data from included studies. Data sources: Electronic databases CINAHL, MEDLINE, PubMed, Embase and SAGE journals for primary papers, 2015 to 2021, were searched between December 2020 and March 2021, followed by hand-searching key journals, and reference lists of retrieved papers. Methods: The review followed the guidance of PRISMA. Data were extracted using a predesigned data extraction tool. Quality appraisal was undertaken using RevMan 'risk of bias' tool. Meta-analysis was undertaken using RevMan software. Results: This review integrates evidence from eight studies, five Random Control Trials, two observational studies and one retrospective study. The studies span three continents, Asia, Europe and North America, and include 3604 participants with COPD. Home-based management in patients with COPD resulted in a statistically significant reduction in rates of hospital readmission. For the outcomes, length of stay and mortality, while slightly in favour of home-based management, the results were not statistically significant. Conclusion: Given the burden of COPD on healthcare systems, and crucially on individuals, this review identified a reduction in hospital re-admission rate, a clinically important outcome. Impact: This study focused on the impact on hospital re-admission rates among the COPD patient cohort when home-based management was involved. A statistically significant reduction in rates of re-admission to the hospital was identified. This is positive for the patient, in terms of hospital avoidance, and reduces the burden on hospital systems. Further research is needed to determine the impact on cost-effectiveness and to quantify the most ideal type of care package that would be recommended for home-based management.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	197634-5
ISSN	1365-2648 ; 0309-2402
ISSN (online)	1365-2648
ISSN	0309-2402
DOI	10.1111/jan.16168
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