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Article ; Online: E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.

Pruenster, Monika / Immler, Roland / Roth, Jonas / Kuchler, Tim / Bromberger, Thomas / Napoli, Matteo / Nussbaumer, Katrin / Rohwedder, Ina / Wackerbarth, Lou Martha / Piantoni, Chiara / Hennis, Konstantin / Fink, Diana / Kallabis, Sebastian / Schroll, Tobias / Masgrau-Alsina, Sergi / Budke, Agnes / Liu, Wang / Vestweber, Dietmar / Wahl-Schott, Christian /

Roth, Johannes / Meissner, Felix / Moser, Markus / Vogl, Thomas / Hornung, Veit / Broz, Petr / Sperandio, Markus

Nature immunology

2023 Volume 24, Issue 12, Page(s) 2021–2031

Abstract: ... of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation ... occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers ...

Abstract	S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation occurs in an NLRP3 inflammasome-dependent fashion. Mechanistically, E-selectin engagement triggers Bruton's tyrosine kinase-dependent tyrosine phosphorylation of NLRP3. Concomitant potassium efflux via the voltage-gated potassium channel K
MeSH term(s)	Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Gasdermins ; Neutrophils/metabolism ; E-Selectin/metabolism ; Calgranulin A/metabolism ; Calgranulin B/metabolism ; Inflammation/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Gasdermins ; E-Selectin ; Calgranulin A ; Calgranulin B
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01656-1
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Article ; Online: D-to-E and T19V Variants of the pH-Low Insertion Peptide and Their Doxorubicin Conjugates Interact with Membrane at Higher pH Ranges Than WT.

Wachira, Faith W / Githirwa, Dancan C / McPartlon, Thomas / Nazarenko, Vladyslav / Gonzales, Jerel J C / Gazura, Makenzie M / Leen, Caitlin / Clary, Hannah R / Alston, Claire / Klees, Lukas M / Yao, Lan / An, Ming

Biochemistry

2023 Volume 62, Issue 20, Page(s) 2997–3011

Abstract: To improve targeted cargo delivery to cancer cells, pH-Low Insertion Peptide (pHLIP) variants were developed to interact with the membrane at pH values higher than those of the WT. The Asp-to-Glu variants aim to increase side chain ... ...

Abstract	To improve targeted cargo delivery to cancer cells, pH-Low Insertion Peptide (pHLIP) variants were developed to interact with the membrane at pH values higher than those of the WT. The Asp-to-Glu variants aim to increase side chain p
MeSH term(s)	Hydrogen-Ion Concentration ; Doxorubicin/chemistry ; Antineoplastic Agents ; Peptides/chemistry
Chemical Substances	Doxorubicin (80168379AG) ; Antineoplastic Agents ; Peptides
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.3c00218
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Article ; Online: Efficacy of water application of a humic substance, butyric acid, vitamins C, D, and E and/or electrolytes on performance and mortality in health-challenged nursery pigs¹.

Edmonds, Michael S / Weber, Thomas E

Translational animal science

2023 Volume 7, Issue 1, Page(s) txad115

Abstract: Health challenges continue to be rampant in nursery pigs which has led to increased industry-wide mortality trends. Therefore, the objective of these three studies was to evaluate a water supplement ( ...

Abstract	Health challenges continue to be rampant in nursery pigs which has led to increased industry-wide mortality trends. Therefore, the objective of these three studies was to evaluate a water supplement (
Language	English
Publishing date	2023-10-02
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txad115
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Article ; Online: First measurement of the form factors in the decays D0 → ρ- e+ ν(e) and D+ → ρ0 e+ ν(e).

Dobbs, S / Metreveli, Z / Seth, K K / Tomaradze, A / Xiao, T / Martin, L / Powell, A / Wilkinson, G / Mendez, H / Asner, D M / Tatishvili, G / Ge, J Y / Huang, G S / Miller, D H / Pavlunin, V / Shipsey, I P J / Xin, B / Adams, G S / Hu, D /

