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  1. Article ; Online: Donor specific antibodies (DSA): the only risk factor for primary graft failure?

    Bacigalupo, Andrea

    Bone marrow transplantation

    2024  Volume 59, Issue 3, Page(s) 299–300

    MeSH term(s) Humans ; Antibodies ; Risk Factors ; Graft Rejection ; HLA Antigens ; Graft Survival ; Isoantibodies ; Tissue Donors
    Chemical Substances Antibodies ; HLA Antigens ; Isoantibodies
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-02163-5
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    Zs.A 2168: Show issues Location:
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  2. Article ; Online: Clinical Workflow Efficiencies to Alleviate Physician Burnout and Reduce Work After Clinic.

    Bacigalupo, Angela

    Family practice management

    2023  Volume 30, Issue 3, Page(s) 21–25

    MeSH term(s) Humans ; Workflow ; Burnout, Professional/prevention & control ; Burnout, Psychological ; Ambulatory Care Facilities
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226804-5
    ISSN 1531-1929 ; 1069-5648
    ISSN (online) 1531-1929
    ISSN 1069-5648
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  3. Article ; Online: Long-term survivors in severe aplastic anemia: standard mortality rates now comparable to controls?

    Bacigalupo, Andrea

    Haematologica

    2023  Volume 108, Issue 12, Page(s) 3199–3200

    MeSH term(s) Humans ; Anemia, Aplastic/therapy ; Bone Marrow Transplantation ; Immunosuppressive Agents ; Survivors
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-12-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283523
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  4. Article ; Online: Post-transplant cyclophosphamide: overcoming the HLA barrier to hematopoietic stem cell transplants.

    Bacigalupo, Andrea

    Haematologica

    2022  Volume 107, Issue 6, Page(s) 1230–1231

    MeSH term(s) Cyclophosphamide/therapeutic use ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation ; Humans
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-06-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281256
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  5. Article ; Online: HLA still matters in allogeneic transplants.

    Bacigalupo, Andrea

    Blood

    2021  Volume 138, Issue 3, Page(s) 209–211

    MeSH term(s) Allografts ; Bone Marrow Transplantation ; Humans ; Tissue Donors
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011975
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  6. Article ; Online: 2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.

    Ali, Haris / Bacigalupo, Andrea

    American journal of hematology

    2024  Volume 99, Issue 5, Page(s) 938–945

    Abstract: Background: Allogeneic hemopoietic stem cell transplantation (HSCT) currently remains the only curative treatment for patients with myelofibrosis (MF). Transplant related mortality (TRM) and relapse, remain two significant complications which need to be ...

    Abstract Background: Allogeneic hemopoietic stem cell transplantation (HSCT) currently remains the only curative treatment for patients with myelofibrosis (MF). Transplant related mortality (TRM) and relapse, remain two significant complications which need to be addressed.
    Aims: The aim of this manuscript is to review current available reports on changes which have recently occurred, to improve the outcome of MF patients undergoing an allogeneic HSCT.
    Methods: Published papers were used to analyze different aspects of allogeneic HSCT.
    Results: Changes and updates are provided on selection of patients, prognostic systems, managing splenomegaly, conditioning regimens, predicting transplant outcome, stem cell sources, stem cell donors, graft versus host disease (GvHD) prophylaxis, patients with blast phase, hematopoietic reconstitution, disease markers, donor chimerism, and treatment of relapse.
    Conclusions: The review outlines new transplant platforms which are now available for patients with myelofibrosis, together with persisting problems, among which, older age combined with marrow fibrosis and an inflammatory disease. Relapse also requires aggressive monitoring of drivers mutations, and early cellular therapy.
    MeSH term(s) Humans ; Primary Myelofibrosis ; Transplantation, Homologous/adverse effects ; Graft vs Host Disease/etiology ; Treatment Outcome ; Neoplasm Recurrence, Local/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Chronic Disease ; Recurrence ; Risk Assessment ; Transplantation Conditioning/adverse effects
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27274
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  7. Article ; Online: PTCy: The "new" standard for GVHD prophylaxis.

    Bacigalupo, Andrea / Jones, Richard

    Blood reviews

    2023  Volume 62, Page(s) 101096

    Abstract: High dose Post transplant cyclophosphamide (PTCy) is now regarded as a very effective way of preventing acute and chronic GvHD, and it's use has rapidly expanded world-wide. ...

