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Article ; Online: Removal efficiency of dibenzofuran using CuZn-zeolitic imidazole frameworks as a catalyst and adsorbent

Nguyen Thanh Q. C. / Tran Huy B. / Nguyen Nghia K. / Nguyen Nhut M. / Dang Giao H.

Green Processing and Synthesis, Vol 12, Iss 1, Pp 251-

2023 Volume 61

Keywords	adsorption ; bimetallic ; catalyst ; dibenzofuran ; zeolitic imidazolate framework ; Chemistry ; QD1-999
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article ; Online: Automated pupillometry and optic nerve sheath diameter ultrasound to define tuberculous meningitis disease severity and prognosis.

Casey, Flora / Van, Hoang Minh Tu / Donovan, Joseph / Nghia, Ho Dang Trung / Oanh, Pham Kieu Nguyet / Thwaites, C Louise / Phu, Nguyen Hoan / Thwaites, Guy E

Journal of the neurological sciences

2023 Volume 453, Page(s) 120808

Abstract: Background: Tuberculous meningitis (TBM) causes high mortality and morbidity, in part due to raised intracranial pressure (ICP). Automated pupillometry (NPi) and optic nerve sheath diameter (ONSD) are both low-cost, easy-to-use and non-invasive ... ...

Abstract	Background: Tuberculous meningitis (TBM) causes high mortality and morbidity, in part due to raised intracranial pressure (ICP). Automated pupillometry (NPi) and optic nerve sheath diameter (ONSD) are both low-cost, easy-to-use and non-invasive techniques that correlate with ICP and neurological status. However, it is uncertain how to apply these techniques in the management of TBM. Methods: We conducted a pilot study enrolling 20 adults with TBM in the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Our objective was to investigate the relationships between baseline and serial measurements of NPi and ONSD and disease severity and outcome. Serial NPi and ONSD were performed for 30 days, at discharge, and at 3-months, with measurements correlated with clinical progression and outcomes. Results: ONSD and NPi measurements had an inverse relationship. Higher ONSD and lower NPi values were associated with lower Glasgow coma score. Baseline NPi was a strong predictor 3-month outcome (median NPi 4.55, interquartile range 4.35-4.65 for good outcomes versus 2.60, IQR 0.65-3.95 for poor outcomes, p = 0.002). Pupil inequality (NPi ≥0.7) was also strongly associated with poor 3-month outcomes (p = 0.006). Individual participants' serial NPi and ONSD were variable during initial treatment and correlated with clinical condition and outcome. Conclusion: Pupillometry and ONSD may be used to predict clinical deterioration and outcome from TBM. Future, larger studies are need explore the optimal timing of measurements and to define how they might be used to optimise treatments and improve outcomes from TBM.
MeSH term(s)	Adult ; Humans ; Tuberculosis, Meningeal/diagnostic imaging ; Tuberculosis, Meningeal/complications ; Pilot Projects ; Ultrasonography/methods ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/etiology ; Prognosis ; Optic Nerve/diagnostic imaging ; Intracranial Pressure/physiology
Language	English
Publishing date	2023-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120808
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Article ; Online: Efficient degradation of methyl orange and methylene blue in aqueous solution using a novel Fenton-like catalyst of CuCo-ZIFs

Luong Thanh H. V. / Nguyen Thao H. T. / Nguyen Binh V. / Nguyen Nghia K. / Nguyen Thanh Q. C. / Dang Giao H.

Green Processing and Synthesis, Vol 11, Iss 1, Pp 71-

2022 Volume 83

Keywords	cuco-zifs ; heterogeneous catalyst ; novel fenton-like catalyst ; methyl blue ; methyl orange ; Chemistry ; QD1-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	De Gruyter
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Article ; Online: Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults.

Donovan, Joseph / Bang, Nguyen D / Imran, Darma / Nghia, Ho D T / Burhan, Erlina / Huong, Dau T T / Hiep, Nguyen T T / Ngoc, Lam H B / Thanh, Dang V / Thanh, Nguyen T / Wardhani, Anna L S / Maharani, Kartika / Gasmara, Cakra P / Hanh, Nguyen H H / Oanh, Pham K N / Estiasari, Riwanti / Thu, Do D A / Kusumaningrum, Ardiana / Dung, Le T /

Giang, Do C / Ha, Dang T M / Lan, Nguyen H / Chau, Nguyen V V / Nguyet, Nguyen T M / Geskus, Ronald B / Thuong, Nguyen T T / Kestelyn, Evelyne / Hamers, Raph L / Phu, Nguyen H / Thwaites, Guy E

The New England journal of medicine

2023 Volume 389, Issue 15, Page(s) 1357–1367

Abstract: Background: Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)-associated tuberculous meningitis despite limited data supporting their safety and efficacy.: Methods: We conducted a double-blind, randomized, placebo- ...

