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  1. Article ; Online: Corrigendum to "N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression"[Eur. J. Med. Chem. 2020 Jan 1;185:111725].

    Mehndiratta, Samir / Lin, Mei-Hsiang / Wu, Yi-Wen / Chen, Chun-Han / Wu, Tung-Yun / Chuang, Kuo-Hsiang / Chao, Min-Wu / Chen, Yi-Ying / Pan, Shiow-Lin / Chen, Mei-Chuan / Liou, Jing-Ping

    European journal of medicinal chemistry

    2020  Volume 199, Page(s) 112406

    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country France
    Document type Journal Article ; Published Erratum
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2020.112406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  2. Article ; Online: Re: Alison J. Price, Ruth C. Travis, Paul N. Appleby, et al. Circulating Folate and Vitamin B

    Chang, Xu / Chao, Zhang / Zheng-Yan, Gao

    European urology

    2017  Volume 71, Issue 1, Page(s) e25

    Language English
    Publishing date 2017-01
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 294: Show issues

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  3. Article: Corrigendum to "N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression"[Eur. J. Med. Chem. 2020 Jan 1;185:111725]

    Mehndiratta, Samir / Lin, Mei-Hsiang / Wu, Yi-Wen / Chen, Chun-Han / Wu, Tung-Yun / Chuang, Kuo-Hsiang / Chao, Min-Wu / Chen, Yi-Ying / Pan, Shiow-Lin / Chen, Mei-Chuan / Liou, Jing-Ping

    Eur J Med Chem

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32408215
    Database COVID19

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  4. Book ; Online: A reassessment of the cost-effectiveness of water and sanitation interventions in programmes for controlling childhood diarrhoea / R. C. G. Varley, J. Tarvid, and D. N. W. Chao ; Réévaluation de la rentabilité des interventions "eau/assainissement" dans les programmes de lutte contre les diarrhées de l' enfant

    Varley, R. C. G / Tarvid, J / Chao, D. N. W

    résumé

    1998  

    Abstract: In English with summary in ... ...

    Abstract In English with summary in French
    Keywords Diarrhea ; Sanitation ; Water supply ; Health education ; Rehydration solutions ; Cost-benefit analysis ; Cost of illness ; Models ; Economic ; Comparative study ; Diarrhoeal Diseases ; in infancy and childhood prevention and control ; economics ; therapeutic use
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: A reassessment of the cost-effectiveness of water and sanitation interventions in programmes for controlling childhood diarrhoea / R. C. G. Varley, J. Tarvid, and D. N. W. Chao ; Réévaluation de la rentabilité des interventions "eau/assainissement" dans les programmes de lutte contre les diarrhées de l' enfant

    Varley, R. C. G / Tarvid, J / Chao, D. N. W

    résumé

    1998  

    Abstract: In English with summary in ... ...

    Abstract In English with summary in French
    Keywords Diarrhea ; Sanitation ; Water supply ; Health education ; Rehydration solutions ; Cost-benefit analysis ; Cost of illness ; Models ; Economic ; Comparative study ; Diarrhoeal Diseases ; in infancy and childhood prevention and control ; economics ; therapeutic use
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Social integration and utilization of national basic public health services among China's internal migrants with chronic diseases: A structural equation modelling approach.

    Wang, Leixia / Chao, Jianqian / Wu, Yanqian / Zhang, Na / Bao, Min

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25797

    Abstract: Internal migrants with chronic diseases (IMCDs) are a specific subgroup of the internal migrants, but few studies have focused on health service utilization among this group. Social integration is an essential element in the maintenance of health and ... ...

    Abstract Internal migrants with chronic diseases (IMCDs) are a specific subgroup of the internal migrants, but few studies have focused on health service utilization among this group. Social integration is an essential element in the maintenance of health and well-being in migrants. However, the measurement of social integration remains inconsistent. This study aimed to measure social integration more comprehensively and evaluate the association between social integration and National Basic Public Health Services (NBPHS) utilization among IMCDs in China, thereby providing theoretical support for health promotion among IMCDs. The data of this study were obtained from the China Migrants Dynamic Survey (CMDS) in 2017. A total of 9272 internal migrants who self-reported hypertension and/or type 2 diabetes were included in the analysis. Four factors were extracted through exploratory factor analysis to measure the social integration of IMCDs: psychological identity, community involvement, social security, and sociocultural adaptation. The results show the IMCDs underutilized NBPHS, with 26.80 % stating that they have not used any of the services in the NBPHS. We confirmed the positive association between social integration and NBPHS use among IMCDs. The social integration of IMCDs in developed regions was relatively worse than in developing regions, further exacerbating the underutilization of NBPHS in developed regions. Therefore, targeted government measures and supportive policies are necessary, especially in developed regions, to encourage IMCDs to participate in social organizations and community activities and stimulate their active participation in the NBPHS.
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predictive value of machine learning on fracture risk in osteoporosis: a systematic review and meta-analysis.

