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Article: Hydrochemical characteristics and quality evaluation of groundwater in terms of health risks in Luohe aquifer in Wuqi County of the Chinese Loess Plateau, northwest China

He, Xiaodong / Wu, Jianhua / He, Song

Human and ecological risk assessment. 2019 Feb. 17, v. 25, no. 1-2

2019

Abstract: Groundwater is the main source of water for domestic and agricultural purposes in Wuqi County ...

Abstract	Groundwater is the main source of water for domestic and agricultural purposes in Wuqi County on the Loess Plateau. The present study was carried out to assess the hydrochemical characteristics and quality of groundwater in the Luohe aquifer, which is a crucial aquifer for water supply. For this study, 22 groundwater samples and 6 surface water samples were collected for analysis. Hydrochemistry and hydrochemical facies of groundwater were analyzed using statistical analysis and Tri-linear diagram. Gibbs diagram, correlation analysis and bivariate plots were used to investigate the natural evolution mechanisms of groundwater and surface water. Potential health risks of nitrate and Cr6+ through drinking water ingestion for adults and children were estimated. The results show that the major hydrochemical facies is Cl·SO4-Na, mixed Cl·SO4·HCO3-Na and SO4·Cl-Mg·Na types, and high concentration of Na+ is a remarkable feature of groundwater in the study area. Groundwater chemistry evolution is affected by rock weathering and evaporation. The high concentrations of Na+, SO42− and TDS suggest that groundwater is not suitable for irrigation purposes. According to WQI values, above 80% of the groundwater samples are fair quality water. It is also found that the groundwater of the study area is contaminated with nitrate and Cr6+. Children are at higher health risk than adults. Multiple measures such as establishing new centralized water supply sources and inter-basin water transfer projects have also been proposed in this study to guarantee the safety of sustainable groundwater supply.
Keywords	adults ; aquifers ; children ; chromium ; drinking water ; evaporation ; groundwater ; hydrochemistry ; ingestion ; irrigation ; nitrates ; risk ; sodium ; statistical analysis ; sulfates ; surface water ; water supply ; weathering ; China
Language	English
Dates of publication	2019-0217
Size	p. 32-51.
Publishing place	Taylor & Francis
Document type	Article
ISSN	1549-7860
DOI	10.1080/10807039.2018.1531693
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gelsolin Inhibits the Proliferation of Colon Cancer Cells by Enhancing the Expression of TNFR2/CASP10 as a Death Receptor Pathway.

Wang, Zihang / Song, Wuqi

Protein and peptide letters

2023 Volume 30, Issue 3, Page(s) 214–220

Abstract: Background: Colon cancer has the second highest incidence rate of digestive system tumors. It relies on surgical treatment, radiotherapy and chemotherapy, and targeted drug therapy.: Objective: To study the mechanism of GSN in the proliferation of ... ...

Abstract	Background: Colon cancer has the second highest incidence rate of digestive system tumors. It relies on surgical treatment, radiotherapy and chemotherapy, and targeted drug therapy. Objective: To study the mechanism of GSN in the proliferation of colon cancer cells. Materials and methods: The expression of gelsolin (GSN) was analyzed with the data of colon cancer patients in the TCGA database. SW620 cells were treated by GSN in vitro and the gene expression was detected by immunoblotting and quantitative PCR. Results: The expression of GSN was found significantly low in colon cancer cells and correlated with the prognosis of patients. The SW620 cell line cultured in vitro was treated with exogenous GSN. SW620 can be significantly inhibited above the concentration of 250 μg/ml. The results of immunoblotting and quantitative PCR showed that exogenous GSN can effectively improve the transcription level of death receptor-related pathway genes such as TNFR2 and CASP10. Conclusion: This study found that GSN inhibited the proliferation of SW620 cells in vitro by upregulating the expression of death receptor pathway-related proteins.
MeSH term(s)	Humans ; Gelsolin/genetics ; Gelsolin/metabolism ; Receptors, Tumor Necrosis Factor, Type II/metabolism ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Cell Proliferation ; Receptors, Death Domain/metabolism ; Caspase 10/metabolism
Chemical Substances	Gelsolin ; Receptors, Tumor Necrosis Factor, Type II ; Receptors, Death Domain ; CASP10 protein, human (EC 3.4.22.63) ; Caspase 10 (EC 3.4.22.-)
Language	English
Publishing date	2023-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866530666230124113639
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Zs.A 4452: Show issues

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Article ; Online: Photobiomodulation with 630-nm LED Inhibits M1 Macrophage Polarization via STAT1 Pathway Against Sepsis-Induced Acute Lung Injury.

