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  1. Article ; Online: Characterization of the complete mitochondrial genomes of two Critically Endangered wedgefishes:

    Groeneveld, M J / Klein, J D / Bennett, R H / Bester-van der Merwe, A E

    Mitochondrial DNA. Part B, Resources

    2023  Volume 8, Issue 3, Page(s) 352–358

    Abstract: We present the complete mitochondrial genomes of the Critically Endangered whitespotted wedgefish, ...

    Abstract We present the complete mitochondrial genomes of the Critically Endangered whitespotted wedgefish,
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2023.2167479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy.

    Groeneveld, Nina S / Olie, Sabine E / Visser, Douwe H / Snoek, Linde / van de Beek, Diederik / Brouwer, Matthijs C / Bijlsma, Merijn W

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 142, Page(s) 106970

    Abstract: Objectives: We evaluated the diagnostic accuracy of cerebrospinal fluid (CSF) inflammatory markers for diagnosing bacterial meningitis in neonates with sepsis and/or meningitis.: Methods: Cases were identified from a prospective multicenter study ... ...

    Abstract Objectives: We evaluated the diagnostic accuracy of cerebrospinal fluid (CSF) inflammatory markers for diagnosing bacterial meningitis in neonates with sepsis and/or meningitis.
    Methods: Cases were identified from a prospective multicenter study including patients aged 0-3 months with Group B Streptococcal (GBS) or Escherichia coli culture positive sepsis/meningitis. CSF CXCL10, MDC, IL-6, IL-8, IL-10, TNF- α, MIF, IL-1RA, CXCL13, IL-1β, CRP and procalcitonin concentrations were measured with Luminex technology.
    Results: In 61/373 patients (17%) residual CSF from the lumbar puncture was available, of whom 16 (26%) had definitive meningitis, 15 (25%) probable meningitis and 30 (49%) had sepsis. All biomarkers were detectable in CSF and showed significantly higher concentrations in definitive meningitis versus sepsis patients and six biomarkers in probable meningitis versus sepsis patients. Discrimination between definitive meningitis and sepsis was excellent for IL-1RA (area under the receiver operating characteristic curve [AUC] 0.93), TNF-α (AUC 0.92), CXCL10 (AUC 0.90), IL-1β (AUC 0.92), IL-6 (AUC 0.94), IL-10 (AUC 0.93) and a combination of IL-1RA, TNF-α, CXCL-10 and CSF leukocyte count (AUC 0.95). CSF leukocyte count remained the predictor with the highest diagnostic accuracy (AUC 0.96).
    Conclusion: CSF inflammatory markers can be used to differentiate between neonatal sepsis and meningitis.
    MeSH term(s) Infant, Newborn ; Humans ; Prospective Studies ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-10 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/cerebrospinal fluid ; Sepsis/diagnosis ; Bacteria ; Biomarkers/cerebrospinal fluid ; Infant, Newborn, Diseases ; Bacteremia ; Cerebrospinal Fluid/microbiology
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Biomarkers
    Language English
    Publishing date 2024-02-21
    Publishing country Canada
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.02.013
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  3. Article ; Online: Perceived contribution of a hybrid serious game to the development of collaborative problem solving among undergraduate nursing students: A mixed method design.

    de Beer, Eveline E H M / van Os-Medendorp, Harmieke H / Groeneveld, Sjors S W M / Jukema, Jan S J S

    Nurse education in practice

    2023  Volume 73, Page(s) 103794

    Abstract: Background: Community health nurses collaborate in teams to address client care, organise services, and conduct preventive activities. Hence, it is crucial for students in this work context, to practise and enhance their collaborative problem-solving ( ... ...

