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Article ; Online: Comparison of active tuberculosis occurrence associated with Janus kinase inhibitors and biological DMARDs in rheumatoid arthritis.

Song, Yun-Kyoung / Lee, Jaehee / Jo, Junwoo / Kwon, Jin-Won

2024 Volume 10, Issue 2

Abstract: Objectives: This study aimed to evaluate the risk of tuberculosis associated with the use of Janus kinase (JAK) inhibitors or biological disease-modifying antirheumatic drugs (bDMARDs) in patients diagnosed with rheumatoid arthritis (RA) in South Korea.! ...

Abstract	Objectives: This study aimed to evaluate the risk of tuberculosis associated with the use of Janus kinase (JAK) inhibitors or biological disease-modifying antirheumatic drugs (bDMARDs) in patients diagnosed with rheumatoid arthritis (RA) in South Korea. Methods: In this nationwide matched-cohort study, we retrospectively identified adult patients with new-onset RA from the National Health Insurance Service database who were prescribed bDMARDs or JAK inhibitors and recently underwent latent tuberculosis infection (LTBI) screening during 2012‒2021, and followed them up until the end of 2022 for the development of active tuberculosis. HRs were estimated using Cox proportional hazards regression in a propensity score-matched cohort. Results: Among 16 760 matched patients with RA (3352 JAK inhibitor users and 13 408 bDMARD users), 18.8% received tuberculosis preventive therapy for LTBI. Overall, JAK inhibitor users had a significantly lower risk of tuberculosis than bDMARD users (HR (95% CI)=0.37 (0.22 to 0.62)). Among the patients treated for LTBI, patients with low treatment adherence had a significantly higher risk than those without LTBI (HR (95% CI)=2.78 (1.74 to 4.44)). Patients without LTBI and using JAK inhibitors had a significantly lower risk of tuberculosis across all ages and sexes compared with bDMARD users. Conclusion: Patients with RA using JAK inhibitors have a significantly lower risk of active tuberculosis than bDMARD users in South Korea; however, patients with RA having LTBI are equally at risk regardless of the treatment received (JAK inhibitor vs bDMARD). Therefore, vigilant tuberculosis monitoring, especially in patients with low adherence to tuberculosis preventive therapy, is essential.
MeSH term(s)	Adult ; Humans ; Janus Kinase Inhibitors/adverse effects ; Cohort Studies ; Retrospective Studies ; Tuberculosis/epidemiology ; Tuberculosis/etiology ; Tuberculosis/prevention & control ; Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology
Chemical Substances	Janus Kinase Inhibitors ; Antirheumatic Agents
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003946
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The relative importance of friendship to happiness increases with age.

Song, Inmyung / Kwon, Jin-Won / Jeon, Soo Min

PloS one

2023 Volume 18, Issue 7, Page(s) e0288095

Abstract: Happiness is predicted by social relationships in general and contact frequency in particular. This study aims to examine if the relative importance of social contacts with the closest family/relative, friend, and neighbor in happiness changes with ... ...

Abstract	Happiness is predicted by social relationships in general and contact frequency in particular. This study aims to examine if the relative importance of social contacts with the closest family/relative, friend, and neighbor in happiness changes with advancing age. We used data for all participants aged 19 years and older (n = 229,099) in the 2019 Community Health Survey, which measured the frequency of contact with the closest relative/family, neighbor, and friend among a representative sample of Koreans between August 16 and October 31, 2019. The Shapley value decomposition method was used to measure the relative importance of each predictor of happiness. Overall, contact frequency was positively associated with happiness (p<0.001). The relative importance value of contact with the closest family, neighbor, and friend to happiness increased from 4.70%, 3.98%, and 7.35%, respectively, in the 19-29 years group to 8.09%, 4.44%, and 11.00%, respectively, in the 60 years and older group. Frequent interactions with the closest friend could have a greater impact on happiness in old age than those with the closest family and neighbor.
MeSH term(s)	Humans ; Friends ; Happiness ; Interpersonal Relations ; Surveys and Questionnaires ; Health Surveys
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288095
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Article: Cardiovascular risk of Janus kinase inhibitors compared with biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis without underlying cardiovascular diseases: a nationwide cohort study.

