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Book: Ekel ist okay

Krey, Hiltrud

ein Lern- und Lehrbuch zum Umgang mit Emotionen in Pflegeausbildung und Pflegealltag

2015

Author's details	Hiltrud Krey
Keywords	Ekel ; Emotionsregulation ; Krankenpflege ; Altenpflege ; Erfahrungsorientiertes Lernen
Subject	Erfahrungsbezogenes Lernen ; Erfahrungslernen ; Erfahrung ; Erfahrungsgeleitetes Lernen ; Praxisorientiertes Lernen ; Alter ; Altenpflegekonzept ; Altenkrankenpflege ; Geriatrische Altenpflege ; Krankenpflegekonzept ; Gefühlsregulation ; Gefühl ; Emotionale Regulation ; Abscheu
Language	German
Size	153 S. : graph. Darst.
Edition	2. Aufl.
Publisher	Mabuse
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book
HBZ-ID	HT018506650
ISBN	978-3-86321-232-2 ; 3-86321-232-0
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2016 A 1523	available for loan (reading room)	Lesesaal EG

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Article ; Online: NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.

Vomhof-DeKrey, Emilie E / Picklo, Matthew J

Free radical biology & medicine

2012 Volume 53, Issue 4, Page(s) 690–700

Abstract: ... proteins, NAD(P)H:quinone oxidoreductase 1 (NQO1), is implicated in the development of adipose tissue and ...

Abstract	The nuclear factor E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway responds to oxidative stress via control of several antioxidant defense gene expressions. Recent efforts demonstrate that Nrf2 modulates development of adiposity and adipogenesis. One of the major Nrf2-regulated proteins, NAD(P)H:quinone oxidoreductase 1 (NQO1), is implicated in the development of adipose tissue and obesity. However, little is known about in situ disposition of Nrf2, Keap1, and NQO1 during adipogenesis in isolated adipocytes. Based on literature data, we hypothesized that adipocyte differentiation would increase expression of the Nrf2/Keap1 pathway and NQO1. Using murine 3T3-L1 preadipocytes, we mapped an increase in NQO1 protein at limited clonal expansion and postmitotic growth arrest (Days 1-3) stages and a decrease in terminally differentiated (Day 8) adipocytes that lasted for several days afterward. Conversely, NQO1, Nrf2, and Keap1 mRNA expressions were all increased in differentiated adipocytes (Days 11-14), indicating a discrepancy between steady-state mRNA levels and resulting protein. Treatment of differentiated 3T3-L1 adipocytes with glycogen synthase kinase-3β (GSK-3β) inhibitor, LiCl, led to 1.9-fold increase in NQO1 protein. Sulforaphane enhanced NQO1 protein (10.5-fold) and blunted triglyceride and FABP4 accumulation. The decrement in triglyceride content was partially reversed when NQO1 activity was pharmacologically inhibited. These data demonstrate a biphasic response of Nrf2 and NQO1 during adipocyte differentiation that is regulated by Keap1- and GSK-3β-dependent mechanisms, and that hypertrophy is negatively regulated by NQO1 activity.
MeSH term(s)	3T3-L1 Cells ; Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adipocytes/drug effects ; Adipocytes/enzymology ; Adipocytes/physiology ; Animals ; Cell Differentiation ; Cell Enlargement ; Cell Proliferation ; Cytoskeletal Proteins/antagonists & inhibitors ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Gene Expression/drug effects ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Hypertrophy ; Indolequinones/pharmacology ; Insulin/physiology ; Isothiocyanates ; Kelch-Like ECH-Associated Protein 1 ; Lithium Chloride/pharmacology ; Mice ; NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Thiocyanates/pharmacology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; Indolequinones ; Insulin ; Isothiocyanates ; Keap1 protein, mouse ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Thiocyanates ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Nqo1 protein, mouse (EC 1.6.5.2) ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Gsk3b protein, mouse (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Lithium Chloride (G4962QA067) ; sulforaphane (GA49J4310U)
Language	English
Publishing date	2012-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2012.05.047
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Article: NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes

Vomhof-DeKrey, Emilie E / Picklo, Matthew J

Free radical biology & medicine. 2012 Aug. 15, v. 53, no. 4

2012

Abstract: ... proteins, NAD(P)H:quinone oxidoreductase 1 (NQO1), is implicated in the development of adipose tissue and ...

