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Book ; Audio / Video: Richard W. Hanson, Ph.D

Hanson, Richard W / Owen, Oliver E

Leonard and Jean Skeggs professor and chairman, Department of Biochemistry, Case Western Reserve University School of Medicine

(Leaders in American medicine video program)

2008

Institution	Alpha Omega Alpha
Author's details	[presented by] Alpha Omega Alpha
Series title	Leaders in American medicine video program
MeSH term(s)	Physicians ; Biomedical Research ; History, 20th Century ; History, 21st Century ; Molecular Biology
Keywords	United States
Language	English
Size	1 videocassette of 1 (Betacam SP) (46 min.) :, sd., col. ;, 1/2 in. ; 1 videodisc of 1 (DVD) (46 min.) :, sd., col. ;, 4 3/4 in.
Publisher	Alpha Omega Alpha
Publishing place	Menlo Park, Calif.
Document type	Book ; Audio / Video
Note	Last inspected: 200304.
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Optical coherence tomography imaging biomarkers associated with neovascular age-related macular degeneration: a systematic review.

Hanson, Rachel L W / Airody, Archana / Sivaprasad, Sobha / Gale, Richard P

Eye (London, England)

2022 Volume 37, Issue 12, Page(s) 2438–2453

Abstract: The aim of this systematic literature review is twofold, (1) detail the impact of retinal biomarkers identifiable via optical coherence tomography (OCT) on disease progression and response to treatment in neovascular age-related macular degeneration ( ... ...

Abstract	The aim of this systematic literature review is twofold, (1) detail the impact of retinal biomarkers identifiable via optical coherence tomography (OCT) on disease progression and response to treatment in neovascular age-related macular degeneration (nAMD) and (2) establish which biomarkers are currently identifiable by artificial intelligence (AI) models and the utilisation of this technology. Following the PRISMA guidelines, PubMed was searched for peer-reviewed publications dated between January 2016 and January 2022. Population: Patients diagnosed with nAMD with OCT imaging. Settings: Comparable settings to NHS hospitals. Study designs: Randomised controlled trials, prospective/retrospective cohort studies and review articles. From 228 articles, 130 were full-text reviewed, 50 were removed for falling outside the scope of this review with 10 added from the author's inventory, resulting in the inclusion of 90 articles. From 9 biomarkers identified; intraretinal fluid (IRF), subretinal fluid, pigment epithelial detachment, subretinal hyperreflective material (SHRM), retinal pigmental epithelial (RPE) atrophy, drusen, outer retinal tabulation (ORT), hyperreflective foci (HF) and retinal thickness, 5 are considered pertinent to nAMD disease progression; IRF, SHRM, drusen, ORT and HF. A number of these biomarkers can be classified using current AI models. Significant retinal biomarkers pertinent to disease activity and progression in nAMD are identifiable via OCT; IRF being the most important in terms of the significant impact on visual outcome. Incorporating AI into ophthalmology practice is a promising advancement towards automated and reproducible analyses of OCT data with the ability to diagnose disease and predict future disease conversion. Systematic review registration: This review has been registered with PROSPERO (registration ID: CRD42021233200).
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Artificial Intelligence ; Retrospective Studies ; Prospective Studies ; Fluorescein Angiography ; Biomarkers ; Macular Degeneration/drug therapy ; Disease Progression ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/complications ; Angiogenesis Inhibitors/therapeutic use
Chemical Substances	Biomarkers ; Angiogenesis Inhibitors
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-022-02360-4
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Article ; Online: Assessing the structure of the posterior visual pathway in bilateral macular degeneration.

Brown, Holly D H / Gale, Richard P / Gouws, André D / Vernon, Richard J W / Airody, Archana / Hanson, Rachel L W / Baseler, Heidi A / Morland, Antony B

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5008

Abstract: Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there remains a ...

Abstract	Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there remains a need to understand how such changes progress over time. To that end we assessed the posterior pathway, characterising the visual cortex and optic radiations over a ~ 2-year period in MD patients and controls. We performed cross-sectional and longitudinal analysis of the former. Reduced cortical thickness and white matter integrity were observed in patients compared to controls, replicating previous findings. While faster, neither the rate of thinning in visual cortex nor the reduction in white matter integrity during the ~ 2-year period reached significance. We also measured cortical myelin density; cross-sectional data showed this was higher in patients than controls, likely as a result of greater thinning of non-myelinated tissue in patients. However, we also found evidence of a greater rate of loss of myelin density in the occipital pole in the patient group indicating that the posterior visual pathway is at risk in established MD. Taken together, our results revealed a broad decline in grey and white matter in the posterior visual pathway in bilateral MD; cortical thickness and fractional anisotropy show hints of an accelerated rate of loss also, with larger effects emerging in the occipital pole.
MeSH term(s)	Humans ; Visual Pathways/diagnostic imaging ; Cross-Sectional Studies ; Magnetic Resonance Imaging ; Occipital Lobe ; White Matter/diagnostic imaging ; Macular Degeneration/diagnostic imaging
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-31819-x
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Article ; Online: Cortical Atrophy Predicts Visual Performance in Long-Term Central Retinal Disease; GCL, pRNFL and Cortical Thickness Are Key Biomarkers.

