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Article ; Online: Impact of DMPEI on Biofilm Adhesion on Latex Urinary Catheter.

Tarabal, Vinícius S / Silva, Flávia G / Sinisterra, Ruben D / Gonçalves, Daniel / Silva, Jose / Granjeiro, Jose M / Speziali, Marcelo / Granjeiro, Paulo A

Recent patents on biotechnology

2021 Volume 15, Issue 1, Page(s) 51–66

Abstract: Background: Microorganisms can migrate from the external environment to the patient's organism through the insertion of catheters. Despite being indispensable medical device, the catheter surface can be colonized by microorganisms and become a starting ... ...

Abstract	Background: Microorganisms can migrate from the external environment to the patient's organism through the insertion of catheters. Despite being indispensable medical device, the catheter surface can be colonized by microorganisms and become a starting point for biofilm formation. Therefore, new technologies are being developed in order to modify surfaces to prevent the adhesion and survival of microorganisms. Patents with the use of DMPEI have been filed. Objective: In the present work, we coated latex catheter surfaces with 2 mg mL-1 DMPEI in different solvents, evaluated the wettability of the surface and the anti- biofilm activity of the coated catheter against Escherichia coli, Staphylococcus aureus, and Candida albicans. Methods: We coated the inner and outer catheter surfaces with 2 mg mL-1 of DMPEI solubilized in butanol, dimethylformamide, and cyclohexanone and the surfaces were analyzed visually. Contact angle measurement allowed the analysis of the wettability of the surfaces. The CFU mL-1 count evaluated E. coli, S. aureus, and C. albicans adhesion onto the control and treated surfaces. Results: The contact angle decreased from 50.48º to 46.93º on the inner surface and from 55.83º to 50.91º on the outer surface of latex catheters coated with DMPEI. The catheter coated with DMPEI showed anti-biofilm activity of 83%, 88%, and 93% on the inner surface and 100%, 92%, and 86% on the outer surface for E. coli, S. aureus, and C. albicans, respectively. Conclusion: Latex catheter coated with DMPEI efficiently impaired the biofilm formation both on the outer and inner surfaces, showing a potential antimicrobial activity along with a high anti-biofilm activity for medical devices.
MeSH term(s)	Biofilms ; Escherichia coli ; Humans ; Latex ; Patents as Topic ; Staphylococcus aureus ; Urinary Catheters
Chemical Substances	Latex
Language	English
Publishing date	2021-02-15
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2212-4012
ISSN (online)	2212-4012
DOI	10.2174/1872208315666210215084127
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Article ; Online: Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials.

Costa, S / Vilas-Boas, V / Lebre, F / Granjeiro, J M / Catarino, C M / Moreira Teixeira, L / Loskill, P / Alfaro-Moreno, E / Ribeiro, A R

Trends in biotechnology

2023 Volume 41, Issue 10, Page(s) 1282–1298

Abstract: The skin is the body's largest organ, continuously exposed to and affected by natural and anthropogenic nanomaterials (materials with external and internal dimensions in the nanoscale range). This broad spectrum of insults gives rise to irreversible ... ...

Abstract	The skin is the body's largest organ, continuously exposed to and affected by natural and anthropogenic nanomaterials (materials with external and internal dimensions in the nanoscale range). This broad spectrum of insults gives rise to irreversible health effects (from skin corrosion to cancer). Organ-on-chip systems can recapitulate skin physiology with high fidelity and potentially revolutionize the safety assessment of nanomaterials. Here, we review current advances in skin-on-chip models and their potential to elucidate biological mechanisms. Further, strategies are discussed to recapitulate skin physiology on-chip, improving control over nanomaterials exposure and transport across cells. Finally, we highlight future opportunities and challenges from design and fabrication to acceptance by regulatory bodies and industry.
MeSH term(s)	Microfluidics ; Lab-On-A-Chip Devices ; Nanostructures/toxicity ; Skin
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.05.009
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Article ; Online: Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials

Costa, S. / Vilas-Boas, V. / Lebre, F. / Granjeiro, J.M. / Catarino, C.M. / Moreira Teixeira, L. / Loskill, P. / Alfaro-Moreno, E. / Ribeiro, A.R.