Abstract	The nuclear factor E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway responds to oxidative stress via control of several antioxidant defense gene expressions. Recent efforts demonstrate that Nrf2 modulates development of adiposity and adipogenesis. One of the major Nrf2-regulated proteins, NAD(P)H:quinone oxidoreductase 1 (NQO1), is implicated in the development of adipose tissue and obesity. However, little is known about in situ disposition of Nrf2, Keap1, and NQO1 during adipogenesis in isolated adipocytes. Based on literature data, we hypothesized that adipocyte differentiation would increase expression of the Nrf2/Keap1 pathway and NQO1. Using murine 3T3-L1 preadipocytes, we mapped an increase in NQO1 protein at limited clonal expansion and postmitotic growth arrest (Days 1-3) stages and a decrease in terminally differentiated (Day 8) adipocytes that lasted for several days afterward. Conversely, NQO1, Nrf2, and Keap1 mRNA expressions were all increased in differentiated adipocytes (Days 11-14), indicating a discrepancy between steady-state mRNA levels and resulting protein. Treatment of differentiated 3T3-L1 adipocytes with glycogen synthase kinase-3β (GSK-3β) inhibitor, LiCl, led to 1.9-fold increase in NQO1 protein. Sulforaphane enhanced NQO1 protein (10.5-fold) and blunted triglyceride and FABP4 accumulation. The decrement in triglyceride content was partially reversed when NQO1 activity was pharmacologically inhibited. These data demonstrate a biphasic response of Nrf2 and NQO1 during adipocyte differentiation that is regulated by Keap1- and GSK-3β-dependent mechanisms, and that hypertrophy is negatively regulated by NQO1 activity.
Keywords	adipocytes ; adipose tissue ; adiposity ; cell differentiation ; enzyme activity ; gene expression ; hypertrophy ; messenger RNA ; mice ; NADH or NADPH oxidoreductases ; oxidative stress ; triacylglycerols
Language	English
Dates of publication	2012-0815
Size	p. 690-700.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2012.05.047
Database	NAL-Catalogue (AGRICOLA)

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Book: Ekel ist okay

Krey, Hiltrud

ein Lern- und Lehrbuch zum Umgang mit Emotionen in Pflegeausbildung und Pflegealltag

2003

Author's details	Hiltrud Krey
Keywords	Altenpflege ; Ekel ; Krankenpflege ; Erfahrungsorientiertes Lernen ; Unterricht
Subject	Schulunterricht ; Unterrichtsgestaltung ; Unterricht ; Alter ; Altenpflegekonzept ; Altenkrankenpflege ; Geriatrische Altenpflege ; Erfahrungsbezogenes Lernen ; Erfahrungslernen ; Erfahrung ; Erfahrungsgeleitetes Lernen ; Praxisorientiertes Lernen ; Abscheu ; Krankenpflegekonzept
Language	German
Size	122 S. : graph. Darst.
Publisher	Schlütersche
Publishing place	Hannover
Publishing country	Germany
Document type	Book
HBZ-ID	HT014003392
ISBN	3-87706-896-0 ; 978-3-87706-896-0
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2005 A 1133	order for loan	Magazin

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Article ; Online: Effect of argon cold plasma composition on orthodontic bonding-new insights into input parameters and protocols.

Alzahar, Mostafa M / Krey, Karl-Friedrich / Doberschütz, Philine H

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

2023

Abstract: Purpose: Cold atmospheric plasma can functionalize enamel without damaging the substrate morphology. It therefore has the potential to be a gentle alternative to conventional acid etching. To realize the full potential of cold atmospheric plasma in ... ...