Pan, Yue / Zhang, Hanxu / Liu, Qiannan / Wu, Hao / Du, Siqi / Song, Wuqi / Zhang, Fengmin / Liu, Hailiang

Photobiomodulation, photomedicine, and laser surgery

2024 Volume 42, Issue 2, Page(s) 148–158

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Mice ; Animals ; Low-Level Light Therapy ; Mice, Inbred C57BL ; Acute Lung Injury/complications ; Acute Lung Injury/drug therapy ; Macrophages ; Sepsis/complications ; Sepsis/radiotherapy ; Sepsis/drug therapy ; RNA, Messenger
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2023.0034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nanoparticle-based T cell immunoimaging and immunomodulatory for diagnosing and treating transplant rejection.

Ding, Mengdan / Gao, Tang / Song, Yishu / Yi, Luyang / Li, Wenqu / Deng, Cheng / Zhou, Wuqi / Xie, Mingxing / Zhang, Li

Heliyon

2024 Volume 10, Issue 2, Page(s) e24203

Abstract: T cells serve a pivotal role in the rejection of transplants, both by directly attacking the graft and by recruiting other immune cells, which intensifies the rejection process. Therefore, monitoring T cells becomes crucial for early detection of ... ...

Abstract	T cells serve a pivotal role in the rejection of transplants, both by directly attacking the graft and by recruiting other immune cells, which intensifies the rejection process. Therefore, monitoring T cells becomes crucial for early detection of transplant rejection, while targeted drug delivery specifically to T cells can significantly enhance the effectiveness of rejection therapy. However, regulating the activity of T cells within transplanted organs is challenging, and the prolonged use of immunosuppressive drugs is associated with notable side effects and complications. Functionalized nanoparticles offer a potential solution by targeting T cells within transplants or lymph nodes, thereby reducing the off-target effects and improving the long-term survival of the graft. In this review, we will provide an overview of recent advancements in T cell-targeted imaging molecular probes for diagnosing transplant rejection and the progress of T cell-regulating nanomedicines for treating transplant rejection. Additionally, we will discuss future directions and the challenges in clinical translation.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24203
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrated analysis of ferroptosis-related gene signature for overall survival prediction in Asian patients with hepatocellular carcinoma.

Wang, Zihang / Zhang, Lan / Xu, Jinyuan / Song, Wuqi

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2022 Volume 25, Issue 3, Page(s) 721–730

Abstract: Purpose: Hepatocellular carcinoma (HCC) is one of the most prevalent types of cancers in Asia. Accumulating evidence suggests that ferroptosis is a non-apoptotic form of cell death, and has played an important role in cancer biology.: Methods: Based ... ...

Abstract	Purpose: Hepatocellular carcinoma (HCC) is one of the most prevalent types of cancers in Asia. Accumulating evidence suggests that ferroptosis is a non-apoptotic form of cell death, and has played an important role in cancer biology. Methods: Based on the manually curated ferroptosis-related gene set and TCGA-LIHC dataset of Asian patients, we used DESeq2, Kaplan-Meier analysis, and univariate Cox regression to identify differentially expressed ferroptosis-related genes with significantly prognostic capacity. A risk signature was constructed based on the selected genes for predicting the survival of HCC patients in Asia. The survival prediction accuracy was confirmed by the time-dependent receiver operating characteristic (ROC) curve analysis. Gene set variation analysis (GSVA) was used to explore the functional associations of the signature. Ferroptosis potential index (FPI) and xCell algorithm was applied to quantify ferroptosis and immune cell infiltration, respectively. Two independent datasets from the GEO and the ICGC database were used for external validation. Results: The ferroptosis-related signature could accurately predict the survival outcomes of HCC patients in Asian (p value < 0.0001). We showed that the signature was an independent factor and was beneficial in elevating risk stratification of current clinicopathologic features, such as the amount of alpha-fetoprotein (AFP) and residual tumor classification. Functional characterization showed that critical processes in tumorigenesis belonged to the high-risk groups, for example inflammatory response, which may be the main driver of HCC. The high-risk group had higher FPIs and infiltrations of macrophages and T-helper cells than the low-risk group. Furthermore, two independent cohorts confirmed the prognostic value of our signature. Conclusion: Overall, our results demonstrated potential application of ferroptosis-related genes as independent biomarkers in Asian HCC patients. Targeting ferroptosis may be clinically useful beyond known clinicopathological factors and provide benefit in immunotherapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Ferroptosis/genetics ; Liver Neoplasms/genetics ; Algorithms ; Carcinogenesis ; Prognosis
Language	English
Publishing date	2022-11-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-022-02977-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy.