Trends in Biotechnology. 2023 July 05,

2023

Abstract: The skin is the body’s largest organ, continuously exposed to and affected by natural and anthropogenic nanomaterials (materials with external and internal dimensions in the nanoscale range). This broad spectrum of insults gives rise to irreversible ... ...

Abstract	The skin is the body’s largest organ, continuously exposed to and affected by natural and anthropogenic nanomaterials (materials with external and internal dimensions in the nanoscale range). This broad spectrum of insults gives rise to irreversible health effects (from skin corrosion to cancer). Organ-on-chip systems can recapitulate skin physiology with high fidelity and potentially revolutionize the safety assessment of nanomaterials. Here, we review current advances in skin-on-chip models and their potential to elucidate biological mechanisms. Further, strategies are discussed to recapitulate skin physiology on-chip, improving control over nanomaterials exposure and transport across cells. Finally, we highlight future opportunities and challenges from design and fabrication to acceptance by regulatory bodies and industry.
Keywords	biotechnology ; corrosion ; industry ; nanomaterials ; physiology ; safety assessment ; skin-on-chip ; microfluidics ; nanosafety ; standardization
Language	English
Dates of publication	2023-0705
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.05.009
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Article ; Online: Impact of bisphosphonate therapy on dental implant outcomes: An overview of systematic review evidence.

Mendes, V / Dos Santos, G O / Calasans-Maia, M D / Granjeiro, J M / Moraschini, V

International journal of oral and maxillofacial surgery

2018 Volume 48, Issue 3, Page(s) 373–381

Abstract: The purpose of this overview was to assess the methods, quality, and outcomes of systematic reviews conducted to evaluate the impact of bisphosphonates on dental implants and the risk of developing bisphosphonate-related osteonecrosis of the jaw after ... ...

Abstract	The purpose of this overview was to assess the methods, quality, and outcomes of systematic reviews conducted to evaluate the impact of bisphosphonates on dental implants and the risk of developing bisphosphonate-related osteonecrosis of the jaw after dental implant surgery. An electronic search without date or language restriction was performed in the PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, and LILACS databases (to January 2018). Eligibility criteria included systematic reviews that evaluated the impact of bisphosphonates on implant outcomes. The quality assessment of the included reviews was done using AMSTAR 2 guidelines. The protocol of this overview was registered in PROSPERO (CRD42018089617). The search and selection process yielded seven reviews, published between 2009 and 2017. None of the systematic reviews included in this study obtained the maximum score in the quality assessment. The scientific evidence available demonstrates that patients with a history of bisphosphonate use do not present a higher risk of dental implant failure or marginal bone loss compared to patients who have not used bisphosphonates. The literature also suggests that patients who undergo surgical trauma during the installation of dental implants may be more susceptible to bisphosphonate-related osteonecrosis of the jaw.
MeSH term(s)	Humans ; Bisphosphonate-Associated Osteonecrosis of the Jaw/complications ; Bone Density Conservation Agents/adverse effects ; Dental Implantation, Endosseous ; Dental Implants ; Dental Restoration Failure ; Diphosphonates/adverse effects ; Systematic Reviews as Topic
Chemical Substances	Bone Density Conservation Agents ; Dental Implants ; Diphosphonates
Language	English
Publishing date	2018-10-09
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2018.09.006
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Article: Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review.

Lima, Thais S M / Souza, Wanderson / Geaquinto, Luths R O / Sanches, Priscila L / Stepień, Ewa L / Meneses, João / Fernández-de Gortari, Eli / Meisner-Kober, Nicole / Himly, Martin / Granjeiro, José M / Ribeiro, Ana R

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of ... ...

