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  1. Book ; Audio / Video ; Thesis: Inhibitorstudien und niedermolekulare Modifikationen der 5-Lipoxygenase

    Hörnig, Michael

    2009  

    Author's details von Michael Hörnig
    Subject code 572.791
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2009
    HBZ-ID HT016121999
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Can the light of immunometabolism cut through "brain fog"?

    Hornig, Mady

    The Journal of clinical investigation

    2020  Volume 130, Issue 3, Page(s) 1102–1105

    Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been ... ...

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been conclusively linked. In this issue of the JCI, Mandarano et al. illuminate bioenergetic derangements of ME/CFS T cell subsets. CD4+ and CD8+ T cells had impaired resting glycolysis. CD8+ cells additionally showed activation-related metabolic remodeling deficits and decreased mitochondrial membrane potential; a subset had increased resting mitochondrial mass. Immune senescence and exhaustion paradigms offer only partial explanations. Hence, unique mechanisms of disrupted immunometabolism may underlie the complex neuroimmune dysfunction of ME/CFS.
    MeSH term(s) Brain/metabolism ; CD8-Positive T-Lymphocytes ; Cytokines/metabolism ; Fatigue Syndrome, Chronic/metabolism ; Humans ; Mitochondria
    Chemical Substances Cytokines
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI134985
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  3. Article: Odontoid Fracture with Accompanying Severe Atlantoaxial Instability in Elderly Patients-Analysis of Treatment, Adverse Events, and Outcome.

    Kreinest, Michael / Raisch, Philipp / Hörnig, Lukas / Vetter, Sven Y / Grützner, Paul A / Jung, Matthias K

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: 1) Background: In elderly patients with type II odontoid fractures, accompanying severe atlantoaxial instability (AAI) is discussed as a marker possibly warranting more aggressive surgical therapy. This study aimed to characterize adverse events as well ...

    Abstract (1) Background: In elderly patients with type II odontoid fractures, accompanying severe atlantoaxial instability (AAI) is discussed as a marker possibly warranting more aggressive surgical therapy. This study aimed to characterize adverse events as well as the radiological and functional outcomes of surgical vs. conservative therapy in patients with odontoid fracture and AAI. (2) Methods: Patients aged 65 years and older with type II odontoid fracture and AAI treated were included. AAI was assumed if the mean subluxation across both atlantoaxial facet joints in the sagittal plane was greater than 50%. Data on demographics, comorbidities, treatment, adverse events, radiological, and functional outcomes were analyzed. (3) Results: Thirty-nine patients were included. Hospitalization time was significantly shorter in conservatively treated patients compared to patients with ventral or dorsal surgery. Adverse events occurred in 11 patients (28.2%), affecting 10 surgically treated patients (35.7%), and 1 conservatively treated patient (9.1%). Moreover, 25 patients were followed-up (64.1%). One secondary dislocation occurred in the conservative group (11.1%) and three in the surgical group (18.8%). (4) Conclusions: Despite the potential for instability in this injury, conservative treatment does not seem to lead to unfavorable short-term results, less adverse events, and a shorter hospital stay and should thus be considered and discussed with patients as a treatment option, even in the presence of severe AAI.
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051326
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  4. Article ; Online: Odontoid fracture in geriatric patients - analysis of complications and outcome following conservative treatment vs. ventral and dorsal surgery.

    Jung, Matthias K / Hörnig, Lukas / Raisch, Philipp / Grützner, Paul A / Kreinest, Michael

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 748

    Abstract: Background: Different treatment options are discussed for geriatric odontoid fracture. The aim of this study was to compare the treatment options for geriatric odontoid fractures.: Methods: Included were patients with the following criteria: age ≥ 65 ...

