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Article ; Online: Search for Dark Matter Annihilation Signals in the H.E.S.S. Inner Galaxy Survey.

Abdalla, H / Aharonian, F / Benkhali, F Ait / Angüner, E O / Armand, C / Ashkar, H / Backes, M / Baghmanyan, V / Martins, V Barbosa / Batzofin, R / Becherini, Y / Berge, D / Bernlöhr, K / Bi, B / Böttcher, M / Bolmont, J / de Lavergne, M de Bony / Brose, R / Brun, F /

Cangemi, F / Caroff, S / Cerruti, M / Chand, T / Chen, A / Cotter, G / Mbarubucyeye, J Damascene / Devin, J / Djannati-Ataï, A / Dmytriiev, A / Doroshenko, V / Egberts, K / Fiasson, A / de Clairfontaine, G Fichet / Fontaine, G / Funk, S / Gabici, S / Giavitto, G / Glawion, D / Glicenstein, J F / Grondin, M-H / Hinton, J A / Hofmann, W / Holch, T L / Holler, M / Horns, D / Huang, Zhiqiu / Jamrozy, M / Jankowsky, F / Kasai, E / Katarzyński, K / Katz, U / Khélifi, B / Kluźniak, W / Komin, Nu / Kosack, K / Kostunin, D / Lamanna, G / Lemoine-Goumard, M / Lenain, J-P / Leuschner, F / Lohse, T / Luashvili, A / Lypova, I / Mackey, J / Malyshev, D / Marandon, V / Marchegiani, P / Martí-Devesa, G / Marx, R / Maurin, G / Meyer, M / Mitchell, A / Moderski, R / Montanari, A / Moulin, E / Muller, J / de Naurois, M / Niemiec, J / Noel, A Priyana / Ohm, S / Olivera-Nieto, L / Wilhelmi, E de Ona / Ostrowski, M / Panny, S / Panter, M / Parsons, R D / Peron, G / Poireau, V / Prokoph, H / Pühlhofer, G / Punch, M / Quirrenbach, A / Reichherzer, P / Reimer, A / Reimer, O / Renaud, M / Rieger, F / Rowell, G / Rudak, B / Ricarte, H Rueda / Ruiz-Velasco, E / Sahakian, V / Salzmann, H / Santangelo, A / Sasaki, M / Schüssler, F / Schutte, H M / Schwanke, U / Senniappan, M / Shapopi, J N S / Sol, H / Specovius, A / Spencer, S / Stawarz, Ł / Stegmann, C / Steinmassl, S / Steppa, C / Takahashi, T / Tanaka, T / Terrier, R / Thorpe-Morgan, C / Tluczykont, M / Tsirou, M / Tsuji, N / Uchiyama, Y / van Eldik, C / Veh, J / Vink, J / Wagner, S J / White, R / Wierzcholska, A / Wong, Yu Wun / Zacharias, M / Zargaryan, D / Zdziarski, A A / Zech, A / Zhu, S J / Zouari, S / Żywucka, N

Physical review letters

2022 Volume 129, Issue 11, Page(s) 111101

Abstract: ... Survey, at very high energies (≳100 GeV) performed with the H.E.S.S. array of five ground-based ... With the H.E.S.S. Inner Galaxy Survey, ground-based γ-ray observations thus probe ⟨σv⟩ values expected ... reach ⟨σv⟩ values of 3.7×10^{-26} cm^{3} s^{-1} for 1.5 TeV DM mass in the W^{+}W^{-} annihilation ...

Abstract	The central region of the Milky Way is one of the foremost locations to look for dark matter (DM) signatures. We report the first results on a search for DM particle annihilation signals using new observations from an unprecedented γ-ray survey of the Galactic Center (GC) region, i.e., the Inner Galaxy Survey, at very high energies (≳100 GeV) performed with the H.E.S.S. array of five ground-based Cherenkov telescopes. No significant γ-ray excess is found in the search region of the 2014-2020 dataset and a profile likelihood ratio analysis is carried out to set exclusion limits on the annihilation cross section ⟨σv⟩. Assuming Einasto and Navarro-Frenk-White (NFW) DM density profiles at the GC, these constraints are the strongest obtained so far in the TeV DM mass range. For the Einasto profile, the constraints reach ⟨σv⟩ values of 3.7×10^{-26} cm^{3} s^{-1} for 1.5 TeV DM mass in the W^{+}W^{-} annihilation channel, and 1.2×10^{-26} cm^{3} s^{-1} for 0.7 TeV DM mass in the τ^{+}τ^{-} annihilation channel. With the H.E.S.S. Inner Galaxy Survey, ground-based γ-ray observations thus probe ⟨σv⟩ values expected from thermal-relic annihilating TeV DM particles.
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.129.111101
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Article ; Online: Forecasting individual progression trajectories in Alzheimer’s disease

