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Article: Chang qing formula ameliorates colitis-associated colorectal cancer

Luo, Qihan / Huang, Shuo / Zhao, Lisha / Liu, Jingqun / Ma, Qing / Wang, Yiheng / Dong, Yu / Li, Changyu / Qiu, Ping

2022 Volume 13, Page(s) 893231

Abstract: ... Chang Qing formula (CQF) is a Chinese herbal formula used clinically for the treatment of CAC ...

Abstract	Colitis-associated colorectal cancer (CAC) is a specific type of colorectal cancer (CRC) with high mortality and morbidity, the chronic inflammation in the intestinal mucosal is the characteristic of CAC. Chang Qing formula (CQF) is a Chinese herbal formula used clinically for the treatment of CAC with remarkable clinical efficacy, but its mechanism remains unclear. In the present work, Combined network pharmacology and transcriptomics were used to analyze the potential active ingredients and elucidate molecular mechanism of CQF in treating CAC. Firstly, the constituents migrating to blood of CQF were analyzed and identified by UPLC-Q-TOF-MS/MS, and core genes and pathways were screened by network pharmacology analysis. Encyclopedia of Genes and Genomes (KEGG) analysis showed that the IL-17 signaling pathway involved in CAC may be closely associated with the potential mechanismof action of CQF. Subsequently, the results from animal studies indicated that CQF profoundly reduced tumor numbers and tumor size in AOM/DSS mice. The RNA-seq data was analysed utilizing Ingenuity Pathway Analysis (IPA), and the results supported the idea that CQF exerts a tumour-suppressive effect via the IL-17 signalling pathway. Further studies demonstrated that CQF significantly reduced IL-17A levels, which in turn inhibited NF-κB/IL-6/STAT3 signaling cascade, suppressed MMP9 expression and promoted tumor cell apoptosis. In conclusion, the current study demonstrated that CQF remarkably improved inflammatory tumor microenvironment, and hindered the transformation of inflammation into cancer. These findings may help to design future strategies for the treatment of CAC.
Language	English
Publishing date	2022-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.893231
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Qing Hua Chang Yin on lipopolysaccharide‑induced intestinal epithelial tight junction injury in Caco‑2 cells.

Fang, Wenyi / Zhao, Peilin / Shen, Aling / Liu, Liya / Chen, Hongwei / Chen, Youqin / Peng, Jun / Sferra, Thomas J / Sankararaman, Senthilkumar / Luo, Yunfeng / Ke, Xiao

Molecular medicine reports

2021 Volume 23, Issue 3

Abstract: ... traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent ...

Abstract	Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore considered a drug discovery target for IBD. The well‑known traditional Chinese formulation Qing Hua Chang Yin (QHCY) has been suggested as a potential therapeutic agent for the treatment of ulcerative colitis. However, the possible underlying molecular mechanisms regarding its therapeutic effect remain unclear. Consequently, the present study investigated the effects of QHCY on lipopolysaccharide (LPS)‑induced loss of intestinal epithelial barrier integrity
MeSH term(s)	Caco-2 Cells ; Drugs, Chinese Herbal/pharmacology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Intestinal Mucosa/injuries ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Lipopolysaccharides/toxicity ; Tight Junctions/metabolism ; Tight Junctions/pathology
Chemical Substances	Drugs, Chinese Herbal ; Lipopolysaccharides
Language	English
Publishing date	2021-01-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.11844
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Article ; Online: Randomised clinical trial: Efficacy and safety of Qing-Chang-Hua-Shi granules in a multicenter, randomized, and double-blind clinical trial of patients with moderately active ulcerative colitis.