Abstract	Background: Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)-associated tuberculous meningitis despite limited data supporting their safety and efficacy. Methods: We conducted a double-blind, randomized, placebo-controlled trial involving HIV-positive adults (≥18 years of age) with tuberculous meningitis in Vietnam and Indonesia. Participants were randomly assigned to receive a 6-to-8-week tapering course of either dexamethasone or placebo in addition to 12 months of antituberculosis chemotherapy. The primary end point was death from any cause during the 12 months after randomization. Results: A total of 520 adults were randomly assigned to receive either dexamethasone (263 participants) or placebo (257 participants). The median age was 36 years; 255 of 520 participants (49.0%) had never received antiretroviral therapy, and 251 of 484 participants (51.9%) with available data had a baseline CD4 count of 50 cells per cubic millimeter or less. Six participants withdrew from the trial, and five were lost to follow-up. During the 12 months of follow-up, death occurred in 116 of 263 participants (44.1%) in the dexamethasone group and in 126 of 257 participants (49.0%) in the placebo group (hazard ratio, 0.85; 95% confidence interval, 0.66 to 1.10; P = 0.22). Prespecified analyses did not reveal a subgroup that clearly benefited from dexamethasone. The incidence of secondary end-point events, including cases of immune reconstitution inflammatory syndrome during the first 6 months, was similar in the two trial groups. The numbers of participants with at least one serious adverse event were similar in the dexamethasone group (192 of 263 participants [73.0%]) and the placebo group (194 of 257 participants [75.5%]) (P = 0.52). Conclusions: Among HIV-positive adults with tuberculous meningitis, adjunctive dexamethasone, as compared with placebo, did not confer a benefit with respect to survival or any secondary end point. (Funded by the Wellcome Trust; ACT HIV ClinicalTrials.gov number, NCT03092817.).
MeSH term(s)	Adult ; Humans ; Dexamethasone/adverse effects ; Dexamethasone/therapeutic use ; Double-Blind Method ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Seropositivity/complications ; HIV Seropositivity/drug therapy ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/drug therapy ; Antitubercular Agents/adverse effects ; Antitubercular Agents/therapeutic use ; Drug Therapy, Combination/adverse effects ; Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use
Chemical Substances	Dexamethasone (7S5I7G3JQL) ; Glucocorticoids ; Antitubercular Agents ; Anti-Retroviral Agents
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMoa2216218
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Article: Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus.

Du, Duc Hong / Hao, Nguyen Quan Nhu / Van Hao, Nguyen / Thanh, Tran Tan / Loan, Huynh Thi / Yen, Lam Minh / Thuy, Tran Thi Diem / Thuy, Duong Bich / Nguyen, Nguyen Thanh / Dung, Nguyen Thi Phuong / Kestelyn, Evelyne / Duong, Ha Thi Hai / Phong, Nguyen Thanh / Tuyen, Pham Thi / Phu, Nguyen Hoan / Nghia, Ho Dang Trung / Hanh, Bui Thi Bich / Oanh, Pham Kieu Nguyet / Tho, Phan Vinh /

Nhat, Phung Tran Huy / Khanh, Phan Nguyen Quoc / Wyncoll, Duncan / Day, Nicholas P J / Van Vinh Chau, Nguyen / van Doorn, H Rogier / Van Tan, Le / Geskus, Ronald B / Thwaites, C Louise

Tropical medicine and health

2023 Volume 51, Issue 1, Page(s) 20

Abstract: Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of cardiovascular ... ...