    Abstract Background: Community health nurses collaborate in teams to address client care, organise services, and conduct preventive activities. Hence, it is crucial for students in this work context, to practise and enhance their collaborative problem-solving (CPS) skills. To facilitate this, a hybrid serious game called "Carion" was developed, immersing second-year nursing students in a semester-long experience of working as district nurses in self-managed teams. The game challenges them to collectively tackle authentic and fictional problems. However, the extent and manner in which this hybrid serious game contributes to students' CPS skill development is unknown.
    Aim: The aim of this study is to explore how students perceive the development of CPS by doing assignments carried out in the learning context of the hybrid serious game Carion.
    Participants: Two teams each consisting of five second-year nursing students, were selected for the qualitative case study. Two lecturers acting as team coaches also participated in this study. 110 (response rate 61 %) second-year students participated in the quantitative survey at the beginning of the semester, 109 students at the end of the semester.
    Methods: The study is a mixed method design. The qualitative component involves a case study while the quantitative component consists of an online survey. Qualitative and quantitative data regarding collaborative problem solving was collected at different time points using focus group interviews, one-on-one interviews, digital logbooks and an online self-assessment tool.
    Results: Qualitative analysis revealed insights into three key themes: (1) Collaboration, encompassing consulting with each other, and capitalising on each other's qualities and strengths; (2) Problem solving, encompassing quicker and easier problem solving, allocating assignments, coming to a joint solution, and problem-solving method; and (3) Learning from each other, encompassing learning from each other's knowledge and experience, and from each other's ideas. No growth in collaborative problem-solving development was statistically shown in the group.
    Conclusions: This study gives an ambiguous view on students' perception of their CPS development through involvement in various Carion assignments. Based on this exploratory investigation, prematurely labelling Carion as a potential educational environment for developing CPS among undergraduate nursing students in community healthcare would be unwarranted. Further research is needed, particularly in scrutinising the interplay between CPS and diverse learning activities, assignments and learning outcomes within this specific hybrid serious game context.
    MeSH term(s) Humans ; Education, Nursing, Baccalaureate/methods ; Students, Nursing ; Problem-Based Learning/methods ; Focus Groups ; Problem Solving
    Language English
    Publishing date 2023-10-04
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2058575-5
    ISSN 1873-5223 ; 1471-5953
    ISSN (online) 1873-5223
    ISSN 1471-5953
    DOI 10.1016/j.nepr.2023.103794
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  4. Article ; Online: Influenzavaccinatie bij hartpatiënten voorkomt cardiale complicaties.

    Vollaard, Albert M / Slok, Edwin N E / van Dijkman, Paul R M / Dekkers, Olaf M / Groeneveld, Geert H

    Nederlands tijdschrift voor geneeskunde

    2023  Volume 167

    Abstract: Influenza infection increases the risk of cardiovascular complications and mortality in patients with heart disease. In patients with coronary artery disease influenza vaccination has been shown to reduce cardiovascular mortality, but high-quality ... ...

    Title translation Influenza vaccination as secondary prevention for cardiovascular disease.
    Abstract Influenza infection increases the risk of cardiovascular complications and mortality in patients with heart disease. In patients with coronary artery disease influenza vaccination has been shown to reduce cardiovascular mortality, but high-quality evidence was missing. New trial data from a RCT in patients shortly after myocardial infarction has confirmed the significant reduction of the risk of major adverse cardiovascular events (MACE) and cardiovascular death after influenza vaccination. Also in patients with heart failure the first published RCT in heart failure shows a clinical benefit of influenza vaccination versus placebo during the influenza season, confirming preceding observational studies. Meta-analyses from the study data estimate that after influenza vaccination a risk reduction of MACE of at least 25% is possible in patients with heart disease. The current underutilization of influenza vaccines in heart patients should be addressed because influenza vaccination has proven to be an effective and safe instrument for secondary prevention.
    MeSH term(s) Humans ; Influenza, Human/complications ; Influenza, Human/prevention & control ; Cardiovascular Diseases/drug therapy ; Secondary Prevention ; Influenza Vaccines ; Myocardial Infarction/complications ; Heart Failure/complications ; Vaccination
    Chemical Substances Influenza Vaccines
    Language Dutch
    Publishing date 2023-10-12
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  5. Article ; Online: Multidisciplinary teams, efficient communication, procedure services, and telehealth improve cirrhosis care: A qualitative study.

    Serper, Marina / Agha, Aneeza / Garren, Patrik A / Taddei, Tamar H / Kaplan, David E / Groeneveld, Peter W / Werner, Rachel M / Shea, Judy A

    Hepatology communications

    2023  Volume 7, Issue 6

    Abstract: Background: Cirrhosis care and outcomes are improved with access to subspecialty gastroenterology and hepatology care. In qualitative interviews, we investigated clinicians' perceptions of factors that optimize or impede cirrhosis care.: Methods: We ... ...