    Abstract High dose Post transplant cyclophosphamide (PTCy) is now regarded as a very effective way of preventing acute and chronic GvHD, and it's use has rapidly expanded world-wide.
    MeSH term(s) Humans ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Cyclophosphamide/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101096
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  8. Article ; Online: Antithymocyte globulin and cyclosporin: standard of care also for older patients with aplastic anemia.

    Bacigalupo, Andrea

    Haematologica

    2019  Volume 104, Issue 2, Page(s) 215–216

    MeSH term(s) Aged ; Anemia, Aplastic ; Antilymphocyte Serum ; Cyclosporine ; Humans ; Immunosuppressive Agents ; Standard of Care ; Surveys and Questionnaires
    Chemical Substances Antilymphocyte Serum ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2019-01-31
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.207167
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  9. Article ; Online: Alternative donor transplants for severe aplastic anemia.

    Bacigalupo, Andrea

    Hematology. American Society of Hematology. Education Program

    2018  Volume 2018, Issue 1, Page(s) 467–473

    Abstract: Allogeneic hematopoietic stem-cell transplantation remains the only curative treatment for patients with acquired severe aplastic anemia (SAA). When a matched sibling is not available, one can search for a matched unrelated donor or a cord blood unit (CB) ...

    Abstract Allogeneic hematopoietic stem-cell transplantation remains the only curative treatment for patients with acquired severe aplastic anemia (SAA). When a matched sibling is not available, one can search for a matched unrelated donor or a cord blood unit (CB) in the international registries or, more recently, for an HLA haploidentical (HAPLO) family member. International guidelines call for a course of antithymocyte globulin (ATG) and cyclosporine before a patient with SAA receives a transplant from a donor other than an HLA identical sibling, but whether this is necessary for patients age <20 years is less clear. Here I will examine the rapid increase in HAPLO transplantations for SAA, showing encouraging early results both in children and young adults. Graft-versus-host disease prophylaxis remains of primary importance in patients with SAA, and in vivo T-cell depletion with either ATG or alemtuzumab offers a significant survival advantage. Finally, I will discuss the strong age effect, which is particularly evident at >40 and 50 years of age for reasons not entirely clear and which should be taken into account when designing a treatment strategy for a given patient.
    MeSH term(s) Allografts ; Anemia, Aplastic/blood ; Anemia, Aplastic/pathology ; Anemia, Aplastic/therapy ; Antilymphocyte Serum/therapeutic use ; Cyclosporine/therapeutic use ; Graft vs Host Disease/blood ; Graft vs Host Disease/pathology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation ; Humans ; Severity of Illness Index ; Unrelated Donors
    Chemical Substances Antilymphocyte Serum ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2018-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/asheducation-2018.1.467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The next horizon now that everyone has a donor: Precision allogeneic transplantation.

    Jones, Richard J / Bacigalupo, Andrea

    Blood reviews

    2022  Volume 62, Page(s) 100990

    Abstract: Post-transplant cyclophosphamide (PTCy) allows safe and effective partially matched donor allogeneic blood or marrow transplantation (alloBMT), so that almost everyone in need of the procedure now has a donor. Moreover, PTCy and other recent advances ... ...

    Abstract Post-transplant cyclophosphamide (PTCy) allows safe and effective partially matched donor allogeneic blood or marrow transplantation (alloBMT), so that almost everyone in need of the procedure now has a donor. Moreover, PTCy and other recent advances have lowered alloBMT mortality rates to less than half of that seen before the turn of the century, at costs that are substantially less than most newly approved anticancer agents. These advances also make tailoring BMT based on patients' unique diseases and characteristics now feasible for further improving outcomes. Personalizing every aspect of alloBMT, including conditioning, donor, graft type, and post-transplant maintenance is now possible. For example, alloBMT's antitumor activity historically was restricted to the allogeneic graft-versus-tumor effect directed against histocompatibility antigens. However, replacing exhausted immune systems with healthy non-exhausted, non-tolerant ones likely can enhance the activity of novel targeted therapies. The impressive results seen with tyrosine kinase inhibitors after alloBMT for patients with both Ph+ acute lymphoblastic leukemia and FLT/ITD+ acute myeloid leukemia herald the potential of precision BMT.
    MeSH term(s) Humans ; Bone Marrow Transplantation/methods ; Transplantation, Homologous ; Cyclophosphamide ; Antineoplastic Agents ; Tissue Donors ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Acute Disease ; Lymphoma, B-Cell ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Transplantation Conditioning/methods ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Antineoplastic Agents
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2022.100990
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