    Wu, Yanqian / Chao, Jianqian / Bao, Min / Zhang, Na

    BMJ open

    2023  Volume 13, Issue 12, Page(s) e071430

    Abstract: Objectives: Early identification of fracture risk in patients with osteoporosis is essential. Machine learning (ML) has emerged as a promising technique to predict the risk, whereas its predictive performance remains controversial. Therefore, we ... ...

    Abstract Objectives: Early identification of fracture risk in patients with osteoporosis is essential. Machine learning (ML) has emerged as a promising technique to predict the risk, whereas its predictive performance remains controversial. Therefore, we conducted this systematic review and meta-analysis to explore the predictive efficiency of ML for the risk of fracture in patients with osteoporosis.
    Methods: Relevant studies were retrieved from four databases (PubMed, Embase, Cochrane Library and Web of Science) until 31 May 2023. A meta-analysis of the C-index was performed using a random-effects model, while a bivariate mixed-effects model was used for the meta-analysis of sensitivity and specificity. In addition, subgroup analysis was performed according to the types of ML models and fracture sites.
    Results: Fifty-three studies were included in our meta-analysis, involving 15 209 268 patients, 86 prediction models specifically developed for the osteoporosis population and 41 validation sets. The most commonly used predictors in these models encompassed age, BMI, past fracture history, bone mineral density T-score, history of falls, BMD, radiomics data, weight, height, gender and other chronic diseases. Overall, the pooled C-index of ML was 0.75 (95% CI: 0.72, 0.78) and 0.75 (95% CI: 0.71, 0.78) in the training set and validation set, respectively; the pooled sensitivity was 0.79 (95% CI: 0.72, 0.84) and 0.76 (95% CI: 0.80, 0.81) in the training set and validation set, respectively; and the pooled specificity was 0.81 (95% CI: 0.75, 0.86) and 0.83 (95% CI: 0.72, 0.90) in the training set and validation set, respectively.
    Conclusions: ML has a favourable predictive performance for fracture risk in patients with osteoporosis. However, most current studies lack external validation. Thus, external validation is required to verify the reliability of ML models.
    Prospero registration number: CRD42022346896.
    MeSH term(s) Humans ; Bone Density ; Reproducibility of Results ; Osteoporosis/complications ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporotic Fractures/etiology ; Risk Assessment/methods
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-071430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neighborhood-level disadvantages increase risk for invasive pneumococcal disease.

    Minassian, Daniel / Shan, Liang / Dong, Chaoling / Charania, Arzoo N / Orihuela, Carlos J / He, Chao

    The American journal of the medical sciences

    2024  Volume 367, Issue 5, Page(s) 304–309

    Abstract: Background: Streptococcus pneumoniae (Spn) infection remains common worldwide despite recent vaccine efforts. Invasive pneumococcal disease (IPD) is the most severe form of Spn infection. Known individual risk factors for IPD include male gender and ... ...

