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  1. Article: The dark side of nursing: what happened to the man in bed 14?

    Shivnan, J

    Nursing mirror

    1979  Volume 148, Issue 14, Page(s) 14–15

    MeSH term(s) Attitude to Death ; Humans ; Male ; Nursing Care ; Stress, Psychological ; Terminal Care
    Language English
    Publishing date 1979-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 603412-3
    ISSN 0029-6511
    ISSN 0029-6511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bone marrow transplantation: issues for critical care nurses.

    Shivnan, J / Shelton, B K / Onners, B K

    AACN clinical issues

    1996  Volume 7, Issue 1, Page(s) 95–108; quiz 179–80

    Abstract: Bone marrow transplantation (BMT) is becoming a wide used therapeutic modality in the field of cancer care. Offering long-term disease-free survival in more than half of some patients with previously fatal diseases, this therapy has challenged clinicians ...

    Abstract Bone marrow transplantation (BMT) is becoming a wide used therapeutic modality in the field of cancer care. Offering long-term disease-free survival in more than half of some patients with previously fatal diseases, this therapy has challenged clinicians to reevaluate critical care management strategies for such patients. Critical illness occurs in approximately one third of allogeneic transplants, necessitating that critical care nurses be familiar with this therapy and its reported complications. Critical care nurses are an integral part of producing the reported cure and remission rates, despite significant complications. In this article, the authors outline the common critical care problems of this patient population. The chronologic format enables the practitioner to correlate and differentiate key characteristics of potential complications. A case study, with clinical symptoms representing several potential etiologies, demonstrates the application of these concepts. Through the use of nursing knowledge of the unique needs of these patients, there is the potential to continue to improve patient outcomes.
    MeSH term(s) Adult ; Bone Marrow Transplantation/adverse effects ; Bone Marrow Transplantation/nursing ; Critical Care/methods ; Female ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Oncology Nursing/methods
    Language English
    Publishing date 1996-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1315695-0
    ISSN 1079-0713
    ISSN 1079-0713
    DOI 10.1097/00044067-199602000-00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: WITHDRAWN: Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting.

    Ezzo, Jeanette / Richardson, Mary Ann / Vickers, Andrew / Allen, Claire / Dibble, Suzanne / Issell, Brian F / Lao, Lixing / Pearl, Michael / Ramirez, Gilbert / Roscoe, Joseph A / Shen, Joannie / Shivnan, Jane C / Streitberger, Konrad / Treish, Imad / Zhang, Grant / Manheimer, Eric

    The Cochrane database of systematic reviews

    2014  , Issue 11, Page(s) CD002285

    MeSH term(s) Acupuncture Points ; Antiemetics/therapeutic use ; Antineoplastic Agents/adverse effects ; Electroacupuncture ; Humans ; Nausea/chemically induced ; Nausea/therapy ; Randomized Controlled Trials as Topic ; Vomiting/chemically induced ; Vomiting/therapy
    Chemical Substances Antiemetics ; Antineoplastic Agents
    Language English
    Publishing date 2014-11-21
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD002285.pub3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bone marrow transplantation: overview and nursing implications.

    Freedman, S / Shivnan, J / Tilles, J / Klemm, P

    Critical care nursing quarterly

    1990  Volume 13, Issue 2, Page(s) 51–62

    MeSH term(s) Bone Marrow Transplantation/adverse effects ; Bone Marrow Transplantation/methods ; Bone Marrow Transplantation/nursing ; Humans ; Patient Care Planning
    Language English
    Publishing date 1990-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639095-x
    ISSN 0887-9303
    ISSN 0887-9303
    DOI 10.1097/00002727-199009000-00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Laser Doppler imaging determines need for excision and grafting in advance of clinical judgment: a prospective blinded trial.

