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Article ; Online: Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.

Murata, Kozue / Makino, Akiko / Tomonaga, Keizo / Masumoto, Hidetoshi

iScience

2023 Volume 27, Issue 1, Page(s) 108641

Abstract: Patients with chronic cardiomyopathy may have persistent viral infections in their hearts, particularly with SARS-CoV-2, which targets the ACE2 receptor highly expressed in human hearts. This raises concerns about a potential global heart failure ... ...

Abstract	Patients with chronic cardiomyopathy may have persistent viral infections in their hearts, particularly with SARS-CoV-2, which targets the ACE2 receptor highly expressed in human hearts. This raises concerns about a potential global heart failure pandemic stemming from COVID-19, an SARS-CoV-2 pandemic in near future. Although faced with this healthcare caveat, there is limited research on persistent viral heart infections, and no models have been established. In this study, we created an SARS-CoV-2 persistent infection model using human iPS cell-derived cardiac microtissues (CMTs). Mild infections sustained viral presence without significant dysfunction for a month, indicating persistent infection. However, when exposed to hypoxic conditions mimicking ischemic heart diseases, cardiac function deteriorated alongside intracellular SARS-CoV-2 reactivation in cardiomyocytes and disrupted vascular network formation. This study demonstrates that SARS-CoV-2 persistently infects the heart opportunistically causing cardiac dysfunction triggered by detrimental stimuli such as ischemia, potentially predicting a post COVID-19 era heart failure pandemic.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.108641
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Article ; Online: Experiences and care needs of post-discharge patients who underwent cardiac surgery: A qualitative study.

Makino, Akiko / Nakata, Satoshi / Yoshida, Toshiko

Japan journal of nursing science : JJNS

2023 Volume 21, Issue 1, Page(s) e12561

Abstract: Aim: This study clarifies the physical, psychological, and social forms of distress in, and care needs of, cardiac surgery patients, including optimal times for supporting them in their post-hospital discharge daily lives.: Methods: Semi-structured ... ...

Abstract	Aim: This study clarifies the physical, psychological, and social forms of distress in, and care needs of, cardiac surgery patients, including optimal times for supporting them in their post-hospital discharge daily lives. Methods: Semi-structured qualitative interviews were conducted. Participants included 12 adults (11 male and one female, mean age = 66.5 years) who had undergone cardiac surgery, experienced intensive care, and received outpatient care at the first post-discharge visit (around 2 ~ 3 weeks after discharge), around 3 months after discharge, and between 3 months and 1 year after discharge. Verbatim transcripts were analyzed based on similarities and differences for codes based on assessment items, and subcategories and categories were generated. Results: After surgery, patients experienced physical, psychological, and social distress. First, they experienced physical pain shortly after discharge. Moreover, as they recovered at home, a gap between their sense of their recovery and the perceptions of those around them about their recovery often persisted, which led to psychological and social distress. Patients gained a sense of safety through "assurance of physical recovery" and security through "shared subjective distress." Conclusions: Post-cardiac surgery patients seek reassurance and safety by sharing experiences owing to daily life distress. Our findings could help provide better support to meet the care needs of such patients.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Aged ; Patient Discharge ; Aftercare ; Cardiac Surgical Procedures ; Pain ; Critical Care ; Qualitative Research
Language	English
Publishing date	2023-09-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2156618-5
ISSN	1742-7924 ; 1742-7932
ISSN (online)	1742-7924
ISSN	1742-7932
DOI	10.1111/jjns.12561
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Article ; Online: Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1.

Kanda, Takehiro / Sakai, Madoka / Makino, Akiko / Tomonaga, Keizo

The Journal of general virology

2022 Volume 103, Issue 7

Abstract: Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that is characterized by persistent infection in the nucleus and low production of progeny virions. This feature impedes not only the harvesting of infectious viral particles ... ...