    Abstract Background: Different treatment options are discussed for geriatric odontoid fracture. The aim of this study was to compare the treatment options for geriatric odontoid fractures.
    Methods: Included were patients with the following criteria: age ≥ 65 years, identification of seniors at risk (ISAR score ≥ 2), and odontoid fracture type A/B according to Eysel and Roosen. Three groups were compared: conservative treatment, surgical therapy with ventral screw osteosynthesis or dorsal instrumentation. At a follow-up examination, the range of motion and the trabecular bone fracture healing rate were evaluated. Furthermore, demographic patient data, neurological status, length of stay at the hospital and at the intensive care unit (ICU) as well as the duration of surgery and occurring complications were analyzed.
    Results: A total of 72 patients were included and 43 patients could be re-examined (range: 2.7 ± 2.1 months). Patients with dorsal instrumentation had a better rotation. Other directions of motion were not significantly different. The trabecular bone fracture healing rate was 78.6%. The patients with dorsal instrumentation were hospitalized significantly longer; however, their duration at the ICU was shortest. There was no significant difference in complications.
    Conclusion: Geriatric patients with odontoid fracture require individual treatment planning. Dorsal instrumentation may offer some advantages.
    MeSH term(s) Humans ; Aged ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Conservative Treatment/adverse effects ; Odontoid Process/diagnostic imaging ; Odontoid Process/surgery ; Odontoid Process/injuries ; Fractures, Bone ; Fracture Fixation, Internal/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04472-2
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  5. Article ; Online: Personalized Management of Sodium and Volume Imbalance in Hemodialysis to Mitigate High Costs of Hospitalization.

    Hornig, Carsten / Canaud, Bernard J M / Bowry, Sudhir Kumar

    Blood purification

    2023  Volume 52, Issue 6, Page(s) 564–577

    Abstract: The primary objective of hemodialysis (HD) is lowering concentrations of organic uremic toxins that accumulate in blood in end-stage kidney disease (ESKD) and redress imbalances of inorganic compounds in particular sodium and water. Removal by ... ...

    Abstract The primary objective of hemodialysis (HD) is lowering concentrations of organic uremic toxins that accumulate in blood in end-stage kidney disease (ESKD) and redress imbalances of inorganic compounds in particular sodium and water. Removal by ultrafiltration of excess fluid that has accumulated during the dialysis-free interval is a vital aspect of each HD session. Most HD patients are volume overloaded, with ∼25% of patients having severe (>2.5 L) fluid overload (FO). The potentially serious complications of FO contribute to the high cardiovascular morbidity and mortality observed in the HD population. Weekly cycles imposed by the schedule of HD treatments create a deleterious and unphysiological "tide phenomenon" marked by sodium-volume overload (loading) and depletion (unloading). Fluid overload-related hospitalizations are frequent and costly, with average cost estimates of $ 6,372 per episode, amounting to some $ 266 million total costs over a 2-year period in a US dialysis population. Various strategies (e.g., dry weight management or use of fluids with different sodium concentrations) have been attempted to rectify FO in HD patients but have met with limited success largely due to imprecise and cumbersome, or costly, approaches. In recent years, conductivity-based technologies have been refined to actively restore sodium and fluid imbalance and maintain the predialysis plasma sodium set point (plasma tonicity) of each patient. By automatically controlling the dialysate-plasma sodium gradient based on the specific patient needs throughout a session, an individualized sodium dialysate prescription can be delivered. Maintaining precise sodium mass balance helps better control of blood pressure, reduces FO, and thus tends to prevent hospitalization for congestive heart failure. We present the case for personalized salt and fluid management via a machine-integrated sodium management tool. Results from proof-of-principle clinical trials indicate that the tool enables individualized sodium-fluid volume control during each HD session. Its application in routine clinical practice has the potential to mitigate the substantial economic burden of hospitalizations attributed to volume overload complications in HD. Additionally, such a tool would contribute toward reduced symptomology and dialysis-induced multiorgan damage in HD patients and to improving their treatment perception and quality of life which matters most to patients.
    MeSH term(s) Humans ; Sodium ; Quality of Life ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Kidney Failure, Chronic ; Dialysis Solutions ; Water-Electrolyte Imbalance/etiology ; Water-Electrolyte Imbalance/prevention & control ; Heart Failure/complications
    Chemical Substances Sodium (9NEZ333N27) ; Dialysis Solutions
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000530816
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  6. Article ; Online: Motion Artifact Reduction in Contrast-Enhanced Dual-Energy Mammography - A Multireader Study about the Effect of Nonrigid Registration as Motion Correction on Image Quality.

    Sistermanns, Markus / Kowall, Bernd / Hörnig, Mathias / Beiderwellen, Karsten / Uhlenbrock, Detlev

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2021  Volume 193, Issue 10, Page(s) 1183–1188

    Abstract: ... Citation format: · Sistermanns M, Kowall B, Hörnig M et al. Motion Artifact Reduction in Contrast-Enhanced ...

