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Book ; Thesis: Duplexsonographische Untersuchungen der Nieren gesunder Kinder und von Kindern mit hämolytisch-urämischem Syndrom

Scholbach, Thomas

1998

Author's details	eingereicht von Thomas Scholbach
Language	German
Size	135, 4 Bl. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Leipzig, Univ., Diss., 1998
HBZ-ID	HT009319157
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Surgical treatment of abdominal compression syndromes: The significance of hypermobility-related disorders.

Sandmann, Wilhelm / Scholbach, Thomas / Verginis, Konstantinos

American journal of medical genetics. Part C, Seminars in medical genetics

2021 Volume 187, Issue 4, Page(s) 570–578

Abstract: Case reports and systematic studies of the most common hypermobility-related disorders, hypermobile Ehlers-Danlos syndrome (hEDS), and hypermobility spectrum disorder (HSD) typically describe gastroenterological symptoms and complaints attributed to ... ...

Abstract	Case reports and systematic studies of the most common hypermobility-related disorders, hypermobile Ehlers-Danlos syndrome (hEDS), and hypermobility spectrum disorder (HSD) typically describe gastroenterological symptoms and complaints attributed to structural malfunction, autonomic dysfunction, or inflammation of the gastrointestinal tract. However, abdominal compression syndromes (CS) may also contribute to pain and dysfunction in these individuals and be the leading pathology given symptoms significantly reduce or cease after decompressive surgery. Arising not only in the abdomen and causing pain (median arcuate ligament syndrome [MALS] and superior mesenteric artery syndrome [SMAS]), CS also occur in the retroperitoneum and the pelvis (nutcracker syndrome and May-Thurner syndrome), these latter conditions causing chronic pelvic congestion syndrome (PCS). Here, we report primarily on our experience of the assessment and management of MALS and SMAS in a cohort of cases with a surprising prevalence of HSD and hEDS. To our knowledge, this is the first cohort report of its kind in hEDS, HSD, and CS. We recommend that CS are considered in hEDS and HSD individuals with gastrointestinal and other painful complaints within the "belt" area. These CS can be identified using functional ultrasound duplex examination in experienced hands, and in appropriate cases stabilizing surgery can substantially improve quality of life.
MeSH term(s)	Abdomen/diagnostic imaging ; Abdomen/surgery ; Ehlers-Danlos Syndrome/complications ; Humans ; Joint Instability/etiology ; Joint Instability/surgery ; Quality of Life ; Syndrome
Language	English
Publishing date	2021-11-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2108622-9
ISSN	1552-4876 ; 0148-7299 ; 1552-4868
ISSN (online)	1552-4876
ISSN	0148-7299 ; 1552-4868
DOI	10.1002/ajmg.c.31949
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Article: From the nutcracker-phenomenon of the left renal vein to the midline congestion syndrome as a cause of migraine, headache, back and abdominal pain and functional disorders of pelvic organs.

Scholbach, Thomas

Medical hypotheses

2007 Volume 68, Issue 6, Page(s) 1318–1327

Abstract: This paper presents the hypothesis, that pain and functional disturbances of organs which lie on the midline of the body might be caused by a venous congestion of these organs. Cause of their congestion is the participation of these organs (vertebral ... ...

