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  1. Article ; Online: Editorial: Tubulin and axonal transport disturbances in CNS and PNS diseases.

    Bartolini, Francesca / Cavaletti, Guido

    Experimental neurology

    2023  Volume 362, Page(s) 114343

    MeSH term(s) Humans ; Tubulin/metabolism ; Axonal Transport ; Axons/metabolism ; Neurons/metabolism ; Peripheral Nervous System Diseases/metabolism
    Chemical Substances Tubulin
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114343
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 184: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Mobile Applications to Support Multiple Sclerosis Communities: The Post-COVID-19 Scenario.

    Vacchi, Laura / Zirone, Eleonora / Strina, Veronica / Cavaletti, Guido / Ferrarese, Carlo

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2024  

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2023.0515
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    Zs.A 4576: Show issues Location:
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  3. Article ; Online: Toxic medications in Charcot-Marie-Tooth patients: A systematic review.

    Cavaletti, Guido / Forsey, Katherine / Alberti, Paola

    Journal of the peripheral nervous system : JPNS

    2023  Volume 28, Issue 3, Page(s) 295–307

    Abstract: Background and aims: Several widely used medications, with a relevant efficacy profile, are toxic to the peripheral nervous system and an even larger number of agents are suspected to be neurotoxic. There are concerns about the use of these drugs in ... ...

    Abstract Background and aims: Several widely used medications, with a relevant efficacy profile, are toxic to the peripheral nervous system and an even larger number of agents are suspected to be neurotoxic. There are concerns about the use of these drugs in patients with Charcot-Marie-Tooth disease (CMT), a hereditary motor and sensory neuropathy. This review provides evidence-based updated recommendations on this clinically relevant topic.
    Methods: A systematic review of the available studies/reports written in English was performed from July to September 2022 including in the search string all reported putative neurotoxic drugs.
    Results: The results of our systematic review provide evidence-based support for the statement that use of vincristine, and possibly paclitaxel, can occasionally induce an atypical, and more severe, course of drug-related peripheral neurotoxicity in CMT patients. It is therefore reasonable to recommend caution in the use of these compounds in CMT patients. However, no convincing evidence for a similar recommendation could be found for all other drugs.
    Interpretation: It is important that patients with CMT are not denied effective treatments that may prolong life expectancy for cancer or improve their health status if affected by non-oncological diseases. Accurate monitoring of peripheral nerve function in CMT patients treated with any neurotoxic agent remains mandatory to detect the earliest signs of neuropathy worsening and atypical clinical courses. Neurologists monitoring CMT patients as part of their normal care package or for natural history studies should keep detailed records of exposures to neurotoxic medications and support reporting of accelerated neuropathy progression if observed.
    MeSH term(s) Humans ; Charcot-Marie-Tooth Disease ; Hereditary Sensory and Motor Neuropathy ; Neoplasms ; Neurotoxicity Syndromes
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12566
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    Zs.A 5106: Show issues Location:
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  4. Article: HDACi: The Columbus' Egg in Improving Cancer Treatment and Reducing Neurotoxicity?

    Squarzoni, Angelica / Scuteri, Arianna / Cavaletti, Guido

    Cancers

    2022  Volume 14, Issue 21

    Abstract: Histone deacetylases (HDACs) are a group of enzymes that modify gene expression through the lysine acetylation of both histone and non-histone proteins, leading to a broad range of effects on various biological pathways. New insights on this topic ... ...

    Abstract Histone deacetylases (HDACs) are a group of enzymes that modify gene expression through the lysine acetylation of both histone and non-histone proteins, leading to a broad range of effects on various biological pathways. New insights on this topic broadened the knowledge on their biological activity and even more questions arose from those discoveries. The action of HDACs is versatile in biological pathways and, for this reason, inhibitors of HDACs (HDACis) have been proposed as a way to interfere with HDACs' involvement in tumorigenesis. In 2006, the first HDACi was approved by FDA for the treatment of cutaneous T-cell lymphoma; however, more selective HDACis were recently approved. In this review, we will consider new information on HDACs' expression and their regulation for the treatment of central and peripheral nervous system diseases.
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215251
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  5. Article ; Online: Ubiquitin Proteasome System and Microtubules Are Master Regulators of Central and Peripheral Nervous System Axon Degeneration.

