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  1. Article ; Online: With commentary.

    Chessells, J M

    Archives of disease in childhood

    2010  Volume 58, Issue 2, Page(s) 131–132

    Language English
    Publishing date 2010-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.58.2.131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of bone marrow transplantation in first remission of paediatric all.

    Chessells, J M

    Frontiers in bioscience : a journal and virtual library

    2001  Volume 6, Page(s) G38–42

    Abstract: Although intensive chemotherapy has improved event-free survival for most children with lymphoblastic leukaemia there remain up to 10% who have not benefited from this approach. These include infants, children with Ph1 positive leukaemia, with near- ... ...

    Abstract Although intensive chemotherapy has improved event-free survival for most children with lymphoblastic leukaemia there remain up to 10% who have not benefited from this approach. These include infants, children with Ph1 positive leukaemia, with near-haploidy, and slow remitters in most of whom event free survival remains below 40%. Evaluation of the benefits of Bone Marrow Transplantation in high risk ALL is fraught with difficulties and to date has not produced clear evidence of benefit. The way forward lies in prospective evaluation of BMT in tightly defined subsets of highest risk children, a task which will require international collaboration.
    MeSH term(s) Bone Marrow Transplantation ; Child ; Child, Preschool ; Clinical Trials as Topic ; Humans ; Infant ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Prognosis ; Remission Induction ; Risk Factors
    Language English
    Publishing date 2001-08-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2141320-4
    ISSN 1093-9946
    ISSN 1093-9946
    DOI 10.2741/a717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recent advances in management of acute leukaemia.

    Chessells, J M

    Archives of disease in childhood

    2000  Volume 82, Issue 6, Page(s) 438–442

    Abstract: There have been significant improvements in the outlook for children with acute leukaemia but these advances are only available to a minority of the world's children. There is still room for improvements in conventional chemotherapy and these need ... ...

    Abstract There have been significant improvements in the outlook for children with acute leukaemia but these advances are only available to a minority of the world's children. There is still room for improvements in conventional chemotherapy and these need evaluation in randomised trials. The role of bone marrow transplants in first remission is evolving as chemotherapy becomes more effective. New treatments are needed for relapsed patients. Molecular diagnosis has refined the assessment of prognosis but the extra value afforded by measurement of minimal residual disease is not clear. International collaboration is needed to evaluate treatment for rare subtypes of leukaemia.
    MeSH term(s) Acute Disease ; Antineoplastic Agents/therapeutic use ; Bone Marrow Transplantation/methods ; Child ; Child, Preschool ; Humans ; Leukemia/diagnosis ; Leukemia/therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Recurrence ; Remission Induction ; Risk Assessment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2000-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.82.6.438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The management of high-risk lymphoblastic leukaemia in children.

    Chessells, J M

    British journal of haematology

    1999  Volume 108, Issue 2, Page(s) 204–216

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow Transplantation/methods ; Child ; Clinical Trials as Topic ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 1999-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1046/j.1365-2141.2000.01849.x
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  5. Article: Pitfalls in the diagnosis of childhood leukaemia.

    Chessells, J M

    British journal of haematology

    1999  Volume 114, Issue 3, Page(s) 506–511

    MeSH term(s) Acute Disease ; Anemia, Aplastic/diagnosis ; B-Lymphocytes/immunology ; Bone Marrow Examination ; Child ; Child, Preschool ; Cytogenetics ; Diagnosis, Differential ; Humans ; Immunophenotyping ; Infant ; Leukemia/cerebrospinal fluid ; Leukemia/classification ; Leukemia/diagnosis ; Leukocyte Count ; Myelodysplastic Syndromes/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Recurrence ; T-Lymphocytes/immunology
    Language English
    Publishing date 1999-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1046/j.1365-2141.2001.02994.x
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  6. Article: Relapsed lymphoblastic leukaemia in children: a continuing challenge.

    Chessells, J M

    British journal of haematology

    1998  Volume 102, Issue 2, Page(s) 423–438

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Central Nervous System Neoplasms/therapy ; Child ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Radiotherapy, High-Energy ; Recurrence ; Survival Analysis ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 1998-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1046/j.1365-2141.1998.00776.x
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  7. Article ; Online: Maintenance treatment and shared care in lymphoblastic leukaemia.