Shen, Hong / Zhang, Shengsheng / Zhao, Wenxia / Ren, Shunping / Ke, Xiao / Gu, Qinghua / Tang, Zhipeng / Xie, Jingri / Chen, Suning / Chen, Yan / Zou, Jiandong / Zhang, Lu / Shen, Zhaofeng / Zheng, Kai / Liu, Yajun / Gu, Peiqing / Cheng, Jiafei / Hu, Jingyi / Zhu, Lei

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 139, Page(s) 111580

Abstract: Qing-Chang-Hua-Shi (QCHS) is a Chinese herbal formula, which is composed of 11 herbs. Studies have ... health-related quality of life, endoscopic response rate, and mucosal healing rate. Any changes in mucus/bloody ...

Abstract	Qing-Chang-Hua-Shi (QCHS) is a Chinese herbal formula, which is composed of 11 herbs. Studies have also shown that QCHS granules can alleviate colitis in animal models by preventing inflammatory responses and suppressing apoptosis through the MEK/ERK signaling pathway. To determine the efficacy and safety of QCHS granules in patients with moderately active UC. We performed a multicenter, randomized, placebo-controlled, double-blind study of patients with moderately active UC who did not respond to 4 weeks of mesalazine therapy at the maximum dose. Patients were randomly assigned to groups and administered QCHS granules (125 g/day, n = 59) or an identical placebo, which was similar to the QCHS granules in color and taste (125 g/day, n = 60), with continued 5-ASA 4 g/d therapy for 12 weeks. The primary outcome was the rate of clinical response and clinical remission at week 12. The secondary outcomes were health-related quality of life, endoscopic response rate, and mucosal healing rate. Any changes in mucus/bloody stool and diarrhea were recorded. Out of the 119 enrolled patients at 10 different centers in China, 102 patients completed the trial. Clinical remission and clinical response were seen in 31.48% and 92.59% of QCHS-treated patients, and 12.50% and 72.92% of placebo-treated patients, respectively. There was a significant difference between the two treatment groups. More patients receiving QCHS granules vs. placebo achieved remission of mucus/bloody stool (70.37% vs. 47.92%, P = 0.0361). Adverse event rates were similar (QCHS granules 38.33%; placebo 25.42%). In conclusion, QCHS granules were superior to the placebo in introducing clinical remission and mucosal healing, as well as in relieving mucus/blood stool in patients with moderately active and 5-ASA-refractory UC.
MeSH term(s)	Adult ; Anti-Ulcer Agents/adverse effects ; Anti-Ulcer Agents/therapeutic use ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/psychology ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Intestinal Mucosa/pathology ; Male ; Mesalamine/therapeutic use ; Middle Aged ; Prospective Studies ; Quality of Life ; Sulfasalazine/therapeutic use ; Treatment Outcome
Chemical Substances	Anti-Ulcer Agents ; Drugs, Chinese Herbal ; qing-chang-hua-shi granules ; Sulfasalazine (3XC8GUZ6CB) ; Mesalamine (4Q81I59GXC)
Language	English
Publishing date	2021-04-13
Publishing country	France
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111580
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Article: Modified Qing' e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation.

Lu, Junjie / Hu, Desheng / Ma, Chen / Xu, Xiaojuan / Shen, Lin / Rong, Jianhui / Zhao, Jia / Shuai, Bo

Frontiers in endocrinology

2022 Volume 13, Page(s) 998971

Abstract: Objective: To explore whether the modified Qing' e Pills (MQEP) exerts anti-osteoporotic effects ...