Abstract	The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of extracellular vesicles (EVs), leading to dysfunction in recipient cells. However, there is limited understanding of how the physicochemical characteristics of NMs alter the EV content and their consequent physiological functions. Therefore, this review explored the relevance of EVs in the nanotoxicology field. The current state of the art on how EVs are modulated by NM exposure and the possible regulation and modulation of signaling pathways and physiological responses were assessed in detail. This review followed the manual for reviewers produced by The Joanna Brigs Institute for Scoping Reviews and the PRISMA extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. The research question, "Do NMs modulate cellular responses mediated by EVs?" was analyzed following the PECO model (P (Population) = EVs, E (Exposure) = NMs, C (Comparator) = EVs without exposure to NMs, O (Outcome) = Cellular responses/change in EVs) to help methodologically assess the association between exposure and outcome. For each theme in the PECO acronym, keywords were defined, organized, and researched in PubMed, Science Direct, Scopus, Web of Science, EMBASE, and Cochrane databases, up to 30 September 2021. In vitro, in vivo, ex vivo, and clinical studies that analyzed the effect of NMs on EV biogenesis, cargo, and cellular responses were included in the analysis. The methodological quality assessment was conducted using the ToxRTool, ARRIVE guideline, Newcastle Ottawa and the EV-TRACK platform. The search in the referred databases identified 2944 articles. After applying the eligibility criteria and two-step screening, 18 articles were included in the final review. We observed that depending on the concentration and physicochemical characteristics, specific NMs promote a significant increase in EV secretion as well as changes in their cargo, especially regarding the expression of proteins and miRNAs, which, in turn, were involved in biological processes that included cell communication, angiogenesis, and activation of the immune response, etc. Although further studies are necessary, this work suggests that molecular investigations on EVs induced by NM exposure may become a potential tool for toxicological studies since they are widely accessible biomarkers that may form a bridge between NM exposure and the cellular response and pathological outcome.
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12071231
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Article ; Online: In Vitro and In Vivo Evaluation of Nanostructured Biphasic Calcium Phosphate in Granules and Putty Configurations.

Nascimento, Jhonathan R B / Sartoretto, Suelen C / Alves, Adriana T N N / Mourão, Carlos F A B / Martinez-Zelaya, Victor R / Uzeda, Marcelo J / Granjeiro, José M / Montemezzi, Pietro / Calasans-Maia, Monica D / Calasans-Maia, José A

International journal of environmental research and public health

2021 Volume 18, Issue 2

Abstract: Synthetic biphasic calcium phosphate (BCP) granules and powder are biocompatible biomaterials with a well-known capacity for osteoconduction, presenting very satisfactory clinical and histological results. It remains unanswered if the putty configuration ...

Abstract	Synthetic biphasic calcium phosphate (BCP) granules and powder are biocompatible biomaterials with a well-known capacity for osteoconduction, presenting very satisfactory clinical and histological results. It remains unanswered if the putty configuration impacts the biological response to the material. In this study, we aimed to compare the cytocompatibility and biocompatibility of nanostructured BCP in the putty configuration (moldable nanostructured calcium phosphate, MnCaP) on the healing of critical-sized bone defects (8 mm) in rat calvaria. Cytocompatibility was determined through the viability of fibroblast cells (V-79) to the extracts of different concentrations of MnCaP. Forty-five Wistar rats were randomly divided into three groups (
MeSH term(s)	Animals ; Bone Regeneration ; Bone Substitutes ; Hydroxyapatites ; Rats ; Rats, Wistar
Chemical Substances	Bone Substitutes ; Hydroxyapatites ; hydroxyapatite-beta tricalcium phosphate
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18020533
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Article ; Online: Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients.

de Souza Tesch, R / Ladeira Bonato, L / Quinelato, V / Ladeira Casado, P / Rezende Vieira, A / Granjeiro, J M / Góes, C

International journal of oral and maxillofacial surgery

2019 Volume 49, Issue 2, Page(s) 237–243

Abstract: The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. ... ...