Title translation	Effekte von kaltem Argonplasma im kieferorthopädischen Bonding – neue Erkenntnisse über geeignete Parameter und Protokolle.
Abstract	Purpose: Cold atmospheric plasma can functionalize enamel without damaging the substrate morphology. It therefore has the potential to be a gentle alternative to conventional acid etching. To realize the full potential of cold atmospheric plasma in orthodontic bonding, the input parameters and protocols that are most beneficial to surface modification must first be identified. We aimed to clarify how the admixture of oxygen to cold atmospheric plasma and the rewetting of the enamel affect the conditioning properties for orthodontic bonding. Methods: First, we illustrated the morphological effects of different plasma compositions on the enamel surface by means of scanning electron microscopy. Then, we measured the shear bond strength resulting from different conditioning techniques on bovine enamel specimens: conventional acid etching; no conditioning; pure argon plasma; argon plasma plus 0.5% oxygen admixture; argon plasma plus 0.5% oxygen and rewetting after plasma application. Brackets were bonded using light cured adhesive; all specimens were subjected to thermocycling. The shear bond strength of each specimen was measured in a universal testing machine and compared using Welch one-way analysis of variance (ANOVA) and Games-Howell post hoc test. Results: Specimens conditioned with argon plasma plus 0.5% oxygen and rewetting showed a significantly higher shear bond strength than specimens conditioned with conventional acid etching. Conditioning with pure argon plasma and argon plasma plus 0.5% oxygen without rewetting yielded significantly lower shear bond strength. Conclusion: Admixing 0.5% oxygen and rewetting the enamel after plasma application are crucial steps that could help make cold atmospheric plasma a gentle conditioning technique in orthodontic bonding.
Language	English
Publishing date	2023-03-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1309470-1
ISSN	1615-6714 ; 0015-816X ; 1434-5293
ISSN (online)	1615-6714
ISSN	0015-816X ; 1434-5293
DOI	10.1007/s00056-023-00451-9
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Ul III Zs.85: Show issues

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Article ; Online: The intricate triangular interaction between protective microbe, pathogen and host determines fitness of the metaorganism.

Griem-Krey, Hanne / Petersen, Carola / Hamerich, Inga K / Schulenburg, Hinrich

Proceedings. Biological sciences

2023 Volume 290, Issue 2012, Page(s) 20232193

Abstract: The microbiota shapes host biology in numerous ways. One example is protection against pathogens, which is likely critical for host fitness in consideration of the ubiquity of pathogens. The host itself can affect abundance of microbiota or pathogens, ... ...

Abstract	The microbiota shapes host biology in numerous ways. One example is protection against pathogens, which is likely critical for host fitness in consideration of the ubiquity of pathogens. The host itself can affect abundance of microbiota or pathogens, which has usually been characterized in separate studies. To date, however, it is unclear how the host influences the interaction with both simultaneously and how this triangular interaction determines fitness of the host-microbe assemblage, the so-called metaorganism. To address this current knowledge gap, we focused on a triangular model interaction, consisting of the nematode
MeSH term(s)	Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Microbiota ; Bacillus thuringiensis
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.2193
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Article ; Online: Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.

Andersen, Jens V / Westi, Emil W / Griem-Krey, Nane / Skotte, Niels H / Schousboe, Arne / Aldana, Blanca I / Wellendorph, Petrine

Journal of neurochemistry

2023

Abstract: ... ...

Abstract	Ca
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15814
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Article ; Online: Grapevine trunk diseases of cold-hardy varieties grown in Northern Midwest vineyards coincide with canker fungi and winter injury.