Abstract	Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of cardiovascular disturbance is less clear, but is believed to relate to disinhibition of the autonomic nervous system. The clinical syndrome of autonomic nervous system dysfunction (ANSD) seen in severe tetanus is characterized principally by changes in heart rate and blood pressure which have been linked to increased circulating catecholamines. Previous studies have described varying relationships between catecholamines and signs of ANSD in tetanus, but are limited by confounders and assays used. In this study, we aimed to perform detailed characterization of the relationship between catecholamines (adrenaline and noradrenaline), cardiovascular parameters (heart rate and blood pressure) and clinical outcomes (ANSD, mechanical ventilation required, and length of intensive care unit stay) in adults with tetanus, as well as examine whether intrathecal antitoxin administration affected subsequent catecholamine excretion. Noradrenaline and adrenaline were measured by ELISA from 24-h urine collections taken on day 5 of hospitalization in 272 patients enrolled in a 2 × 2 factorial-blinded randomized controlled trial in a Vietnamese hospital. Catecholamine results measured from 263 patients were available for analysis. After adjustment for potential confounders (i.e., age, sex, intervention treatment, and medications), there were indications of non-linear relationships between urinary catecholamines and heart rate. Adrenaline and noradrenaline were associated with subsequent development of ANSD, and length of ICU stay.
Language	English
Publishing date	2023-03-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2209835-5
ISSN	1349-4147 ; 1348-8945
ISSN (online)	1349-4147
ISSN	1348-8945
DOI	10.1186/s41182-023-00512-0
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Article ; Online: Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Duc Hong Du / Nguyen Quan Nhu Hao / Nguyen Van Hao / Tran Tan Thanh / Huynh Thi Loan / Lam Minh Yen / Tran Thi Diem Thuy / Duong Bich Thuy / Nguyen Thanh Nguyen / Nguyen Thi Phuong Dung / Evelyne Kestelyn / Ha Thi Hai Duong / Nguyen Thanh Phong / Pham Thi Tuyen / Nguyen Hoan Phu / Ho Dang Trung Nghia / Bui Thi Bich Hanh / Pham Kieu Nguyet Oanh / Phan Vinh Tho /

Phung Tran Huy Nhat / Phan Nguyen Quoc Khanh / Duncan Wyncoll / Nicholas P. J. Day / Nguyen Van Vinh Chau / H. Rogier van Doorn / Le Van Tan / Ronald B. Geskus / C. Louise Thwaites

Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-

2023 Volume 6

Abstract: Abstract Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of ... ...

Abstract	Abstract Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of cardiovascular disturbance is less clear, but is believed to relate to disinhibition of the autonomic nervous system. The clinical syndrome of autonomic nervous system dysfunction (ANSD) seen in severe tetanus is characterized principally by changes in heart rate and blood pressure which have been linked to increased circulating catecholamines. Previous studies have described varying relationships between catecholamines and signs of ANSD in tetanus, but are limited by confounders and assays used. In this study, we aimed to perform detailed characterization of the relationship between catecholamines (adrenaline and noradrenaline), cardiovascular parameters (heart rate and blood pressure) and clinical outcomes (ANSD, mechanical ventilation required, and length of intensive care unit stay) in adults with tetanus, as well as examine whether intrathecal antitoxin administration affected subsequent catecholamine excretion. Noradrenaline and adrenaline were measured by ELISA from 24-h urine collections taken on day 5 of hospitalization in 272 patients enrolled in a 2 × 2 factorial-blinded randomized controlled trial in a Vietnamese hospital. Catecholamine results measured from 263 patients were available for analysis. After adjustment for potential confounders (i.e., age, sex, intervention treatment, and medications), there were indications of non-linear relationships between urinary catecholamines and heart rate. Adrenaline and noradrenaline were associated with subsequent development of ANSD, and length of ICU stay.
Keywords	Catecholamine ; Tetanus ; Infectious diseases ; Cardiovascular ; Mechanical ventilation ; Autonomic nervous system dysfunction ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial.

Van Hao, Nguyen / Loan, Huynh Thi / Yen, Lam Minh / Kestelyn, Evelyne / Hong, Duc Du / Thuy, Duong Bich / Nguyen, Nguyen Thanh / Duong, Ha Thi Hai / Thuy, Tran Thi Diem / Nhat, Phung Tran Huy / Khanh, Phan Nguyen Quoc / Dung, Nguyen Thi Phuong / Phu, Nguyen Hoan / Phong, Nguyen Thanh / Lieu, Pham Thi / Tuyen, Pham Thi / Hanh, Bui Thi Bich / Nghia, Ho Dang Trung / Oanh, Pham Kieu Nguyet /

Tho, Phan Vinh / Tan Thanh, Tran / Turner, Hugo C / van Doorn, H Rogier / Van Tan, Le / Wyncoll, Duncan / Day, Nicholas Pj / Geskus, Ronald B / Thwaites, Guy E / Van Vinh Chau, Nguyen / Thwaites, C Louise

The Lancet. Global health

2022 Volume 10, Issue 6, Page(s) e862–e872

Abstract: Background: Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, ... ...

