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Article ; Online: Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case.

Vannella, Kevin M / Oguz, Cihan / Stein, Sydney R / Pittaluga, Stefania / Dikoglu, Esra / Kanwal, Arjun / Ramelli, Sabrina C / Briese, Thomas / Su, Ling / Wu, Xiaolin / Ramos-Benitez, Marcos J / Perez-Valencia, Luis J / Babyak, Ashley / Cha, Nu Ri / Chung, Joon-Yong / Ylaya, Kris / Madathil, Ronson J / Saharia, Kapil K / Scalea, Thomas M /

Tran, Quincy K / Herr, Daniel L / Kleiner, David E / Hewitt, Stephen M / Notarangelo, Luigi D / Grazioli, Alison / Chertow, Daniel S

Frontiers in immunology

2021 Volume 12, Page(s) 779026

Abstract: ... Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue ... repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones ... frequency T-cell clones that mediated fatal myocarditis. ...

Abstract	A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/immunology ; COVID-19/pathology ; Humans ; Male ; Myocarditis/immunology ; Myocarditis/pathology ; Myocarditis/virology ; RNA, Viral/analysis ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/pathology ; T-Lymphocytes/immunology
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-12-09
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.779026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves.

Lüningschrör, Patrick / Slotta, Carsten / Heimann, Peter / Briese, Michael / Weikert, Ulrich M / Massih, Bita / Appenzeller, Silke / Sendtner, Michael / Kaltschmidt, Christian / Kaltschmidt, Barbara

Frontiers in cellular neuroscience

2020 Volume 14, Page(s) 185

Abstract: ... directly by Schwann cells or by macrophages, which are modulated by T-lymphocytes. Here, we show ... in the regulation of both Schwann cell autophagy and recruitment of T-lymphocytes in peripheral nerves during ...

Abstract	Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous system (PNS), myelin can be degraded in an autophagy-dependent manner directly by Schwann cells or by macrophages, which are modulated by T-lymphocytes. Here, we show that the NF-κB activator Pleckstrin homology containing family member 5 (Plekhg5) is involved in the regulation of both Schwann cell autophagy and recruitment of T-lymphocytes in peripheral nerves during motoneuron disease.
Language	English
Publishing date	2020-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2020.00185
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Article: Complete genome sequence of T’Ho virus, a novel putative flavivirus from the Yucatan Peninsula of Mexico

Briese, Thomas / Maria A. Loroño-Pino / Julian E. Garcia-Rejon / Jose A. Farfan-Ale / Carlos Machain-Williams / Karin S. Dorman / W. Ian Lipkin / Bradley J. Blitvich

Virology journal. 2017 Dec., v. 14, no. 1

2017

Abstract: BACKGROUND: We previously reported the discovery of a novel, putative flavivirus designated T’Ho ... of T’Ho virus was sequenced using a combination of unbiased high-throughput sequencing, 5′ and 3′ rapid ... and 556-nt, respectively. Genome sequence alignments revealed that T’Ho virus is most closely related ...

Abstract	BACKGROUND: We previously reported the discovery of a novel, putative flavivirus designated T’Ho virus in Culex quinquefasciatus mosquitoes in the Yucatan Peninsula of Mexico. A 1358-nt region of the NS5 gene was amplified and sequenced but an isolate was not recovered. RESULTS: The complete genome of T’Ho virus was sequenced using a combination of unbiased high-throughput sequencing, 5′ and 3′ rapid amplification of cDNA ends, reverse transcription-polymerase chain reaction and Sanger sequencing. The genome contains a single open reading frame of 10,284 nt which is flanked by 5′ and 3′ untranslated regions of 97 and 556-nt, respectively. Genome sequence alignments revealed that T’Ho virus is most closely related to Rocio virus (67.4% nucleotide identity) and Ilheus virus (65.9%), both of which belong to the Ntaya group, followed by other Ntaya group viruses (58.8–63.3%) and Japanese encephalitis group viruses (62.0–63.7%). Phylogenetic inference is in agreement with these findings. CONCLUSIONS: This study furthers our understanding of flavivirus genetics, phylogeny and diagnostics. Because the two closest known relatives of T’Ho virus are human pathogens, T’Ho virus could be an unrecognized cause of human disease. It is therefore important that future studies investigate the public health significance of this virus.
Keywords	Ilheus virus ; complementary DNA ; diagnostic techniques ; encephalitis ; genes ; high-throughput nucleotide sequencing ; human diseases ; open reading frames ; phylogeny ; rapid amplification of cDNA ends ; reverse transcriptase polymerase chain reaction ; sequence alignment ; transcription (genetics) ; viruses ; Mexico
Language	English
Dates of publication	2017-12
Size	p. 110.
Publishing place	BioMed Central
Document type	Article
ISSN	1743-422X
DOI	10.1186/s12985-017-0777-6
Database	NAL-Catalogue (AGRICOLA)

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Book: Krankheiten in der Schwangerschaft