Abstract	Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that is characterized by persistent infection in the nucleus and low production of progeny virions. This feature impedes not only the harvesting of infectious viral particles from infected cells but also the rescue of high titres of recombinant BoDV-1 (rBoDV-1) by reverse genetics. Here, we demonstrate that exogenous expression of both matrix protein (M) and glycoprotein (G), which are constituents of the viral lipid envelope, significantly facilitates the formation of infectious particles and propagation of BoDV-1 without affecting its viral RNA synthesis. Furthermore, simultaneous transfection of M and G expression plasmids with N, P and L helper plasmids by reverse genetics drastically enhances the rescue efficiency of rBoDV-1. On the other hand, we also show that overexpression of M induces obvious cytotoxicity similar to that of other Mononegaviruses. Together with our recent report showing that excess expression of G induces aberrant accumulation of immature G, a potential stimulator of the host innate immune response, it is conceivable that BoDV-1 may suppress excess expression of M and G to reduce the cytopathic effect, thereby leading to maintenance of persistent infection. Our results contribute not only to the establishment of an efficient method to recover high-titre BoDV-1 but also to understanding the unique mechanism of persistent BoDV-1 infection.
MeSH term(s)	Animals ; Borna disease virus/genetics ; Cell Nucleus ; Glycoproteins/genetics ; RNA, Viral/genetics ; Virion
Chemical Substances	Glycoproteins ; RNA, Viral
Language	English
Publishing date	2022-07-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001767
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Article ; Online: Correction to: Drug-interaction between paclitaxel and goshajinkigan extract and its constituents.

Nakayama, Akiko / Tsuchiya, Kazuaki / Xu, Lingyu / Matsumoto, Takashi / Makino, Toshiaki

Journal of natural medicines

2021 Volume 76, Issue 1, Page(s) 68

Language	English
Publishing date	2021-10-16
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-021-01578-y
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Book ; Online: Spatially Continuous Non-Contact Cold Sensation Presentation Based on Low-Temperature Airflows

Makino, Koyo / Xu, Jiayi / Kaneko, Akiko / Ienaga, Naoto / Kuroda, Yoshihiro

2023

Abstract: Our perception of cold enriches our understanding of the world and allows us to interact with it. Therefore, the presentation of cold sensations will be beneficial in improving the sense of immersion and presence in virtual reality and the metaverse. ... ...

Abstract	Our perception of cold enriches our understanding of the world and allows us to interact with it. Therefore, the presentation of cold sensations will be beneficial in improving the sense of immersion and presence in virtual reality and the metaverse. This study proposed a novel method for spatially continuous cold sensation presentation based on low-temperature airflows. We defined the shortest distance between two airflows perceived as different cold stimuli as a local cold stimulus group discrimination threshold (LCSGDT). By setting the distance between airflows within the LCSGDT, spatially continuous cold sensations can be achieved with an optimal number of cold airflows. We hypothesized that the LCSGDTs are related to the heat-transfer capability of airflows and developed a model to relate them. We investigated the LCSGDTs at a flow rate of 25 L/min and presentation distances ranging from 10 to 50 mm. The results showed that under these conditions, the LCSGDTs are 131.4 $\pm$ 1.9 mm, and the heat-transfer capacity of the airflow corresponding to these LCSGDTs is an almost constant value, that is, 0.92. Comment: 7 pages
Keywords	Computer Science - Human-Computer Interaction
Publishing date	2023-10-13
Publishing country	us
Document type	Book ; Online
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Article ; Online: Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation.

Komorizono, Ryo / Fujino, Kan / Kessler, Susanne / Runge, Solveig / Kanda, Takehiro / Horie, Masayuki / Makino, Akiko / Rubbenstroth, Dennis / Tomonaga, Keizo

Journal of virology

2023 Volume 97, Issue 8, Page(s) e0050923

Abstract: Viruses can utilize host splicing machinery to enable the expression of multiple genes from a limited-sized genome. Orthobornaviruses use alternative splicing to regulate the expression level of viral proteins and achieve efficient viral replication in ... ...

Abstract	Viruses can utilize host splicing machinery to enable the expression of multiple genes from a limited-sized genome. Orthobornaviruses use alternative splicing to regulate the expression level of viral proteins and achieve efficient viral replication in the nucleus. Although more than 20 orthobornaviruses have been identified belonging to eight different viral species, virus-specific splicing has not been demonstrated. Here, we demonstrate that the glycoprotein (G) transcript of parrot bornavirus 4 (PaBV-4; species
MeSH term(s)	Animals ; Bird Diseases ; Bornaviridae/genetics ; Glycoproteins/genetics ; Mononegavirales Infections/pathology ; Mononegavirales Infections/virology ; Parrots/genetics ; Protein Isoforms/genetics ; Reverse Genetics ; RNA, Messenger
Chemical Substances	Glycoproteins ; Protein Isoforms ; RNA, Messenger
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00509-23
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Article ; Online: Drug-interaction between paclitaxel and goshajinkigan extract and its constituents.