Moziak, B / Napolitano, J / Ecklund, K M / Insler, J / Muramatsu, H / Park, C S / Pearson, L J / Thorndike, E H / Ricciardi, S / Thomas, C / Artuso, M / Blusk, S / Mountain, R / Skwarnicki, T / Stone, S / Zhang, L M / Bonvicini, G / Cinabro, D / Lincoln, A / Smith, M J / Zhou, P / Zhu, J / Naik, P / Rademacker, J / Edwards, K W / Randrianarivony, K / Briere, R A / Vogel, H / Onyisi, P U E / Rosner, J L / Alexander, J P / Cassel, D G / Das, S / Ehrlich, R / Gibbons, L / Gray, S W / Hartill, D L / Heltsley, B K / Kreinick, D L / Kuznetsov, V E / Patterson, J R / Peterson, D / Riley, D / Ryd, A / Sadoff, A J / Shi, X / Sun, W M / Yelton, J / Rubin, P / Lowrey, N / Mehrabyan, S / Selen, M / Wiss, J / Libby, J / Kornicer, M / Mitchell, R E / Tarbert, C M / Besson, D / Pedlar, T K / Cronin-Hennessy, D / Hietala, J

Physical review letters

2013 Volume 110, Issue 13, Page(s) 131802

Abstract: ... with the form factors for D → K* e+ ν(e) and B → V ℓ+ ℓ- and D → ρ e+ ν(e). Using the entire CLEO-c ψ(3770) → DD ... events, we measure the form factors for the decays D0 → ρ- e+ ν(e) and D+ → ρ0 e+ ν(e) for the first time ... of the branching fraction for D+ → ω e+ ν(e) with improved precision. ...

Abstract	The beauty to up quark coupling constant \|V(ub)\| can be extracted from B → ρ e+ ν(e) combined with the form factors for D → K* e+ ν(e) and B → V ℓ+ ℓ- and D → ρ e+ ν(e). Using the entire CLEO-c ψ(3770) → DD event sample, corresponding to an integrated luminosity of 818 pb(-1) and approximately 5.4×10(6) DD events, we measure the form factors for the decays D0 → ρ- e+ ν(e) and D+ → ρ0 e+ ν(e) for the first time and the branching fractions with improved precision. A four-dimensional unbinned maximum likelihood fit determines the form factor ratios to be V(0)/A1(0)=1.48±0.15±0.05 and A2(0)/A1(0)=0.83±0.11±0.04. Assuming Cabibbo-Kobayashi-Maskawa unitarity, the known D meson lifetimes, and our measured branching fractions we obtain the form factor normalizations A1(0), A2(0), and V(0). We also present a measurement of the branching fraction for D+ → ω e+ ν(e) with improved precision.
Language	English
Publishing date	2013-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.110.131802
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Article: Reply from e-d. Schulze.

Thomas, S / Moniz-Barreto, J P / Fell, D A / Woods, J H / Poolman, M G

Trends in ecology & evolution

2011 Volume 10, Issue 6, Page(s) 245

Language	English
Publishing date	2011-01-14
Publishing country	England
Document type	Letter
ZDB-ID	284965-3
ISSN	1872-8383 ; 0169-5347
ISSN (online)	1872-8383
ISSN	0169-5347
DOI	10.1016/0169-5347(95)91049-2
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Article: Synthesis of epi-Chloranthalactones A, B, D and E

Fenlon, Thomas W. / Jones, Michael W. / Adlington, Robert M. / Lee, Victor

Synlett

2018 Volume 29, Issue 08, Page(s) 1020–1023

Abstract: The synthesis of various epimers of the lindenane class of sesquiterpenes from epi -lindenene, based on a possible biosynthetic hypothesis, is described. ...

Abstract	The synthesis of various epimers of the lindenane class of sesquiterpenes from epi -lindenene, based on a possible biosynthetic hypothesis, is described.
Keywords	sesquiterpenes ; chloranthalactones ; Aldol reaction ; biosynthesis ; oxidation
Language	English
Publishing date	2018-02-06
Publisher	© Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/s-0036-1591901
Database	Thieme publisher's database

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Article ; Online: Randomised phase I/II study to evaluate c arbon i o n ra d ioth e rapy ve r sus fractionat e d stereotactic radiotherapy in patients with recurrent or progressive g l iom a s

Haselmann Renate / Haberer Thomas / Jäkel Oliver / Habermehl Daniel / Rieken Stefan / Edler Lutz / Burkholder Iris / Combs Stephanie E / Unterberg Andreas / Wick Wolfgang / Debus Jürgen

BMC Cancer, Vol 10, Iss 1, p

The CINDERELLA trial

2010 Volume 533

Abstract: Abstract Background Treatment of patients with recurrent glioma includes neurosurgical resection, chemotherapy, or radiation therapy. In most cases, a full course of radiotherapy has been applied after primary diagnosis, therefore application of re- ... ...