    Title translation Bewegungsartefakte in der kontrastverstärkten Dual-Energy Mammografie – eine Multireader-Studie zur Wertigkeit der nicht-rigiden Registrierung auf die Bildqualität.
    Abstract Purpose:  The technically caused delay between low-energy (LE) and high-energy (HE) acquisitions allows motion artifacts in contrast-enhanced dual-energy mammography (CEDEM). In this study the effect of motion correction by nonrigid registration on image quality of the recombined images was investigated.
    Materials and methods:  Retrospectively for 354 recombined CEDEM images an additional recombined image was processed from the raw data of LE and HE images using the motion correction algorithm. Five radiologists with many years of experience in breast cancer diagnostic imaging compared side-by-side one conventional processed CEDEM image with the corresponding image processed by the motion correction algorithm. Every pair of images was compared based on six criteria: General image quality (1), sharpness of skin contour (2), reduction of image artifacts (3), sharpness of lesion contour (4), contrast of lesion (5), visibility of lymph nodes (6). These criteria were rated on a Likert scale (improvement: + 1, + 2; deterioration: -1, -2).
    Results:  The mean ratings concerning criteria 1-5 showed a superiority of the recombined images processed by the motion correction algorithm. For example, the mean rating of general image quality was 0.86 (95 % CI: 0.78; 0.93). Only the mean rating concerning criterion 6 showed an inferiority of the recombined images processed by the motion correction algorithm (-0.29 (-0.46; -0.13)).
    Conclusion:  The usage of nonrigid registration for motion correction significantly improves the general image quality and the quality of subordinate criteria on the recombined CEDEM images at the expense of somewhat reduced lymph node visibility in some cases.
    Key points:   · The usage of motion correction in CEDEM improves the general image quality. · Motion correction might have the potential to increase diagnostic accuracy. · Alternative methods of motion artifact reduction are not yet available in clinical practice.
    Citation format: · Sistermanns M, Kowall B, Hörnig M et al. Motion Artifact Reduction in Contrast-Enhanced Dual-Energy Mammography - A Multireader Study about the Effect of Nonrigid Registration as Motion Correction on Image Quality. Fortschr Röntgenstr 2021; 193: 1183 - 1188.
    MeSH term(s) Algorithms ; Artifacts ; Humans ; Mammography ; Motion ; Retrospective Studies
    Language English
    Publishing date 2021-03-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-1388-7712
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  7. Article: Das Krankenhausein besonderer Begleitungsort in der Kinder- und Jugendhospizarbeit

    Hörnig, Martin / Winter, Katrin

    Die Hospiz-Zeitschrift

    2020  Volume 22, Issue 4=Ausg.88, Page(s) 35

    Language German
    Document type Article
    ZDB-ID 2014650-4
    ISSN 1617-3686
    Database Current Contents Medicine

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  8. Article ; Online: Unexplained post-acute infection syndromes.

    Choutka, Jan / Jansari, Viraj / Hornig, Mady / Iwasaki, Akiko

    Nature medicine

    2022  Volume 28, Issue 5, Page(s) 911–923

    Abstract: SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a ... ...

    Abstract SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute infections have long been associated with an unexplained chronic disability in a minority of patients. These post-acute infection syndromes (PAISs) represent a substantial healthcare burden, but there is a lack of understanding of the underlying mechanisms, representing a significant blind spot in the field of medicine. The relatively similar symptom profiles of individual PAISs, irrespective of the infectious agent, as well as the overlap of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggest the potential involvement of a common etiopathogenesis. In this Review, we summarize what is known about unexplained PAISs, provide context for post-acute sequelae of SARS-CoV-2 infection (PASC), and delineate the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses.
    MeSH term(s) COVID-19/complications ; Disease Progression ; Fatigue Syndrome, Chronic/diagnosis ; Fatigue Syndrome, Chronic/etiology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01810-6
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  9. Article ; Online: Author Correction: Unexplained post-acute infection syndromes.

    Choutka, Jan / Jansari, Viraj / Hornig, Mady / Iwasaki, Akiko

    Nature medicine

    2022  Volume 28, Issue 8, Page(s) 1723

    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01952-7
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  10. Article ; Online: THE AUTHORS REPLY.

    Gilman, Stephen E / Hornig, Mady

    American journal of epidemiology

    2020  Volume 190, Issue 1, Page(s) 185–186

    Language English
    Publishing date 2020-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2937-3
    ISSN 1476-6256 ; 0002-9262
    ISSN (online) 1476-6256
    ISSN 0002-9262
    DOI 10.1093/aje/kwaa101
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