    Jeng, J C / Bridgeman, A / Shivnan, L / Thornton, P M / Alam, H / Clarke, T J / Jablonski, K A / Jordan, M H

    Burns : journal of the International Society for Burn Injuries

    2003  Volume 29, Issue 7, Page(s) 665–670

    Abstract: Introduction: Clinicians' judgment as to which burns require excision and grafting remains one aspect of burn care without objective measurements. This study presents a prospective, blinded trial to assess decision to operate by laser Doppler imaging ( ... ...

    Abstract Introduction: Clinicians' judgment as to which burns require excision and grafting remains one aspect of burn care without objective measurements. This study presents a prospective, blinded trial to assess decision to operate by laser Doppler imaging (numerical criteria) versus the clinical judgment of an experienced burn surgeon.
    Methods: A number of 23 patients were enrolled in this prospective trial and 41 representative wounds of indeterminate depth were selected for observation. Daily determination of need to operate (burn depth) was made by a single burn surgeon. Laser Doppler imager (LDI) scans of the same wounds were simultaneously obtained, and not revealed to the clinician. Data analysis compared quickness of decision to operate by LDI to the clinician's judgment. Concurrence of decisions by either method was compared.
    Results: A total of 23 patients and 41 wounds were analyzed. LDI and the surgeon agreed in determination of wound depth 56% of the time (23/41, P=0.031). Biopsy confirmation was obtained for 21 wounds. The surgeon's determination of burn depth was accurate in 71.4% of wounds biopsied (15/21). When the LDI scan median flux indicated need for excision, it was 100% accurate (7/7). When both the surgeon and the LDI were correct in assessing wound depth, LDI would have saved median number of 2 days (minimum=0, maximum=4).
    Conclusion: LDI allowed for earlier, objective determination of need to operate. Concurrence with clinical judgment in this blinded study was excellent. LDI should be seen as an effective aid to clinical judgment when contemplating excision of burns with indeterminate depth.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Burns/pathology ; Burns/surgery ; Decision Making ; Humans ; Image Processing, Computer-Assisted ; Laser-Doppler Flowmetry/methods ; Middle Aged ; Prospective Studies ; Single-Blind Method ; Skin Transplantation
    Language English
    Publishing date 2003-11
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/s0305-4179(03)00078-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Challenges to behavioral research in oncology.

    Mock, V / Hill, M N / Dienemann, J A / Grimm, P M / Shivnan, J C

    Cancer practice

    1996  Volume 4, Issue 5, Page(s) 267–273

    Abstract: Purpose: The difficulties encountered by investigators in conducting behavioral research with oncology patients have received little attention in the literature. This article provides a practical guide to problems that might be anticipated in the ... ...

    Abstract Purpose: The difficulties encountered by investigators in conducting behavioral research with oncology patients have received little attention in the literature. This article provides a practical guide to problems that might be anticipated in the planning and conduct of behavioral research.
    Overview: Problems include subject accrual and retention, development of a multidisciplinary research team, control of confounding variables, psychosocial instrumentation issues, and acceptance of the need for behavioral research. Methodological and feasibility issues are examined. Strategies for addressing the issues are presented.
    Clinical implications: Successful behavioral research in oncology requires firm grounding in clinical practice. Clinicians can improve the quality of research and thus, the scientific base for practice by joining or facilitating multidisciplinary research efforts.
    MeSH term(s) Behavioral Sciences ; Humans ; Medical Oncology ; Neoplasms/psychology ; Research Design
    Language English
    Publishing date 1996-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1237073-3
    ISSN 1065-4704
    ISSN 1065-4704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The clinical application of research utilization: amphotericin B.

    Reedy, A M / Shivnan, J C / Hanson, J L / Haisfield, M E / Gregory, R E

    Oncology nursing forum

    1994  Volume 21, Issue 4, Page(s) 715–719

    Abstract: Purpose/objectives: To describe the first application of the research utilization process by clinical nurses using the Stetler-Marram Model of Research Utilization to the practice of amphotericin B administration; to share the findings; and to discuss ... ...

