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  1. Article ; Online: The flare phenomenon: still learning after 35 years.

    Fogelman, Ignac

    European journal of nuclear medicine and molecular imaging

    2010  Volume 38, Issue 1, Page(s) 5–6

    MeSH term(s) Bone Neoplasms/diagnosis ; Bone Neoplasms/secondary ; Bone Neoplasms/therapy ; Humans ; Nuclear Medicine/methods ; Prognosis ; Sensitivity and Specificity
    Language English
    Publishing date 2010-09-09
    Publishing country Germany
    Document type Comment ; Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-010-1609-8
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    Zs.A 1227: Show issues Location:
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  2. Article ; Online: Letter from the Guest Editor: Pitfalls and Limitations of Radionuclide and Hybrid Imaging--Part I.

    Gnanasegaran, Gopinath / Fogelman, Ignac

    Seminars in nuclear medicine

    2015  Volume 45, Issue 5, Page(s) 346

    MeSH term(s) Adult ; Child ; Humans ; Multimodal Imaging ; Radionuclide Imaging
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2015.04.003
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  3. Article ; Online: Pitfalls and Limitations of Radionuclide and Hybrid Imaging: Part 2.

    Gnanasegaran, Gopinath / Fogelman, Ignac

    Seminars in nuclear medicine

    2015  Volume 45, Issue 6, Page(s) 480

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Multimodal Imaging/methods ; Positron-Emission Tomography ; Radionuclide Imaging/methods ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2015.07.001
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  4. Book: An atlas of planar and SPECT bone scans

    Fogelman, Ignac / Collier, B. D.

    1989  

    Author's details Ignac Fogelman ; B. David Collier
    Keywords Bone and Bones / radionuclide imaging / atlases ; Tomography, Emission-Computed / atlases ; Skelett ; Röntgendiagnostik ; Knochen
    Subject Röntgenuntersuchung ; Röntgendiagnose ; Röntgendiagnostisches Verfahren ; Bone ; Bones ; Os ; Knochengewebe ; Knochenbau
    Language English
    Size 320 S. : zahlr. Ill., graph. Darst.
    Publisher Dt. Ärzte-Verl
    Publishing place Köln
    Document type Book
    HBZ-ID HT003380520
    ISBN 3-7691-0177-4 ; 978-3-7691-0177-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1989 C 51 order for loan Magazin

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  5. Article: Where now for the management of osteoporosis?

    Fogelman, Ignac

    Hospital medicine (London, England : 1998)

    2005  Volume 66, Issue 5, Page(s) 284–287

    Abstract: Osteoporosis is a metabolic bone disorder, leading to bone fragility and fracture. Recent guidance from the National Institute for Clinical Excellence (NICE) emphasizes the importance of secondary prevention of fragility fractures in postmenopausal women. ...

    Abstract Osteoporosis is a metabolic bone disorder, leading to bone fragility and fracture. Recent guidance from the National Institute for Clinical Excellence (NICE) emphasizes the importance of secondary prevention of fragility fractures in postmenopausal women. What impact can the expanding range of treatments make on the growing and costly burden of osteoporosis?
    MeSH term(s) Calcium/therapeutic use ; Diphosphonates/therapeutic use ; Humans ; Organometallic Compounds/therapeutic use ; Osteoporosis/drug therapy ; Parathyroid Hormone/therapeutic use ; Practice Guidelines as Topic ; Receptors, Estrogen/therapeutic use ; Thiophenes/therapeutic use ; Vitamin D/therapeutic use
    Chemical Substances Diphosphonates ; Organometallic Compounds ; Parathyroid Hormone ; Receptors, Estrogen ; Thiophenes ; strontium ranelate (04NQ160FRU) ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2005-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604229-6
    ISSN 1462-3935 ; 0007-1064
    ISSN 1462-3935 ; 0007-1064
    DOI 10.12968/hmed.2005.66.5.18422
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    Zs.A 651: Show issues Location:
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    Zs.A 1515: Show issues Location:
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  6. Article: Osteoblastic bone metastases in breast cancer: is not seeing believing?