Maheux, Etienne / Koval, Igor / Ortholand, Juliette / Birkenbihl, Colin / Archetti, Damiano / Bouteloup, Vincent / Epelbaum, Stephane / Dufouil, Carole / Hofmann-Apitius, Martin / Durrleman, Stanley

2023

Abstract: The anticipation of progression of Alzheimer’s disease (AD) is crucial for evaluations ...

Abstract	The anticipation of progression of Alzheimer’s disease (AD) is crucial for evaluations of secondary prevention measures thought to modify the disease trajectory. However, it is difficult to forecast the natural progression of AD, notably because several functions decline at different ages and different rates in different patients. We evaluate here AD Course Map, a statistical model predicting the progression of neuropsychological assessments and imaging biomarkers for a patient from current medical and radiological data at early disease stages. We tested the method on more than 96,000 cases, with a pool of more than 4,600 patients from four continents. We measured the accuracy of the method for selecting participants displaying a progression of clinical endpoints during a hypothetical trial. We show that enriching the population with the predicted progressors decreases the required sample size by 38% to 50%, depending on trial duration, outcome, and targeted disease stage, from asymptomatic individuals at risk of AD to subjects with early and mild AD. We show that the method introduces no biases regarding sex or geographic locations and is robust to missing data. It performs best at the earliest stages of disease and is therefore highly suitable for use in prevention trials. 14
Subject code	610 ; 519
Language	English
Publishing date	2023-02-10
Publishing country	de
Document type	Article ; Online
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Article ; Online: Pharmaceutical pollution of the world’s rivers

Wilkinson, J. L. / Boxall, A. B. A. / Kolpin, D. W. / Leung, K. M. Y. / Lai, R. W. S. / Galban-Malagon, C. / Adell, A. D. / Mondon, J. / Metian, M. / Marchant, R. A. / Bouzas-Monroy, A. / Cuni-Sanchez, A. / Coors, A. / Carriquiriborde, P. / Rojo, M. / Gordon, C. / Cara, M. / Moermond, M. / Luarte, T. /

Petrosyan, V. / Perikhanyan, Y. / Mahon, C. S. / McGurk, C. J. / Hofmann, T. / Kormoker, T. / Iniguez, V. / Guzman-Otazo, J. / Tavares, J. L. / De Figueiredo, F. G. / Razzolini, M. T. P. / Dougnon, V. / Gbaguidi, G. / Traore, O. / Blais, J. M. / Kimpe, L. E. / Wong, M. / Wong, D. / Ntchantcho, R. / Pizarro, J. / Ying, G.-G. / Chen, C.-E. / Paez, M. / Martinez-Lara, J. / Otamonga, J.-P. / Pote, J. / Ifo, S. A. / Wilson, P. / Echeverria-Saenz, S. / Udikovic-Kolic, N. / Milakovic, M. / Fatta-Kassinos, D. / Ioannou-Ttofa, L. / Belusova, V. / Vymazal, J. / Cardenas-Bustamante, M. / Kassa, B. A. / Garric, J. / Chaumot, A. / Gibba, P. / Kunchulia, I. / Seidensticker, S. / Lyberatos, G. / Halldorsson, H. P. / Melling, M. / Shashidhar, T. / Lamba, M. / Nastiti, A. / Supriatin, A. / Pourang, N. / Abedini, A. / Abdullah, O. / Gharbia, S. S. / Pilla, F. / Chefetz, B. / Topaz, T. / Yao, K. M. / Aubakirova, B. / Beisenova, R. / Olaka, L. / Mulu, J. K. / Chatanga, P. / Ntuli, V. / Blama, N. T. / Sherif, S. / Aris, A. Z. / Looi, L. J. / Niang, M. / Traore, S. T. / Oldenkamp, R. / Ogunbanwo, O. / Ashfaq, M. / Iqbal, M. / Abdeen, Z. / O’Dea, A. / Morales-Saldana, J. M. / Custodio, M. / de la Cruz, H. / Navarrete, I. / Carvalho, F. / Gogra, A. B. / Koroma, B. M. / Cerkvenik-Flajs, V. / Gombac, M. / Thwala, M. / Choi, K. / Kang, H. / Ladu, J. L. C. / Rico, A. / Amerasinghe, Priyanie / Sobek, A. / Horlitz, G. / Zenker, A. K. / King, A. C. / Jiang, J.-J. / Kariuki, R. / Tumbo, M. / Tezel, U. / Onay, T. T. / Lejju, J. B. / Vystavna, Y. / Vergeles, Y. / Heinzen, H. / Perez-Parada, A. / Sims, D. B. / Figy, M. / Good, D. / Teta, C.