DeKrey, David H / Klodd, Annie E / Clark, Matthew D / Blanchette, Robert A

PloS one

2022 Volume 17, Issue 6, Page(s) e0269555

Abstract: Grapevine trunk diseases make up a disease complex associated with several vascular fungal pathogenic species. Surveys to characterize the composition of grapevine trunk diseases have been conducted for most major grape growing regions of the world. This ...

Abstract	Grapevine trunk diseases make up a disease complex associated with several vascular fungal pathogenic species. Surveys to characterize the composition of grapevine trunk diseases have been conducted for most major grape growing regions of the world. This study presents a similar survey characterizing the fungi associated with grapevine trunk diseases of cold-hardy interspecific hybrid grape varieties grown nearly exclusively in the atypical harsh winter climate of Northern Midwestern United states vineyards. From the 172 samples collected in 2019, 640 isolates obtained by culturing were identified by ITS sequencing and represent 420 sample-unique taxa. From the 420 representative taxa, opportunistic fungi of the order Diaporthales including species of Cytospora and Diaporthe were most frequently identified. Species of Phaeoacremonium, Paraconiothyrium, and Cadophora were also prevalent. In other milder Mediterranean growing climates, species of Xylariales and Botryosphaeriales are often frequently isolated but in this study they were isolated in small numbers. No Phaeomoniellales taxa were isolated. We discuss the possible compounding effects of winter injury, the pathogens isolated, and management strategies. Additionally, difficulties in researching and understanding the grapevine trunk disease complex are discussed.
MeSH term(s)	Ascomycota ; Farms ; Plant Diseases/microbiology ; Vitis/microbiology ; Xylariales
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0269555
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Topische Östrogene bei postmenopausaler, atrophischer Vaginitis

Steinmüller Krey, Helga

Zur Wirksamkeit und zur Frage systemischer Nebenwirkungen einer niedrig dosierten lokalen Applikationsform von 17-beta-Östradiol

1998

Author's details	vorgelegt von Helga Steinmüller-Krey
Language	German
Size	36 S. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Kiel, Univ., Diss., 1998
HBZ-ID	HT009634103
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: TCDD exposure alters fecal IgA concentrations in male and female mice.

Foxx, Christine L / Nagy, Madeline R / King, Aspen E / Albin, Dreycey / DeKrey, Gregory K

BMC pharmacology & toxicology

2022 Volume 23, Issue 1, Page(s) 25

Abstract: ... were determined in samples collected every 4 h over 4 days.: Results: Fecal sIgA concentrations were ...

Abstract	Background: Activation of the aryl hydrocarbon receptor (AhR) can alter diurnal rhythms including those for innate lymphoid cell numbers, cytokine and hormone levels, and feeding behaviors. Because immune responses and antibody levels are modulated by exposure to AhR agonists, we hypothesized that some of the variation previously reported for the effects of AhR activation on fecal secretory immunoglobulin A (sIgA) levels could be explained by dysregulation of the diurnal sIgA rhythm. Methods: C57Bl/6 J mice were exposed to peanut oil or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 10 or 40 μg/Kg) and fecal sIgA levels were determined in samples collected every 4 h over 4 days. Results: Fecal sIgA concentrations were not significantly different between light and dark phases of the photoperiod in either male or female mice, and there were no significant circadian rhythms observed, but TCDD exposure significantly altered both fecal mesor sIgA and serum IgA concentrations, in parallel, in male (increased) and female (biphasic) mice. Conclusions: AhR activation can contribute to the regulation of steady state IgA/sIgA concentrations.
MeSH term(s)	Animals ; Female ; Immunity, Innate ; Immunoglobulin A ; Immunoglobulin A, Secretory ; Lymphocytes ; Male ; Mice ; Mice, Inbred C57BL ; Polychlorinated Dibenzodioxins/toxicity ; Receptors, Aryl Hydrocarbon/agonists
Chemical Substances	Immunoglobulin A ; Immunoglobulin A, Secretory ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon
Language	English
Publishing date	2022-04-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-022-00563-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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