    Abstract Purpose/objectives: To describe the first application of the research utilization process by clinical nurses using the Stetler-Marram Model of Research Utilization to the practice of amphotericin B administration; to share the findings; and to discuss issues encountered in the process and their solutions.
    Data sources: Published articles identified through computerized literature searches, published abstracts and books, personal communication with one author, and an informal survey of other cancer centers' amphotericin B infusion practices; research articles were selected for review if studies included settings and patient populations similar to those of the authors and if they used experimental designs.
    Data synthesis: Studies were reviewed for scientific merit and clinical applicability according to the Stetler-Marram model; findings were used to develop a specific nursing protocol for infusion times of amphotericin B based on clinical criteria.
    Conclusions: The Stetler-Marram model helped staff nurses decide how to apply research findings to practice, although using it was difficult and required mentorship. A research base exists for amphotericin B administration time but not for test doses or premedications to prevent or minimize side effects.
    Implications for nursing practice: Staff nurses can use the Stetler-Marram model but need resources and support from individuals, committees, and administration. A specific protocol representing a practice change was implemented and may be applicable to other settings.
    MeSH term(s) Amphotericin B/administration & dosage ; Amphotericin B/adverse effects ; Clinical Nursing Research/organization & administration ; Clinical Protocols ; Humans ; Infusions, Parenteral/methods ; Infusions, Parenteral/nursing ; Models, Theoretical ; Premedication ; Time Factors
    Chemical Substances Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 1994-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604886-9
    ISSN 0190-535X ; 0190-535X ; 1538-0688
    ISSN (online) 0190-535X
    ISSN 0190-535X ; 1538-0688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting.

    Ezzo, Jeanette / Vickers, Andrew / Richardson, Mary Ann / Allen, Claire / Dibble, Suzanne L / Issell, Brian / Lao, Lixing / Pearl, Michael / Ramirez, Gilbert / Roscoe, Joseph A / Shen, Joannie / Shivnan, Jane / Streitberger, Konrad / Treish, Imad / Zhang, Grant

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2005  Volume 23, Issue 28, Page(s) 7188–7198

    Abstract: Purpose: Assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients.: Materials and methods: Randomized trials of acupuncture-point stimulation by needles, electrical ... ...

    Abstract Purpose: Assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients.
    Materials and methods: Randomized trials of acupuncture-point stimulation by needles, electrical stimulation, magnets, or acupressure were retrieved. Data were provided by investigators of the original trials and pooled using a fixed-effects model.
    Results: Eleven trials (N = 1,247) were pooled. Overall, acupuncture-point stimulation reduced the proportion of acute vomiting (relative risks [RR] = 0.82; 95% CI, 0.69 to 0.99; P = .04), but not the mean number of acute emetic episodes or acute or delayed nausea severity compared with controls. By modality, stimulation with needles reduced the proportion of acute vomiting (RR = 0.74; 95% CI, 0.58 to 0.94; P = .01), but not acute nausea severity. Electroacupuncture reduced the proportion of acute vomiting (RR = 0.76; 95% CI, 0.60 to 0.97; P = .02), but manual acupuncture did not; delayed symptoms were not reported. Acupressure reduced mean acute nausea severity (standardized mean difference = -0.19; 95% CI, -0.38 to -0.01; P = .03) and most severe acute nausea, but not acute vomiting or delayed symptoms. Noninvasive electrostimulation showed no benefit for any outcome. All trials used concomitant pharmacologic antiemetics, and all, except electroacupuncture trials, used state-of-the-art antiemetics.
    Conclusion: This review complements data on postoperative nausea and vomiting, suggesting a biologic effect of acupuncture-point stimulation. Electroacupuncture has demonstrated benefit for chemotherapy-induced acute vomiting, but studies with state-of-the-art antiemetics as well as studies for refractory symptoms are needed to determine clinical relevance. Acupressure seems to reduce chemotherapy-induced acute nausea severity, though studies did not involve a placebo control. Noninvasive electrostimulation seems unlikely to have a clinically relevant impact when patients are given state-of-the-art pharmacologic antiemetic therapy.
    MeSH term(s) Acupuncture Points ; Acute Disease ; Antineoplastic Agents/adverse effects ; Electric Stimulation Therapy ; Humans ; Nausea/chemically induced ; Nausea/therapy ; Neoplasms/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Vomiting, Anticipatory/etiology ; Vomiting, Anticipatory/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2005-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2005.06.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: CD3 and CD2 antigen-mediated CD3 gamma-chain phosphorylation in permeabilized human T cells. Regulation by cytosolic phosphatases.

