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Article ; Online: Evaluation of a two-step model of opportunistic genomic screening.

Martyn, Melissa / Lee, Ling / Jan, Alli / Lynch, Elly / Weerasuriya, Rona / Kanga-Parabia, Anaita / Gaff, Clara

European journal of human genetics : EJHG

2024

Abstract: Increasing use of diagnostic genomic sequencing is pushing health services to confront the issue of opportunistic genomic screening (OGS). To date, OGS has been offered concomitant with diagnostic testing. In contrast, we piloted a service offering OGS ... ...

Abstract	Increasing use of diagnostic genomic sequencing is pushing health services to confront the issue of opportunistic genomic screening (OGS). To date, OGS has been offered concomitant with diagnostic testing. In contrast, we piloted a service offering OGS after return of diagnostic testing results. Evaluation was designed to provide insights for future models of service and included patient surveys at three time points, semi-structured interviews with genetic counsellors (GCs) and a focus group with medical scientists. Uptake was relatively low: 83 of 200 patients approached (42%) attended the OGS service, with 81 accepting OGS. Whilst many who declined to attend the service cited practical barriers, others gave reasons that indicated this was a considered decision. Despite specific genetic counselling, one third of patients did not understand the scope of re-analysis. Yet after post-test counselling, all respondents with novel pathogenic additional findings (AF) understood the implications and reported relevant follow-up. Recall was high: five months after last contact, 75% recalled being offered OGS without prompting. GC interviews and patient survey responses provide insights into complexities that influence patient support needs, including diagnostic status and AF result type. There was no consensus among patients or professionals about when to offer OGS. There was a clear preference for multiple, flexible methods of information provision; achieving this whilst balancing patient support needs and resource requirements is a challenge requiring further investigation. Decisions about whether, when and how to offer OGS are complex; our study shows the two-step approach warrants further exploration.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-024-01592-0
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Article ; Online: Secondary use of genomic data: patients' decisions at point of testing and perspectives to inform international data sharing.

Martyn, Melissa / Forbes, Emily / Lee, Ling / Kanga-Parabia, Anaita / Weerasuriya, Rona / Lynch, Elly / Gleeson, Penny / Gaff, Clara

European journal of human genetics : EJHG

2024

Abstract: International sharing of genomic data files arising from clinical testing of patients is essential to further improve genomic medicine. Whilst the general public are reluctant to donate DNA for research, the choices patients actually make about sharing ... ...

Abstract	International sharing of genomic data files arising from clinical testing of patients is essential to further improve genomic medicine. Whilst the general public are reluctant to donate DNA for research, the choices patients actually make about sharing their clinical genomic data for future re-use (research or clinical) are unknown. We ascertained the data-sharing choices of 1515 patients having genomic testing for inherited conditions or cancer treatment from clinical consent forms. To understand the experiences and preferences of these patients, surveys were administered after test consent (RR 73%). Almost all patients (98%) consented to share their data. Survey respondents' decision recall was high (90%), but poorer if English was an additional language (p < 0.001). Parents deciding on behalf of children were over-represented amongst data-sharing decliners (p = 0.047) and decliners were more likely to believe that stored data could be easily reidentified (p < 0.001). A quarter of respondents did not know if reidentification would be easy and 44% of them were concerned about this possibility. Of those willing to share data overseas (60%), 23% indicated the recipient researcher's country would affect their decision. Most respondents (89%) desired some ongoing control over research use of their data. Four preliminary data-sharing profiles emerged; their further development could inform tailored patient resources. Our results highlight considerations for establishment of systems to make clinical genomic data files available for reanalysis locally and across borders. Patients' willingness to share their data - and value of the resulting research - should encourage clinical laboratories to consider sharing data systematically for secondary uses.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-023-01531-5
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Article ; Online: Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

Suzanne Fischer / David Creytens / Sofie De Geyter / Elly De Vlieghere / Piet Pattyn / Sarah‐Lee Bekaert / Kaat Durinck / Nadine Van Roy / An Hendrix / Lore Lapeire / Gwen Sys / Olivier De Wever

Clinical and Translational Medicine, Vol 13, Iss 6, Pp n/a-n/a (2023)

2023

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Post-operative minimal residual disease models to study metastatic relapse in soft-tissue sarcoma patient-derived xenografts.

