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  1. Book ; Online: Applications of Mathematical Models in Engineering

    Dulf, Eva H. / Muresan, Cristina I.

    2022  

    Keywords Technology: general issues ; History of engineering & technology ; fractional order IMC ; first order plus dead-time processes ; event-based implementation ; numerical simulations ; comparative closed loop results ; nonlinear wave phenomen ; RBF ; local RBF-FD ; stability ; unmanned aerial vehicle (UAV) ; quaternion-based estimator ; low-cost design ; automatic optical inspection ; kinetic theory ; parallel robots ; robust control ; sliding mode control ; basinI ; basinII ; mean pressure head ; pressure head with different probabilities of occurrence ; standard deviation of the pressure fluctuations ; statistical modeling ; USBR ; desalination ; humidification-dehumidification ; waste heat recovery ; mathematical model ; yearly analysis ; thermo-economics ; multi-objective optimization ; cruise altitude ; fuel consumption ; time to climb ; Hermite-Simpson method ; trajectory optimization ; terminal residual analysis (TRA) ; m-σ terminal residual analysis (m-σ TRA) ; power transformer ; stray losses ; analytical methods ; finite element method ; gridshell structures ; shape ratio ; length ratio ; regularity ; particle swarm optimization ; genetic algorithm ; hybrid nanofluid ; dual solutions ; mixed convection ; stagnation point ; radiation ; stability analysis ; machine learning ; eXterme Gradient Boosting ; Computation Fluid Dynamics ; blade vibration ; unsteady aerodynamic model ; active disturbance rejection control (ADRC) ; multiobjective optimization ; time delay systems ; tuning rules ; soft robotics ; fractional calculus ; CACSD toolbox ; operating point linearization ; automatic uncertainty bound computation ; Model-in-the-Loop simulation ; hybrid simulation ; ℋ∞ control ; μ synthesis ; DC-to-DC power converters ; buck ; boost ; SEPIC ; rainfall-runoff model ; curve number ; inferential statistics ; 3D runoff difference model ; model calibration ; PAT model ; modified affinity laws ; hydraulic simulation tool ; μ-synthesis ; fractional-order control ; swarm optimization ; artificial bee colony optimization ; CNC machine ; mixed sensitivity ; D-K iteration ; Linear Matrix Inequality ; biotechnology ; fermentation process ; batch bioreactors ; modeling ; control system design and synthesis ; linear control ; adaptive control ; model reference adaptive control ; control system realization ; mixed-sensitivity ; FO-PID ; twin rotor aerodynamic system
    Language 0|e
    Size 1 electronic resource (418 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021608984
    ISBN 9783036538488 ; 3036538488
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: C-reactive Protein: An Inflammatory Biomarker and a Predictor of Neurodegenerative Disease in Patients With Inflammatory Bowel Disease?

    Muresan, Simona / Slevin, Mark

    Cureus

    2024  Volume 16, Issue 4, Page(s) e59009

    Abstract: Inflammatory bowel disease (IBD) refers to two chronic conditions of the digestive tract: ulcerative colitis (UC) and Crohn's disease (CD), representing a progressive inflammatory process that mainly occurs in the gut, with frequent extra-intestinal ... ...

    Abstract Inflammatory bowel disease (IBD) refers to two chronic conditions of the digestive tract: ulcerative colitis (UC) and Crohn's disease (CD), representing a progressive inflammatory process that mainly occurs in the gut, with frequent extra-intestinal manifestations. Even if remission is periodically obtained for some patients, the histological activity and digestive symptoms may continue, maintaining a persistent systemic inflammation that could induce further extra-intestinal complications and contribute to the development of neurodegenerative disease. C-reactive protein (CRP) is an acute-phase reactant that is widely accepted as a dominant serum biomarker in IBD. CRP consequently activates the complement cascade, supports the release of pro-inflammatory cytokines, and the clearance of microbial pathogens. All these processes facilitate further processes, including atherosclerosis and hypercoagulability, alteration of the intestinal microbiota, and the increased permeability of the intestinal barrier for neurotoxic substances produced by gut microorganisms, due to the presence of a high level of lipopolysaccharides. For IBD, the connection between intestinal inflammation and central nervous system inflammation could be explained through the activity of the vagus nerve, a carrier of cytokines, CRP, and toxic materials to the brain, potentially inducing vascular lesions and damage of the glial vascular unit, with further risk for degeneration within the central nervous system. CRP is a key marker for IBD pathogenesis and is able to dissociate into its monomeric form, mCRP, on contact with activated cell and tissue components via the systemic circulation. We hypothesize that the chronic inflammatory process within IBD could initiate neuroinflammation and neurodegeneration, and therefore, further investigation of the significance of chronically raised plasma of CRP and mCRP in patients with IBD is warranted, as it may represent a critical predictive factor associated with a later neurodegenerative risk. Any future initiative aimed at pharmacologic modulation of CRP (e.g., blocking CRP-mCRP dissociation), could represent a new therapeutic approach protecting against intestinal inflammation and concomitantly reducing the risk of neuroinflammation, neurodegeneration, and cognitive decline.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.59009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Feasibility of Shellac Wax Emulsion Oleogels as Low-Fat Spreads Analyzed by Means of Multidimensional Statistical Analysis.