Song, Yun-Kyoung / Lee, Gaeun / Hwang, Jinseub / Kim, Ji-Won / Kwon, Jin-Won

Frontiers in pharmacology

2023 Volume 14, Page(s) 1165711

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1165711
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Article ; Online: Factors Associated With People's Accessibility to Mental Healthcare Services in Ukraine: Focusing on Household Head Vulnerability.

Heo, Min-Hee / Song, Eun-Mi / Jeon, Hui-Won / Kim, Kyoung-Beom / Noh, Jin-Won

International journal of public health

2023 Volume 68, Page(s) 1605890

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Humans ; Health Services Accessibility ; Ukraine ; Mental Health Services ; Family Characteristics ; Health Expenditures
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2274130-6
ISSN	1661-8564 ; 1661-8556
ISSN (online)	1661-8564
ISSN	1661-8556
DOI	10.3389/ijph.2023.1605890
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Article ; Online: Performance of Cardiovascular Risk Prediction Models in Korean Patients With New-Onset Rheumatoid Arthritis: National Cohort Study.

Kim, Jae Hyun / Lee, Gaeun / Hwang, Jinseub / Kim, Ji-Won / Kwon, Jin-Won / Song, Yun-Kyoung

Journal of the American Heart Association

2023 , Page(s) e030604

Abstract: Background: This study aimed to compare the performance of established cardiovascular risk algorithms in Korean patients with new-onset rheumatoid arthritis.: Methods and results: This retrospective cohort study identified patients newly diagnosed ... ...

Abstract	Background: This study aimed to compare the performance of established cardiovascular risk algorithms in Korean patients with new-onset rheumatoid arthritis. Methods and results: This retrospective cohort study identified patients newly diagnosed with rheumatoid arthritis without a history of cardiovascular diseases between 2013 and 2019 using the National Health Insurance Service database. The cohort was followed up until 2020 for the development of the first major adverse cardiovascular event. General cardiovascular risk prediction algorithms, such as the systematic coronary risk evaluation model, the Korean risk prediction model for atherosclerotic cardiovascular diseases, the American College of Cardiology/American Heart Association pooled equations, and the Framingham Risk Score, were used. The discrimination and calibration of cardiovascular risk prediction models were evaluated. Hazard ratios were estimated using Cox proportional hazards regression. A total of 611 patients among 24 889 patients experienced a major adverse cardiovascular event during follow-up. The median 10-year atherosclerotic cardiovascular diseases risk score was significantly higher in patients with major adverse cardiovascular events than those without. The C-statistics of risk algorithms ranged between 0.72 and 0.74. Compared with the low-risk group, the actual risk of developing major adverse cardiovascular events increased significantly in the intermediate- and high-risk groups for all algorithms. However, the risk predictions calculated from all algorithms overestimated the observed cardiovascular risk in the middle to high deciles, and only the systematic coronary risk evaluation algorithm showed comparable observed and predicted event rates in the low-intermediate deciles with the highest sensitivity. Conclusions: The systematic coronary risk evaluation model algorithm and the general risk prediction models discriminated patients with rheumatoid arthritis appropriately. However, overestimation should be considered when applying the cardiovascular risk prediction model in Korean patients.
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.030604
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Article ; Online: Current status and needs in the primary healthcare system in Yangon, Myanmar: a mixed-method evaluation.

Moon, Jihyun / Kang, Su Jin / Kwon, Young Dae / Song, Eun-Mi / Noh, Jin-Won

Primary health care research & development

2023 Volume 24, Page(s) e37

Abstract: Background: Many low- and middle-income countries and international organisations have invested resources to strengthen primary health care (PHC). This study aimed to identify the challenges and unmet needs in the current PHC by assessing the ... ...