Abstract	Objective: To explore whether the modified Qing' e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis. Methods: Network pharmacology was used to assess whether MQEP has a pro-angiogenic capacity and to predict its potential targets. Human umbilical vein endothelial cells were treated with glucocorticoids and MQEP to assess cell viability. The expression of angiotensin II type 1 receptor, angiotensin II type 2 receptor, and angiotensin converting enzyme, which are associated with the activation of the renin-angiotensin-aldosterone system, and the expression of vascular endothelial growth factor and hypoxia-inducible factor 1 alpha, which are associated with the formation of type H blood vessels, were examined by western blot and RT-qPCR. Thereafter, the glucocorticoid-induced osteoporosis model was established and intervened with MQEP. Femur scanning was performed with micro-computed tomography; trabecular spacing, trabecular thickness, and trabecular number were observed and calculated; the expression of nuclear factor-kappa B ligand and osteoprotegerin was detected by ELISA, and the ratio was calculated to evaluate the degree of bone resorption. Finally, type H blood vessels that were highly coupled to osteogenic cells were identified by immunohistochemistry staining and flow cytometry. Results: This is the first study to reveal and confirm that MQEP could prevent bone loss in glucocorticoid-induced osteoporosis by promoting the expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor, which are highly associated with type H blood vessel formation. Conclusion: MQEP exerts anti-osteoporosis effects and prevents bone loss by alleviating vascular injury caused by renin-angiotensin-aldosterone system activation and promoting type H blood vessel formation.
MeSH term(s)	Bone Diseases, Metabolic ; Endothelial Cells/metabolism ; Glucocorticoids/adverse effects ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Ligands ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control ; Osteoprotegerin/metabolism ; Peptidyl-Dipeptidase A/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Receptor, Angiotensin, Type 2/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular System Injuries ; X-Ray Microtomography
Chemical Substances	Glucocorticoids ; Hypoxia-Inducible Factor 1 ; Ligands ; Osteoprotegerin ; Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Vascular Endothelial Growth Factor A ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.998971
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Article ; Online: Modified Qing’ e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation

Junjie Lu / Desheng Hu / Chen Ma / Xiaojuan Xu / Lin Shen / Jianhui Rong / Jia Zhao / Bo Shuai

Frontiers in Endocrinology, Vol

2022 Volume 13

Abstract: ObjectiveTo explore whether the modified Qing’ e Pills (MQEP) exerts anti-osteoporotic effects and ...

Abstract	ObjectiveTo explore whether the modified Qing’ e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis.MethodsNetwork pharmacology was used to assess whether MQEP has a pro-angiogenic capacity and to predict its potential targets. Human umbilical vein endothelial cells were treated with glucocorticoids and MQEP to assess cell viability. The expression of angiotensin II type 1 receptor, angiotensin II type 2 receptor, and angiotensin converting enzyme, which are associated with the activation of the renin-angiotensin-aldosterone system, and the expression of vascular endothelial growth factor and hypoxia-inducible factor 1 alpha, which are associated with the formation of type H blood vessels, were examined by western blot and RT-qPCR. Thereafter, the glucocorticoid-induced osteoporosis model was established and intervened with MQEP. Femur scanning was performed with micro-computed tomography; trabecular spacing, trabecular thickness, and trabecular number were observed and calculated; the expression of nuclear factor-kappa B ligand and osteoprotegerin was detected by ELISA, and the ratio was calculated to evaluate the degree of bone resorption. Finally, type H blood vessels that were highly coupled to osteogenic cells were identified by immunohistochemistry staining and flow cytometry.ResultsThis is the first study to reveal and confirm that MQEP could prevent bone loss in glucocorticoid-induced osteoporosis by promoting the expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor, which are highly associated with type H blood vessel formation. In vitro experiments confirmed that MQEP could effectively promote the proliferation of vascular endothelial cells and alleviate glucocorticoids-induced activation of the renin-angiotensin-aldosterone system, thereby reducing vascular injury.ConclusionMQEP exerts anti-osteoporosis effects and prevents bone loss by alleviating vascular injury caused by renin-angiotensin-aldosterone system activation and ...
Keywords	osteoporosis ; bone loss ; angiotensin ; alternative medicine ; type H blood vessels ; vessel formation ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Modified Qing'e Formula protects against UV-induced skin oxidative damage

Zhu, Shan / Qin, Wenxiao / Liu, Tao / Ma, Hongfei / Hu, Cunyu / Yue, Xiaofeng / Yan, Yiqi / Lv, Yingshuang / Wang, Zijing / Zhao, Zhiyue / Wang, Xiang / Liu, Yan / Xia, Qingmei / Zhang, Han / Li, Nan

Frontiers in pharmacology

2022 Volume 13, Page(s) 976473

Abstract: ... the protective effect of Modified Qing'e Formula (MQEF) on UV-induced skin oxidative damage and its molecular mechanisms ...