Abstract	This paper presents the hypothesis, that pain and functional disturbances of organs which lie on the midline of the body might be caused by a venous congestion of these organs. Cause of their congestion is the participation of these organs (vertebral column, skull, brain, spinal medullary, uterus, prostate, left ovary/testis, urinary bladder rectum, vagina, urethra) in the collateral circulation of the left renal vein. In many patients with complaints of the above mentioned organs the left renal vein is compressed inside the fork formed by the superior mesenteric artery and the aorta. This so called nutcracker phenomenon is incompletely understood today. It can lead to a marked reduction of left renal perfusion and forces the left renal blood to bypass the venous compression site via abundant collaterals. These collaterals are often not sufficient. Their walls become stretched and distorted - varices with inflamed walls are formed. These dilated veins are painful, interfere with the normal organ's function and demand more space than usual. This way pain in the midline organs and functional derangement of the midline organs can occur. The term "midline congestion syndrome" seems appropriate to reflect the comprehensive nature of this frequent disorder. The rationale for this hypothesis is based on the novel PixelFlux-technique (www.chameleon-software.de) of renal tissue perfusion measurement. With this method a relevant decline of left renal cortical perfusion was measured in 16 affected patients before therapy (left/right ratio: 0.79). After a treatment with acetylsalicylic acid in doses from 15 to 200mg/d within 14-200 days a complete relief of so far long lasting therapy-resistant midline organ symptoms was achieved. Simultaneously the left/right renal perfusion ratio increased significantly to 1.24 (p=0.021). This improvement of left renal perfusion can be explained by a better drainage of collateral veins, diminution of their wall distension, thereby decline of their intramural inflammation, reduction of their mass effects (especially by the replaced spinal fluid inside the spinal canal and the skull), and altogether a reduction of pain and functional derangement in the affected midline organs. The proposed theory might influence the current understanding of such frequent and difficult to treat diseases as chronic back pain, headaches, frequent cystitis, enuresis, abdominal pain, flank pain and might spur new theories of arterial hypertension, placental insufficiency, prostate diseases and myelopathies.
MeSH term(s)	Abdominal Pain/etiology ; Adolescent ; Aspirin/therapeutic use ; Back Pain/drug therapy ; Back Pain/etiology ; Child ; Child, Preschool ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/drug therapy ; Constriction, Pathologic/pathology ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Headache/drug therapy ; Headache/etiology ; Humans ; Male ; Migraine Disorders/drug therapy ; Migraine Disorders/etiology ; Migraine Disorders/therapy ; Models, Biological ; Pelvic Pain/drug therapy ; Pelvic Pain/etiology ; Renal Circulation/drug effects ; Renal Veins/diagnostic imaging ; Renal Veins/drug effects ; Renal Veins/pathology ; Time Factors ; Treatment Outcome ; Ultrasonography, Doppler, Color
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2007
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2006.10.040
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Article ; Online: Interprofessional Management of Median Arcuate Ligament Syndrome (Dunbar Syndrome) Related to Lumbar Lordosis and Hip Dysplasia: A Patient's Perspective.

Janssen, Sclinda Lea / Scholbach, Thomas / Jeno, Susan / Laurie, Holte / Meyer, Mandy / Combs, Colin

European journal of case reports in internal medicine

2020 Volume 7, Issue 7, Page(s) 1605

Abstract: We present a 53-year-old female patient with median arcuate ligament syndrome (MALS), also known as Dunbar syndrome or celiac artery compression syndrome, related to lumbar lordosis and hip dysplasia. She utilized interprofessional management strategies, ...

Abstract	We present a 53-year-old female patient with median arcuate ligament syndrome (MALS), also known as Dunbar syndrome or celiac artery compression syndrome, related to lumbar lordosis and hip dysplasia. She utilized interprofessional management strategies, which were beneficial in reducing lumbar lordosis and MALS-related symptoms. This finding is important because there are no other reports in the literature describing interprofessional strategies to manage symptoms for patients who are waiting for surgery or are not candidates for surgery. Learning points: Excessive lumbar lordosis is related to the development of median arcuate ligament syndrome (MALS) due to the greater distance the median arcuate ligament stretches around the vertebral curves, causing compression of the celiac nerves and artery.It is important to consider the effects MALS has on multiple body systems when diagnosing and developing symptom management strategies.Referrals to interprofessional team members can help the patient manage the vast array of symptoms related to MALS.
Language	English
Publishing date	2020-04-16
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2020_001605
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Article: Association of Dunbar, May-Thurner and Nutcracker Compression Syndromes in One Patient

Zalizko, Poļina / Tropina, Evija / Scholbach, Thomas / Puķītis, Aldis

Proceedings of the Latvian Academy of Sciences. 2020 Apr. 01, v. 74, no. 2

2020

Abstract: We report a case of Dunbar syndrome, May–Thurner syndrome and Nutcracker syndrome diagnosed in one patient with clinical presentation and imaging findings on Doppler ultrasonography. Dunbar syndrome or truncus coeliacus compression syndrome is an under- ... ...