    Abstract Background: Streptococcus pneumoniae (Spn) infection remains common worldwide despite recent vaccine efforts. Invasive pneumococcal disease (IPD) is the most severe form of Spn infection. Known individual risk factors for IPD include male gender and African American race. However, area-level socioeconomic factors have not been assessed. We examined the association of neighborhood-level disadvantages and risk of IPD in a tertiary medical center located in a socioeconomic diverse urban area in the Southeastern United States.
    Methods: Patients hospitalized with culture-confirmed Streptococcus pneumoniae (Spn) infection from 01/01/2010 - 12/31/2019 were identified from electronic health record (EHR). The cohort's demographic and clinical information were obtained from EHR. Patients' residential address was geocoded and matched to 2015 area deprivation index (ADI). The association of ADI and IPD was evaluated using logistic regression after controlling for the demographic information (age, sex, race) and clinical factors (BMI, smoking status, alcoholism, immunosuppressive status, vaccination status, comorbidities).
    Results: A total of 268 patients were hospitalized with culture-positive Streptococcus pneumoniae infection and 92 (34.3%) of them had IPD. The analysis showed that higher neighborhood deprivation (ADI in 79-100) was associated with increased risk of developing IPD in younger patients with age less than 65 (p = 0.007) after controlling for the individual demographic information and clinical factors.
    Conclusions: ADI is a risk factor for IPD in younger adults. Community-level socioeconomic risk factors should be considered when developing prevention strategies such as increasing vaccine uptake in high risk population to reduce the disease burden of IPD.
    MeSH term(s) Adult ; Humans ; Male ; Infant ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Infections/etiology ; Streptococcus pneumoniae ; Risk Factors ; Comorbidity ; Vaccines ; Pneumococcal Vaccines ; Incidence
    Chemical Substances Vaccines ; Pneumococcal Vaccines
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition.

    Hayden, Ashley N / Brandel, Katie L / Merlau, Paul R / Vijayakumar, Priyadharshini / Leptich, Emily J / Pietryk, Edward W / Gaytan, Elizabeth S / Ni, Connie W / Chao, Hsiao-Tuan / Rosenfeld, Jill A / Arey, Rachel N

    bioRxiv : the preprint server for biology

    2024  

    Abstract: RNA-binding proteins (RBPs) are key regulators of translation and plasticity in the nervous system, which are processes required for learning and memory. Indeed, RBP dysfunction has been linked to a wide range of neurological disorders where cognitive ... ...

    Abstract RNA-binding proteins (RBPs) are key regulators of translation and plasticity in the nervous system, which are processes required for learning and memory. Indeed, RBP dysfunction has been linked to a wide range of neurological disorders where cognitive impairments are a key symptom. However, the human genome encodes nearly 2,000 RBPs, many of which have yet to be characterized with regards to neurological phenotypes like associative behaviors. To address this, we used the model organism
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.05.574402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sleep deprivation affects interference control: A diffusion model analysis.

    Luo, Jiaorong / Hao, Chao / Ma, Ning / Wang, Ling

    Journal of experimental psychology. Human perception and performance

    2024  Volume 50, Issue 2, Page(s) 193–215

    Abstract: Previous studies suggest that interference control may be unaffected by sleep deprivation based on the unchanged interference effects (reaction time [RT] differences between incongruent and congruent conditions), while ignoring the overall slower RTs ... ...

    Abstract Previous studies suggest that interference control may be unaffected by sleep deprivation based on the unchanged interference effects (reaction time [RT] differences between incongruent and congruent conditions), while ignoring the overall slower RTs after sleep deprivation. In the present study, we interpreted these results from a new angle using a variant of diffusion model, diffusion model for conflict tasks (DMC), and investigated whether and how interference control is affected by sleep deprivation. Mathematical derivations and model simulations showed that unchanged task-irrelevant information processing (i.e., unaffected interference control) may not lead to the observed unchanged interference effects when considering the overall slower RTs after sleep deprivation (due to either decreased drift rate of task-relevant information or increased decision boundary). Therefore, the unchanged interference effects do not necessarily indicate unchanged interference control. We then conducted a Simon task following one night of sleep deprivation or normal sleep, and fitted the DMC to the data. Experimental results showed that the Simon effect was reversed when most of the trials were incongruent, indicating that participants used learned spatially incompatible stimulus-response associations to predict responses. However, the Simon effects in both mean RTs and RT distributions were not significantly modulated by sleep deprivation. Model fits showed that the drift rate of task-relevant information decreased and the time-to-peak of task-irrelevant activation increased after sleep deprivation. These results suggest that central information processing was degraded after sleep loss, and most importantly, task-irrelevant activation increased after sleep deprivation as interference control was impaired. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    MeSH term(s) Humans ; Sleep Deprivation ; Cognition ; Learning
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189734-2
    ISSN 1939-1277 ; 0096-1523
    ISSN (online) 1939-1277
    ISSN 0096-1523
    DOI 10.1037/xhp0001180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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