Fischer, Suzanne / Creytens, David / De Geyter, Sofie / De Vlieghere, Elly / Pattyn, Piet / Bekaert, Sarah-Lee / Durinck, Kaat / Van Roy, Nadine / Hendrix, An / Lapeire, Lore / Sys, Gwen / De Wever, Olivier

Clinical and translational medicine

2023 Volume 13, Issue 6, Page(s) e1290

MeSH term(s)	Animals ; Humans ; Neoplasm, Residual ; Heterografts ; Neoplasm Recurrence, Local ; Sarcoma/pathology ; Sarcoma/surgery ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Disease Models, Animal
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Letter
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1290
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Article: Career and life development intervention for non-engaged youth: Evaluating the Hong Kong Benchmarks (Community) Pilot Program.

Ngai, Steven Sek-Yum / Cheung, Chau-Kiu / Zhou, Qiushi / Wang, Lin / Ng, Yuen-Hang / Leung, Winnie Pui-Ching / Yu, Elly Nga-Hin / Wong, Laing-Ming / Tang, Hon-Yin / Lee, Horace Cheuk-Him

Frontiers in psychology

2023 Volume 14, Page(s) 1117251

Abstract: In our study, aimed at examining the effectiveness and impact of the Hong Kong Benchmarks (Community) Pilot Program, a career and life development (CLD) intervention program targeting non-engaged youth (NEY) in Hong Kong, we employed a pretest-posttest ... ...

Abstract	In our study, aimed at examining the effectiveness and impact of the Hong Kong Benchmarks (Community) Pilot Program, a career and life development (CLD) intervention program targeting non-engaged youth (NEY) in Hong Kong, we employed a pretest-posttest quasi-experimental design to compare changes in career-related competencies between a pilot group (
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1117251
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Article ; Online: Cross-sector Collaboration Between Public Health, Healthcare and Social Services Improves Retention: Findings from a Nurse Home Visiting Program.

Williams, Venice Ng / McManus, Beth / Brooks-Russell, Ashley / Yost, Elly / Olds, David Lee / Tung, Gregory Jackson

Prevention science : the official journal of the Society for Prevention Research

2023 Volume 24, Issue 6, Page(s) 1209–1224

Abstract: The study aimed to examine the association between cross-sector collaboration in Nurse-Family Partnership (NFP), a model home visiting program, and participant retention. We used the 2018 NFP Collaboration Survey that measured agency-level collaboration, ...

Abstract	The study aimed to examine the association between cross-sector collaboration in Nurse-Family Partnership (NFP), a model home visiting program, and participant retention. We used the 2018 NFP Collaboration Survey that measured agency-level collaboration, operationalized as relational coordination and structural integration, among nine community provider types (including obstetrics care, substance use treatment, child welfare). This dataset was linked to 2014-2018 NFP program implementation data (n = 36,900). We used random-intercept models with nurse-level random effects to examine the associations between provider-specific collaborations and participant retention adjusting for client, nurse, and agency characteristics. The adjusted models suggest that stronger relational coordination between nurses and substance use treatment providers (OR:1.177, 95% CI: 1.09-1.26) and greater structural integration with child welfare (OR: 1.062, CI: 1.04-1.09) were positively associated with participant retention at birth. Stronger structural integration between other home visiting programs and supplemental nutrition for women, infants, and children was negatively associated with participant retention at birth (OR: 0.985, CI: 0.97-0.99). Structural integration with child welfare remained significantly associated with participant retention at 12-month postpartum (OR: 1.032, CI: 1.01-1.05). In terms of client-level characteristics, clients who were unmarried, African-American, or visited by nurses who ceased NFP employment prior to their infant's birth were more likely to drop out of the NFP program. Older clients and high school graduates were more likely to remain in NFP. Visits by a nurse with a master's degree, agency rurality, and healthcare systems that implement the program were associated with participant retention. Cross-sector collaboration in a home visiting setting that bridges healthcare and addresses social determinants of health has potential to improve participant retention. This study sets the groundwork for future research to explore the implications of collaborative activities between preventive services and community providers.
MeSH term(s)	Infant, Newborn ; Child ; Infant ; Pregnancy ; Humans ; Female ; Public Health ; Social Work ; Child Welfare ; Black or African American ; Delivery of Health Care
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-023-01538-w
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Article ; Online: Career and life development intervention for non-engaged youth