Abstract	We report a case of Dunbar syndrome, May–Thurner syndrome and Nutcracker syndrome diagnosed in one patient with clinical presentation and imaging findings on Doppler ultrasonography. Dunbar syndrome or truncus coeliacus compression syndrome is an under-diagnosed vascular compression syndrome with a lot of controversy around it because of insufficient differentiation from celiac artery stenosis. May–Thurner syndrome or iliac vein compression syndrome is an anatomically variable condition of venous outflow obstruction caused by extrinsic compression by the right common iliac artery as it crosses the iliac vein anteriorly. In Nutcracker syndrome due to compression the outflow from the left renal vein into the inferior vena cava is obstructed. The combination of all these syndromes in one patient was not described before.
Keywords	iliac artery ; inferior vena cava ; patients ; ultrasonography
Language	English
Dates of publication	2020-0401
Size	p. 150-155.
Publishing place	Sciendo
Document type	Article
Note	NAL-AP-2-clean
ISSN	2255-890X
DOI	10.2478/prolas-2020-0024
Database	NAL-Catalogue (AGRICOLA)

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Article: Celiac artery compression syndrome in children, adolescents, and young adults: clinical and color duplex sonographic features in a series of 59 cases.

Scholbach, Thomas

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2005 Volume 25, Issue 3, Page(s) 299–305

Abstract: Objective: Abdominal pain is one of the most common conditions in childhood and adolescence. Celiac artery compression syndrome (CACS) is rarely suspected in this population. We present clinical and sonographic features from a series of 59 patients with ...

Abstract	Objective: Abdominal pain is one of the most common conditions in childhood and adolescence. Celiac artery compression syndrome (CACS) is rarely suspected in this population. We present clinical and sonographic features from a series of 59 patients with this disorder. Methods: A total of 3449 patients from 0 to 18 years were investigated with 7639 abdominal color duplex sonographic examinations. Celiac artery flow velocity was measured at the branching off from the aorta in inspiration, expiration, and in between. Diagnosis of CACS was made if a greater than 2-fold acceleration of peak systolic flow in the celiac artery compared to the abdominal aorta or a peak systolic velocity greater than 200 cm/s was measured in the mid position and if a variation of flow velocity occurred during respiration. In 22 cases, angiography (21 magnetic resonance angiography and 1 digital subtraction angiography) was used to prove sonographic diagnosis. Results: Fifty-nine patients (among them 81% female) from 22 months to 19 years (clustering between 14 and 17 years) fulfilling color Doppler sonographic criteria of CACS were found, for a prevalence of 1.7%. Their symptoms included, among others, abdominal pain (71%), nausea (29%), thoracic pain (22%), heartburn (17%), weight loss (15%), vomiting (15%), systolic murmur (15%), postprandial accentuation of symptoms (15%), diarrhea (14%), respiratory discomfort (14%), and syncope (12%). Conclusions: Celiac artery compression syndrome is more prevalent than expected, and conditions not usually connected to the disease were found. Alertness to CACS is recommended, especially in patients with a combination of characteristic symptoms. Color Doppler sonography is the modality of choice for diagnosing CACS.
MeSH term(s)	Abdominal Pain/etiology ; Adolescent ; Adult ; Blood Flow Velocity/physiology ; Celiac Artery/diagnostic imaging ; Celiac Artery/physiopathology ; Child ; Child, Preschool ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/epidemiology ; Constriction, Pathologic/physiopathology ; Diagnosis, Differential ; Female ; Humans ; Infant ; Male ; Prevalence ; Radiography ; Syndrome ; Ultrasonography, Doppler, Color/methods ; Vascular Diseases/diagnosis ; Vascular Diseases/epidemiology ; Vascular Diseases/physiopathology
Language	English
Publishing date	2005-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.7863/jum.2006.25.3.299
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Article: Borna Disease Virus infection in young children

SCHOLBACH, THOMAS

APMIS. 2008 June., v. 116, suppl. 124

2008

Language	English
Dates of publication	2008-06
Size	p. 83-88.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ISSN	0108-0172 ; 0903-465X ; 0903-4641
ISSN	0108-0172 ; 0903-465X ; 0903-4641
DOI	10.1111/j.1600-0463.2008.00m16.x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Interprofessional Management of Median Arcuate Ligament Syndrome (Dunbar Syndrome) Related to Lumbar Lordosis and Hip Dysplasia

