LIVIVO - Search results -

Search results

Result 1 - 10 of total 98

Search options

Article: Human infections by Bornaviruses: are they real?

Gonzalez-Dunia, Daniel / Bourgade, Karine

2022 Volume 26, Issue 4, Page(s) 275–281

Abstract: The reality of human infections by Bornaviridae (and particularly by mammalian Orthobornaviruses BoDV-1 and BoDV-2) has long been the centre of debate and controversies. New data, however, have profoundly modified the game by providing strong and ... ...

Title translation	Quelle est la réalité des infections humaines par les Bornavirus ?
Abstract	The reality of human infections by Bornaviridae (and particularly by mammalian Orthobornaviruses BoDV-1 and BoDV-2) has long been the centre of debate and controversies. New data, however, have profoundly modified the game by providing strong and unambiguous pieces of evidence, even if many points still need to be clarified. This review aims at presenting the current state of the question, based on today’s knowledge.
MeSH term(s)	Animals ; Bornaviridae/genetics ; Humans ; Mammals ; RNA, Viral
Chemical Substances	RNA, Viral
Language	French
Publishing date	2022-09-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2022.0965
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Real-Time and High-Resolution Monitoring of Neuronal Electrical Activity and pH Variations Based on the Co-Integration of Nanoelectrodes and Chem-FinFETs.

Bettamin, Luca / Mathieu, Fabrice / Marty, Florent H / Blatche, Marie Charline / Gonzalez-Dunia, Daniel / Suberbielle, Elsa / Larrieu, Guilhem

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2309055

Abstract: Developing new approaches amenable to the measurement of neuronal physiology in real-time is a very active field of investigation, as it will offer improved methods to assess the impact of diverse insults on neuronal homeostasis. Here, the development of ...

Abstract	Developing new approaches amenable to the measurement of neuronal physiology in real-time is a very active field of investigation, as it will offer improved methods to assess the impact of diverse insults on neuronal homeostasis. Here, the development of an in vitro bio platform is reported which can record the electrical activity of cultured primary rat cortical neurons with extreme sensitivity, while simultaneously tracking the localized changes in the pH of the culture medium. This bio platform features passive vertical nanoprobes with ultra-high signal resolution (several mV amplitude ranges) and Chem-FinFETs (pH sensitivity of sub-0.1 pH units), covering an area as little as a neuronal soma. These multi-sensing units are arranged in an array to probe both chemically and electrically an equivalent surface of ≈ 0.5 mm
Language	English
Publishing date	2024-03-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202309055
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Bornavirus et cellules cibles : une amitié presque sincère.

Charlier, Caroline M / Gonzalez-Dunia, Daniel / Malnou, Cécile E

Virologie (Montrouge, France)

2020 Volume 18, Issue 4, Page(s) 187–200

Abstract: Viruses have to meet the challenge to cope with the limited capacity of renewal of neuronal cells in order to allow their replication and persistence in the central nervous system (CNS). Accordingly, many neurotropic viruses establish latency to optimize ...

Title translation	Bornavirus et cellules cibles : une amitié presque sincère.
Abstract	Viruses have to meet the challenge to cope with the limited capacity of renewal of neuronal cells in order to allow their replication and persistence in the central nervous system (CNS). Accordingly, many neurotropic viruses establish latency to optimize their maintenance in the CNS. Bornaviruses have evolved a different and original strategy to persist in neurons, which involves an active replication without associated cytopathic effect. Despite their small genomes and limited number of proteins, bornaviruses hijack multiple signaling pathways, leading to escape from immune surveillance or protection of cells against apoptosis. Long term persistence has even led to integration of genome elements within the host cell genome, leading to "fossil bornaviruses" in a wide range of vertebrate species. Hence, bornaviruses represent the ideal host-cell adaptation example and can thus be considered as the "best enemy" for its hosts.
Language	English
Publishing date	2020-09-11
Publishing country	France
Document type	Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2014.0574
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus.

Volmer, Romain / Bajramovic, Jeffrey J / Schneider, Urs / Ufano, Sandra / Pochet, Sylvie / Gonzalez-Dunia, Daniel

Journal of virology

2005 Volume 79, Issue 7, Page(s) 4514–4518

Abstract: ... D-arabinofuranosylcytosine (Ara-C) was a potent inhibitor of BDV. This finding was surprising ...

Abstract	Borna disease virus (BDV) is a nonsegmented, negative-stranded RNA virus that causes neurological diseases in a variety of warm-blooded animal species. Recently, we showed that the nucleoside analog 1-beta-D-arabinofuranosylcytosine (Ara-C) was a potent inhibitor of BDV. This finding was surprising for an RNA virus, since Ara-C is a DNA polymerase inhibitor. Thus, we sought to better define the mechanism of action of Ara-C on BDV. Here, we show that (i) this effect is specific for an arabinoside ring carrying a cytosine base, (ii) it requires phosphorylation of the nucleotide, and (iii) it can be reversed by an excess of cytidine. Using the recently described minigenome assay for BDV, we provide evidence suggesting that Ara-C may act as a competitive inhibitor of the BDV replication complex.
MeSH term(s)	Antiviral Agents/pharmacology ; Borna disease virus/drug effects ; Borna disease virus/physiology ; Cytarabine/pharmacology ; Enzyme Inhibitors/pharmacology ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Enzyme Inhibitors ; Cytarabine (04079A1RDZ)
Language	English
Publishing date	2005-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.79.7.4514-4518.2005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 609: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.