Wang, Xiaoyuan / Song, Wuqi / Zhang, Fengmin / Huang, Renping

Drug design, development and therapy

2021 Volume 15, Page(s) 973–981

Abstract: Background: The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit the progression of ... ...

Abstract	Background: The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit the progression of fibrosis; however, whether DHA can alleviate the formation of HS remains unclear. Methods: In the present study, in order to examine the effects of DHA on the progression of HS, human Tenon's capsule fibroblasts (HTFs) were isolated from patients who underwent glaucoma surgery. In addition, Western blot analysis, microtubule associated protein 1 light chain 3 α staining and reverse transcription-quantitative PCR were performed to detect protein and mRNA expression levels in the HTFs, respectively. Cell proliferation was detected by Ki67 staining. Flow cytometry was used to examine apoptosis and reactive oxygen species (ROS) levels in the HTFs. Results: The results revealed that TGF-β promoted the proliferation and fibrosis of HTFs; however, DHA significantly reversed the effects of TGF-β by increasing cell autophagy. In addition, DHA notably induced the apoptosis of TGF-β-stimulated HTFs by increasing the ROS levels, while these increases were partially reversed by 3-methyladenine. Furthermore, DHA notably increased the expression of microRNA (miR)-145-5p in HTFs in a dose-dependent manner. Conclusion: The present study demonstrated that DHA inhibits the TGF-β-induced fibrosis of HTFs by inducing autophagy. These findings may aid in the development of novel agents for the prevention of the formation of HS following glaucoma surgery.
MeSH term(s)	Artemisinins/pharmacology ; Autophagy/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Fibrosis/pathology ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Tenon Capsule/drug effects ; Tenon Capsule/metabolism ; Tenon Capsule/pathology ; Transforming Growth Factor beta/antagonists & inhibitors ; Transforming Growth Factor beta/metabolism
Chemical Substances	Artemisinins ; Transforming Growth Factor beta ; artenimol (6A9O50735X)
Language	English
Publishing date	2021-03-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S280322
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Web Crawling and mRNA Sequencing Analyze Mechanisms of Photobiomodulation.

Wu, Hao / Liu, Qiannan / Meng, Caiyun / Xia, Qing / Pan, Yue / Zhang, Hanxu / Zhang, Fengmin / Song, Wuqi / Liu, Hailiang

Photobiomodulation, photomedicine, and laser surgery

2022 Volume 40, Issue 4, Page(s) 252–260

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Anti-Inflammatory Agents ; Computational Biology ; Cytokines/genetics ; Humans ; Internet ; Low-Level Light Therapy ; RNA, Messenger/genetics
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; RNA, Messenger
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2021.0142
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research Progress in Ultrasonic Regulation of Cholinergic Anti-inflammatory Pathwa

Wuqi Zhou, MD, Yishu Song, MD, Rui Wang, MD, Qiaofeng Jin, MD, Mingxing Xie, PhD, Li Zhang, PhD

Advanced Ultrasound in Diagnosis and Therapy, Vol 6, Iss 4, Pp 147-

2022 Volume 152

Abstract: The cholinergic anti-inflammatory pathway is a neuro-immune regulatory pathway that mediates anti-inflammatory effects based on the vagus nerve, acetylcholine and α7 nicotinic acetylcholine receptors. In recent years, the effect of nerve stimulation by ... ...

Abstract	The cholinergic anti-inflammatory pathway is a neuro-immune regulatory pathway that mediates anti-inflammatory effects based on the vagus nerve, acetylcholine and α7 nicotinic acetylcholine receptors. In recent years, the effect of nerve stimulation by ultrasound has attracted much attention and has been widely studied. Ultrasound can stimulate the vagus nerve or spleen nerve and activate the cholinergic anti-inflammatory pathway, exerting anti-inflammatory and organ protection effects, which is expected to provide a new treatment for many inflammatory diseases. The purpose of this review is to introduce the composition, mechanisms and regulation methods of cholinergic anti-inflammatory pathway, and discuss its therapeutic implications.
Keywords	\|ultrasound\|vagus nerve\|the cholinergic anti-inflammatory pathway\|α7 nicotinic acetylcholine receptors ; Medical technology ; R855-855.5 ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Editorial Office of Advanced Ultrasound in Diagnosis and Therapy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel FK506-loading mesoporous silica nanoparticle homing to lymph nodes for transplant rejection treatment.