Abstract	The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. Individuals were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders and were divided into three groups: unaffected (no TMD) (n=154); exclusively muscular TMD (n=49); exclusively articular TMD (n=49). Genomic DNA was obtained from saliva samples, and single nucleotide polymorphisms in the COMT (rs165774, rs6269, rs9332377) and ADRB2 (rs2053044, rs1042713, rs1042714) genes were investigated. The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P= 0.03). With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P= 0.05). This study supports the hypothesis that alterations in the COMT and ADRB2 genes influence the muscular pathophysiology.
MeSH term(s)	Brazil ; Case-Control Studies ; Catechol O-Methyltransferase ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Receptors, Adrenergic, beta-2 ; Temporomandibular Joint Disorders
Chemical Substances	ADRB2 protein, human ; Receptors, Adrenergic, beta-2 ; COMT protein, human (EC 2.1.1.6) ; Catechol O-Methyltransferase (EC 2.1.1.6)
Language	English
Publishing date	2019-07-06
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2019.06.027
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Article ; Online: Evaluation of the effects of the solution used for electrochemical dissolution of nickel-titanium endodontic files on dentine structure, microhardness and cell viability.

Amaral, C C F / Ormiga, F / Boldrini, L C / Miranda, P G / Mendonça, T A / Granjeiro, J M / Gomes, J A C P

International endodontic journal

2018 Volume 51, Issue 12, Page(s) 1434–1445

Abstract: Aim: To evaluate the effects of the [NaF 12 g L: Methodology: Sixty single-rooted human teeth were evaluated for dentine microhardness using the Vickers hardness test and the area and number of dentinal tubules by scanning electron microscopy. The ... ...

Abstract	Aim: To evaluate the effects of the [NaF 12 g L Methodology: Sixty single-rooted human teeth were evaluated for dentine microhardness using the Vickers hardness test and the area and number of dentinal tubules by scanning electron microscopy. The samples were divided according to the dentine surface treatment: distilled water; 17% EDTA; [NaF 12 g L Results: The [NaF 12 g L Conclusions: The [NaF 12 g L
MeSH term(s)	Adolescent ; Cell Culture Techniques ; Cell Line ; Cell Survival/drug effects ; Child ; Child, Preschool ; Dentin/drug effects ; Dentin/pathology ; Electrochemical Techniques ; Electrolysis ; Equipment Failure ; Fibroblasts/drug effects ; Hardness ; Humans ; Infant ; Microscopy, Electron, Scanning ; Nickel/chemistry ; Nickel/toxicity ; Root Canal Preparation/instrumentation ; Skin ; Sodium Chloride/pharmacology ; Sodium Fluoride/pharmacology ; Sodium Hypochlorite/pharmacology ; Solubility ; Time Factors ; Titanium/chemistry ; Titanium/toxicity
Chemical Substances	titanium nickelide (12035-60-8) ; Sodium Chloride (451W47IQ8X) ; Nickel (7OV03QG267) ; Sodium Fluoride (8ZYQ1474W7) ; Titanium (D1JT611TNE) ; Sodium Hypochlorite (DY38VHM5OD)
Language	English
Publishing date	2018-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	603734-3
ISSN	1365-2591 ; 0143-2885
ISSN (online)	1365-2591
ISSN	0143-2885
DOI	10.1111/iej.12950
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Article ; Online: The hypertrophic cartilage induction influences the building-block capacity of human adipose stem/stromal cell spheroids for biofabrication.

Kronemberger, Gabriela S / Beatrici, Anderson / Dalmônico, Gisele M L / Rossi, André L / Miranda, Guilherme A S C / Boldrini, Leonardo C / Mauro Granjeiro, José / Baptista, Leandra Santos

Artificial organs

2021 Volume 45, Issue 10, Page(s) 1208–1218

Abstract: As an alternative to the classical tissue engineering approach, bottom-up tissue engineering emerges using building blocks in bioassembly technologies. Spheroids can be used as building blocks to reach a highly complex ordered tissue by their fusion ( ... ...