Nakayama, Akiko / Tsuchiya, Kazuaki / Xu, Lingyu / Matsumoto, Takashi / Makino, Toshiaki

Journal of natural medicines

2021 Volume 76, Issue 1, Page(s) 59–67

Abstract: Paclitaxel, a standard chemotherapeutic agent for several types of cancer, including ovarian, breast, and non-small-cell lung cancer, causes peripheral neuropathy as an adverse effect in 60-70% of the patients. The utility of combination therapy with ... ...

Abstract	Paclitaxel, a standard chemotherapeutic agent for several types of cancer, including ovarian, breast, and non-small-cell lung cancer, causes peripheral neuropathy as an adverse effect in 60-70% of the patients. The utility of combination therapy with paclitaxel and goshajinkigan, a traditional Japanese Kampo medicine, in managing paclitaxel-induced neuropathy during chemotherapy has been explored. Paclitaxel is predominantly metabolized in the liver by cytochrome P450 (CYP) 2C8 to produce 6α-hydroxypaclitaxel and by CYP3A4 to produce 3'-p-hydroxypaclitaxel. In this study, we evaluated the inhibitory or inducing effects of goshajinkigan extract (GJG) and its representative and bioavailable constituents, geniposidic acid, plantagoguanidinic acid, paeoniflorin, catalpol, loganin, and neoline, on the metabolism of paclitaxel via CYP2C8 and CYP3A4 using pooled human liver microsomes and cultured human cryopreserved hepatocytes to provide the drug information about the pharmacokinetic interaction of this combination therapy. GJG significantly inhibited the production of 3'-p-hydroxypaclitaxel and 6α-hydroxypaclitaxel in vitro in a concentration-dependent manner. The half maximal inhibitory concentration (IC
MeSH term(s)	Carcinoma, Non-Small-Cell Lung ; Cytochrome P-450 CYP2C8 ; Cytochrome P-450 CYP3A ; Drug Interactions ; Drugs, Chinese Herbal/pharmacology ; Humans ; Lung Neoplasms ; Microsomes, Liver ; Paclitaxel
Chemical Substances	Drugs, Chinese Herbal ; gosha-jinki-gan ; Cytochrome P-450 CYP2C8 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2021-07-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-021-01552-8
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Article ; Online: Stability of Borna disease virus-based episomal vector under physical and chemical stimulation.

Yanai, Mako / Sakai, Madoka / Komorizono, Ryo / Makino, Akiko / Tomonaga, Keizo

Microbiology and immunology

2021 Volume 66, Issue 1, Page(s) 24–30

Abstract: Borna disease virus (BoDV), a nonsegmented, negative-sense RNA virus, establishes persistent infection and replicates in the cell nucleus. Since BoDV genomic RNA exists as episomal RNA, the host genome is not invaded by BoDV infection. These unique ... ...

Abstract	Borna disease virus (BoDV), a nonsegmented, negative-sense RNA virus, establishes persistent infection and replicates in the cell nucleus. Since BoDV genomic RNA exists as episomal RNA, the host genome is not invaded by BoDV infection. These unique features make BoDV a promising gene delivery system as an RNA virus-based episomal vector (REVec). Previously, the stable expression of genes of interest in vitro and in vivo using a REVec was reported. For the clinical application of a REVec, the fundamental properties under various physical and chemical conditions must be determined to develop purification processes, supply chains, and biosafety management. This study investigated the effects of the following conditions on the inducibility of transmission-defective ΔG-REVec: freeze-thaw cycles, dehydration, UV, temperature, pH, and reagents for virucides and laboratory experiments. Although the titer of ΔG-REVec was not influenced by the freeze-thaw process or 5 minute incubation at ≤50°C, ΔG-REVec was significantly inactivated by incubation at ≥70°C for 5 minutes. The induction titer of ΔG-REVec was decreased by long-term incubation, dehydration, and UV irradiation in a temperature- and time-dependent manner. ΔG-REVec was sensitive to lower pH and inactivated by chemical reagents under general conditions. These results provide important knowledge for developing the clinical use of REVec and biosafety management.
MeSH term(s)	Animals ; Borna disease virus/genetics ; Persistent Infection ; Plasmids/genetics ; Stimulation, Chemical ; Virus Replication
Language	English
Publishing date	2021-10-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.12946
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Article: Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants.