Hanson, Rachel L W / Baseler, Heidi A / Airody, Archana / Morland, Antony B / Gale, Richard P

Investigative ophthalmology & visual science

2022 Volume 63, Issue 5, Page(s) 35

Abstract: Purpose: The aim of this study was to assess both retinal and cortical structure in a cohort of patients with long-term acquired central retinal disease in order to identify potential disease biomarkers and to explore the relationship between the ... ...

Abstract	Purpose: The aim of this study was to assess both retinal and cortical structure in a cohort of patients with long-term acquired central retinal disease in order to identify potential disease biomarkers and to explore the relationship between the anterior and posterior visual pathways. Methods: Fourteen participants diagnosed with long-term central retinal disease underwent structural assessments of the retina using spectral-domain optical coherence tomography, including macular ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness. Structural magnetic resonance imaging was used to measure visual cortex, including cortical volume of the entire occipital lobe and cortical thickness of the occipital pole and calcarine sulcus, representing the central and peripheral retina, respectively. Results: Mean thickness was significantly reduced in both the macular GCL and the inferior temporal pRNFL across patients. Cortical thickness was significantly reduced in both the occipital pole and calcarine sulcus, representing the central and peripheral retina, respectively. Disease duration significantly correlated with GCL thickness with a large effect size, whereas a medium effect size suggests the possibility that cortical thickness in the occipital pole may correlate with visual acuity. Conclusions: Long-term central retinal disease is associated with significant structural changes to both the retina and the brain. Exploratory analysis suggests that monitoring GCL thickness may be a sensitive biomarker of disease progression and reductions in visual cortical thickness may be associated with reduced visual acuity. Although this study is limited by its heterogeneous population, larger cohort studies would be needed to better establish some of the relationships detected between disease dependent structural properties of the anterior and posterior visual pathway given the effect sizes reported in our exploratory analysis.
MeSH term(s)	Atrophy/pathology ; Biomarkers ; Humans ; Neurodegenerative Diseases/pathology ; Retina/pathology ; Retinal Diseases/pathology ; Retinal Ganglion Cells/pathology
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.63.5.35
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Article ; Online: Improved Structure and Function in Early-Detected Second-Eye Neovascular Age-Related Macular Degeneration: FASBAT/Early Detection of Neovascular Age-Related Macular Degeneration Report 1.

Gale, Richard P / Airody, Archana / Sivaprasad, Sobha / Hanson, Rachel L W / Allgar, Victoria / McKibbin, Martin / Morland, Antony B / Peto, Tunde / Porteous, Mia / Chakravarthy, Usha

Ophthalmology. Retina

2024

Abstract: Purpose: Visual acuity (VA) and structural biomarker assessment before and 24-months after early detection and routine treatment of second-eye involvement with neovascular age-related macular degeneration (nAMD) and additional comparison with the first ... ...

