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  1. Article ; Online: Galectins: Their Network and Roles in Infection/Immunity/Tumor Growth Control 2021.

    Hattori, Toshio

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Galectins constitute a protein family of soluble and non-glycosylated animal lectins that show a β-galactoside-binding activity via a conserved sequence of approximately 130-140 amino acids located in the carbohydrate recognition domain (CRD) [ ... ]. ...

    Abstract Galectins constitute a protein family of soluble and non-glycosylated animal lectins that show a β-galactoside-binding activity via a conserved sequence of approximately 130-140 amino acids located in the carbohydrate recognition domain (CRD) [...].
    MeSH term(s) Amino Acid Sequence ; Amino Acids ; Animals ; Carbohydrates/chemistry ; Galectins/metabolism ; Neoplasms
    Chemical Substances Amino Acids ; Carbohydrates ; Galectins
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Memorial Paper on Professor Takatsuki, Who Devoted Himself to the Case Report

    Toshio Hattori

    Reports, Vol 4, Iss 37, p

    2021  Volume 37

    Abstract: This is a memorial paper for Prof [.] ...

    Abstract This is a memorial paper for Prof [.]
    Keywords n/a ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  3. Article ; Online: Case Reports Are the Starting Point to Medical Science

    Toshio Hattori

    Reports, Vol 3, Iss 8, p

    2020  Volume 8

    Abstract: I am serving as the Editor-in-Chief of an OPEN ACCESS medical journal Reports published by MDPI (Indexed by DOAJ and CLOCKSS, http://www [.] ...

    Abstract I am serving as the Editor-in-Chief of an OPEN ACCESS medical journal Reports published by MDPI (Indexed by DOAJ and CLOCKSS, http://www [.]
    Keywords n/a ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Possibility to Open Up New Areas by COVID-19 Infection

    Toshio Hattori / Yugo Ashino

    Reports, Vol 5, Iss 16, p

    2022  Volume 16

    Abstract: The rapid increase of COVID-19 cases has brought the number of patients to 513 million [.] ...

    Abstract The rapid increase of COVID-19 cases has brought the number of patients to 513 million [.]
    Keywords n/a ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Corrigendum: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19.

    Yatsenko, Tetiana / Rios, Ricardo / Nogueira, Tatiane / Salama, Yousef / Takahashi, Satoshi / Tabe, Yoko / Naito, Toshio / Takahashi, Kazuhisa / Hattori, Koichi / Heissig, Beate

    Frontiers in immunology

    2024  Volume 15, Page(s) 1390698

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1299792.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1299792.].
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1390698
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  6. Article ; Online: The first case of deep neck abscess due to Filifactor alocis co-infected with Eggerthia catenaformis, Parvimonas micra, and Streptococcusconstellatus.

    Furuya, Kento / Ito, Kenta / Sugiyama, Kyohei / Hattori, Norishige / Shimada, Toshio

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2023  Volume 29, Issue 7, Page(s) 707–709

    Abstract: Filifactor alocis, an anaerobic Gram-positive rod, has garnered interest from its association with periodontal disease. Extraoral infections by F. alocis are rare; only seven cases have been reported. We report the first case in which we identified F. ... ...

    Abstract Filifactor alocis, an anaerobic Gram-positive rod, has garnered interest from its association with periodontal disease. Extraoral infections by F. alocis are rare; only seven cases have been reported. We report the first case in which we identified F. alocis as one of the causative organisms of a deep neck abscess. A 71-year-old male on hemodialysis came to our hospital with a fever and left buccal pain. The patient's left neck was swollen, and contrast-enhanced computed tomography showed an abscess with gas extending from the left cheek to the deep neck. We diagnosed the patient with a deep neck abscess and performed an urgent neck drainage. We isolated F. alocis, Eggerthia catenaformis, Parvimonas micra, and Streptococcus constellatus in the abscess and identified them using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Blood cultures were negative. We initiated treatment with piperacillin-tazobactam and vancomycin. The patient improved but developed a hemorrhagic duodenal ulcer on the third day of admission. We attempted endoscopic hemostasis, but the patient's bleeding continued. Ultimately, he died of the duodenal ulcer hemorrhage on the sixth day of admission. This is the first case of F. alocis detected in a deep neck abscess.
    MeSH term(s) Male ; Humans ; Aged ; Abscess ; Duodenal Ulcer/complications ; Lactobacillus
    Language English
    Publishing date 2023-03-31
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2023.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19.