Abstract	Exposure to ultraviolet (UV) light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, which increases oxidative stress damage and leads to photoaging. Nuclear factor E2-related factor 2 (Nrf2) modulates the antioxidant defense of skin cells against environmental factors, especially ultraviolet radiation. Natural products that target Nrf2-regulated antioxidant reactions are promising candidates for anti-photoaging. The aim of this study was to investigate the protective effect of Modified Qing'e Formula (MQEF) on UV-induced skin oxidative damage and its molecular mechanisms. In this study, the photoaging models of human keratinocytes (HaCaT) and ICR mice were established by UV irradiation.
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.976473
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Article: Famine, migration and war: Comparison of climate change impacts and social responses in North China between the late Ming and late Qing dynasties

Xiao, Lingbo / Jingyun Zheng / Wanyi Zhao / Xiuqi Fang

Holocene. , v. 25, no. 6

2015

Abstract: ... the late Ming dynasty (1560–1644) and late Qing dynasty (1780–1911), were selected and compared. It is ... and interregional migration, which was an effective responsive measure in the late Qing, was not ... disaster relief and refugee settlement, was considerably greater in the late Qing. ...

Abstract	The human-climate-ecosystem interactions in the past were valuable for today’s human beings who face the challenge of global change. The multi-proxy reconstruction of climate change impacts and social responses and the comparative study between typical periods form an effective tool for elucidating the mechanisms of the interactions. In this paper, with a reconstruction of the proxy series of famine, migration and wars, the most typical social consequences related to climate change and disasters (flood/drought) in North China in 1470–1911 were quantitatively described, and two typical periods of human-climate interaction with similar climate change backgrounds (cold periods of the ‘Little Ice Age’), which were the late Ming dynasty (1560–1644) and late Qing dynasty (1780–1911), were selected and compared. It is determined that the climate deterioration (rapid cooling and increasing extreme disasters) in the late 16th and 18th centuries both resulted in severe social consequences characterized by more famine and popular unrest. The differences were that the climatic impacts in the late Ming were much more serious, and interregional migration, which was an effective responsive measure in the late Qing, was not important in the late Ming; they were primarily influenced by three factors based on the analytical framework of the impacts of historical climate change and social responses: (1) climate deterioration in the late Ming was more severe (more rapid cooling and more extreme disasters), (2) social system were more sensitive to climate change in the late Ming because of its mode of agricultural production (especially cropping system and crop species), and (3) the capacity of social response to climate disaster, especially disaster relief and refugee settlement, was considerably greater in the late Qing.
Keywords	climate ; climate change ; cold ; cooling ; cropping systems ; crops ; disaster recovery ; disasters ; drought ; famine ; humans ; social impact ; China
Language	English
Dates of publication	2015-06
Size	p. 900-910.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	2027956-5
ISSN	1477-0911 ; 0959-6836
ISSN (online)	1477-0911
ISSN	0959-6836
DOI	10.1177/0959683615572851
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Automatic individual recognition of wild Crested Ibis based on hybrid method of self-supervised learning and clustering

Zhao, Sibo / Xie, Jiangjian / Ding, Chang-qing

Ecological Informatics. 2023 July, v. 75 p.102089-

2023

Abstract: Automatic individual recognition of wild Crested Ibis is challenged by two factors: the lack of labeled data and an unpredictable number of individuals. In this paper, we propose a hybrid method of self-supervised learning and clustering to automatically ...