Abstract	Purpose: Visual acuity (VA) and structural biomarker assessment before and 24-months after early detection and routine treatment of second-eye involvement with neovascular age-related macular degeneration (nAMD) and additional comparison with the first eye affected. Design: Prospective, 22-center observational study of participants with unilateral nAMD in the Early Detection of Neovascular AMD (EDNA) study, coenrolled into the Observing Fibrosis, Macular Atrophy and Subretinal Highly Reflective Material, Before and After Intervention with anti-VEGF Treatment (FASBAT) study for an additional 2-year follow-up. Participants: Older adults (> 50 years) with new onset nAMD in the first eye. Methods: Assessment of both eyes with OCT, color fundus photography (CFP), clinic-measured VA, and quality of life (QoL). Main outcome measures: Prevalence of atrophy, subretinal hyperreflective material (SHRM), intraretinal fluid (IRF), subretinal fluid (SRF), and changes in VA over the study duration in both the first and second eyes affected with nAMD. Composite QoL scores over time. Results: Of 431 participants recruited to the FASBAT study, the second eye converted to nAMD in 100 participants at a mean of 18.9 months. Visual acuity was 18 letters better at the time of early diagnosis in the second eye compared with conventional diagnosis in the first eye (72.9 vs. 55.6 letters). Visual acuity remained better in the second eye 24.9 months postconversion, at 69.5 letters compared with 59.7 letters at a similar matched time point in the first eye (18.9 months). A greater proportion of participants had vision > 70 letters in the second eye versus the first eye, 24.9 months postconversion (61 vs. 35). Prevalence of SHRM and IRF was lower in the second eye compared with the first eye 24.9 months postconversion. However, SRF prevalence was greater in the second eye 24.9 months postconversion. The development and progression of total area of atrophy appears similar in both eyes. Mean composite QoL scores increased over time, with a significant correlation between VA for the second eye only 24.9 months postconversion. Conclusion: This study has shown that early detection of exudative AMD in the second eye is associated with reduced prevalence of SHRM and IRF and greater VA, which is significantly correlated with maintained QoL. Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ISSN	2468-6530
ISSN (online)	2468-6530
DOI	10.1016/j.oret.2023.12.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Peer Learning in Radiology: Effect of a Pay-for-Performance Initiative on Clinical Impact and Usage.

Zhao, Anna H / Burk, Kristine S / Enamandram, Sheila S / Hanson, Richard / Boland, Giles W / Khorasani, Ramin

AJR. American journal of roentgenology

2021 Volume 216, Issue 6, Page(s) 1659–1667

Abstract: OBJECTIVE. ...

Abstract	OBJECTIVE.
MeSH term(s)	Clinical Competence/statistics & numerical data ; Diagnostic Errors/prevention & control ; Humans ; Peer Group ; Radiologists/economics ; Radiologists/education ; Radiology/economics ; Radiology/education ; Referral and Consultation ; Reimbursement, Incentive/economics ; Reimbursement, Incentive/statistics & numerical data ; Retrospective Studies
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.20.23253
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Article ; Online: Assessing the structure of the posterior visual pathway in bilateral macular degeneration

Holly D. H. Brown / Richard P. Gale / André D. Gouws / Richard J. W. Vernon / Archana Airody / Rachel L. W. Hanson / Heidi A. Baseler / Antony B. Morland

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there ... ...

Abstract	Abstract Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there remains a need to understand how such changes progress over time. To that end we assessed the posterior pathway, characterising the visual cortex and optic radiations over a ~ 2-year period in MD patients and controls. We performed cross-sectional and longitudinal analysis of the former. Reduced cortical thickness and white matter integrity were observed in patients compared to controls, replicating previous findings. While faster, neither the rate of thinning in visual cortex nor the reduction in white matter integrity during the ~ 2-year period reached significance. We also measured cortical myelin density; cross-sectional data showed this was higher in patients than controls, likely as a result of greater thinning of non-myelinated tissue in patients. However, we also found evidence of a greater rate of loss of myelin density in the occipital pole in the patient group indicating that the posterior visual pathway is at risk in established MD. Taken together, our results revealed a broad decline in grey and white matter in the posterior visual pathway in bilateral MD; cortical thickness and fractional anisotropy show hints of an accelerated rate of loss also, with larger effects emerging in the occipital pole.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Obesity and perioperative adverse events in patients undergoing complex revision surgery for the thoracolumbar spine.

Hirase, Takashi / Ling, Jeremiah F / Haghshenas, Varan / Fuld, Richard / Dong, David / Hanson, Darrell S / Meyer, B Christoph / Marco, Rex A W

BMC musculoskeletal disorders

2022 Volume 23, Issue 1, Page(s) 534

Abstract: Background: There are no previous studies that evaluate the effect of obesity on patients undergoing complex revision thoracolumbar spine surgery. The primary objective was to determine the relationship between obesity and perioperative adverse events ( ... ...