    Yatsenko, Tetiana / Rios, Ricardo / Nogueira, Tatiane / Takahashi, Satoshi / Tabe, Yoko / Naito, Toshio / Takahashi, Kazuhisa / Hattori, Koichi / Heissig, Beate

    Frontiers in immunology

    2024  Volume 14, Page(s) 1299792

    Abstract: Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases in plasminogen activator inhibitor-1 (PAI-1) and a shut-down of ... ...

    Abstract Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases in plasminogen activator inhibitor-1 (PAI-1) and a shut-down of fibrinolysis (blood clot dissolution). Decreased urokinase-type plasminogen activator (uPA), a protease necessary for cell-associated plasmin generation, and increased tissue-type plasminogen activator (tPA) and PAI-1 levels have been reported in COVID-19 patients. Because these factors can occur in free and complexed forms with differences in their biological functions, we examined the predictive impact of uPA, tPA, and PAI-1 in their free forms and complexes as a biomarker for COVID-19 severity and the development of ARDS. In this retrospective study of 69 Japanese adults hospitalized with COVID-19 and 20 healthy donors, we found elevated free, non-complexed PAI-1 antigen, low circulating uPA, and uPA/PAI-1 but not tPA/PAI-1 complex levels to be associated with COVID-19 severity and ARDS development. This biomarker profile was typical for patients in the complicated phase. Lack of PAI-1 activity in circulation despite free, non-complexed PAI-1 protein and plasmin/α2anti-plasmin complex correlated with suPAR and sVCAM levels, markers indicating endothelial dysfunction. Furthermore, uPA/PAI-1 complex levels positively correlated with TNFα, a cytokine reported to trigger inflammatory cell death and tissue damage. Those levels also positively correlated with lymphopenia and the pro-inflammatory factors interleukin1β (IL1β), IL6, and C-reactive protein, markers associated with the anti-viral inflammatory response. These findings argue for using uPA and uPA/PAI-1 as novel biomarkers to detect patients at risk of developing severe COVID-19, including ARDS.
    MeSH term(s) Adult ; Humans ; Urokinase-Type Plasminogen Activator/metabolism ; Plasminogen Activator Inhibitor 1 ; Retrospective Studies ; Fibrinolysin ; COVID-19 ; Biomarkers ; Respiratory Distress Syndrome ; Thrombosis
    Chemical Substances Urokinase-Type Plasminogen Activator (EC 3.4.21.73) ; Plasminogen Activator Inhibitor 1 ; Fibrinolysin (EC 3.4.21.7) ; Biomarkers
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1299792
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  8. Article ; Online: The elevation of plasma galectin-9 levels in patients with psoriasis and its associations with inflammatory and immune checkpoint molecules in skin tissues.

    Chagan-Yasutan, Haorile / He, Nagongbilige / Arlud, Sarnai / Fang, Jun / Hattori, Toshio

    Human immunology

    2023  Volume 85, Issue 1, Page(s) 110741

    Abstract: Psoriasis is a chronic, immune-mediated disorder that mainly affects the skin, with an estimated global prevalence of 2-3%. Galectin-9 (Gal-9) is a β-galactoside-binding lectin capable of promoting or suppressing the progression of infectious and immune- ... ...

    Abstract Psoriasis is a chronic, immune-mediated disorder that mainly affects the skin, with an estimated global prevalence of 2-3%. Galectin-9 (Gal-9) is a β-galactoside-binding lectin capable of promoting or suppressing the progression of infectious and immune-mediated diseases. Here, we determined if the expression of Gal-9 is observed in psoriasis. Gal-9 levels were measured in plasma of psoriasis (n = 62) and healthy control (HC) (n = 31) using an enzyme-linked immunosorbent assay. In addition, skin samples from seven patients were screened for RNA transcriptomes and the expression of Gal-9 was compared with inflammatory, immune checkpoint molecules (ICMs) and Foxp3. The plasma Gal-9 levels in patients with psoriasis were significantly higher (841 pg/mL) than in HCs (617 pg/mL) (P < 0.0001) and were associated with white blood cell numbers, eosinophils (%) and alanine transaminase. The levels of inflammatory molecules IL-36B, IL-17RA, IL-6R, IL-10, IRF8, TGFb1, and IL-37, and those of ICMs of Tim-3, CTLA-4, CD86, CD80, PD-1LG2, CLEC4G, and Foxp3 were significantly correlated with Gal-9 (LGALS9) in skin. However, HMGB1, CD44, CEACAM1 and PDL1-known to be associated with a variety of Gal-9 biological functions were not correlated with LGALS9. Thus, it is likely that Gal-9 expression affects the disease state of PS.
    MeSH term(s) Humans ; Immune Checkpoint Proteins ; Galectins/genetics ; Galectins/metabolism ; Psoriasis ; Enzyme-Linked Immunosorbent Assay ; Forkhead Transcription Factors
    Chemical Substances Immune Checkpoint Proteins ; Galectins ; Forkhead Transcription Factors
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2023.110741
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: An X-ray and Neutron Scattering Study of Aqueous MgCl 2 Solution in the Gigapascal Pressure Range