    Fogelman, Ignac

    European journal of nuclear medicine and molecular imaging

    2005  Volume 32, Issue 11, Page(s) 1250–1252

    MeSH term(s) Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Osteoblasts/diagnostic imaging ; Positron-Emission Tomography/methods ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Technetium Tc 99m Medronate/analogs & derivatives
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; technetium Tc 99m hydroxymethylene diphosphonate (72945-61-0) ; Technetium Tc 99m Medronate (X89XV46R07)
    Language English
    Publishing date 2005-11
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 1619-7070 ; 0340-6997
    ISSN (online) 1619-7089
    ISSN 1619-7070 ; 0340-6997
    DOI 10.1007/s00259-005-1869-x
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  7. Article ; Online: Integrated microRNA and mRNA gene expression in peripheral blood mononuclear cells in response to acute psychosocial stress: a repeated-measures within-subject pilot study.

    Jurkiewicz, Magdalena Maria / Mueller-Alcazar, Anett / Moser, Dirk Alexander / Jayatilaka, Indralatha / Mikhailik, Anatoly / Ferri, Jamie / Fogelman, Nia / Canli, Turhan

    BMC research notes

    2021  Volume 14, Issue 1, Page(s) 222

    Abstract: Objective: The impact of psychosocial stress on a variety of negative health outcomes is well documented, with current research efforts directed at possible mechanisms. Here, we focused on a potential mechanism involving differential expression of mRNA ... ...

    Abstract Objective: The impact of psychosocial stress on a variety of negative health outcomes is well documented, with current research efforts directed at possible mechanisms. Here, we focused on a potential mechanism involving differential expression of mRNA and microRNA in response to acute psychosocial stress. We utilized a validated behavioral paradigm, the Trier Social Stress Test (TSST), to induce acute psychosocial stress in a cohort of volunteers. Stress reactivity was assessed repeatedly during the TSST using saliva samples that were analyzed for levels of cortisol. Peripheral blood mononuclear cells were extracted from blood drawn at baseline and at two time points following the stress paradigm. Total RNA was extracted, and mRNA and microRNA microarrays were utilized to assess within-subject changes in gene expression between baseline and the two post-stressor time points.
    Results: For microarray gene expression analysis, we focused on 12 participants who showed a robust cortisol response to the task, as an indicator of robust HPA-axis activation. We discovered a set of mRNAs and miRNAs that exhibited dynamic expression change in response to the TSST in peripheral blood mononuclear cells, further characterizing the link between psychosocial stress and cellular response mechanisms.
    MeSH term(s) Gene Expression ; Humans ; Hydrocortisone ; Leukocytes, Mononuclear ; MicroRNAs/genetics ; Pilot Projects ; RNA, Messenger/genetics ; Saliva ; Stress, Psychological/genetics
    Chemical Substances MicroRNAs ; RNA, Messenger ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-021-05635-3
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  8. Article ; Online: Comparison of ordered-subset expectation maximization and filtered back projection reconstruction based on quantitative outcome from dynamic [18F]NaF PET images.

    Wong, James M / Puri, Tanuj / Siddique, Muhammad Musib / Frost, Michelle L / Moore, Amelia E B / Blake, Glen M / Fogelman, Ignac

    Nuclear medicine communications

    2021  Volume 42, Issue 6, Page(s) 699–706

    Abstract: 18F]NaF PET imaging is a useful tool for measuring regional bone metabolism. However, due to tracer in urine, [18F]NaF PET images of the hip reconstructed using filtered back projection (FBP) frequently show streaking artifacts in slices through the ... ...

    Abstract [18F]NaF PET imaging is a useful tool for measuring regional bone metabolism. However, due to tracer in urine, [18F]NaF PET images of the hip reconstructed using filtered back projection (FBP) frequently show streaking artifacts in slices through the bladder leading to noisy time-activity curves unsuitable for quantification. This study compares differences between quantitative outcomes at the hip derived from images reconstructed using the FBP and ordered-subset expectation maximization (OSEM) methods. Dynamic [18F]NaF PET data at the hip for four postmenopausal women were reconstructed using FBP and nine variations of the OSEM algorithm (all combinations of 1, 5, 15 iterations and 10, 15, 21 subsets). Seven volumes of interest were placed in the hip. Bone metabolism was measured using standardized uptake values, Patlak analysis (Ki-PAT) and Hawkins model Ki-4k. Percentage differences between the standardized uptake values and Ki values from FBP and OSEM images were assessed. OSEM images appeared visually smoother and without the streaking artifacts seen with FBP. However, due to loss of counts, they failed to recover the quantitative values in VOIs close to the bladder, including the femoral head and femoral neck. This was consistent for all quantification methods. Volumes of interest farther from the bladder or larger and receiving greater counts showed good convergence with 5 iterations and 21 subsets. For VOIs close to the bladder, including the femoral neck and femoral head, 15 iterations and 10, 15 or 21 subsets were not enough to obtain OSEM images suitable for measuring bone metabolism and showed no improvement compared to FBP.
    MeSH term(s) Algorithms ; Humans ; Image Processing, Computer-Assisted ; Middle Aged ; Phantoms, Imaging ; Positron-Emission Tomography
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001393
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  9. Article ; Online: Bone: Strontium ranelate does not have an anabolic effect on bone.