Abstract	Background: Many low- and middle-income countries and international organisations have invested resources to strengthen primary health care (PHC). This study aimed to identify the challenges and unmet needs in the current PHC by assessing the experiences and perceptions of healthcare workers in three townships (Htan Ta Pin, Hmawbi, and Taikkyi) in Yangon, Myanmar. Methods: The study was conducted among healthcare professionals and community leaders in three townships. Adopting a mixed-method approach, a cross-sectional health needs assessment survey was conducted for quantitative data ( Findings: Enhancing the management and leadership capacity had the lowest average score on the current achievement (2.81 out of 5 ratings) while strengthening infectious disease control service and accessibility was perceived as the highest mean on the priority of intervention (4.28) and the impact of the intervention (4.7). The FGDs revealed that while specific infrastructures and equipment were reported insufficient and necessary, the need for financial support has been the recurrent theme throughout the discussions. Interpretation: Utilising the World Health Organisation's six building block frameworks, our findings suggest that a long-term targeted financial investment in the PHC system is critical in Myanmar through increasing healthcare expenditure per capita.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Myanmar ; Delivery of Health Care ; Health Personnel ; Primary Health Care
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2027892-5
ISSN	1477-1128 ; 1477-1128
ISSN (online)	1477-1128
ISSN	1477-1128
DOI	10.1017/S1463423623000178
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Article: Potential Adverse Events Reported With the Janus Kinase Inhibitors Approved for the Treatment of Rheumatoid Arthritis Using Spontaneous Reports and Online Patient Reviews.

Song, Yun-Kyoung / Song, Junu / Kim, Kyungim / Kwon, Jin-Won

Frontiers in pharmacology

2022 Volume 12, Page(s) 792877

Abstract: The aim of this study was to analyze the potential adverse events (AEs) caused by Janus kinase (JAK) inhibitors, including tofacitinib, baricitinib, and upadacitinib, used to treat rheumatoid arthritis using spontaneous AE reports from the FDA (FAERS) ... ...

Abstract	The aim of this study was to analyze the potential adverse events (AEs) caused by Janus kinase (JAK) inhibitors, including tofacitinib, baricitinib, and upadacitinib, used to treat rheumatoid arthritis using spontaneous AE reports from the FDA (FAERS) and interpreting them in correlation with those from Korea (KAERS) and an online patient review (WebMD). Potential AEs were identified based on a disproportionality analysis using the proportional reporting ratio (PRR), reporting odds ratio (ROR), and the information component (IC). A total of 23,720 reports were analyzed from FAERS database, of which 91.5% were reports on tofacitinib. Potentially important medical AEs related to infections were reported frequently, as well as thromboembolism-related AEs. The AEs, such as malignancy, interstitial lung diseases, myocardial infarction, and gastrointestinal disorder, also reported. In an online patient review report, the ineffectiveness of the drug and gastrointestinal AEs were frequently reported. Infection with baricitinib and symptoms related to pain or edema due to upadacitinib were the main discomfort experienced by patients. In conclusion, the results of this study highlight the possible safety issues associated with JAK inhibitors. Routine clinical observations and further research using various real-world databases are needed.
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.792877
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Article ; Online: A Development of Rapid Whole-Genome Sequencing of

Park, Kyungmin / Noh, Juyoung / Kim, Kijin / Kim, Jongwoo / Cho, Hee-Kyung / Kim, Seong-Gyu / Yang, Eunyoung / Kim, Won-Keun / Song, Jin-Won

Viruses

2023 Volume 15, Issue 7

Abstract: Whole-genome sequencing provides a robust platform for investigating the epidemiology and transmission of emerging viruses. Oxford Nanopore Technologies allows for real-time viral sequencing on a local laptop system for point-of-care testing. ...