Abstract	Automatic individual recognition of wild Crested Ibis is challenged by two factors: the lack of labeled data and an unpredictable number of individuals. In this paper, we propose a hybrid method of self-supervised learning and clustering to automatically recognize wild Crested Ibis based on vocalizations. To address the first challenge, we enhance the Bootstrap Your Own Latent for Audio (BYOL-A) model by using an improved augmentation module and Spatial Group-wise Enhance (SGE) attention module to create the self-supervised learning model BYOL-AIS. This model aims to extract a more discriminative representation of Crested Ibis vocalizations. To handle the second challenge, we introduce a clustering method that combines Uniform Manifold Approximation and Projection (UMAP) and Hierarchical Density-Based Spatial Clustering of Applications with Noise (HDBSCAN) to distinguish the representation of Crested Ibis vocalizations. We evaluate our proposed method using vocalizations collected from 10 Crested Ibis individuals and achieve a recognition accuracy of 0.864. This accuracy is comparable to the performance of commonly used supervised methods. Our results suggest that our proposed method is a feasible method for wild bird recognition in the absence of labeled data and has the potential to be an analytical tool for processing huge amounts of monitoring data.
Keywords	automatic detection ; clothing ; extracts ; learning ; models ; monitoring ; vocalization ; wild birds ; Crested Ibis vocalizations ; Individual recognition ; Self-supervised learning ; Clustering ; BYOL-A
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2212016-6
ISSN	1878-0512 ; 1574-9541
ISSN (online)	1878-0512
ISSN	1574-9541
DOI	10.1016/j.ecoinf.2023.102089
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The reduce of water vapor permeability of polysaccharide-based films in food packaging: A comprehensive review.

Long, Jiyang / Zhang, Wenyu / Zhao, Minzi / Ruan, Chang-Qing

Carbohydrate polymers

2023 Volume 321, Page(s) 121267

Abstract: Polysaccharide-based films are favored in the food packaging industry because of their advantages of green and safe characters, as well as natural degradability, but due to the structural defects of polysaccharides, they also have the disadvantages of ... ...

Abstract	Polysaccharide-based films are favored in the food packaging industry because of their advantages of green and safe characters, as well as natural degradability, but due to the structural defects of polysaccharides, they also have the disadvantages of high water vapor permeability (WVP), which greatly limits their application in the food packaging industry. To break the limitation, numerous methods, e.g., physical and/or chemical methods, have been employed. This review mainly elaborates the up-to-date research status of the application of polysaccharide-based films (PBFs) in food packaging area, including various films from cellulose and its derivatives, starch, chitosan, pectin, alginate, pullulan and so on, while the methods of reducing the WVP of PBFs, mainly divided into physical and chemical methods, are summarized, as well as the discussions about the existing problems and development trends of PBFs. In the end, suggestions about the future development of WVP of PBFs are presented.
MeSH term(s)	Steam ; Food Packaging ; Polysaccharides ; Starch ; Permeability
Chemical Substances	Steam ; Polysaccharides ; Starch (9005-25-8)
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.121267
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Article ; Online: Pharmacokinetics of cyanidin-3-

Chen, Yan / Zhao, Jing / Li, Han-Han / Qian, Wen / Zhou, Bing-Yu / Yang, Chang-Qing

Journal of Asian natural products research

2023 Volume 26, Issue 6, Page(s) 714–725

Abstract: Cyanidin-3- ...

Abstract	Cyanidin-3-
MeSH term(s)	Anthocyanins/pharmacokinetics ; Anthocyanins/chemistry ; Animals ; Galactosides/chemistry ; Galactosides/pharmacokinetics ; Rats ; Molecular Structure ; Administration, Intravenous ; Male ; Rats, Sprague-Dawley ; Chromatography, High Pressure Liquid
Chemical Substances	Anthocyanins ; Galactosides ; cyanidin 3-galactoside (FC7L938Y12)
Language	English
Publishing date	2023-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2023.2279541
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