    Abstract Background: Cirrhosis care and outcomes are improved with access to subspecialty gastroenterology and hepatology care. In qualitative interviews, we investigated clinicians' perceptions of factors that optimize or impede cirrhosis care.
    Methods: We conducted 24 telephone interviews with subspecialty clinicians at 7 Veterans Affairs medical centers with high- and low-complexity services. Purposive sampling stratified Veterans Affairs medical centers on timely post-hospitalization follow-up, a quality measure. We asked open-ended questions about facilitators and barriers of care coordination, access to appointments, procedures, transplantation, management of complications, keeping up to date with medical knowledge, and telehealth use.
    Results: Key themes that facilitated care were structural: multidisciplinary teams, clinical dashboards, mechanisms for appointment tracking and reminders, and local or virtual access to transplant and liver cancer specialists through the "specialty care access network extension for community health care outcomes" program. Coordination and efficient communication between transplant and non-transplant specialists and between transplant and primary care facilitated timely care. Same-day access to laboratory, procedural, and clinical services is an indicator of high-quality care. Barriers included lack of on-site procedural services, clinician turnover, patient social needs related to transportation, costs, and patient forgetfulness due to HE. Telehealth enabled lower complexity sites to obtain recommendations for complex patient cases. Barriers to telehealth included lack of credit (eg, VA billing equivalent), inadequate staff, lack of audiovisual technology support, and patient and staff discomfort with technology. Telehealth was optimal for return visits, cases where physical examination was nonessential, and where distance and transportation precluded in-person care. Rapid telehealth uptake during the COVID-19 pandemic was a positive disruptor and facilitated use.
    Conclusions: We identify multi-level factors related to structure, staffing, technology, and care organization to optimize cirrhosis care delivery.
    MeSH term(s) Humans ; Pandemics ; COVID-19 ; Liver Cirrhosis ; Telemedicine ; Communication ; Patient Care Team
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000157
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  6. Article ; Online: A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

    Hijma, Hemme / Koopmans, Ingrid / Klaassen, Erica / Doll, Robert Jan / Zuiker, Rob / Groeneveld, Geert Jan

    British journal of clinical pharmacology

    2022  Volume 89, Issue 1, Page(s) 361–371

    Abstract: Aim: We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects.: Methods: This was ...

    Abstract Aim: We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects.
    Methods: This was a two-part randomized crossover study in 24 healthy men and 24 women. Subjects were randomized 1:1 to first complete a day of nonsleep-deprived nociceptive threshold testing, followed directly by a TSD night and morning of sleep-deprived testing, or first complete the TSD night and morning sleep-deprived testing, returning 7 days later for a day of nonsleep-deprived testing. A validated pain test battery (heat, pressure, electrical burst and stair, cold pressor pain test and conditioned pain modulation [CPM] paradigm) and sleep questionnaires were performed.
    Results: Subjects were significantly sleepier after TSD as measured using sleepiness questionnaires. Cold pressor pain tolerance (PTT, estimate of difference [ED] -10.8%, 95% CI -17.5 to -3.6%), CPM PTT (ED -0.69 mA, 95% CI -1.36 to -0.03 mA), pressure PTT (ED -11.2%, 95% CI -17.5% to -4.3%) and heat pain detection thresholds (ED -0.74 °C, 95% CI -1.34 to -0.14 °C) were significantly decreased after TSD compared to the baseline morning assessment in the combined analysis (men + women). Heat hyperalgesia was primarily driven by an effect of TSD in men, whereas cold and pressure hyperalgesia was primarily driven by the effects of TSD observed in women.
    Conclusions: TSD induced sex-dependent hyperalgesia on cold, heat and pressure pain, and CPM response. These results suggest that the TSD model may be suitable to evaluate (novel) analgesics in early-phase drug studies.
    MeSH term(s) Male ; Humans ; Female ; Sleep Deprivation ; Hyperalgesia ; Cross-Over Studies ; Nociception ; Healthy Volunteers ; Pain ; Pain Threshold ; Analgesics/pharmacology
    Chemical Substances Analgesics
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15505
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  7. Article ; Online: Underestimated Factors Regarding the Use of Technology in Daily Practice of Long-Term Care: Qualitative Study Among Health Care Professionals.