Briese, Volker / Bolz, Michael / Reimer, Toralf

Handbuch der Diagnosen von A - Z

2015

Author's details	Volker Briese ; Michael Bolz ; Toralf Reimer
Keywords	Schwangerschaft ; Krankheit
Subject	Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Gestation ; Gravidität
Language	German
Size	X, 404 S.
Edition	2., vollst. überarb. und aktualisierte Aufl.
Publisher	De Gruyter
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
Note	Hier auch später erschienene, unveränderte Nachdrucke
HBZ-ID	HT018691098
ISBN	978-3-11-031302-4 ; 978-3-11-055447-2 ; 3-11-031302-2 ; 9783110374032 ; 9783110314618 ; 3-11-055447-X ; 311037403X ; 3110314614
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2015 A 2456	available for loan (reading room)	Lesesaal EG

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Article ; Online: Building a global immune system.

Lipkin, W I / Briese, T

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 4, Page(s) 2036069

Abstract: The COVID-19 pandemic exposed global vulnerabilities to emerging infectious diseases, heralded by earlier outbreaks, that did not result in appropriate investments in surveillance, international collaboration, and response. We propose specific steps that ...

Abstract	The COVID-19 pandemic exposed global vulnerabilities to emerging infectious diseases, heralded by earlier outbreaks, that did not result in appropriate investments in surveillance, international collaboration, and response. We propose specific steps that should be taken to reduce future risks to public health, economic and political stability, and food security.
MeSH term(s)	COVID-19/epidemiology ; Global Health ; Humans ; Immune System ; International Cooperation ; Pandemics/prevention & control
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2036069
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Book: Krankheiten in der Schwangerschaft

Briese, Volker / Bolz, Michael / Reimer, Toralf

Handbuch der Diagnosen von A bis Z

2010

Author's details	Volker Briese ; Michael Bolz ; Toralf Reimer
Keywords	Schwangerschaft ; Krankheit
Subject	Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Gestation ; Gravidität
Language	German
Size	X, 392 S.
Publisher	de Gruyter
Publishing place	Berlin
Publishing country	Germany
Document type	Book
HBZ-ID	HT016285007
ISBN	978-3-11-022692-8 ; 3-11-022692-8
Database	Catalogue ZB MED Medicine, Health

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2010 A 1467	order for loan	Magazin

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Article: Primary extranodal NK/T cell lymphoma ("nasal type") of the endometrium: report of an unusual case diagnosed at autopsy.

Briese, Juliane / Noack, Frank / Harland, Albrecht / Horny, Hans-Peter

Gynecologic and obstetric investigation

2006 Volume 61, Issue 3, Page(s) 164–166

Abstract: Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here ... report the case of a "nasal type" NK/T cell lymphoma arising in the uterus. The diagnosis was established ...

Abstract	Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report the case of a "nasal type" NK/T cell lymphoma arising in the uterus. The diagnosis was established only at autopsy.
MeSH term(s)	Aged ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Autopsy ; Biomarkers, Tumor/metabolism ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Fatal Outcome ; Female ; Humans ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/pathology ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/pathology
Chemical Substances	Antigens, Differentiation, T-Lymphocyte ; Biomarkers, Tumor
Language	English
Publishing date	2006
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	800003-7
ISSN	1423-002X ; 0378-7346
ISSN (online)	1423-002X
ISSN	0378-7346
DOI	10.1159/000091002
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Zs.A 688: Show issues

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Article: Comparison of Time-Zero Primary Stability Between a Biodegradable Magnesium Bone Staple and Metal Bone Staples for Knee Ligament Fixation: A Biomechanical Study in a Porcine Model.

Deichsel, Adrian / Glasbrenner, Johannes / Raschke, Michael J / Klimek, Matthias / Peez, Christian / Briese, Thorben / Herbst, Elmar / Kittl, Christoph

Orthopaedic journal of sports medicine

2024 Volume 12, Issue 3, Page(s) 23259671241236783

Abstract: Background: Bone staples have been shown previously to be a viable modality for cortical tendon graft fixation in ligament knee surgery. However, soft tissue reactions have been reported, making implant removal necessary. Magnesium alloys are a ... ...