    Chessells, J M

    Archives of disease in childhood

    1995  Volume 73, Issue 4, Page(s) 368–373

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow Examination ; Chickenpox/prevention & control ; Child ; Female ; Follow-Up Studies ; Humans ; Immunization ; Male ; Measles/prevention & control ; Neutropenia/prevention & control ; Patient Care Planning ; Pneumonia/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Recurrence ; Spinal Puncture
    Language English
    Publishing date 1995-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.73.4.368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Risk analysis in acute lymphoblastic leukaemia: problems and pitfalls.

    Chessells, J M

    European journal of cancer (Oxford, England : 1990)

    1995  Volume 31A, Issue 10, Page(s) 1656–1659

    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/classification ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Prognosis ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 1995-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0959-8049 ; 0277-5379 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0959-8049 ; 0277-5379 ; 0964-1947
    DOI 10.1016/0959-8049(95)00343-h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Central nervous system directed therapy in acute lymphoblastic leukaemia.

    Chessells, J M

    Bailliere's clinical haematology

    1994  Volume 7, Issue 2, Page(s) 349–363

    Abstract: CNS-directed treatment is an essential component of therapy for both children and adults with acute lymphoblastic leukaemia. The choice between combinations of i.t. drugs, radiotherapy and high-dose systemic chemotherapy is not a clear one and will ... ...

    Abstract CNS-directed treatment is an essential component of therapy for both children and adults with acute lymphoblastic leukaemia. The choice between combinations of i.t. drugs, radiotherapy and high-dose systemic chemotherapy is not a clear one and will depend on the age of the patient, the type of leukaemia and indeed the available treatment facilities. A plea is made for any prospective trials of CNS-directed therapy to incorporate formal assessment of neuropsychological performance, and in the young child, of growth and pubertal progression.
    MeSH term(s) Adrenal Cortex Hormones/pharmacokinetics ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Child ; Clinical Trials as Topic ; Combined Modality Therapy/adverse effects ; Cranial Irradiation/adverse effects ; Cytarabine/administration & dosage ; Cytarabine/therapeutic use ; Female ; Growth Disorders/etiology ; Humans ; Injections, Spinal ; Leukemic Infiltration/diagnosis ; Leukemic Infiltration/physiopathology ; Leukemic Infiltration/prevention & control ; Leukemic Infiltration/therapy ; Male ; Meninges/pathology ; Mental Disorders/etiology ; Methotrexate/administration & dosage ; Methotrexate/adverse effects ; Methotrexate/therapeutic use ; Neoplasms, Radiation-Induced ; Neoplasms, Second Primary ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Prospective Studies ; Quality of Life ; Radiation Injuries/etiology ; Risk Factors ; Survival Rate ; Survivors ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones ; Cytarabine (04079A1RDZ) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 1994-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 93114-7
    ISSN 1879-2804 ; 0950-3536
    ISSN (online) 1879-2804
    ISSN 0950-3536
    DOI 10.1016/s0950-3536(05)80207-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Leukaemia in the young child.

    Chessells, J M

    The British journal of cancer. Supplement

    1992  Volume 18, Page(s) S54–7

    Abstract: Leukaemia is rare in infancy with an equal predominance of lymphoblastic and myeloblastic cases. Acute lymphoblastic leukaemia in infants under one year is characterised by a high leucocyte count, organomegaly, early B-cell phenotype, sometimes with ... ...

    Abstract Leukaemia is rare in infancy with an equal predominance of lymphoblastic and myeloblastic cases. Acute lymphoblastic leukaemia in infants under one year is characterised by a high leucocyte count, organomegaly, early B-cell phenotype, sometimes with evidence of monocytoid differentiation and cytogenetic abnormalities. This is reflected in its poor prognosis. The toddler (aged 1-2) tends to develop typical childhood ALL which is responsive to treatment, but remains vulnerable to late effects of therapy, particularly radiation. The distribution of subtypes of AML differs in the younger and older child and results of treatment have improved in all age groups. A uniform strategy appears desirable for all cases of childhood AML. It seems probable that different genetic and environmental factors may be involved in the genesis of infant ALL, childhood ALL and AML in children. The management of leukaemia in children under two poses a considerable challenge.
    MeSH term(s) Acute Disease ; Antineoplastic Agents/therapeutic use ; Bone Marrow Transplantation ; Child ; Child, Preschool ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Leukemia, Myeloid/drug therapy ; Leukemia, Myeloid/surgery ; Leukemia, Myeloid/therapy ; Leukocyte Count ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Retrospective Studies
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 1992-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0306-9443
    ISSN 0306-9443
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