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  1. Book ; Thesis: Untersuchung zum Einfluss des Zinkfingertranskriptionsfaktors Bcl11b/Ctip2 auf morphologische Marker der dopaminergen, serotonergen und cholinergen Neurotransmittersysteme bei Bcl11bflox/flox; Emx1-Cre Mäusen

    Niemeier, Matthias / Albrecht, Anne / Heimrich, Bernd

    2022  

    Title variant B cell leukemia 11b Protein, Coup-TF interacting protein 2
    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details von Matthias Michael Niemeier ; Gutachter: Prof. Dr. Anne Albrecht ; Prof. Dr. Bernd Heimrich
    Keywords Hirnfunktion ; Maus
    Subject Labormaus ; Weiße Maus ; Gehirn ; Hirnleistung ; Hirnaktivität ; Hirnphysiologie ; Gehirnphysiologie ; Gehirnaktivität ; Gehirnfunktion
    Subject code 610
    Language German
    Size 3 ungezählte Blätter, X, 107 Blätter, Illustrationen, Diagramme
    Publisher Otto-von-Guericke-Universität Magdeburg
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Magdeburg, 2023
    HBZ-ID HT030638090
    Database Catalogue ZB MED Medicine, Health

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    2024 E 287 order for loan Magazin

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  2. Article: K

    Pethe, Abhishek / Hamze, Mira / Giannaki, Marina / Heimrich, Bernd / Medina, Igor / Hartmann, Anna-Maria / Roussa, Eleni

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1253424

    Abstract: ... ...

    Abstract K
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1253424
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  3. Article ; Online: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway.

    Koumoundourou, Artemis / Rannap, Märt / De Bruyckere, Elodie / Nestel, Sigrun / Reissner, Carsten / Egorov, Alexei V / Liu, Pengtao / Missler, Markus / Heimrich, Bernd / Draguhn, Andreas / Britsch, Stefan

    eLife

    2024  Volume 12

    Abstract: The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and functional ... ...

    Abstract The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and functional integrity of mossy fiber-CA3 synapses. The underlying molecular mechanisms, however, remained unclear. We show in mice that the synaptic organizer molecule C1ql2 is a direct functional target of Bcl11b that regulates synaptic vesicle recruitment and long-term potentiation at mossy fiber-CA3 synapses in vivo and in vitro. Furthermore, we demonstrate C1ql2 to exert its functions through direct interaction with a specific splice variant of neurexin-3, Nrxn3(25b+). Interruption of C1ql2-Nrxn3(25b+) interaction by expression of a non-binding C1ql2 mutant or by deletion of Nrxn3 in the dentate gyrus granule neurons recapitulates major parts of the Bcl11b as well as C1ql2 mutant phenotype. Together, this study identifies a novel C1ql2-Nrxn3(25b+)-dependent signaling pathway through which Bcl11b controls mossy fiber-CA3 synapse function. Thus, our findings contribute to the mechanistic understanding of neurodevelopmental disorders accompanied by synaptic dysfunction.
    MeSH term(s) Animals ; Mice ; Mossy Fibers, Hippocampal ; Synapses ; Transcription Factors ; Synaptic Vesicles ; Tumor Suppressor Proteins ; Repressor Proteins
    Chemical Substances Transcription Factors ; Tumor Suppressor Proteins ; Bcl11b protein, mouse ; Repressor Proteins
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89854
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  4. Article: Zika Virus-Mediated Death of Hippocampal Neurons Is Independent From Maturation State.

    Büttner, Caroline / Heer, Maxi / Traichel, Jasmin / Schwemmle, Martin / Heimrich, Bernd

    Frontiers in cellular neuroscience

    2019  Volume 13, Page(s) 389

    Abstract: Zika virus (ZIKV) infection of pregnant women and diaplazental transmission to the fetus is linked to the congenital syndrome of microcephaly in newborns. This neuropathology is believed to result from significant death of neuronal progenitor cells (NPC). ...