Abstract	Abstract Background Treatment of patients with recurrent glioma includes neurosurgical resection, chemotherapy, or radiation therapy. In most cases, a full course of radiotherapy has been applied after primary diagnosis, therefore application of re-irradiation has to be applied cauteously. With modern precision photon techniques such as fractionated stereotactic radiotherapy (FSRT), a second course of radiotherapy is safe and effective and leads to survival times of 22, 16 and 8 months for recurrent WHO grade II, III and IV gliomas. Carbon ions offer physical and biological characteristics. Due to their inverted dose profile and the high local dose deposition within the Bragg peak precise dose application and sparing of normal tissue is possible. Moreover, in comparison to photons, carbon ions offer an increased relative biological effectiveness (RBE), which can be calculated between 2 and 5 depending on the GBM cell line as well as the endpoint analyzed. Protons, however, offer an RBE which is comparable to photons. First Japanese Data on the evaluation of carbon ion radiation therapy for the treatment of primary high-grade gliomas showed promising results in a small and heterogeneous patient collective. Methods Design In the current Phase I/II-CINDERELLA-trial re-irradiation using carbon ions will be compared to FSRT applied to the area of contrast enhancement representing high-grade tumor areas in patients with recurrent gliomas. Within the Phase I Part of the trial, the Recommended Dose (RD) of carbon ion radiotherapy will be determined in a dose escalation scheme. In the subsequent randomized Phase II part, the RD will be evaluated in the experimental arm, compared to the standard arm, FSRT with a total dose of 36 Gy in single doses of 2 Gy. Primary endpoint of the Phase I part is toxicity. Primary endpoint of the randomized part II is survival after re-irradiation at 12 months, secondary endpoint is progression-free survival. Discussion The Cinderella trial is the first study to evaluate carbon ion radiotherapy for recurrent gliomas, and to compare this treatment to photon FSRT in a randomized setting using an ion beam delivered by intensity modulated rasterscanning. Trial Registration NCT01166308
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Obesity is a Pulmonary Function Confounder, Re: Mathias KC, Graham E, Stewart D, Smith DL. Decreased Pulmonary Function in US Firefighters. JOEM 2020;62(10):816-819.

Kurt, Thomas L

Journal of occupational and environmental medicine

2021 Volume 63, Issue 7, Page(s) e477

MeSH term(s)	Body Mass Index ; Firefighters ; Humans ; Lung/diagnostic imaging ; Obesity
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000002227
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Book ; Online: Redesign of the didactics of S(E)IR(D) -> SI(EY)A(CD) models of infectious epidemics

Thomas Colignatus

2020

Abstract: ... step is to relabel to SI(EY)A(CD). The acquitted A = C + D are the cleared or deceased. This avoids ... the triple use of R for removed, recovered and reproductive number. The infected I = E + Y are the exposed ... of ordinary differential equations (ODE) should not distract. The deceased are a fraction of the acquitted, D ...

Abstract	This notebook and package redesign the didactics of the classic SIR, SIRD and SEIRD models. A first step is to relabel to SI(EY)A(CD). The acquitted A = C + D are the cleared or deceased. This avoids the triple use of R for removed, recovered and reproductive number. The infected I = E + Y are the exposed and infectious. The basic structure is given by the Euler-Lotka renewal equation. The format of ordinary differential equations (ODE) should not distract. The deceased are a fraction of the acquitted, D = φ A, with φ the infection fatality factor (IFF). The ODE format D' = μ I or D' = μ Y can be rejected since it turns the model into a course in differential equations, with the need to prove D = φ A what can already be stated from the start. The ODE format also causes distracting questions what μ might be and whether there is a difference between a lethal acquittal period and a clearing acquittal period, and how parameters values must be adapted when the acquittal rate γ changes. The didactic redesign is discussed with the example of the SARS-CoV-2 pandemic. The common formula on herd immunity 1 - 1 / R0 assumes a steady state, but unless infections are zero then they actually proceed in a steady state, and thus not with the promised protection. SI(EY)A(CD) has only an asymptotic steady state so that this formula does not even apply. For SI(EY)A(CD) a notion of "near herd immunity" might be 95% of the limit values. For SARS-CoV-2, RIVM (the Dutch CDC) has mentioned R0 = 2.5 and herd immunity of 60%, presumably using another type of model. In SI(EY)A(CD) an infection with R0 = 2.5 proceeds after 60% till the limit value of 89.3%, which, with IFF = 1.5%, would mean another 78,000 deceased in Holland, compared to 9,000 at the end of May. For Public Health, it is important to balance medical and economic issues. A better understanding of the SI(EY)A(CD) family of models helps to gauge exit strategies for the pandemic and its economic crisis. A possible strategy is to eradicate the virus: with test, test, and test it would be possible to put positively tested persons in quarantine till they have cleared. Another possible strategy is that the vulnerable (elderly and comorbid younger) are put into quarantine while the less vulnerable are infected (in cohorts dictated by ICU capacity), effectively using the virus as its own vaccine, for a period of 12-16 months until there is a proper vaccine for the vulnerable compartment of society. It is remarkable that these scenario's are so little discussed in policy making circles, where there seems to be a preference for a lock-on-off approach, that is risky and prolongs the economic crisis. Epidemiology exists for longer than a century and there have been many warnings about the risk of pandemics. Lessons learnt at the level of cities and nations are now learnt at world level. There is something fundamentally wrong in the relation between society in general and science & learning. For the democratic setup of each nation it is advisable to have both an Economic Supreme Court and a National Assembly of Science and Learning. We want to save lives and livelihoods but let us not forget fundamental insights about democracy and science & learning. The PDF is available at 10.5281/zenodo.3894161
Keywords	92D30 (Epidemiology) ; 92C60 (Medical epidemiology) ; 91B64 (Macroeconomic theory) ; 91B76 (Environmental economics) ; 00-01 (Introductory exposition) ; SARS-CoV-2 ; Public Health ; covid19
Subject code	320
Language	English
Publishing date	2020-06-15
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Redesign of the didactics of S(E)IR(D) -> SI(EY)A(CD) models of infectious epidemics