    Toshio Yamaguchi / Nami Fukuyama / Koji Yoshida / Yoshinori Katayama / Shinichi Machida / Takanori Hattori

    Liquids, Vol 3, Iss 19, Pp 288-

    2023  Volume 302

    Abstract: The structure of electrolyte solutions under pressure at a molecular level is a crucial issue in the fundamental science of understanding the nature of ion solvation and association and application fields, such as geological processes on the Earth, ... ...

    Abstract The structure of electrolyte solutions under pressure at a molecular level is a crucial issue in the fundamental science of understanding the nature of ion solvation and association and application fields, such as geological processes on the Earth, pressure-induced protein denaturation, and supercritical water technology. We report the structure of an aqueous 2 m (=mol kg −1 ) MgCl 2 solution at pressures from 0.1 MPa to 4 GPa and temperatures from 300 to 500 K revealed by X-ray- and neutron-scattering measurements. The scattering data are analyzed by empirical potential structure refinement (EPSR) modeling to derive the pair distribution functions, coordination number distributions, angle distributions, and spatial density functions (3D structure) as a function of pressure and temperature. Mg 2+ forms rigid solvation shells extended to the third shell; the first solvation shell of six-fold octahedral coordination with about six water molecules at 0 GPa transforms into about five water molecules and one Cl − due to the formation of the contact ion pairs in the GPa pressure range. The Cl − solvation shows a substantial pressure dependence; the coordination number of a water oxygen atom around Cl − increases from 8 at 0.1 MPa/300 K to 10 at 4 GPa/500 K. The solvent water transforms the tetrahedral network structure at 0.1 MPa/300 K to a densely packed structure in the GPa pressure range; the number of water oxygen atoms around a central water molecule gradually increases from 4.6 at 0.1 MPa/298 K to 8.4 at 4 GPa/500 K.
    Keywords ion solvation ; X-ray scattering ; neutron scattering ; Organic chemistry ; QD241-441
    Subject code 541
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  10. Article ; Online: A Case of Sarcoid-Lymphoma Syndrome with Various Etiological Factors

    Kazuki Furuyama / Makiko Tsukita / Yoichi Shirato / Yusaku Sasaki / Yugo Ashino / Toshio Hattori

    Reports, Vol 6, Iss 19, p

    2023  Volume 19

    Abstract: A 75-year-old female with a history of stomach cancer and depression was referred to our hospital for left cervical lymphadenopathy. The biopsy of her left cervical lymph node revealed noncaseating granulomas with multinucleated giant cells. The positron ...

    Abstract A 75-year-old female with a history of stomach cancer and depression was referred to our hospital for left cervical lymphadenopathy. The biopsy of her left cervical lymph node revealed noncaseating granulomas with multinucleated giant cells. The positron emission tomography/computed tomography (PET/CT) indicated general lymphadenopathy (left supraclavicular left axillary, hepatic lymph nodes), except for the hilar lymph node. Both histology by transbronchial lung biopsy (TBLB) and analysis of broncho alveolar lavage fluid (BALF) were indicative of sarcoidosis. C-reactive protein (CRP) and soluble interleukin-2 receptor (sIL-2R) were increased in the sera. An alternative cause of granulomatous disease was ruled out, and on follow-up, she was diagnosed with sarcoidosis. Two years later, she was hospitalized for fever, anorexia, lymph node tenderness, and erythema nodosum with significant increases in CRP and sIL-2R. After admission, the repetitive axillary lymph biopsy showed the same histological findings as before, but the G-band staining showed clonal abnormalities. Bone marrow biopsy revealed abnormal lymphocytes with petal-like nuclei. Finally, she was diagnosed with malignant lymphoma infiltrating the bone marrow. After CHOP-based chemotherapy, her laboratory data, lymphadenopathy, and clinical findings improved, and she was discharged from the hospital on the 90th day. Careful medical treatment, including genetic analysis of the lymph node, is necessary in patients with sarcoidosis if lymphadenopathy is predominant.
    Keywords sarcoid-lymphoma syndrome ; sarcoidosis ; lymphoma ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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