    Abstract Zika virus (ZIKV) infection of pregnant women and diaplazental transmission to the fetus is linked to the congenital syndrome of microcephaly in newborns. This neuropathology is believed to result from significant death of neuronal progenitor cells (NPC). Here, we examined the fate of neurons in the developing hippocampus, a brain structure which houses neuronal populations of different maturation states. For this purpose, we infected hippocampal slice cultures from immunocompetent newborn mice with ZIKV and monitored changes in hippocampal architecture. In neurons of all hippocampal subfields ZIKV was detected by immunofluorescence labeling and electron microscopy. This includes pyramidal neurons that maturate during the embryonic phase. In the dentate gyrus, ZIKV could be found in the Cajal-Retzius (CR) cells which belong to the earliest born cortical neurons, but also in granule cells that are predominantly generated postnatally. Intriguingly, virus particles were also present in the correctly outgrowing mossy fiber axons of juvenile granule cells, suggesting that viral infection does not impair region- and layer-specific formation of this projection. ZIKV infection of hippocampal tissue was accompanied by both a profound astrocyte reaction indicating tissue injury and a microglia response suggesting phagocytotic activity. Furthermore, depending on the viral load and incubation time, we observed extensive overall neuronal loss in the cultured hippocampal slice cultures. Thus, we conclude ZIKV can replicate in various neuronal populations and trigger neuronal death independent of the maturation state of infected cells.
    Language English
    Publishing date 2019-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2019.00389
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  5. Book ; Online ; Thesis: <dc:title>Effekte von CNTF und LIF in Kulturen adulter neuraler Stammzellen</dc:title>

    Reiser, Johanna [Verfasser] / Heimrich, Bernd [Akademischer Betreuer]

    2017  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Further Evidence for the Neuroplastic Role of Cannabinoids: A Study in Organotypic Hippocampal Slice Cultures.

    Caltana, Laura Romina / Heimrich, Bernd / Brusco, Alicia

    Journal of molecular neuroscience : MN

    2015  Volume 56, Issue 4, Page(s) 773–781

    Abstract: Endocannabinoid receptors CB1R and CB2R are present in the CNS and modulate synaptic activity. By using an in vitro model, two concentrations of CB1R agonist ACEA at 0.5 and 5 μM doses and CB1R antagonist AM251 at 1 and 10 μM doses were administered in ... ...

    Abstract Endocannabinoid receptors CB1R and CB2R are present in the CNS and modulate synaptic activity. By using an in vitro model, two concentrations of CB1R agonist ACEA at 0.5 and 5 μM doses and CB1R antagonist AM251 at 1 and 10 μM doses were administered in organotypic slice cultures of mouse hippocampus, and their effects on neurons and glial cells were analyzed at different time points. Exposure to low concentrations of ACEA (0.5 μM) did not seem to affect tissue organization, neuronal morphology, or glial response. In contrast, at a higher concentration of ACEA, many neurons in the dentate gyrus exhibited strong caspase-3 immunoreactivity. After treatment with AM251, we observed an increase in caspase-3 immunoreactivity and a downregulation of CB1R expression. Results show that long-term hippocampal slice cultures respond to both CB1R activation and inactivation by changing neuronal protein expression patterns. In the present study, we demonstrate that CB1R agonist ACEA promotes alterations in the neuronal cytoskeleton as well as changes in CB1R expression in organotypic hippocampal slice cultures, and that CB1R antagonist AM251 promotes neuronal death and astroglial reaction.
    MeSH term(s) Animals ; Arachidonic Acids/pharmacology ; Cannabinoids/metabolism ; Caspase 3/metabolism ; Cells, Cultured ; Cytoskeleton/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism
    Chemical Substances Arachidonic Acids ; Cannabinoids ; Piperidines ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; arachidonyl-2-chloroethylamide ; AM 251 (3I4FA44MAI) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-015-0499-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Kommt es durch einen unrunden Tritt beim Ergometerfahren zu Kraftspitzen im Hüftgelenk?

    Abed, Abduljabbar / Franz, Julius / Heimrich, Bernd

    Medizinisch-orthopädische Technik

    2016  Volume 136, Issue 3, Page(s) 27

    Language German
    Document type Article
    ZDB-ID 193146-5
    ISSN 0340-5508
    Database Current Contents Medicine

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    Zs.A 965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Viral interference with neuronal integrity: what can we learn from the Borna disease virus?