Abstract	Whole-genome sequencing provides a robust platform for investigating the epidemiology and transmission of emerging viruses. Oxford Nanopore Technologies allows for real-time viral sequencing on a local laptop system for point-of-care testing.
MeSH term(s)	Animals ; Rats ; Seoul virus/genetics ; Nanopores ; Seoul ; Hemorrhagic Fever with Renal Syndrome/diagnosis ; Hemorrhagic Fever with Renal Syndrome/epidemiology ; Orthohantavirus
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15071542
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Article ; Online: Comparison of Online Patient Reviews and National Pharmacovigilance Data for Tramadol-Related Adverse Events: Comparative Observational Study.

Park, Susan / Choi, So Hyun / Song, Yun-Kyoung / Kwon, Jin-Won

JMIR public health and surveillance

2022 Volume 8, Issue 1, Page(s) e33311

Abstract: Background: Tramadol is known to cause fewer adverse events (AEs) than other opioids. However, recent research has raised concerns about various safety issues.: Objective: We aimed to explore these new AEs related to tramadol using social media and ... ...

Abstract	Background: Tramadol is known to cause fewer adverse events (AEs) than other opioids. However, recent research has raised concerns about various safety issues. Objective: We aimed to explore these new AEs related to tramadol using social media and conventional pharmacovigilance data. Methods: This study used 2 data sets, 1 from patients' drug reviews on WebMD (January 2007 to January 2021) and 1 from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS; January 2016 to December 2020). We analyzed 2062 and 29,350 patient reports from WebMD and FAERS, respectively. Patient posts on WebMD were manually assigned the preferred terms of the Medical Dictionary for Regulatory Activities. To analyze AEs from FAERS, a disproportionality analysis was performed with 3 measures: proportional reporting ratio, reporting odds ratio, and information component. Results: From the 869 AEs reported, we identified 125 new signals related to tramadol use not listed on the drug label that satisﬁed all 3 signal detection criteria. In addition, 20 serious AEs were selected from new signals. Among new serious AEs, vascular disorders had the largest signal detection criteria value. Based on the disproportionality analysis and patients' symptom descriptions, tramadol-induced pain might also be an unexpected AE. Conclusions: This study detected several novel signals related to tramadol use, suggesting newly identified possible AEs. Additionally, this study indicates that unexpected AEs can be detected using social media analysis alongside traditional pharmacovigilance data.
MeSH term(s)	Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Humans ; Pharmacovigilance ; Tramadol/adverse effects ; United States/epidemiology ; United States Food and Drug Administration
Chemical Substances	Tramadol (39J1LGJ30J)
Language	English
Publishing date	2022-01-04
Publishing country	Canada
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/33311
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Article ; Online: VirPipe: an easy-to-use and customizable pipeline for detecting viral genomes from Nanopore sequencing.

Kim, Kijin / Park, Kyungmin / Lee, Seonghyeon / Baek, Seung-Hwan / Lim, Tae-Hun / Kim, Jongwoo / Manavalan, Balachandran / Song, Jin-Won / Kim, Won-Keun

Bioinformatics (Oxford, England)

2023 Volume 39, Issue 5

Abstract: Detection and analysis of viral genomes with Nanopore sequencing has shown great promise in the surveillance of pathogen outbreaks. However, the number of virus detection pipelines supporting Nanopore sequencing is very limited. Here, we present VirPipe, ...

Abstract	Detection and analysis of viral genomes with Nanopore sequencing has shown great promise in the surveillance of pathogen outbreaks. However, the number of virus detection pipelines supporting Nanopore sequencing is very limited. Here, we present VirPipe, a new pipeline for the detection of viral genomes from Nanopore or Illumina sequencing input featuring streamlined installation and customization. Availability and implementation: VirPipe source code and documentation are freely available for download at https://github.com/KijinKims/VirPipe, implemented in Python and Nextflow.
MeSH term(s)	Nanopore Sequencing ; Software ; Genome, Viral ; Nanopores ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btad293
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