Proceedings of the National Academy of Sciences of the United States of America

2022

Abstract: ... of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million ...

Abstract	Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
Keywords	pharmaceutical pollution ; rivers ; water pollution ; contamination ; aquatic environment ; antimicrobials ; environmental health ; human health ; environmental monitoring ; wastewater ; socioeconomic aspects ; national income ; datasets
Language	English
Publishing date	2022-02-28T13:10:23Z
Publisher	Proceedings of the National Academy of Sciences
Publishing country	fr
Document type	Article ; Online
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Book: Bäder Sach(s)en

Hofmann, Reiner

Wissenswertes über Bäder und Badewasser in Sachsen

2007

Title variant	Bäder Sachen
Author's details	Reiner Hofmann. GHUSS, Gesellschaft für Hygiene, Umweltmedizin und Schutzimpfungen in Sachsen
Subject code	614.43094321
Language	German
Size	104 S. : Ill., graph. Darst., Kt., 24 cm
Publisher	GHUSS
Publishing place	Chemnitz
Publishing country	Germany
Document type	Book
Note	Literaturverz. S. 99 - 103
HBZ-ID	HT016508910
ISBN	978-3-00-020885-0 ; 3-00-020885-2
Database	Catalogue ZB MED Medicine, Health

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2010 A 4976	order for loan	Magazin

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Article ; Online: Zn deficiency disrupts Cu and S homeostasis in Chlamydomonas resulting in over accumulation of Cu and Cysteine.

Strenkert, Daniela / Schmollinger, Stefan / Hu, Yuntao / Hofmann, Christian / Holbrook, Kristen / Liu, Helen W / Purvine, Samuel O / Nicora, Carrie D / Chen, Si / Lipton, Mary S / Northen, Trent R / Clemens, Stephan / Merchant, Sabeeha S

Metallomics : integrated biometal science

2023 Volume 15, Issue 7

Abstract: ... responder" proteins involved in sulfur (S) assimilation and consequently accumulate more intracellular S ... Interestingly, classic S-containing metal binding ligands like glutathione and phytochelatins do not increase ... X-ray fluorescence microscopy showed foci of S accumulation in Zn-limited cells that co-localize with Cu ...

Abstract	Growth of Chlamydomonas reinhardtii in zinc (Zn) limited medium leads to disruption of copper (Cu) homeostasis, resulting in up to 40-fold Cu over-accumulation relative to its typical Cu quota. We show that Chlamydomonas controls its Cu quota by balancing Cu import and export, which is disrupted in a Zn deficient cell, thus establishing a mechanistic connection between Cu and Zn homeostasis. Transcriptomics, proteomics and elemental profiling revealed that Zn-limited Chlamydomonas cells up-regulate a subset of genes encoding "first responder" proteins involved in sulfur (S) assimilation and consequently accumulate more intracellular S, which is incorporated into L-cysteine, γ-glutamylcysteine, and homocysteine. Most prominently, in the absence of Zn, free L-cysteine is increased ∼80-fold, corresponding to ∼2.8 × 109 molecules/cell. Interestingly, classic S-containing metal binding ligands like glutathione and phytochelatins do not increase. X-ray fluorescence microscopy showed foci of S accumulation in Zn-limited cells that co-localize with Cu, phosphorus and calcium, consistent with Cu-thiol complexes in the acidocalcisome, the site of Cu(I) accumulation. Notably, cells that have been previously starved for Cu do not accumulate S or Cys, causally connecting cysteine synthesis with Cu accumulation. We suggest that cysteine is an in vivo Cu(I) ligand, perhaps ancestral, that buffers cytosolic Cu.
MeSH term(s)	Cysteine/metabolism ; Chlamydomonas/metabolism ; Zinc/metabolism ; Copper/metabolism ; Homeostasis
Chemical Substances	Cysteine (K848JZ4886) ; Zinc (J41CSQ7QDS) ; Copper (789U1901C5)
Language	English
Publishing date	2023-07-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1093/mtomcs/mfad043
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Article: Completeness of cohort-linked U.S. Medicare data: An example from the Agricultural Health Study (1999-2016).