Steven Sek-yum Ngai / Chau-kiu Cheung / Qiushi Zhou / Lin Wang / Yuen-hang Ng / Winnie Pui-ching Leung / Elly Nga-hin Yu / Laing-ming Wong / Hon-yin Tang / Horace Cheuk-him Lee

Frontiers in Psychology, Vol

Evaluating the Hong Kong Benchmarks (Community) Pilot Program

2023 Volume 14

Abstract	In our study, aimed at examining the effectiveness and impact of the Hong Kong Benchmarks (Community) Pilot Program, a career and life development (CLD) intervention program targeting non-engaged youth (NEY) in Hong Kong, we employed a pretest–posttest quasi-experimental design to compare changes in career-related competencies between a pilot group (N = 289) and a comparison group (N = 160). We also conducted five focus group interviews with the leaders of nongovernmental organizations, social workers, NEY, parents, and employers to explore the program’s impacts on the CLD service provisions. Our quantitative results indicate that the piloting group showed greater improvement in two career-related competencies—youth career development competency and career and life development hope—than the comparison group. Meanwhile, our qualitative results suggest both the benefits and difficulties experienced by stakeholders in the program. The findings thus provide preliminary evidence of the Hong Kong Benchmarks (Community) Pilot Program’s positive impacts on NEY and other important stakeholders. The implications of expanding the existing program and theorizing the community-based benchmark approach are also discussed.
Keywords	career and life development intervention ; non-engaged youth ; program evaluation ; school-to-work transition ; career-related competencies ; Psychology ; BF1-990
Subject code	796 ; 300
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies.

Faber, Bart W / Yeoh, Lee M / Kurtovic, Liriye / Mol, Wim E M / Poelert, Martin / Smits, Elly / Rodriguez Garcia, Roberto / Mandalawi-Van der Eijk, Marjolein / van der Werff, Nicole / Voorberg-van der Wel, Annemarie / Remarque, Edmond J / Beeson, James G / Kocken, Clemens H M

Vaccine

2024 Volume 42, Issue 7, Page(s) 1785–1792

Abstract: Plasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system ...

Abstract	Plasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system and poor access to P. vivax sporozoites. The recent generation of Plasmodium falciparum parasites that express a functional P. vivax AMA1 molecule has provided a platform for in vitro evaluation of PvAMA1 as a potential blood stage vaccine. Three so-called PvAMA1 Diversity Covering (DiCo) proteins were designed to assess their potential to induce a functional and broad humoral immune response to the polymorphic PvAMA1 molecule. Rabbits were immunized with the mixture of three, Pichia-produced, PvAMA1 DiCo proteins, as well as with 2 naturally occurring PvAMA1 alleles. For these three groups, the experimental adjuvant raffinose fatty acid sulfate ester (RFASE) was used, while in a fourth group the purified main mono-esterified constituent (RSL10) of this adjuvant was used. Animals immunized with the mixture of the three PvAMA1 DiCo proteins in RFASE showed high anti-PvAMA1 antibody titers against three naturally occurring PvAMA1variants while also high growth-inhibitory capacity was observed against P. falciparum parasites expressing PvAMA1. This supports further clinical development of the PvAMA1 DiCo mixture as a potential malaria vaccine. However, as the single allele PvAMA1 SalI-group showed similar characteristics in antibody titer and inhibition levels as the PvAMA1 DiCo mixture-group, this raises the question whether a mixture is really necessary to overcome the polymorphism in the vaccine candidate. RFASE induced strong humoral responses, as did the animals immunized with the purified component, RSL10. This suggests that RSL10 is the active ingredient. However, one of the RSL10-immunized animal showed a delayed response, necessitating further research into the clinical development of RSL10.
MeSH term(s)	Animals ; Rabbits ; Protozoan Proteins/genetics ; Plasmodium vivax ; Raffinose ; Sulfates ; Membrane Proteins/genetics ; Antigens, Protozoan/genetics ; Adjuvants, Immunologic ; Malaria, Falciparum/prevention & control ; Plasmodium falciparum ; Malaria, Vivax/prevention & control ; Malaria Vaccines ; Parasites ; Antibodies, Protozoan
Chemical Substances	Protozoan Proteins ; Raffinose (N5O3QU595M) ; Sulfates ; Membrane Proteins ; Antigens, Protozoan ; Adjuvants, Immunologic ; Malaria Vaccines ; Antibodies, Protozoan
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.029
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Article ; Online: Bonuses and pitfalls of a paperless drive-through screening and COVID-19: A field report.