Sclinda Lea Janssen / Thomas Scholbach / Susan Jeno / Holte Laurie / Mandy Meyer / Colin Combs

European Journal of Case Reports in Internal Medicine (2020)

A Patient’s Perspective

2020

Abstract	We present a 53-year-old female patient with median arcuate ligament syndrome (MALS), also known as Dunbar syndrome or celiac artery compression syndrome, related to lumbar lordosis and hip dysplasia. She utilized interprofessional management strategies, which were beneficial in reducing lumbar lordosis and MALS-related symptoms. This finding is important because there are no other reports in the literature describing interprofessional strategies to manage symptoms for patients who are waiting for surgery or are not candidates for surgery.
Keywords	median arcuate ligament syndrome ; lumbar lordosis ; hip dysplasia ; symptom management strategies ; interprofessional ; Medicine ; R
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Venous blood flow in maternal kidneys in third trimester of pregnancy.

Moe Eggebø, Torbjørn / Leknes Jensen, Eva Johanne / Deibele, Karin Ulrike / Scholbach, Thomas

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2018 Volume 33, Issue 13, Page(s) 2246–2252

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adult ; Blood Flow Velocity ; Female ; Humans ; Kidney/blood supply ; Kidney/diagnostic imaging ; Pregnancy ; Pregnancy Trimester, Third ; Prospective Studies ; Renal Artery/diagnostic imaging ; Renal Artery/physiology ; Renal Veins/diagnostic imaging ; Renal Veins/physiology ; Ultrasonography, Doppler/methods
Language	English
Publishing date	2018-12-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2018.1547705
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Article: Correlation Between Fetal Weight Gain and Birth Weight with Blood Flow in the Uterine Arteries Calculated with the PixelFlux Technique.

Arneberg, Helene Caroline / Andersen, Thea Anette / Lorås, Liv / Torp, Hans / Scholbach, Thomas Manfred / Eggebø, Torbjørn Moe

Ultrasound international open

2018 Volume 4, Issue 1, Page(s) E16–E22

Abstract: Introduction: The aim was to investigate correlations between fetal weight gain/day and birthweight with blood flow estimates in the uterine arteries calculated with the PixelFlux technique and with measurements from TAmax. We also aimed to examine the ... ...

Abstract	Introduction: The aim was to investigate correlations between fetal weight gain/day and birthweight with blood flow estimates in the uterine arteries calculated with the PixelFlux technique and with measurements from TAmax. We also aimed to examine the agreement between estimates using the two methods. Material and methods: We conducted a prospective observational pilot study in pregnancy week 24-25 in women with risk pregnancies referred to the fetal medical centre at St. Olavs Hospital, Trondheim, Norway from March 2016 to June 2016. Blood flow in the uterine arteries was calculated using time-averaged peak velocity (TAmax) and the PixelFlux technique. PixelFlux is a method based on pixelwise calculation of spatially angle-corrected velocities and areas of all pixels inside a vessel during a heart cycle. Results: The mean flow calculated from PixelFlux and TAmax was 811 ml/minute and 787 ml/minute, respectively. The intra-class correlation coefficient was 0.83 (95% CI 0.72-0.90) and limits of agreement were -441 ml/minute (95% CI -558 to -324 ml/minute) to 489 ml/minute (95% CI 372 to 606 ml/minute). We observed a significant correlation between mean flow calculated from PixelFlux and birthweight (r=0.41; p<0.01) and between flow calculated from PixelFlux and weight gain/day (r=0.33; p=0.02). Calculation based on TAmax was significant correlated to birthweight (r=0.34; p=0.02), but not to weight-gain/day. Pulsatile index was not correlated to flow, birthweight or fetal weight-gain/day. Conclusions: We found significant correlations between estimated blood flow in the uterine arteries using the PixelFlux technique with fetal weight-gain/day and with birthweight. Estimates from two methods showed good agreement.
Language	English
Publishing date	2018-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2838384-9
ISSN	2199-7152 ; 2509-596X
ISSN (online)	2199-7152
ISSN	2509-596X
DOI	10.1055/s-0044-102005
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