Parks, Christine G / Shrestha, Srishti / Long, Stuart / Flottemesch, Thomas / Woodruff, Sarah / Chen, Honglei / Andreotti, Gabriella / Hofmann, Jonathan N / Beane Freeman, Laura E / Sandler, Dale P

Preventive medicine reports

2022 Volume 27, Page(s) 101766

Abstract: ... services, provide a valuable resource for research on older adults (≥65 year) in linked U.S. cohorts. Here ...

Abstract	Medicare Fee for Service (FFS) claims data, including inpatient (Part A) and outpatient (Part B) services, provide a valuable resource for research on older adults (≥65 year) in linked U.S. cohorts. Here we describe our experience linking the Agricultural Health Study cohort, including 47,501 licensed pesticide applicators and spouses from North Carolina (NC) and Iowa (IA) to Medicare claims data from 1999 to 2016. Given increased Part C (i.e., managed care/Medicare Advantage) enrollment during this period, and a resulting lack of available Part C claims data prior to 2015, we also explored potential for informative missingness. We compared those with partial or limited/no FFS to those with complete FFS coverage (i.e., ≥11 months per year parts AB, but not C, throughout Medicare enrollment) in relation to baseline farm size, general pesticide use, and mortality, in logistic regression models adjusted for age, sex, race, education, and smoking, and stratified by state. While 46,689 participants (98%) were linked to Medicare IDs, only 33,487 (70%) had complete FFS, 9353 (20%) had partial FFS (≥1 year FFS but not complete), and 3849 (8%) had limited/no FFS (Part A or Part C-only). Incomplete FFS was more common in NC, mostly due to Part C, and was associated with farm characteristics, pesticide use, and mortality. These findings indicate that, in addition to reduced sample size in analyses limited to complete FFS, missingness may not be random. The potential impact of incomplete FFS data and changes in coverage type need to be considered when planning linked analyses and interpreting results.
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2022.101766
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Article ; Online: Forecasting individual progression trajectories in Alzheimer’s disease

Etienne Maheux / Igor Koval / Juliette Ortholand / Colin Birkenbihl / Damiano Archetti / Vincent Bouteloup / Stéphane Epelbaum / Carole Dufouil / Martin Hofmann-Apitius / Stanley Durrleman

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 15

Abstract: Accurate prediction of disease progression in Alzheimer’s disease (AD) is necessary for optimal ...

Abstract	Accurate prediction of disease progression in Alzheimer’s disease (AD) is necessary for optimal recruitment of patients to clinical trials. Here, the authors present AD Course Map, a statistical model which helps to predict disease progression in participants, thus decreasing the required sample size for a hypothetical trial.
Keywords	Science ; Q
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase.

Pristup, Julika / Schaeffeler, Elke / Arjune, Sita / Hofmann, Ute / Angel Santamaria-Araujo, Jose / Leuthold, Patrick / Friedrich, Nele / Nauck, Matthias / Mayr, Simon / Haag, Mathias / Muerdter, Thomas / Marner, Franz-Josef / Relling, Mary V / Evans, William E / Schwarz, Guenter / Schwab, Matthias

Clinical pharmacology and therapeutics

2022 Volume 112, Issue 4, Page(s) 808–816

Abstract: ... peptide mass fingerprinting. We show that the catabolic Moco S-methylating enzyme corresponds ... to thiopurine S-methyltransferase (TPMT), a highly polymorphic drug-metabolizing enzyme associated with drug ...