    Schwemmle, Martin / Heimrich, Bernd

    Cell and tissue research

    2011  Volume 344, Issue 1, Page(s) 13–16

    Abstract: The neurotropic Borna disease virus (BDV) is unusual in that it can persistently infect neurons of the central nervous system (CNS) without causing general cell death, reflecting its favourable adaptation to the brain. The activity-dependent enhancement ... ...

    Abstract The neurotropic Borna disease virus (BDV) is unusual in that it can persistently infect neurons of the central nervous system (CNS) without causing general cell death, reflecting its favourable adaptation to the brain. The activity-dependent enhancement of neuronal network activity is however disturbed after BDV infection, possibly by its effect on the protein kinase C signalling pathway. The best model for studying BDV, which has a non-cytolytic replication strategy in primary neurons, is the rat. Infection of adult rats results in a fatal immune-mediated disease, whereas BDV establishes persistent infection of the brain in newborn rats resulting in progressive neuronal cell loss in defined regions of the CNS. Our recently developed system of BDV-infected hippocampal slice cultures has clearly shown that the onset of granule cell loss begins after the formation of the mossy fibre projection. Quantitative analysis has revealed a significant increase in synaptic density on identified remaining granule cell dendrites at 6 weeks after infection, followed by a decline. Granule cells are the major target of entorhinal afferents. However, despite an almost complete loss of dentate granule cells during BDV infection, entorhinal axons persist in their correct layer, both in vivo and in slice cultures, possibly exploiting rewiring capabilities and thereby allowing new synapse formation with available targets. These morphological observations, together with electrophysiological and biochemical data, indicate that BDV is a suitable model virus for studying virus-induced morphological and functional changes of neurons and connectivity patterns.
    MeSH term(s) Animals ; Borna Disease/pathology ; Borna disease virus/physiology ; Brain/pathology ; Brain/virology ; Cells, Cultured ; Host-Pathogen Interactions ; Neurons/pathology ; Neurons/virology ; Rats ; Rats, Inbred Lew
    Language English
    Publishing date 2011-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-011-1141-6
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    Ub I Zs.94: Show issues Location:
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  9. Article ; Online: Involvement of GPR17 in Neuronal Fibre Outgrowth.

    Braune, Max / Scherf, Nico / Heine, Claudia / Sygnecka, Katja / Pillaiyar, Thanigaimalai / Parravicini, Chiara / Heimrich, Bernd / Abbracchio, Maria P / Müller, Christa E / Franke, Heike

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: Characterization of new pharmacological targets is a promising approach in research of neurorepair mechanisms. The G protein-coupled receptor 17 (GPR17) has recently been proposed as an interesting pharmacological target, e.g., in neuroregenerative ... ...

    Abstract Characterization of new pharmacological targets is a promising approach in research of neurorepair mechanisms. The G protein-coupled receptor 17 (GPR17) has recently been proposed as an interesting pharmacological target, e.g., in neuroregenerative processes. Using the well-established
    MeSH term(s) Acetates/pharmacology ; Animals ; Animals, Newborn ; Coculture Techniques ; Cyclopropanes/pharmacology ; Drug Evaluation, Preclinical ; Female ; Leukotriene Antagonists/pharmacology ; Male ; Nerve Regeneration/drug effects ; Neuronal Outgrowth/drug effects ; Neuronal Outgrowth/genetics ; Quinolines/pharmacology ; Rats ; Receptors, G-Protein-Coupled/metabolism ; Sulfides/pharmacology
    Chemical Substances Acetates ; Cyclopropanes ; GPR17 protein, rat ; Leukotriene Antagonists ; Quinolines ; Receptors, G-Protein-Coupled ; Sulfides ; montelukast (MHM278SD3E)
    Language English
    Publishing date 2021-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111683
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  10. Book ; Online ; Thesis: <dc:title>Zellbiologische und funktionelle Analyse humaner Mutationen im L1CAM-Gen nach Detektion in einem Fall von X-chromosomal gekoppeltem Hydrocephalus</dc:title>

    Marx, Mariola [Verfasser] / Heimrich, Bernd [Akademischer Betreuer]

    2015  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
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