Marty, Florent Henri / Bettamin, Luca / Thouard, Anne / Bourgade, Karine / Allart, Sophie / Larrieu, Guilhem / Malnou, Cécile Evelyne / Gonzalez-Dunia, Daniel / Suberbielle, Elsa

iScience

2021 Volume 25, Issue 1, Page(s) 103621

Abstract: Borna disease viruses (BoDV) have recently emerged as zoonotic neurotropic pathogens. These persistent RNA viruses assemble nuclear replication centers (vSPOT) in close interaction with the host chromatin. However, the topology of this interaction and ... ...

Abstract	Borna disease viruses (BoDV) have recently emerged as zoonotic neurotropic pathogens. These persistent RNA viruses assemble nuclear replication centers (vSPOT) in close interaction with the host chromatin. However, the topology of this interaction and its consequences on neuronal function remain unexplored. In neurons, DNA double-strand breaks (DSB) have been identified as novel epigenetic mechanisms regulating neurotransmission and cognition. Activity-dependent DSB contribute critically to neuronal plasticity processes, which could be impaired upon infection. Here, we show that BoDV-1 infection, or the singled-out expression of viral Nucleoprotein and Phosphoprotein, increases neuronal DSB levels. Of interest, inducing DSB promoted the recruitment anew of vSPOT colocalized with DSB and increased viral RNA replication. BoDV-1 persistence decreased neuronal activity and response to stimulation by dampening the surface expression of glutamate receptors. Taken together, our results propose an original mechanistic cross talk between persistence of an RNA virus and neuronal function, through the control of DSB levels.
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.103621
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Fatal encephalitis and Borna Disease Virus-1 seropositivity in two kidney-transplant patients living in the same nonendemic area.

Bourgade, Karine / Thouard, Anne / Abravanel, Florence / Hebral, Anne-Laure / Del Bello, Arnaud / Viguier, Alain / Gonzalez-Dunia, Daniel / Kamar, Nassim

Transplant infectious disease : an official journal of the Transplantation Society

2021 Volume 23, Issue 6, Page(s) e13734

MeSH term(s)	Animals ; Borna disease virus ; Encephalitis ; Humans ; Kidney ; Zoonoses
Language	English
Publishing date	2021-12-14
Publishing country	Denmark
Document type	Letter ; Comment
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13734
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5100: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread.

Bajramovic, Jeffrey J / Syan, Sylvie / Brahic, Michel / de la Torre, Juan Carlos / Gonzalez-Dunia, Daniel

Journal of virology

2002 Volume 76, Issue 12, Page(s) 6268–6276

Abstract: ... beta-D-arabinofuranosylcytosine (Ara-C), a known inhibitor of DNA polymerases, inhibits BDV replication ...

Abstract	Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial, experimental BDV infection is a well-described model for human neuropsychiatric diseases. To date, there is no effective treatment against BDV. In this paper, we demonstrate that the nucleoside analog 1-beta-D-arabinofuranosylcytosine (Ara-C), a known inhibitor of DNA polymerases, inhibits BDV replication. Ara-C treatment inhibited BDV RNA and protein synthesis and prevented BDV cell-to-cell spread in vitro. Replication of other negative-strand RNA viruses such as influenza virus or measles virus was not inhibited by Ara-C, underscoring the particularity of the replication machinery of BDV. Strikingly, Ara-C treatment induced nuclear retention of viral ribonucleoparticles. These findings could not be attributed to known effects of Ara-C on the host cell, suggesting that Ara-C directly inhibits the BDV polymerase. Finally, we show that Ara-C inhibits BDV replication in vivo in the brain of infected rats, preventing persistent infection of the central nervous system as well as the development of clinical disease. These findings open the way to the development of effective antiviral therapy against BDV.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Borna Disease/drug therapy ; Borna Disease/transmission ; Borna Disease/virology ; Borna disease virus/drug effects ; Borna disease virus/physiology ; Cell Line ; Chlorocebus aethiops ; Cytarabine/pharmacology ; Cytarabine/therapeutic use ; Hippocampus/cytology ; Hippocampus/drug effects ; Hippocampus/virology ; Neurons/drug effects ; Neurons/virology ; Rats ; Rats, Inbred Lew ; Vero Cells ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Cytarabine (04079A1RDZ)
Language	English
Publishing date	2002-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.76.12.6268-6286.2002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 609: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.

Tarbouriech, Nicolas / Chenavier, Florian / Kawasaki, Junna / Bachiri, Kamel / Bourhis, Jean-Marie / Legrand, Pierre / Freslon, Lily L / Laurent, Estelle M N / Suberbielle, Elsa / Ruigrok, Rob W H / Tomonaga, Keizo / Gonzalez-Dunia, Daniel / Horie, Masayuki / Coyaud, Etienne / Crépin, Thibaut

Viruses

2022 Volume 14, Issue 11

Abstract: Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a ...