Abstract	Background: Bone staples have been shown previously to be a viable modality for cortical tendon graft fixation in ligament knee surgery. However, soft tissue reactions have been reported, making implant removal necessary. Magnesium alloys are a promising material for biodegradable orthopaedic implants, with mechanical properties closely resembling those of human bone. Purpose: To compare the primary stability of a biodegradable bone staple prototype made from magnesium to bone staples made from metal in the cortical fixation of tendon grafts during knee surgery. Study design: Controlled laboratory study. Methods: Primary stability of peripheral tendon graft fixation was assessed in a porcine model of medial collateral ligament reconstruction. Two commercially available metal bone staples (Richards fixation staple with spikes [Me1] and spiked ligament staple [Me2]) were compared with a magnesium bone staple prototype for soft tissue fixation. Primary stability was assessed using a uniaxial materials testing machine. Cyclic loading at 50 and 100 N was applied for 500 cycles each, followed by load-to-failure testing. Results: After 500 cycles at 50 N, elongation was 1.5 ± 0.5 mm in the Me1 group, 1.9 ± 0.5 mm in the Me2 group, and 1.8 ± 0.4 mm in the magnesium group. After 1000 cycles of loading (500 cycles at 50 N and 500 at 100 N), elongation was 3.6 ± 0.9 mm in the Me1 group, 3.5 ± 0.6 mm in the Me2 group, and 4.1 ± 1.0 mm in the magnesium group. No significant differences regarding elongation were found between the groups. Load to failure was 352 ± 115 N in the Me1 group, 373 ± 77 N in the Me2 group, and 449 ± 92 N in the magnesium group, with no significant difference between the groups. Conclusion: In this study, the magnesium bone staples provided appropriate time-zero biomechanical primary stability in comparison with metal bone staples and may therefore be a feasible alternative for cortical fixation of tendon grafts in knee surgery. Clinical relevance: The biodegradability of magnesium bone staples would eliminate the need for later implant removal.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671241236783
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Article: Primary Extranodal NK/T Cell Lymphoma (‘Nasal Type’) of the Endometrium: Report of an Unusual Case Diagnosed at Autopsy

Briese, Juliane / Noack, Frank / Harland, Albrecht / Horny, Hans-Peter

Gynecologic and Obstetric Investigation

2006 Volume 61, Issue 3, Page(s) 164–166

Abstract: Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here ... report the case of a ‘nasal type’ NK/T cell lymphoma arising in the uterus. The diagnosis was established ...

Institution	Department of Gynaecopathology, Institute of Pathology, University Clinic, Hamburg Institute of Pathology, University of Lübeck, Lübeck, and Medical Hospital, Mölln-Ratzeburg, Germany
Abstract	Primary natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report the case of a ‘nasal type’ NK/T cell lymphoma arising in the uterus. The diagnosis was established only at autopsy.
Keywords	Lymphoid lesions ; NK/T cell lymphoma ; Uterus ; Endometrium
Language	English
Publishing date	2006-04-05
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Case Report
ZDB-ID	800003-7
ISSN	1423-002X ; 0378-7346
ISSN (online)	1423-002X
ISSN	0378-7346
DOI	10.1159/000091002
Database	Karger publisher's database

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Zs.A 688: Show issues

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Article ; Online: Additional Plate Fixation of Hinge Fractures After Varisation Distal Femoral Osteotomies Provides Favorable Torsional Stability: A Biomechanical Study.

Peez, Christian / Grosse-Allermann, Arian / Deichsel, Adrian / Raschke, Michael J / Glasbrenner, Johannes / Briese, Thorben / Wermers, Jens / Herbst, Elmar / Kittl, Christoph

The American journal of sports medicine

2023 Volume 51, Issue 14, Page(s) 3732–3741

Abstract: ... of the hinge fracture; and (4) locking T-plate fixation of the hinge fracture. Using a servo-hydraulic ...

Abstract	Background: Hinge fractures are considered risk factors for delayed or nonunion of the osteotomy gap in distal femoral osteotomies (DFOs). Limited evidence exists regarding the treatment of hinge fractures after DFO, which could improve stability and thus bone healing. Purpose: To (1) examine the effect of hinge fractures on the biomechanical properties of the bone-implant construct, (2) evaluate the biomechanical advantages of an additional fixation of a hinge fracture, and (3) test the biomechanical properties of different types of varisation DFOs. Study design: Controlled laboratory study. Methods: A total of 32 fresh-frozen human distal femora equally underwent medial closing wedge DFO or lateral opening wedge DFO using a unilateral locking compression plate. The following conditions were serially tested: (1) preserved hinge; (2) hinge fracture along the osteotomy plane; (3) screw fixation of the hinge fracture; and (4) locking T-plate fixation of the hinge fracture. Using a servo-hydraulic materials testing machine, we subjected each construct to 15 cycles of axial compression (400 N; 20 N/s) and internal and external rotational loads (10 N·m; 0.5 N·m/s) to evaluate the stiffness. The axial and torsional hinge displacement was recorded using a 3-dimensional optical measuring system. Repeated-measures 1-way analysis of variance and post hoc Bonferroni correction were used for multiple comparisons. Statistical significance was set at Results: Independent from the type of osteotomy, a fractured hinge significantly ( Conclusion: Hinge fractures after medial closing wedge DFO and lateral opening wedge DFO caused decreased bone-implant construct rotational stiffness and increased fracture-site displacement. In contrast, the axial stiffness remained unchanged in the cadaveric model. Clinical relevance: When considering an osteosynthesis of a hinge fracture in a DFO, an additional plate fixation was the construct with the highest stiffness and least displacement, which could restore intact hinge rotational displacement.
MeSH term(s)	Humans ; Bone Plates ; Fractures, Bone ; Osteotomy/methods ; Fracture Fixation, Internal/methods ; Femur/surgery ; Biomechanical Phenomena ; Femoral Fractures/surgery
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/03635465231206947
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