    Alexander, D R / Brown, M H / Tutt, A L / Crumpton, M J / Shivnan, E

    The Biochemical journal

    1992  Volume 288 Pt 1, Page(s) 69–77

    Abstract: The role of cytosolic and membrane-associated phosphatases in regulating dephosphorylation of the CD3 antigen gamma-chain has been investigated using streptolysin-O-permeabilized T lymphoblasts and Jurkat T leukaemia cells. Permeabilization of T cells ... ...

    Abstract The role of cytosolic and membrane-associated phosphatases in regulating dephosphorylation of the CD3 antigen gamma-chain has been investigated using streptolysin-O-permeabilized T lymphoblasts and Jurkat T leukaemia cells. Permeabilization of T cells caused a rapid extrusion of cytosolic type 2A phosphatases, but a membrane-associated phosphorylase phosphatase activity remained inside the cells. This activity had the properties characteristic of type 2A phosphatases, being resistant to inhibition by type 1 phosphatase inhibitors, though it was inhibited in a time-dependent manner by ATP or by non-hydrolysable ATP analogues, but not by GTP, CTP, ITP or PPi. The membrane-associated type 2A phosphatase in permeabilized cells did not dephosphorylate the CD3 antigen gamma-chain, suggesting that cytosolic phosphatases dephosphorylate the gamma-chain in situ. Cross-linking the CD2 and CD3 antigens with a bivalent monoclonal antibody in the absence of cytosolic phosphatases induced marked phosphorylation of the CD3 gamma-chain, immunoprecipitated using a novel gamma-chain peptide analogue directed antiserum (TG1). Phosphorylation was inhibited by a protein kinase C (PKC) pseudosubstrate inhibitor, indicating that CD2/CD3-induced gamma-chain phosphorylation is a PKC-mediated event. Activation of T cells either with phorbol 12,13-dibutyrate or by CD2-CD3 cross-linking caused [32P]Pi incorporation into the same gamma-chain Ser residues. The site-mapping data suggested that PKC in situ may incorporate phosphate at the CD3 gamma-chain Ser-123 and Ser-126 residues, but that phosphate is rapidly lost from Ser-123 by cytosolic phosphatase action. Our findings underline the importance of the dual actions of kinases and phosphatases as potential regulators of T cell antigen-receptor complex function.
    MeSH term(s) Adenosine Triphosphate/pharmacology ; Amino Acid Sequence ; Antibodies, Monoclonal ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Bacterial Proteins ; Binding Sites ; CD2 Antigens ; CD3 Complex/metabolism ; Cell Membrane Permeability ; Cross-Linking Reagents ; Cytosol/enzymology ; Humans ; Immunosorbent Techniques ; Lymphocyte Activation/drug effects ; Molecular Sequence Data ; Phorbol 12,13-Dibutyrate/pharmacology ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/blood ; Phosphorylation ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Receptors, Immunologic/metabolism ; Streptolysins ; T-Lymphocytes/enzymology ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Monoclonal ; Antigens, Differentiation, T-Lymphocyte ; Bacterial Proteins ; CD2 Antigens ; CD3 Complex ; Cross-Linking Reagents ; Receptors, Immunologic ; Streptolysins ; streptolysin O ; Phorbol 12,13-Dibutyrate (37558-16-0) ; Adenosine Triphosphate (8L70Q75FXE) ; Protein Kinase C (EC 2.7.11.13) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 1992-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
    ISSN (online) 1470-8728
    ISSN 0264-6021 ; 0006-2936 ; 0306-3275
    DOI 10.1042/bj2880069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting.