    Cartelli, Daniele / Cavaletti, Guido / Lauria, Giuseppe / Meregalli, Cristina

    Cells

    2022  Volume 11, Issue 8

    Abstract: Axonal degeneration is an active process that differs from neuronal death, and it is the hallmark of many disorders affecting the central and peripheral nervous system. Starting from the analyses of Wallerian degeneration, the simplest experimental model, ...

    Abstract Axonal degeneration is an active process that differs from neuronal death, and it is the hallmark of many disorders affecting the central and peripheral nervous system. Starting from the analyses of Wallerian degeneration, the simplest experimental model, here we describe how the long projecting neuronal populations affected in Parkinson's disease and chemotherapy-induced peripheral neuropathies share commonalities in the mechanisms and molecular players driving the earliest phase of axon degeneration. Indeed, both dopaminergic and sensory neurons are particularly susceptible to alterations of microtubules and axonal transport as well as to dysfunctions of the ubiquitin proteasome system and protein quality control. Finally, we report an updated review on current knowledge of key molecules able to modulate these targets, blocking the on-going axonal degeneration and inducing neuronal regeneration. These molecules might represent good candidates for disease-modifying treatment, which might expand the window of intervention improving patients' quality of life.
    MeSH term(s) Axons/metabolism ; Humans ; Microtubules/metabolism ; Peripheral Nervous System Diseases/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Quality of Life ; Sensory Receptor Cells/metabolism ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11081358
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  6. Article ; Online: Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria.

    Alberti, Paola / Semperboni, Sara / Cavaletti, Guido / Scuteri, Arianna

    Cells

    2022  Volume 11, Issue 16

    Abstract: Neurons are permanent cells whose key feature is information transmission via chemical and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain function and preserve neuronal lifelong survival. The cytoskeleton, and in ... ...

    Abstract Neurons are permanent cells whose key feature is information transmission via chemical and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain function and preserve neuronal lifelong survival. The cytoskeleton, and in particular microtubules, are far from being inert actors in the maintenance of this complex cellular equilibrium, and they participate in the mobilization of molecular cargos and organelles, thus influencing neuronal migration, neuritis growth and synaptic transmission. Notably, alterations of cytoskeletal dynamics have been linked to alterations of neuronal excitability. In this review, we discuss the characteristics of the neuronal cytoskeleton and provide insights into alterations of this component leading to human diseases, addressing how these might affect excitability/synaptic activity, as well as neuronal functioning. We also provide an overview of the microscopic approaches to visualize and assess the cytoskeleton, with a specific focus on mitochondrial trafficking.
    MeSH term(s) Cytoskeleton/metabolism ; Humans ; Ion Channels/metabolism ; Microtubules/metabolism ; Mitochondria/metabolism ; Neurons/metabolism
    Chemical Substances Ion Channels
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11162499
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  7. Article: Management of Oxaliplatin-Induced Peripheral Sensory Neuropathy.

    Cavaletti, Guido / Marmiroli, Paola

    Cancers

    2020  Volume 12, Issue 6

    Abstract: Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe and potentially permanent side effect of cancer treatment affecting the majority of oxaliplatin-treated patients, mostly with the onset of acute symptoms, but also with the establishment of ... ...

    Abstract Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe and potentially permanent side effect of cancer treatment affecting the majority of oxaliplatin-treated patients, mostly with the onset of acute symptoms, but also with the establishment of a chronic sensory loss that is supposed to be due to dorsal root ganglia neuron damage. The pathogenesis of acute as well as chronic OIPN is still not completely known, and this is a limitation in the identification of effective strategies to prevent or limit their occurrence. Despite intense investigation at the preclinical and clinical levels, no treatment can be suggested for the prevention of OIPN, and only limited evidence for the efficacy of duloxetine in the treatment setting has been provided. In this review, ongoing neuroprotection clinical trials in oxaliplatin-treated patients will be analyzed with particular attention paid to the hypothesis leading to the study, to the trial strengths and weaknesses, and to the outcome measures proposed to test the efficacy of the therapeutic approach. It can be concluded that 1) prevention and treatment of OIPN still remains an important and unmet clinical need, 2) further, high-quality research is mandatory in order to achieve reliable and effective results, and 3) dose and schedule modification of OHP-based chemotherapy is currently the most effective approach to limit the severity of OIPN.
    Language English
    Publishing date 2020-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12061370
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  8. Article ; Online: Axonal degeneration in chemotherapy-induced peripheral neurotoxicity: clinical and experimental evidence.