Song, Yishu / Jin, Qiaofeng / Zhou, Binqian / Deng, Cheng / Zhou, Wuqi / Li, Wenqu / Yi, Luyang / Ding, Mengdan / Chen, Yihan / Gao, Tang / Zhang, Li / Xie, Mingxing

International journal of pharmaceutics

2024 Volume 656, Page(s) 124074

Abstract: Tacrolimus (FK506) is an effective therapeutic for transplant rejection in clinical practice, primarily inhibiting rejection by suppressing the activation and proliferation of allogeneic T cells in the lymph nodes (LNs). However, conventional ... ...

Abstract	Tacrolimus (FK506) is an effective therapeutic for transplant rejection in clinical practice, primarily inhibiting rejection by suppressing the activation and proliferation of allogeneic T cells in the lymph nodes (LNs). However, conventional administration methods face challenges in directly delivering free FK506 to the LNs. In this study, we introduce a novel LN-targeted delivery system based on mesoporous silica nanoparticles (MSNs-FK506-MECA79). These particles were designed to selectively target high endothelial venules in LNs; this was achieved through surface modification with MECA79 antibodies. Their mean size and zeta potential were 201.18 ± 5.98 nm and - 16.12 ± 0.36 mV, respectively. Our findings showed that MSNs-FK506-MECA79 could accumulate in LNs and increase the local concentration of FK506 from 28.02 ± 7.71 ng/g to 123.81 ± 76.76 ng/g compared with the free FK506 treatment group. Subsequently, the therapeutic efficacy of MSNs-FK506-MECA79 was evaluated in a skin transplantation model. The treatment with MSNs-FK506-MECA79 could lead to a decrease in the infiltration of T cells in the grafts, a reduction in the grade of rejection, and a significant prolongation of survival. Consequently, this study presents a promising strategy for the active LN-targeted delivery of FK506 and improving the immunotherapeutic effects on transplant rejection.
Language	English
Publishing date	2024-03-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.124074
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Article ; Online: The rules and regulatory mechanisms of FOXO3 on inflammation, metabolism, cell death and aging in hosts.

Cao, Guoding / Lin, Monan / Gu, Wei / Su, Zaiyu / Duan, Yagan / Song, Wuqi / Liu, Hailiang / Zhang, Fengmin

Life sciences

2023 Volume 328, Page(s) 121877

Abstract: The FOX family of transcription factors was originally identified in 1989, comprising the FOXA to FOXS subfamilies. FOXO3, a well-known member of the FOXO subfamily, is widely expressed in various human organs and tissues, with higher expression levels ... ...

Abstract	The FOX family of transcription factors was originally identified in 1989, comprising the FOXA to FOXS subfamilies. FOXO3, a well-known member of the FOXO subfamily, is widely expressed in various human organs and tissues, with higher expression levels in the ovary, skeletal muscle, heart, and spleen. The biological effects of FOXO3 are mostly determined by its phosphorylation, which occurs in the nucleus or cytoplasm. Phosphorylation of FOXO3 in the nucleus can promote its translocation into the cytoplasm and inhibit its transcriptional activity. In contrast, phosphorylation of FOXO3 in the cytoplasm leads to its translocation into the nucleus and exerts regulatory effects on biological processes, such as inflammation, aerobic glycolysis, autophagy, apoptosis, oxidative stress, cell cycle arrest and DNA damage repair. Additionally, FOXO3 isoform 2 acts as an important suppressor of osteoclast differentiation. FOXO3 can also interfere with the development of various diseases, including inhibiting the proliferation and invasion of tumor cells, blocking the production of inflammatory factors in autoimmune diseases, and inhibiting β-amyloid deposition in Alzheimer's disease. Furthermore, FOXO3 slows down the aging process and exerts anti-aging effects by delaying telomere attrition, promoting cell self-renewal, and maintaining genomic stability. This review suggests that changes in the levels and post-translational modifications of FOXO3 protein can maintain organismal homeostasis and improve age-related diseases, thus counteracting aging. Moreover, this may indicate that alterations in FOXO3 protein levels are also crucial for longevity, offering new perspectives for therapeutic strategies targeting FOXO3.
MeSH term(s)	Humans ; Forkhead Box Protein O3/genetics ; Forkhead Transcription Factors/genetics ; Aging ; Apoptosis/genetics ; Inflammation
Chemical Substances	Forkhead Box Protein O3 ; Forkhead Transcription Factors ; FOXO3 protein, human
Language	English
Publishing date	2023-06-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.121877
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