    Ezzo, J M / Richardson, M A / Vickers, A / Allen, C / Dibble, S L / Issell, B F / Lao, L / Pearl, M / Ramirez, G / Roscoe, Ja / Shen, J / Shivnan, J C / Streitberger, K / Treish, I / Zhang, G

    The Cochrane database of systematic reviews

    2006  , Issue 2, Page(s) CD002285

    Abstract: Background: There have been recent advances in chemotherapy-induced nausea and vomiting using 5-HT(3) inhibitors and dexamethasone. However, many still experience these symptoms, and expert panels encourage additional methods to reduce these symptoms.!## ...

    Abstract Background: There have been recent advances in chemotherapy-induced nausea and vomiting using 5-HT(3) inhibitors and dexamethasone. However, many still experience these symptoms, and expert panels encourage additional methods to reduce these symptoms.
    Objectives: The objective was to assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients.
    Search strategy: We searched MEDLINE, EMBASE, PsycLIT, MANTIS, Science Citation Index, CCTR (Cochrane Controlled Trials Registry), Cochrane Complementary Medicine Field Trials Register, Cochrane Pain, Palliative Care and Supportive Care Specialized Register, Cochrane Cancer Specialized Register, and conference abstracts.
    Selection criteria: Randomized trials of acupuncture-point stimulation by any method (needles, electrical stimulation, magnets, or acupressure) and assessing chemotherapy-induced nausea or vomiting, or both.
    Data collection and analysis: Data were provided by investigators of the original trials and pooled using a fixed effect model. Relative risks were calculated on dichotomous data. Standardized mean differences were calculated for nausea severity. Weighted mean differences were calculated for number of emetic episodes.
    Main results: Eleven trials (N = 1247) were pooled. Overall, acupuncture-point stimulation of all methods combined reduced the incidence of acute vomiting (RR = 0.82; 95% confidence interval 0.69 to 0.99; P = 0.04), but not acute or delayed nausea severity compared to control. By modality, stimulation with needles reduced proportion of acute vomiting (RR = 0.74; 95% confidence interval 0.58 to 0.94; P = 0.01), but not acute nausea severity. Electroacupuncture reduced the proportion of acute vomiting (RR = 0.76; 95% confidence interval 0.60 to 0.97; P = 0.02), but manual acupuncture did not; delayed symptoms for acupuncture were not reported. Acupressure reduced mean acute nausea severity (SMD = -0.19; 95% confidence interval -0.37 to -0.01; P = 0.04) but not acute vomiting or delayed symptoms. Noninvasive electrostimulation showed no benefit for any outcome. All trials used concomitant pharmacologic antiemetics, and all, except electroacupuncture trials, used state-of-the-art antiemetics.
    Authors' conclusions: This review complements data on post-operative nausea and vomiting suggesting a biologic effect of acupuncture-point stimulation. Electroacupuncture has demonstrated benefit for chemotherapy-induced acute vomiting, but studies combining electroacupuncture with state-of-the-art antiemetics and in patients with refractory symptoms are needed to determine clinical relevance. Self-administered acupressure appears to have a protective effect for acute nausea and can readily be taught to patients though studies did not involve placebo control. Noninvasive electrostimulation appears unlikely to have a clinically relevant impact when patients are given state-of-the-art pharmacologic antiemetic therapy.
    MeSH term(s) Acupuncture Points ; Antiemetics/therapeutic use ; Antineoplastic Agents/adverse effects ; Electroacupuncture ; Humans ; Nausea/chemically induced ; Nausea/therapy ; Randomized Controlled Trials as Topic ; Vomiting/chemically induced ; Vomiting/therapy
    Chemical Substances Antiemetics ; Antineoplastic Agents
    Language English
    Publishing date 2006-04-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD002285.pub2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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