Thomas Colignatus

2020

Abstract	This notebook and package redesign the didactics of the classic SIR, SIRD and SEIRD models. A first step is to relabel to SI(EY)A(CD). The acquitted A = C + D are the cleared or deceased. This avoids the triple use of R for removed, recovered and reproductive number. The infected I = E + Y are the exposed and infectious. The basic structure is given by the Euler-Lotka renewal equation. The format of ordinary differential equations (ODE) should not distract. The deceased are a fraction of the acquitted, D = φ A, with φ the infection fatality factor (IFF). The ODE format D' = μ I or D' = μ Y can be rejected since it turns the model into a course in differential equations, with the need to prove D = φ A what can already be stated from the start. The ODE format also causes distracting questions what μ might be and whether there is a difference between a lethal acquittal period and a clearing acquittal period, and how parameters values must be adapted when the acquittal rate γ changes. The didactic redesign is discussed with the example of the SARS-CoV-2 pandemic. The common formula on herd immunity 1 - 1 / R0 assumes a steady state, but unless infections are zero then they actually proceed in a steady state, and thus not with the promised protection. SI(EY)A(CD) has only an asymptotic steady state so that this formula does not even apply. For SI(EY)A(CD) a notion of "near herd immunity" might be 95% of the limit values. For SARS-CoV-2, RIVM (the Dutch CDC) has mentioned R0 = 2.5 and herd immunity of 60%, presumably using another type of model. In SI(EY)A(CD) an infection with R0 = 2.5 proceeds after 60% till the limit value of 89.3%, which, with IFF = 1.5%, would mean another 78,000 deceased in Holland, compared to 9,000 at the end of May. For Public Health, it is important to balance medical and economic issues. A better understanding of the SI(EY)A(CD) family of models helps to gauge exit strategies for the pandemic and its economic crisis. A possible strategy is to eradicate the virus: with test, test, and test it would be possible to put positively tested persons in quarantine till they have cleared. Another possible strategy is that the vulnerable (elderly and comorbid younger) are put into quarantine while the less vulnerable are infected (in cohorts dictated by ICU capacity), effectively using the virus as its own vaccine, for a period of 12-16 months until there is a proper vaccine for the vulnerable compartment of society. It is remarkable that these scenario's are so little discussed in policy making circles, where there seems to be a preference for a lock-on-off approach, that is risky and prolongs the economic crisis. Epidemiology exists for longer than a century and there have been many warnings about the risk of pandemics. Lessons learnt at the level of cities and nations are now learnt at world level. There is something fundamentally wrong in the relation between society in general and science & learning. For the democratic setup of each nation it is advisable to have both an Economic Supreme Court and a National Assembly of Science and Learning. We want to save lives and livelihoods but let us not forget fundamental insights about democracy and science & learning. The Mathematica notebook is available at 10.5281/zenodo.3894209
Keywords	92D30 (Epidemiology) ; 92C60 (Medical epidemiology) ; 91B64 (Macroeconomic theory) ; 91B76 (Environmental economics) ; 00-01 (Introductory exposition) ; SARS-CoV-2 ; Public Health ; covid19
Subject code	320
Language	English
Publishing date	2020-06-15
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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