    Park, Susanna B / Cetinkaya-Fisgin, Aysel / Argyriou, Andreas A / Höke, Ahmet / Cavaletti, Guido / Alberti, Paola

    Journal of neurology, neurosurgery, and psychiatry

    2023  Volume 94, Issue 11, Page(s) 962–972

    Abstract: Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the molecular mechanisms underlying chemotherapy-induced axonal degeneration. This review ... ...

    Abstract Multiple pathological mechanisms are involved in the development of chemotherapy-induced peripheral neurotoxicity (CIPN). Recent work has provided insights into the molecular mechanisms underlying chemotherapy-induced axonal degeneration. This review integrates evidence from preclinical and clinical work on the onset, progression and outcome of axonal degeneration in CIPN. We review likely triggers of axonal degeneration in CIPN and highlight evidence of molecular pathways involved in axonal degeneration and their relevance to CIPN, including SARM1-mediated axon degeneration pathway. We identify potential clinical markers of axonal dysfunction to provide early identification of toxicity as well as present potential treatment strategies to intervene in axonal degeneration pathways. A greater understanding of axonal degeneration processes in CIPN will provide important information regarding the development and progression of axonal dysfunction more broadly and will hopefully assist in the development of successful interventions for CIPN and other neurodegenerative disorders.
    MeSH term(s) Humans ; Axons/pathology ; Neurotoxicity Syndromes/etiology ; Neurodegenerative Diseases/pathology ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/metabolism
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2021-328323
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  9. Article ; Online: Chemotherapy-induced peripheral neurotoxicity (CIPN): what we need and what we know.

    Cavaletti, Guido

    Journal of the peripheral nervous system : JPNS

    2014  Volume 19, Issue 2, Page(s) 66–76

    Abstract: Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent and severe long-term side effects of cancer chemotherapy. Preclinical and clinical studies have extensively investigated CIPN searching for effective strategies to limit its ...

    Abstract Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent and severe long-term side effects of cancer chemotherapy. Preclinical and clinical studies have extensively investigated CIPN searching for effective strategies to limit its severity or to treat CIPN-related impairment, but the results have been disappointing. Among the reasons for this failure are methodological flaws in both preclinical and clinical investigations. Their successful resolution might provide a brighter perspective for future studies. Among the several neurotoxic chemotherapy drugs, oxaliplatin may offer a clear example of a methodological approach eventually leading to successful clinical trials. However, the same considerations apply to the other neurotoxic agents and, although frequently neglected, also to the new "targeted" agents.
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions/complications ; Humans ; Neurotoxicity Syndromes/complications ; Neurotoxicity Syndromes/economics ; Neurotoxicity Syndromes/etiology ; Peripheral Nervous System Diseases/complications ; Peripheral Nervous System Diseases/economics ; Peripheral Nervous System Diseases/etiology
    Keywords covid19
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article ; Lectures ; Review
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns5.12073
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    Zs.A 5106: Show issues Location:
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  10. Article ; Online: Chemotherapy-induced peripheral neurotoxicity: Facts, needs and future directions.

    Cavaletti, Guido / Cornblath, David R

    Journal of the peripheral nervous system : JPNS

    2019  Volume 24 Suppl 2, Page(s) S86–S87

    MeSH term(s) Antineoplastic Agents/adverse effects ; Clinical Trials as Topic/methods ; Forecasting ; Health Services Needs and Demand/trends ; Humans ; Neurotoxicity Syndromes/diagnosis ; Neurotoxicity Syndromes/therapy ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12332
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