    Groeneveld, Sjors W M / den Ouden, Marjolein E M / van Gemert-Pijnen, J E W C / Verdaasdonk, Rudolph M / van Os-Medendorp, Harmieke

    JMIR nursing

    2023  Volume 6, Page(s) e41032

    Abstract: Background: Increasing life expectancy is resulting in a growing demand for long-term care; however, there is a shortage of qualified health care professionals (HCPs) to deliver it. If used optimally, technology can provide a solution to this challenge. ...

    Abstract Background: Increasing life expectancy is resulting in a growing demand for long-term care; however, there is a shortage of qualified health care professionals (HCPs) to deliver it. If used optimally, technology can provide a solution to this challenge. HCPs play an important role in the use of technology in long-term care. However, technology influences several core aspects of the work that HCPs do, and it is therefore important to have a good understanding of their viewpoint regarding the use of technology in daily practice of long-term care.
    Objective: The aim of this study was to identify the factors that HCPs consider as relevant for using technology in daily practice of long-term care.
    Methods: In this qualitative study, 11 focus groups were organized with 73 HCPs. The focus group discussions were guided by an innovative game, which was specifically developed for this study. The content of the game was categorized into 4 categories: health care technology and me; health care technology, the patient, and me; health care technology, the organization, and me; and facilitating conditions. The perspectives of HCPs about working with technology were discussed based on this game. The focus groups were recorded and transcribed, followed by an inductive thematic analysis using ATLAS.ti 9x (ATLAS.ti Scientific Software Development GmbH).
    Results: Overall, 2 main domain summaries were developed from the data: technology should improve the quality of care and acceptance and use of technology in care. The first factor indicates the need for tailored and personalized care and balance between human contact and technology. The second factor addresses several aspects regarding working with technology such as trusting technology, learning to work with technology, and collaboration with colleagues.
    Conclusions: HCPs are motivated to use technology in daily practice of long-term care when it adds value to the quality of care and there is sufficient trust, expertise, and collaboration with colleagues. Their perspectives need to be considered as they play a crucial part in the successful use of technology, transcending their role as an actor in implementation. On the basis of the findings from this study, we recommend focusing on developing technology for situations where both efficiency and quality of care can be improved; redefining the roles of HCPs and the impact of technology hereon; involving HCPs in the design process of technology to enable them to link it to their daily practice; and creating ambassadors in care teams who are enthusiastic about working with technology and can support and train their colleagues.
    Language English
    Publishing date 2023-07-26
    Publishing country Canada
    Document type Journal Article
    ISSN 2562-7600
    ISSN (online) 2562-7600
    DOI 10.2196/41032
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  8. Article ; Online: Neurocognitive Effect of Biased µ-Opioid Receptor Agonist Oliceridine, a Utility Function Analysis and Comparison with Morphine.

    Moss, Laurence / Hijma, Hemme / Demitrack, Mark / Kim, Jessica / Groeneveld, Geert Jan / van Velzen, Monique / Niesters, Marieke / Olofsen, Erik / Dahan, Albert

    Anesthesiology

    2023  Volume 139, Issue 6, Page(s) 746–756

    MeSH term(s) Male ; Humans ; Female ; Morphine ; Analgesics, Opioid ; Spiro Compounds ; Receptors, Opioid
    Chemical Substances Morphine (76I7G6D29C) ; ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine ; Analgesics, Opioid ; Spiro Compounds ; Receptors, Opioid
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004758
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  9. Article: Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study.

    Vasylyev, Marta / Wit, Ferdinand W N M / Jordans, Carlijn C E / Soetekouw, Robin / van Lelyveld, Steven F L / Kootstra, Gert-Jan / Delsing, Corine E / Ammerlaan, Heidi S M / van Kasteren, Marjo E E / Brouwer, Annemarie E / Leyten, Eliane M S / Claassen, Mark A A / Hassing, Robert-Jan / den Hollander, Jan G / van den Berge, Marcel / Roukens, Anna H E / Bierman, Wouter F W / Groeneveld, Paul H P / Lowe, Selwyn H /
    van Welzen, Berend J / Richel, Olivier / Nellen, Jeannine F / van den Berk, Guido E L / van der Valk, Marc / Rijnders, Bart J A / Rokx, Casper

    Open forum infectious diseases

    2024  Volume 11, Issue 4, Page(s) ofae160

    Abstract: Background: Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use.: Methods: Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment centers in the Netherlands. HIV ...