Abstract	As an alternative to the classical tissue engineering approach, bottom-up tissue engineering emerges using building blocks in bioassembly technologies. Spheroids can be used as building blocks to reach a highly complex ordered tissue by their fusion (bioassembly), representing the foundation of biofabrication. In this study, we analyzed the biomechanical properties and the fusion capacity of human adipose stem/stromal cell (ASC) we spheroids during an in vitro model of hypertrophic cartilage established by our research group. Hypertrophic induced-ASC spheroids showed a statistically significant higher Young's modulus at weeks 2 (P < .001) and 3 (P < .0005) compared with non-induced. After fusion, non-induced and induced-ASC spheroids increased the contact area and decreased their pairs' total length. At weeks 3 and 5, induced-ASC spheroids did not fuse completely, and the cells migrate preferentially in the fusion contact region. Alizarin red O staining showed the highest intensity of staining in the fused induced-ASC spheroids at week 5, together with intense staining for collagen type I and osteocalcin. Transmission electron microscopy and element content analysis (X-ray Energy Dispersive Spectroscopy) revealed in the fused quartet at week 3 a crystal-like structure. Hypertrophic induction interferes with the intrinsic capacity of spheroids to fuse. The measurements of contact between spheroids during the fusion process, together with the change in viscoelastic profile to the plastic, will impact the establishment of bioassembly protocols using hypertrophic induced-ASC spheroids as building blocks in biofabrication.
MeSH term(s)	Adipose Tissue/cytology ; Adipose Tissue/physiology ; Biomechanical Phenomena ; Cartilage/cytology ; Cartilage/growth & development ; Cartilage/ultrastructure ; Cells, Cultured ; Humans ; Hypertrophy ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/physiology ; Microscopy, Electron, Transmission ; Spheroids, Cellular/physiology ; Spheroids, Cellular/ultrastructure ; Stromal Cells/physiology ; Tissue Engineering/methods
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14000
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Article ; Online: Haplotypes of the RANK and OPG genes are associated with chronic arthralgia in individuals with and without temporomandibular disorders.

Bonato, L L / Quinelato, V / Borojevic, R / Vieira, A R / Modesto, A / Granjeiro, J M / Tesch, R / Casado, P L

International journal of oral and maxillofacial surgery

2017 Volume 46, Issue 9, Page(s) 1121–1129

Abstract: The aim of this study was to evaluate the association between genetic polymorphisms and the comorbid presence of chronic systemic arthralgia in patients with articular temporomandibular disorders (TMD). Subjects were evaluated for the presence of TMD and ...

Abstract	The aim of this study was to evaluate the association between genetic polymorphisms and the comorbid presence of chronic systemic arthralgia in patients with articular temporomandibular disorders (TMD). Subjects were evaluated for the presence of TMD and asked about the presence of chronic joint pain. Four groups were included in the study: articular TMD and systemic arthralgia (n=85), no articular TMD and systemic arthralgia (n=82), articular TMD and no systemic arthralgia (n=21), no articular TMD and no systemic arthralgia (control, n=72). A total of 14 single nucleotide polymorphisms in the OPG, RANK, and RANKL genes were investigated. In the statistical analysis, a P-value of <0.05 was considered significant. For the OPG gene, an association was observed between the group with chronic arthralgia and joint TMD and the control group (P=0.04). There was also a tendency towards an association of the haplotype CGCCAA with an increased risk of developing chronic joint pain, even in the absence of TMD (P=0.06). For the RANK gene, the AGTGC haplotype was associated with the lowest risk of presenting chronic joint pain in individuals without TMD (P=0.03). This study supports the hypothesis that changes in the OPG and RANK genes influence the presence of chronic joint pain in individuals with and without TMD.
Language	English
Publishing date	2017-09
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2017.03.034
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