Lee, Elly / Mohd Esa, Nurul Yaqeen / Wee, Tong Ming / Soo, Chun Ian

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2020 Volume 54, Issue 1, Page(s) 85–88

Abstract: As the world witnessed the rapid spread of SARS-CoV-2, the World Health Organization has called for governing bodies worldwide to intensify case findings, contact tracing, monitoring, and quarantine or isolation of contacts with COVID-19. Drive-through ( ... ...

Abstract	As the world witnessed the rapid spread of SARS-CoV-2, the World Health Organization has called for governing bodies worldwide to intensify case findings, contact tracing, monitoring, and quarantine or isolation of contacts with COVID-19. Drive-through (DT) screening is a form of case detection which has recently gain preference globally. Proper implementation of this system can help remediate the outbreak.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19/transmission ; Contact Tracing ; Disease Outbreaks/prevention & control ; Epidemiological Monitoring ; Humans ; Mass Screening/methods ; Mass Screening/organization & administration ; Medical Records Systems, Computerized ; Public Health Surveillance ; Quarantine ; Research Report ; SARS-CoV-2/isolation & purification ; World Health Organization
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2020.05.011
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Article ; Online: Gastrointestinal parasites in captive olive baboons in a UK safari park.

Juhasz, Alexandra / Spiers, Elly / Tinsley, Ellie / Chapman, Emma / Shaw, William / Head, Marion / Cunningham, Lucas J / Archer, John / Jones, Sam / Haines, Lee R / Davies Walsh, Naomi / Johnson, Bridget / Quayle, Jen / Jones, Jayne / LaCourse, Elwyn James / Cracknell, Jonathan / Stothard, John Russell

Parasitology

2023 Volume 150, Issue 12, Page(s) 1096–1104

Abstract: From the safety inside vehicles, Knowsley Safari offers visitors a close-up encounter with captive olive baboons. As exiting vehicles may be contaminated with baboon stool, a comprehensive coprological inspection was conducted to address public health ... ...

Abstract	From the safety inside vehicles, Knowsley Safari offers visitors a close-up encounter with captive olive baboons. As exiting vehicles may be contaminated with baboon stool, a comprehensive coprological inspection was conducted to address public health concerns. Baboon stools were obtained from vehicles, and sleeping areas, inclusive of video analysis of baboon–vehicle interactions. A purposely selected 4-day sampling period enabled comparative inspections of 2662 vehicles, with a total of 669 baboon stools examined (371 from vehicles and 298 from sleeping areas). As informed by our pilot study, front-line diagnostic methods were: QUIK-CHEK rapid diagnostic test (RDT) (
MeSH term(s)	Animals ; Humans ; Papio anubis ; Cryptosporidiosis/parasitology ; Parasites ; Pilot Projects ; Cryptosporidium ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/veterinary ; Giardiasis/epidemiology ; Papio/parasitology ; Giardia ; Strongyloides ; Feces/parasitology ; United Kingdom
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182023000823
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