Hirose, Akiko / Kuwabara, Yoshitaka / Kanai, Yoko / Kato, Chieko / Makino, Yuji / Yoshi, Fukumoto / Sasaki, Kazumoto

International journal of clinical pharmacology and therapeutics

2022 Volume 60, Issue 12, Page(s) 530–538

Abstract: Objective: Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three compositions, CR-033P, CR-043P using modified starch as an alternative to the ... ...

Abstract	Objective: Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three compositions, CR-033P, CR-043P using modified starch as an alternative to the dispersant gum ghatti used in the CR-033P, and TS-P1 containing the newly developed amorphous curcumin, a randomized double-blind crossover study (3-way, 3-period) was conducted. Materials and methods: A single dose of the curcumin capsules (TS-P1 45 mg, CR-033P 90 mg, and CR-043P 90 mg) was administered to healthy adult participants. Blood sampling was performed 24 hours after capsule administration, and the plasma concentration of total curcumin was determined using high-performance liquid chromatography coupled with tandem mass spectrometry. Results: TS-P1 and CR-043P tended to have a slightly lower area under the concentration time curve (AUC) Conclusion: The newly developed TS-P1 composition seemed to display similar curcumin systemic exposure except for a higher plasma concentration than the CR-033P composition. Further, only a few significant differences were found between CR-043P and CR-033P.
MeSH term(s)	Adult ; Humans ; Biological Availability ; Cross-Over Studies ; Curcumin/pharmacokinetics ; Therapeutic Equivalency ; Area Under Curve
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-10-20
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204257
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Zs.A 467: Show issues

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Article: Association of breakfast styles such as Japanese, Western, and cereals with sleeping habits, eating habits, and lifestyle in preschool and elementary school children.

Kuwahara, Mai / Tahara, Yu / Nitta, Lyie / Furutani, Akiko / Mochida, Seiko / Makino, Naomichi / Nozawa, Yuki / Shibata, Shigenobu

Frontiers in nutrition

2023 Volume 10, Page(s) 1131887

Abstract: Introduction: In Japan, breakfast styles are categorized into five groups; Japanese breakfast (JB; rice and miso soup), Western breakfast (WB; bread and milk), Japanese-Western breakfast (J-WB; alternative daily serving), cereal breakfast (CB), and ... ...

Abstract	Introduction: In Japan, breakfast styles are categorized into five groups; Japanese breakfast (JB; rice and miso soup), Western breakfast (WB; bread and milk), Japanese-Western breakfast (J-WB; alternative daily serving), cereal breakfast (CB), and breakfast skipping. In our recent studies, breakfast style was highly associated with the daily sleep-wake phase (chronotype), and healthy eating habits. In contrast with other breakfast style consumers, JB-consumers were positively associated with the morning chronotype and healthy eating habits such as a high consumption of a variety of protein sources, vegetables, and dietary fibers, and low consumption of sweetened juices. These previous studies included only adult participants; hence, in the current study, we investigated whether similar observations can be made in children. Methods: Preschool (aged 3-5 years) and elementary school children (6-8 years) (N = 6,104, 49.87% boys, 50.13% girls, mean body mass index 15.39 ± 0.03 kg/m Results: The results showed that the morning-evening type index values (chronotype indicator, smaller indicates morning type) were negatively correlated with JB intake (-0.05, Discussion: JB-eating children with a morning chronotype exhibited better sleep and eating habits than WB-eating children with an evening type pattern. The results suggest that JB eating habits may be associated with good eating and sleeping lifestyles, even among preschool and elementary school children.
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1131887
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