    Puşcaş, Andreea / Mureşan, Vlad

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: ... The emulsions containing 7% (m/m) shellac oleogels behaved like the strongest systems, (G′ & GLVR > 30,000 Pa ... 88% for the sample with 3% (m/m) shellac and 20% (m/m) water. The whiteness index (Windex) varied ... between 58.12 and 78.50. The optimization process indicated that a formulation based on 4.29% (m/m ...

    Abstract Shellac wax-based oleogel emulsions were studied with a three level two factorial design in order to find an optimal formulation for a spread formulation. Rheological, textural, colorimetry, and stability analysis were conducted to assess the performance of oleogel emulsions. FTIR spectra were also compared. The similarities between the samples were studied using cluster analysis. Analysis of variance (ANOVA) demonstrates that (i) the texture is influenced by the wax concentration, (ii) the rheology and stability by both the considered numeric factors (wax and water concentration) and their interaction, and (iii) the color by both factors. The emulsions containing 7% (m/m) shellac oleogels behaved like the strongest systems, (G′ & GLVR > 30,000 Pa) and exhibited the highest value of the G′-G″ cross-over. The lowest oil binding capacity (OBC) was 99.88% for the sample with 3% (m/m) shellac and 20% (m/m) water. The whiteness index (Windex) varied between 58.12 and 78.50. The optimization process indicated that a formulation based on 4.29% (m/m) shellac wax and 24.13% (m/m) water was suitable as a low-fat spread.
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8110749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Young Emergency Medicine Doctors refresher course: a decade of education to harmonize emergency medicine training in Europe.

    Lupan-Mureșan, Eugenia Maria / Bonsano, Marco

    European journal of emergency medicine : official journal of the European Society for Emergency Medicine

    2023  Volume 30, Issue 4, Page(s) 227–228

    MeSH term(s) Humans ; Europe ; Emergency Medicine/education ; Physicians
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1233544-7
    ISSN 1473-5695 ; 0969-9546
    ISSN (online) 1473-5695
    ISSN 0969-9546
    DOI 10.1097/MEJ.0000000000001038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4264: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Antimicrobial Prescription Behavior in Equine Asthma Cases: An International Survey.

    van den Brom-Spierenburg, Astrid J / Mureșan, Alexandra N / Westermann, Cornélie M

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 3

    Abstract: Equine asthma is considered a non-infectious respiratory disease characterized by inflammation and hypersensitivity. Given the importance of antimicrobial stewardship, an international survey was designed to investigate the use of antimicrobials in ... ...

    Abstract Equine asthma is considered a non-infectious respiratory disease characterized by inflammation and hypersensitivity. Given the importance of antimicrobial stewardship, an international survey was designed to investigate the use of antimicrobials in asthmatic horses and the factors influencing prescription behavior. An online survey was distributed in six languages by international mailing lists and social media from December 2020 to January 2022. Of the 434 responses recorded, 249 veterinarians working in 25 countries finished the survey. These included 79 ECEIM/ACVIM diplomats. A total of 204 respondents confirmed national regulations concerning antimicrobial use in their country. Knowledge of the asthma definitions as presented in the revised ACVIM consensus statement was greater in veterinarians treating over 95% of equine patients compared to veterinarians treating more species, based on 10 questions (answers consistent with the consensus statement in 7 (IQR 5-9) and 4 (IQR 3-6) questions, respectively, (
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14030457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tailoring the Structure of Lipids, Oleogels and Fat Replacers by Different Approaches for Solving the

    Temkov, Mishela / Mureșan, Vlad

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: The issue of the adverse effects ... ...

    Abstract The issue of the adverse effects of
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10061376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: An Outbreak of Equine Herpesvirus-4 in an Ecological Donkey Milk Farm in Romania.

    Mureşan, Alexandra / Mureşan, Cosmin / Siteavu, Madalina / Avram, Electra / Bochynska, Diana / Taulescu, Marian

    Vaccines

    2022  Volume 10, Issue 3

    Abstract: Equine herpesviruses are important pathogens causing significant economic loss in equine and asinine populations. EHV-1/4 strains are mainly associated with respiratory distress. The aim of this study is to report the first EHV 4-associated respiratory ... ...

    Abstract Equine herpesviruses are important pathogens causing significant economic loss in equine and asinine populations. EHV-1/4 strains are mainly associated with respiratory distress. The aim of this study is to report the first EHV 4-associated respiratory disease in donkeys in Romania. Thirty-seven of three hundred jennies in an ecological donkey farm in southwest Romania started initially showing signs of severe upper respiratory tract disease, with ten concomitant late abortions/neonatal deaths and three neurological cases. There were nine fatalities. Pathological examination was performed, and samples were collected for Real-Time PCR analysis and histology. In addition, serum samples from 28 individuals with respiratory symptoms were collected and tested using indirect ELISA. RT-PCR identified the EHV-4 strain. Acute, diffuse necrotizing bronchointerstitial pneumonia with occasional intraepithelial intranuclear viral inclusion bodies was identified. Additionally, EHV-1/4-specific antibodies were found in 15 of the 28 sampled animals. Few studies on donkeys and herpesviruses have been published, and this is the first reported case of EHV-4 outbreak in Romania. There is a need for more extensive seroprevalence studies as, currently, the status of EHV-4 infection in donkeys in Romania is unknown.
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10030468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Improved space breakdown method - A robust clustering technique for spike sorting.