    Blake, Glen M / Fogelman, Ignac

    Nature reviews. Endocrinology

    2013  Volume 9, Issue 12, Page(s) 696–697

    Abstract: Strontium ranelate, a therapeutic for osteoporosis, was thought to have a dual mode of action, simultaneously stimulating bone formation and reducing resorption. A recent study casts doubt on this explanation, suggesting instead that it has a mild ... ...

    Abstract Strontium ranelate, a therapeutic for osteoporosis, was thought to have a dual mode of action, simultaneously stimulating bone formation and reducing resorption. A recent study casts doubt on this explanation, suggesting instead that it has a mild suppressive effect on bone formation with little effect on bone resorption.
    MeSH term(s) Anabolic Agents/therapeutic use ; Bone Resorption/drug therapy ; Bone and Bones/drug effects ; Humans ; Osteogenesis/drug effects ; Thiophenes/therapeutic use
    Chemical Substances Anabolic Agents ; Thiophenes ; strontium ranelate (04NQ160FRU)
    Language English
    Publishing date 2013-10-22
    Publishing country England
    Document type News
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/nrendo.2013.210
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  10. Article ; Online: Potato root system development and factors that determine its architecture.

    Joshi, Mukul / Fogelman, Edna / Belausov, Eduard / Ginzberg, Idit

    Journal of plant physiology

    2016  Volume 205, Page(s) 113–123

    Abstract: The potato root system is often characterized as shallow and inefficient, with poor ability to extract water and minerals from the soil. Potato root system architecture (RSA) refers to its 3-dimensional structure as determined by adventitious root (AR) ... ...

    Abstract The potato root system is often characterized as shallow and inefficient, with poor ability to extract water and minerals from the soil. Potato root system architecture (RSA) refers to its 3-dimensional structure as determined by adventitious root (AR) growth and branching through lateral roots (LR). Understanding how the root system develops holds potential to increase plant yield and optimize agricultural land use. Root system development was monitored in greenhouse-grown potato while a root-on-a-plate assay was developed to explore factors that affect AR and LR development. Expression study of LR-related genes was conducted. Transgenic plants carrying DR5:GFP and CycB1:GUS reporter genes were used to monitor auxin signaling and cell division during root primordia formation, respectively. Maximum root development occurred mainly during the 6-week post seed-tuber planting and slowed during the onset of tuberization. AR and LR development was coordinated - a positive correlation was found between the length of AR and LR and between LR length and number. The expression of LR-related genes was higher in LR than in AR. High nitrate levels reduced LR number and length, however ablation of root-cap by high temperature (33°C) or cutting resulted with enhanced formation of LR. Growth conditions affect AR and LR development in potato, determining the final architecture of its root system. The overall results indicate that LR formation in potato follows similar pattern as in model plants, facilitating study and manipulation of its RSA to improve soil exploitation and yield.
    MeSH term(s) Cell Division ; Genes, Reporter ; Hot Temperature ; Indoleacetic Acids/metabolism ; Nitrates/metabolism ; Plant Growth Regulators/metabolism ; Plant Tubers/anatomy & histology ; Plant Tubers/genetics ; Plant Tubers/growth & development ; Plants, Genetically Modified ; Signal Transduction ; Solanum tuberosum/anatomy & histology ; Solanum tuberosum/genetics ; Solanum tuberosum/growth & development
    Chemical Substances Indoleacetic Acids ; Nitrates ; Plant Growth Regulators
    Language English
    Publishing date 2016-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2016.08.014
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