Abstract	Background: Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, intrathecal antitoxin administration might improve clinical outcomes compared with intramuscular injection. Methods: In a 2 × 2 factorial trial, all patients aged 16 years or older with a clinical diagnosis of generalised tetanus admitted to the intensive care unit of the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, were eligible for study entry. Participants were randomly assigned first to 3000 IU human or 21 000 U equine intramuscular antitoxin, then to either 500 IU intrathecal human antitoxin or sham procedure. Interventions were delivered by independent clinicians, with attending clinicians and study staff masked to treatment allocations. The primary outcome was requirement for mechanical ventilation. The analysis was done in the intention-to-treat population. The study is registered at ClinicalTrials.gov, NCT02999815; recruitment is completed. Findings: 272 adults were randomly assigned to interventions between Jan 8, 2017, and Sept 29, 2019, and followed up until May, 2020. In the intrathecal allocation, 136 individuals were randomly assigned to sham procedure and 136 to antitoxin; in the intramuscular allocation, 109 individuals were randomly assigned to equine antitoxin and 109 to human antitoxin. 54 patients received antitoxin at a previous hospital, excluding them from the intramuscular antitoxin groups. Mechanical ventilation was given to 56 (43%) of 130 patients allocated to intrathecal antitoxin and 65 (50%) of 131 allocated to sham procedure (relative risk [RR] 0·87, 95% CI 0·66-1·13; p=0·29). For the intramuscular allocation, 48 (45%) of 107 patients allocated to human antitoxin received mechanical ventilation compared with 48 (44%) of 108 patients allocated to equine antitoxin (RR 1·01, 95% CI 0·75-1·36, p=0·95). No clinically relevant difference in adverse events was reported. 22 (16%) of 136 individuals allocated to the intrathecal group and 22 (11%) of 136 allocated to the sham procedure experienced adverse events related or possibly related to the intervention. 16 (15%) of 108 individuals allocated to equine intramuscular antitoxin and 17 (16%) of 109 allocated to human antitoxin experienced adverse events related or possibly related to the intervention. There were no intervention-related deaths. Interpretation: We found no advantage of intramuscular human antitoxin over intramuscular equine antitoxin in tetanus treatment. Intrathecal antitoxin administration was safe, but did not provide overall benefit in addition to intramuscular antitoxin administration. Funding: The Wellcome Trust.
MeSH term(s)	Animals ; Antitoxins/therapeutic use ; Horses ; Humans ; Injections, Intramuscular ; Intensive Care Units ; Tetanus/drug therapy ; Treatment Outcome
Chemical Substances	Antitoxins
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(22)00117-6
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Article ; Online: Acetylmelodorinol isolated from Sphaerocoryne affinis seeds inhibits cell proliferation and activates apoptosis on HeLa cells.

Le-Trung, Nghia / Kanaori, Kenji / Waku, Tomonori / Dang, Thao Thi Phuong / Kamei, Kaeko

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 59

Abstract: Background: Cervical cancer is a major global health concern with a high prevalence in low- and middle-income countries. Natural products, particularly plant-derived compounds, have shown immense potential for developing anticancer drugs. In this study, ...