Abstract	Therapy of molybdenum cofactor (Moco) deficiency has received US Food and Drug Administration (FDA) approval in 2021. Whereas urothione, the urinary excreted catabolite of Moco, is used as diagnostic biomarker for Moco-deficiency, its catabolic pathway remains unknown. Here, we identified the urothione-synthesizing methyltransferase using mouse liver tissue by anion exchange/size exclusion chromatography and peptide mass fingerprinting. We show that the catabolic Moco S-methylating enzyme corresponds to thiopurine S-methyltransferase (TPMT), a highly polymorphic drug-metabolizing enzyme associated with drug-related hematotoxicity but unknown physiological role. Urothione synthesis was investigated in vitro using recombinantly expressed human TPMT protein, liver lysates from Tpmt wild-type and knock-out (Tpmt
MeSH term(s)	Animals ; Genotype ; Humans ; Methyltransferases/physiology ; Mice ; Mice, Knockout ; Molybdenum Cofactors
Chemical Substances	Molybdenum Cofactors ; Methyltransferases (EC 2.1.1.-) ; TPMT protein, human (EC 2.1.1.67) ; thiopurine methyltransferase (EC 2.1.1.67)
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2637
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Article: Apprendre en s’amusant à l’hôpital : réalité ou illusion ?

Merlin Hofmann, Christelle / Naro, Mickaël

Revue de l'infirmiere

2020 Volume 70, Issue 268, Page(s) 40–41

Abstract: Healthcare professionals have an obligation to maintain their knowledge at the highest level throughout their careers. To this end, the hospital team of a pharmacy for indoor use has developed an original and entertaining training course, mainly intended ...

Title translation	Learning through play in the hospital: reality or illusion?
Abstract	Healthcare professionals have an obligation to maintain their knowledge at the highest level throughout their careers. To this end, the hospital team of a pharmacy for indoor use has developed an original and entertaining training course, mainly intended for nurses, on the subject of analgesics.
MeSH term(s)	Humans ; Learning ; Nursing Evaluation Research ; Nursing Staff, Hospital/education ; Nursing Staff, Hospital/psychology ; Play and Playthings
Language	French
Publishing date	2020-12-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	632538-5
ISSN	1293-8505 ; 0397-7900
ISSN	1293-8505 ; 0397-7900
DOI	10.1016/j.revinf.2020.12.016
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Article ; Online: Completeness of cohort-linked U.S. Medicare data

Christine G. Parks / Srishti Shrestha / Stuart Long / Thomas Flottemesch / Sarah Woodruff / Honglei Chen / Gabriella Andreotti / Jonathan N. Hofmann / Laura E. Beane Freeman / Dale P. Sandler

Preventive Medicine Reports, Vol 27, Iss , Pp 101766- (2022)

An example from the Agricultural Health Study (1999–2016)

2022

Abstract: ... services, provide a valuable resource for research on older adults (≥65 year) in linked U.S. cohorts. Here ...

Abstract	Medicare Fee for Service (FFS) claims data, including inpatient (Part A) and outpatient (Part B) services, provide a valuable resource for research on older adults (≥65 year) in linked U.S. cohorts. Here we describe our experience linking the Agricultural Health Study cohort, including 47,501 licensed pesticide applicators and spouses from North Carolina (NC) and Iowa (IA) to Medicare claims data from 1999 to 2016. Given increased Part C (i.e., managed care/Medicare Advantage) enrollment during this period, and a resulting lack of available Part C claims data prior to 2015, we also explored potential for informative missingness. We compared those with partial or limited/no FFS to those with complete FFS coverage (i.e., ≥11 months per year parts AB, but not C, throughout Medicare enrollment) in relation to baseline farm size, general pesticide use, and mortality, in logistic regression models adjusted for age, sex, race, education, and smoking, and stratified by state. While 46,689 participants (98%) were linked to Medicare IDs, only 33,487 (70%) had complete FFS, 9353 (20%) had partial FFS (≥1 year FFS but not complete), and 3849 (8%) had limited/no FFS (Part A or Part C-only). Incomplete FFS was more common in NC, mostly due to Part C, and was associated with farm characteristics, pesticide use, and mortality. These findings indicate that, in addition to reduced sample size in analyses limited to complete FFS, missingness may not be random. The potential impact of incomplete FFS data and changes in coverage type need to be considered when planning linked analyses and interpreting results.
Keywords	Cohort study ; Medicare ; Linked data ; Farmers ; Rural ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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