Abstract	Background: There are no previous studies that evaluate the effect of obesity on patients undergoing complex revision thoracolumbar spine surgery. The primary objective was to determine the relationship between obesity and perioperative adverse events (AEs) with patients undergoing complex revision thoracolumbar spine surgery while controlling for psoas muscle index (PMI) as a confounding variable. The secondary objective was to determine the relationship between obesity and 30-day readmission rates, 30-day re-operation rates, rate of discharge to a facility, and post-operative length of stay (LOS). Methods: Between May 2016 and February 2020, a retrospective analysis of individuals undergoing complex revision surgery of the thoracolumbar spine was performed at a single institution. Obesity was defined as BMI ≥ 30.0 kg/m Results: A total of 114 consecutive patients were included in the study. Fifty-four patients were in the obese cohort and 60 patients in the non-obese cohort. There was not a significant difference in perioperative outcomes of both the obese and non-obese patients. There were 22 obese patients (40.7%) and 33 non-obese patients (55.0%) that experienced any AE (p = 0.130). Multivariable analysis demonstrated that individuals with low muscle mass had a significantly higher likelihood for an AE than individuals with normal or high muscle mass (OR: 7.53, 95% CI: 3.05-18.60). Obesity did not have a significant effect in predicting AEs. Conclusions: Obesity is not associated with perioperative AEs, 30-day readmission rates, 30-day re-operation rates, rate of discharge to a facility, or post-operative length of stay (LOS) among patients undergoing complex revision thoracolumbar spine surgery. Level of evidence: III.
MeSH term(s)	Female ; Humans ; Male ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation ; Retrospective Studies ; Spine/surgery
Language	English
Publishing date	2022-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-022-05505-4
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Article ; Online: Thematic minireview series: a perspective on the biology of phosphoenolpyruvate carboxykinase 55 years after its discovery.

Hanson, Richard W

The Journal of biological chemistry

2009 Volume 284, Issue 40, Page(s) 27021–27023

MeSH term(s)	Animals ; Gene Expression Regulation, Enzymologic ; Humans ; Phosphoenolpyruvate Carboxykinase (GTP)/chemistry ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Transcription, Genetic
Chemical Substances	Phosphoenolpyruvate Carboxykinase (GTP) (EC 4.1.1.32)
Language	English
Publishing date	2009-07-27
Publishing country	United States
Document type	Introductory Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.R109.040519
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Article ; Online: The Characteristics and Clinical Course of Patients with Scrub Typhus and Queensland Tick Typhus Infection Requiring Intensive Care Unit Admission: A 23-year Case Series from Queensland, Tropical Australia.

Bagshaw, Richard J / Stewart, Alexandra G A / Smith, Simon / Carter, Angus W / Hanson, Josh

The American journal of tropical medicine and hygiene

2020 Volume 103, Issue 6, Page(s) 2472–2477

Abstract: Scrub typhus and Queensland tick typhus (QTT)-rickettsial infections endemic to tropical Australia-can cause life-threatening disease. This retrospective study examined the clinical course of all patients with laboratory-confirmed scrub typhus or QTT ... ...

Abstract	Scrub typhus and Queensland tick typhus (QTT)-rickettsial infections endemic to tropical Australia-can cause life-threatening disease. This retrospective study examined the clinical course of all patients with laboratory-confirmed scrub typhus or QTT admitted to the intensive care unit (ICU) of a tertiary referral hospital in tropical Australia between 1997 and 2019. Of the 22 patients, 13 had scrub typhus and nine had QTT. The patients' median (interquartile range [IQR]) age was 50 (38-67) years; 14/22 (64%) had no comorbidity. Patients presented a median (IQR) of seven (5-10) days after symptom onset. Median (IQR) Acute Physiology and Chronic Health Evaluation II scores were 13 (9-17) for scrub typhus and 13 (10-15) for QTT cases (
MeSH term(s)	APACHE ; Acute Kidney Injury/etiology ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Amputation ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Cohort Studies ; Doxycycline/therapeutic use ; Female ; Fluid Therapy/methods ; Hospitalization ; Humans ; Hypotension/etiology ; Hypotension/physiopathology ; Hypotension/therapy ; Hypoxia/etiology ; Hypoxia/physiopathology ; Hypoxia/therapy ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Multiple Organ Failure/etiology ; Multiple Organ Failure/physiopathology ; Multiple Organ Failure/therapy ; Organ Dysfunction Scores ; Purpura Fulminans/etiology ; Purpura Fulminans/physiopathology ; Queensland/epidemiology ; Renal Replacement Therapy/methods ; Respiration, Artificial/methods ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/physiopathology ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Scrub Typhus/complications ; Scrub Typhus/physiopathology ; Scrub Typhus/therapy ; Spotted Fever Group Rickettsiosis/complications ; Spotted Fever Group Rickettsiosis/physiopathology ; Spotted Fever Group Rickettsiosis/therapy ; Tertiary Care Centers ; Vasoconstrictor Agents/therapeutic use ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Vasoconstrictor Agents ; Azithromycin (83905-01-5) ; Doxycycline (N12000U13O)
Language	English
Publishing date	2020-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0780
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