    Ardelean, Eugen-Richard / Ichim, Ana-Maria / Dînşoreanu, Mihaela / Mureşan, Raul Cristian

    Frontiers in computational neuroscience

    2023  Volume 17, Page(s) 1019637

    Abstract: Space Breakdown Method (SBM) is a clustering algorithm that was developed specifically for low-dimensional neuronal spike sorting. Cluster overlap and imbalance are common characteristics of neuronal data that produce difficulties for clustering methods. ...

    Abstract Space Breakdown Method (SBM) is a clustering algorithm that was developed specifically for low-dimensional neuronal spike sorting. Cluster overlap and imbalance are common characteristics of neuronal data that produce difficulties for clustering methods. SBM is able to identify overlapping clusters through its design of cluster centre identification and the expansion of these centres. SBM's approach is to divide the distribution of values of each feature into chunks of equal size. In each of these chunks, the number of points is counted and based on this number the centres of clusters are found and expanded. SBM has been shown to be a contender for other well-known clustering algorithms especially for the particular case of two dimensions while being too computationally expensive for high-dimensional data. Here, we present two main improvements to the original algorithm in order to increase its ability to deal with high-dimensional data while preserving its performance: the initial array structure was substituted with a graph structure and the number of partitions has been made feature-dependent, denominating this improved version as the Improved Space Breakdown Method (ISBM). In addition, we propose a clustering validation metric that does not punish overclustering and such obtains more suitable evaluations of clustering for spike sorting. Extracellular data recorded from the brain is unlabelled, therefore we have chosen simulated neural data, to which we have the ground truth, to evaluate more accurately the performance. Evaluations conducted on synthetic data indicate that the proposed improvements reduce the space and time complexity of the original algorithm, while simultaneously leading to an increased performance on neural data when compared with other state-of-the-art algorithms.
    Code available at: https://github.com/ArdeleanRichard/Space-Breakdown-Method.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452964-3
    ISSN 1662-5188
    ISSN 1662-5188
    DOI 10.3389/fncom.2023.1019637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Nicholas Reactions of Pentadiynyl–Co2(CO)6 Cations. Synthesis of Antimalarial Hinokiresinol Analogues

    Muresan, Marcus / Green, James R.

    Synthesis

    2024  

    Abstract: Penta-1,4-diyn-3-ol–Co 2 (CO) 6 complexes undergo Lewis acid mediated Nicholas reactions with high selectivity at the C-3 site, to give skipped (1,4-)diyne complexes. The compatible nucleophiles have a wide range of reactivity. The methodology has been ... ...

    Abstract Penta-1,4-diyn-3-ol–Co 2 (CO) 6 complexes undergo Lewis acid mediated Nicholas reactions with high selectivity at the C-3 site, to give skipped (1,4-)diyne complexes. The compatible nucleophiles have a wide range of reactivity. The methodology has been applied to the synthesis of both ( E )- and ( Z )-isomers of a hinokiresinol and nyasol analogue, the ( E )-isomer of which is known to have elevated antiplasmodial and antimalarial activity.
    Keywords propargyl ; carbocations ; alkyne complexes ; diynes ; Lewis acids ; norneolignans ; antimalarial agents
    Language English
    Publishing date 2024-01-22
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/a-2250-8050
    Database Thieme publisher's database

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  10. Article ; Online: Unconventional Treatment of Breast Abscess: Case Report.

    Muresan, Marta / Chiorean, Angelica

    Women's health reports (New Rochelle, N.Y.)

    2022  Volume 3, Issue 1, Page(s) 194–197

    Abstract: We describe the case of two lactating mothers with breast abscesses who refused invasive interventions. In the first case, a mother developed a 10 mm abscess and refused needle aspiration. Under ultrasonography (US) follow-up she was treated with ... ...

    Abstract We describe the case of two lactating mothers with breast abscesses who refused invasive interventions. In the first case, a mother developed a 10 mm abscess and refused needle aspiration. Under ultrasonography (US) follow-up she was treated with antibiotics until the abscess disappeared on the US scan, while fully breastfeeding. In the second case, a woman with a large abscess refused invasive interventions. We followed the recommendations in case of breast Adenitis, first to nurse the baby from the affected breast and then squeezing regularly the lump to drain the pus. In this study, we demonstrate that this procedure is also beneficial in the case of breast abscesses. Under antibiotic treatment, the abscess was completely resolved on the US scan after 23 days. In conclusion, when invasive intervention is refused in the case of breast abscess, successful treatment can be applied by using effective breast drainage, US follow-up, and aggressive antibiotic therapy.
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Case Reports
    ISSN 2688-4844
    ISSN (online) 2688-4844
    DOI 10.1089/whr.2021.0087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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