    Abstract Background: Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use.
    Methods: Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment centers in the Netherlands. HIV RNA-suppressed cases were on triple-drug antiretroviral regimens without prior virological failure or resistance and started dolutegravir/lamivudine. Cases were 1:2 matched to controls on triple-drug antiretroviral regimens by the use of dolutegravir-based regimens, age, sex, transmission route, CD4
    Results: The 2040 participants were 680 cases and 1380 controls. Treatment failure in the 390 dolutegravir-based cases versus controls occurred in 8.72% and 12.50% (difference: -3.78% [95% confidence interval {CI}, -7.49% to .08%]) by intention-to-treat and 1.39% and 0.80% (difference: 0.59% [95% CI, -.80% to 1.98%]) by on-treatment analyses. The treatment failure risk in 290 non-dolutegravir-based cases was also noninferior to controls. Antiretroviral regimen modifications unrelated to virological failure explained the higher treatment failure rate by intention-to-treat. A shorter time on triple-drug antiretroviral therapy and being of non-Western origin was associated with treatment failure. Treatment failure, defined as 2 consecutive HIV RNA >50 copies/mL, occurred in 4 cases and 5 controls but without genotypic resistance detected. Viral blips occured comparable in cases and controls but cases gained more weight, especially when tenofovir-based regimens were discontinued.
    Conclusions: In routine care, dolutegravir/lamivudine was noninferior to continuing triple-drug antiretroviral regimens after 1 year, supporting the use of dolutegravir/lamivudine in clinical practice.
    Clinical trials registration: NCT04707326.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Clinical Trial
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae160
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  10. Article ; Online: TheSNPpit-A High Performance Database System for Managing Large Scale SNP Data.

    Groeneveld, Eildert / Lichtenberg, Helmut

    PloS one

    2016  Volume 11, Issue 10, Page(s) e0164043

    Abstract: The fast development of high throughput genotyping has opened up new possibilities in genetics while at the same time producing considerable data handling issues. TheSNPpit is a database system for managing large amounts of multi panel SNP genotype data ... ...

    Abstract The fast development of high throughput genotyping has opened up new possibilities in genetics while at the same time producing considerable data handling issues. TheSNPpit is a database system for managing large amounts of multi panel SNP genotype data from any genotyping platform. With an increasing rate of genotyping in areas like animal and plant breeding as well as human genetics, already now hundreds of thousand of individuals need to be managed. While the common database design with one row per SNP can manage hundreds of samples this approach becomes progressively slower as the size of the data sets increase until it finally fails completely once tens or even hundreds of thousands of individuals need to be managed. TheSNPpit has implemented three ideas to also accomodate such large scale experiments: highly compressed vector storage in a relational database, set based data manipulation, and a very fast export written in C with Perl as the base for the framework and PostgreSQL as the database backend. Its novel subset system allows the creation of named subsets based on the filtering of SNP (based on major allele frequency, no-calls, and chromosomes) and manually applied sample and SNP lists at negligible storage costs, thus avoiding the issue of proliferating file copies. The named subsets are exported for down stream analysis. PLINK ped and map files are processed as in- and outputs. TheSNPpit allows management of different panel sizes in the same population of individuals when higher density panels replace previous lower density versions as it occurs in animal and plant breeding programs. A completely generalized procedure allows storage of phenotypes. TheSNPpit only occupies 2 bits for storing a single SNP implying a capacity of 4 mio SNPs per 1MB of disk storage. To investigate performance scaling, a database with more than 18.5 mio samples has been created with 3.4 trillion SNPs from 12 panels ranging from 1000 through 20 mio SNPs resulting in a database of 850GB. The import and export performance scales linearly with the number of SNPs and is largely independent of panel and database size. Import speed is around 6 mio SNPs/sec, export between 60 and 120 mio SNPs/sec. Being command line based, imports and exports can easily be integrated into pipelines. TheSNPpit is available under the Open Source GNU General Public License (GPL) Version 2.
    MeSH term(s) Animals ; Computational Biology/methods ; Data Mining ; Humans ; Plants/genetics ; Polymorphism, Single Nucleotide ; Software
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0164043
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