Abstract	Background: Cervical cancer is a major global health concern with a high prevalence in low- and middle-income countries. Natural products, particularly plant-derived compounds, have shown immense potential for developing anticancer drugs. In this study, we aimed to investigate the anticancer properties of the pericarp and seeds of Sphaerocoryne affinis fruit on human cervical carcinoma cells (HeLa) and isolate the bioactive compound from the active fraction. Methods: We prepared solvent fractions from the ethanol extracts of the pericarp and the seed portion by partitioning and assessing their cytotoxicity on HeLa cells. Subsequently, we collected acetylmelodorinol (AM), an anticancer compound, from the ethyl acetate fraction of seeds and determined its structure using nuclear magnetic resonance. We employed cytotoxicity assay, western blotting, Annexin V apoptosis assay, measurement of intracellular reactive oxygen species (ROS) levels, 4',6-diamidino-2-phenylindole (DAPI) staining, and a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, to evaluate the anticancer properties of AM on HeLa. Results: The solvent fractions from the seed displayed considerably higher cytotoxic activity against HeLa cells than those of the pericarp. We isolated and identified acetylmelodorinol as an anticancer compound from the ethyl acetate fraction from S. affinis seed extract. Treatment with acetylmelodorinol inhibited HeLa cell proliferation with an IC Conclusion: In contrast to previous reports, this study focuses on the inhibitory effects of AM on the AKT/mTOR pathway, leading to a reduction in cell proliferation in cervical cancer cells. Our findings highlight the promising potential of acetylmelodorinol as an effective treatment for cervical cancer. Additionally, this study establishes a foundation for investigating the molecular mechanisms underlying AM's properties, fostering further exploration into plant-based cancer therapies.
MeSH term(s)	Female ; Humans ; HeLa Cells ; Proto-Oncogene Proteins c-akt/metabolism ; Reactive Oxygen Species/metabolism ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Apoptosis ; Cell Proliferation ; TOR Serine-Threonine Kinases ; Seeds ; Solvents/pharmacology ; Solvents/therapeutic use ; Acetates
Chemical Substances	ethyl acetate (76845O8NMZ) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Reactive Oxygen Species ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Solvents ; Acetates
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04357-w
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Article ; Online: Event-Based Surveillance at Community and Healthcare Facilities, Vietnam, 2016-2017.

Emerging infectious diseases

2018 Volume 24, Issue 9, Page(s) 1649–1658

Abstract: Surveillance and outbreak reporting systems in Vietnam required improvements to function effectively as early warning and response systems. Accordingly, the Ministry of Health of Vietnam, in collaboration with the US Centers for Disease Control and ... ...

Abstract	Surveillance and outbreak reporting systems in Vietnam required improvements to function effectively as early warning and response systems. Accordingly, the Ministry of Health of Vietnam, in collaboration with the US Centers for Disease Control and Prevention, launched a pilot project in 2016 focusing on community and hospital event-based surveillance. The pilot was implemented in 4 of Vietnam's 63 provinces. The pilot demonstrated that event-based surveillance resulted in early detection and reporting of outbreaks, improved collaboration between the healthcare facilities and preventive sectors of the ministry, and increased community participation in surveillance and reporting.
MeSH term(s)	Communicable Disease Control ; Disease Outbreaks/prevention & control ; Health Facilities ; Hospitals ; Humans ; Population Surveillance ; Vietnam/epidemiology
Keywords	covid19
Language	English
Publishing date	2018-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2409.171851
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Article ; Online: Air pollution and risk of respiratory and cardiovascular hospitalizations in a large city of the Mekong Delta Region.

Le, Diep Ngoc / Nguyen, Ha Ai Phan / Ngoc, Dang Tran / Do, Thuong Hoai Thi / Ton, Nghia Tuan / Van Le, Tuan / Ho, Tinh Huu / Van Dang, Chinh / Thai, Phong K / Phung, Dung

Environmental science and pollution research international

2022 Volume 29, Issue 60, Page(s) 91165–91175

Abstract: It is important to explore air pollution and health effects in developing cities for early prevention rather than waiting for conditions to deteriorate as in the current megacities. This study aims to investigate the short-term health effects of air ... ...

Abstract	It is important to explore air pollution and health effects in developing cities for early prevention rather than waiting for conditions to deteriorate as in the current megacities. This study aims to investigate the short-term health effects of air pollution in a large city in the Mekong Delta Region (MDR) of Vietnam. Air pollution data from January 2015 to December 2018 were collected from the Environmental Monitoring Centre of Can Tho City. The data of respiratory and cardiovascular disease (CVD) admissions in 18 hospitals and medical centers were collected. A time-series regression analysis was conducted using distributed lag models to examine the relationship between the air pollutants and hospitalizations including the delayed effect up to 7 days. The research findings reveal that a 10 μg increase in PM
Language	English
Publishing date	2022-07-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22022-y
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