Abstract	Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a significant threat to human health, that appear unique within their family, or for which knowledge is scarce. Among
MeSH term(s)	Animals ; Humans ; Borna disease virus/genetics ; Phosphoproteins/genetics ; Bornaviridae/genetics ; DNA Repair ; DNA ; RNA, Messenger/genetics
Chemical Substances	Phosphoproteins ; DNA (9007-49-2) ; RNA, Messenger
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14112358
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons.

Ferré, Cécile A / Thouard, Anne / Bétourné, Alexandre / Le Dorze, Anne-Louise / Belenguer, Pascale / Miquel, Marie-Christine / Peyrin, Jean-Michel / Gonzalez-Dunia, Daniel / Szelechowski, Marion

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17705

Abstract: Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported into the mitochondrial matrix, which was recently described as a sensor of neuronal stress. Mortalin is down-regulated in neurons of patients with ... ...

Abstract	Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported into the mitochondrial matrix, which was recently described as a sensor of neuronal stress. Mortalin is down-regulated in neurons of patients with neurodegenerative diseases and levels of Mortalin expression are correlated with neuronal fate in animal models of Alzheimer's disease or cerebral ischemia. To date, however, the links between Mortalin levels, its impact on mitochondrial function and morphology and, ultimately, the initiation of neurodegeneration, are still unclear. In the present study, we used lentiviral vectors to over- or under-express Mortalin in primary neuronal cultures. We first analyzed the early events of neurodegeneration in the axonal compartment, using oriented neuronal cultures grown in microfluidic-based devices. We observed that Mortalin down-regulation induced mitochondrial fragmentation and axonal damage, whereas its over-expression conferred protection against axonal degeneration mediated by rotenone exposure. We next demonstrated that Mortalin levels modulated mitochondrial morphology by acting on DRP1 phosphorylation, thereby further illustrating the crucial implication of mitochondrial dynamics on neuronal fate in degenerative diseases.
MeSH term(s)	Animals ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Mitochondrial Dynamics/drug effects ; Mitochondrial Dynamics/physiology ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley ; Rotenone/pharmacology
Chemical Substances	HSP70 Heat-Shock Proteins ; mortalin ; Rotenone (03L9OT429T)
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-97162-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Human cytomegalovirus infection is associated with increased expression of the lissencephaly gene PAFAH1B1 encoding LIS1 in neural stem cells and congenitally infected brains.

Rolland, Maude / Martin, Hélène / Bergamelli, Mathilde / Sellier, Yann / Bessières, Bettina / Aziza, Jacqueline / Benchoua, Alexandra / Leruez-Ville, Marianne / Gonzalez-Dunia, Daniel / Chavanas, Stéphane

The Journal of pathology

2021 Volume 254, Issue 1, Page(s) 92–102

Abstract: Congenital infection of the central nervous system by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae, including mental retardation or neurodevelopmental abnormalities. The most severe complications include smooth brain or ... ...

Abstract	Congenital infection of the central nervous system by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae, including mental retardation or neurodevelopmental abnormalities. The most severe complications include smooth brain or polymicrogyria, which are both indicative of abnormal migration of neural cells, although the underlying mechanisms remain to be determined. To gain better insight on the pathogenesis of such sequelae, we assessed the expression levels of a set of neurogenesis-related genes, using HCMV-infected human neural stem cells derived from embryonic stem cells (NSCs). Among the 84 genes tested, we found dramatically increased expression of the gene PAFAH1B1, encoding LIS1 (lissencephaly-1), in HCMV-infected versus uninfected NSCs. Consistent with these findings, western blotting and immunofluorescence analyses confirmed the increased levels of LIS1 in HCMV-infected NSCs at the protein level. We next assessed the migratory abilities of HCMV-infected NSCs and observed that infection strongly impaired the migration of NSCs, without detectable effect on their proliferation. Moreover, we observed increased immunostaining for LIS1 in brains of congenitally infected fetuses, but not in control samples, highlighting the clinical relevance of our findings. Of note, PAFAH1B1 mutations (resulting in either haploinsufficiency or gain of function) are primary causes of hereditary neurodevelopmental diseases. Notably, mutations resulting in PAFAH1B1 haploinsufficiency cause classic lissencephaly. Taken together, our findings suggest that PAFAH1B1 is a critical target of HCMV infection. They also shine a new light on the pathophysiological basis of the neurological outcomes of congenital HCMV infection, by suggesting that defective neural cell migration might contribute to the pathogenesis of the neurodevelopmental sequelae of infection. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
MeSH term(s)	1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism ; Brain/metabolism ; Brain/virology ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/metabolism ; Humans ; Microtubule-Associated Proteins/metabolism ; Neural Stem Cells/metabolism ; Neural Stem Cells/virology
Chemical Substances	Microtubule-Associated Proteins ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; PAFAH1B1 protein, human (EC 3.1.1.47)
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.5640
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.12: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito