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  1. Article ; Online: Nicotinic acid availability impacts redox cofactor metabolism in Saccharomyces cerevisiae during alcoholic fermentation.

    Duncan, James D / Setati, Mathabatha E / Divol, Benoit

    FEMS yeast research

    2024  Volume 24

    Abstract: Anaerobic alcoholic fermentation, particularly in high-sugar environments, presents metabolic challenges for yeasts. Crabtree-positive yeasts, including Saccharomyces cerevisiae, prefer fermentation even in the presence of oxygen. These yeasts rely on ... ...

    Abstract Anaerobic alcoholic fermentation, particularly in high-sugar environments, presents metabolic challenges for yeasts. Crabtree-positive yeasts, including Saccharomyces cerevisiae, prefer fermentation even in the presence of oxygen. These yeasts rely on internal NAD+ recycling and extracellular assimilation of its precursor, nicotinic acid (vitamin B3), rather than de novo NAD+ production. Surprisingly, nicotinic acid assimilation is poorly characterized, even in S. cerevisiae. This study elucidated the timing of nicotinic acid uptake during grape juice-like fermentation and its impact on NAD(H) levels, the NAD+/NADH ratio, and metabolites produced. Complete uptake of extracellular nicotinic acid occurred premid-exponential phase, thereafter small amounts of vitamin B3 were exported back into the medium. Suboptimal levels of nicotinic acid were correlated with slower fermentation and reduced biomass, disrupting redox balance and impeding NAD+ regeneration, thereby affecting metabolite production. Metabolic outcomes varied with nicotinic acid concentrations, linking NAD+ availability to fermentation efficiency. A model was proposed encompassing rapid nicotinic acid uptake, accumulation during cell proliferation, and recycling with limited vitamin B3 export. This research enhances the understanding of nicotinic acid uptake dynamics during grape juice-like fermentation. These insights contribute to advancing yeast metabolism research and have profound implications for the enhancement of biotechnological practices and the wine-making industry.
    MeSH term(s) Saccharomyces cerevisiae/metabolism ; Fermentation ; Niacin/metabolism ; Oxidation-Reduction ; NAD/metabolism ; Ethanol/metabolism ; Coenzymes/metabolism
    Chemical Substances Niacin (2679MF687A) ; NAD (0U46U6E8UK) ; Ethanol (3K9958V90M) ; Coenzymes
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036775-2
    ISSN 1567-1364 ; 1567-1356
    ISSN (online) 1567-1364
    ISSN 1567-1356
    DOI 10.1093/femsyr/foae015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5454: Show issues Location:
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  2. Article ; Online: Corrigendum to "Redox cofactor metabolism in Saccharomyces cerevisiae and its impact on the production of alcoholic fermentation end-products" [Food Res. Int. 163 (2023) 112276].

    Duncan, James D / Setati, Mathabatha E / Divol, Benoit

    Food research international (Ottawa, Ont.)

    2023  Volume 173, Issue Pt 2, Page(s) 113478

    Language English
    Publishing date 2023-09-21
    Publishing country Canada
    Document type Published Erratum
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113478
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    Z 2972: Show issues

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  3. Article: Laparoscopy, Endoscopy, and Minimally Invasive Colorectal Surgery.

    Duncan, James E

    Clinics in colon and rectal surgery

    2017  Volume 30, Issue 2, Page(s) 89–90

    Language English
    Publishing date 2017-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2048635-2
    ISSN 1531-0043
    ISSN 1531-0043
    DOI 10.1055/s-0036-1597319
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    Zs.A 3931: Show issues Location:
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  4. Article ; Online: Redox cofactor metabolism in Saccharomyces cerevisiae and its impact on the production of alcoholic fermentation end-products.

    Duncan, James D / Setati, Mathabatha E / Divol, Benoit

    Food research international (Ottawa, Ont.)

    2022  Volume 163, Page(s) 112276

    Abstract: The alcoholic fermentation of organic carbon sources by Saccharomyces cerevisiae produces many by-products, with the most abundant originating from central carbon metabolism. The production of these metabolites involves redox reactions and largely ... ...

    Abstract The alcoholic fermentation of organic carbon sources by Saccharomyces cerevisiae produces many by-products, with the most abundant originating from central carbon metabolism. The production of these metabolites involves redox reactions and largely depends on the maintenance of redox homeostasis. Despite the metabolic pathways being mostly conserved across strains of S. cerevisiae, their production of various amounts of metabolic products suggests that their intracellular concentration of redox cofactors and/or redox balance differ. This study explored the redox status dynamics and NAD(H) and NADP(H) cofactor ratios throughout alcoholic fermentation in four S. cerevisiae strains that exhibit different carbon metabolic fluxes. This study focussed on the molecular end-products of fermentation, redox cofactor ratios and the impact thereof on redox homeostasis. Strain-dependent differences were identified in the redox cofactor levels, with NADP(H) ratios and levels remaining stable while NAD(H) levels decreased drastically as the fermentation progressed. Changes in the NAD
    MeSH term(s) Saccharomyces cerevisiae/metabolism ; NAD/metabolism ; Fermentation ; NADP/metabolism ; Oxidation-Reduction
    Chemical Substances NAD (0U46U6E8UK) ; NADP (53-59-8)
    Language English
    Publishing date 2022-11-29
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.112276
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    In stock of ZB MED Bonn / Germany

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  5. Book ; Online: Promoting International Energy Security

    Johnson, Stuart E / Baxter, Caroline / Bartis, James T / Long, Duncan

    Volume 4, The Gulf of Guinea

    2012  

    Keywords Energy industries & utilities ; Treaties & other sources of international law ; Environmental policy & protocols ; Energy ; Political Science ; Business ; Physics
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030609550
    ISBN 9780833068446 ; 083306844X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Replies to commentaries on beyond playing 20 questions with nature.

    Almaatouq, Abdullah / Griffiths, Thomas L / Suchow, Jordan W / Whiting, Mark E / Evans, James / Watts, Duncan J

    The Behavioral and brain sciences

    2024  Volume 47, Page(s) e65

    Abstract: Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of ... ...

    Abstract Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.
    MeSH term(s) Dissent and Disputes
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X23002789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1470: Show issues Location:
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  7. Article ; Online: Thermal capillary waves on bounded nanoscale thin films.

    Liu, Jingbang / Zhao, Chengxi / Lockerby, Duncan A / Sprittles, James E

    Physical review. E

    2023  Volume 107, Issue 1-2, Page(s) 15105

    Abstract: The effect of confining walls on the fluctuation of a nanoscale thin film's free surface is studied using stochastic thin-film equations (STFEs). Two canonical boundary conditions are employed to reveal the influence of the confinement: (1) an imposed ... ...

    Abstract The effect of confining walls on the fluctuation of a nanoscale thin film's free surface is studied using stochastic thin-film equations (STFEs). Two canonical boundary conditions are employed to reveal the influence of the confinement: (1) an imposed contact angle and (2) a pinned contact line. A linear stability analysis provides the wave eigenmodes, after which thermal-capillary-wave theory predicts the wave fluctuation amplitudes. Molecular dynamics (MD) simulations are performed to test the predictions, and a Langevin diffusion model is proposed to capture oscillations of the contact lines observed in MD simulations. Good agreement between the theoretical predictions and the MD simulation results is recovered, and it is discovered that confinement can influence the entire film. Notably, a constraint on the length scale of wave modes is found to affect fluctuation amplitudes from our theoretical model, especially for 3D films. This opens up challenges and future lines of inquiry.
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.015105
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  8. Article ; Online: Identifying patterns of substance use and mental health concerns among adolescents in an outpatient mental health program using latent profile analysis.

    Halladay, Jillian / Georgiades, Katholiki / MacKillop, James / Lipman, Ellen / Pires, Paulo / Duncan, Laura

    European child & adolescent psychiatry

    2023  Volume 33, Issue 3, Page(s) 739–747

    Abstract: ... patterns of substance use (alcohol, cannabis, (e-) cigarettes) and emotional and behavioral disorder ...

    Abstract Though mental health and substance use concerns often co-occur, few studies have characterized patterns of co-occurrence among adolescents in clinical settings. The current investigation identifies and characterizes these patterns among adolescents presenting to an outpatient mental health service in Ontario, Canada. Data come from cross-sectional standardized patient intake assessments from 916 adolescents attending an outpatient mental health program (January 2019-March 2021). Latent profile analysis identified patterns of substance use (alcohol, cannabis, (e-) cigarettes) and emotional and behavioral disorder symptoms. Sociodemographic and clinical correlates of these patterns were examined using multinomial regression. Three profiles were identified including: 1) low substance use and lower frequency and/or severity (relative to other patients in the sample) emotional and behavioral disorder symptoms (26.2%), 2) low substance use with higher emotional and behavioral disorder symptoms (48.2%), and 3) high in both (25.6%). Profiles differed in sociodemographic and clinical indicators related to age, gender, trauma, harm to self, harm to others, and service use. Experiences of trauma, suicide attempts, and thoughts of hurting others increased the odds of adolescents being in the profile high in both substance use and symptoms compared to other profiles. These findings further document the high rates of substance use in adolescents in mental health treatment and the profiles generally map onto three out of four quadrants in the adapted four-quadrant model of concurrent disorders, indicating the importance of assessing and addressing substance use in these settings.
    MeSH term(s) Humans ; Adolescent ; Mental Health ; Outpatients ; Cross-Sectional Studies ; Substance-Related Disorders/epidemiology ; Suicide, Attempted/psychology
    Language English
    Publishing date 2023-03-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-023-02188-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3524: Show issues Location:
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  9. Article: Laparoscopy, Endoscopy, and Minimally Invasive Colorectal Surgery

    Duncan, James E.

    Clinics in Colon and Rectal Surgery

    (Laparoscopy, Endoscopy, and Minimally Invasive Colorectal Surgery)

    2017  Volume 30, Issue 02, Page(s) 89–90

    Series title Laparoscopy, Endoscopy, and Minimally Invasive Colorectal Surgery
    Language English
    Publishing date 2017-04-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072321-0
    ISSN 1530-9681 ; 1531-0043
    ISSN (online) 1530-9681
    ISSN 1531-0043
    DOI 10.1055/s-0036-1597319
    Database Thieme publisher's database

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  10. Article ; Online: Physical activity and substance use among Canadian adolescents: Examining the moderating role of school connectedness.

    Fagan, Matthew James / Duncan, Markus J / Bedi, Robinder P / Puterman, Eli / Leatherdale, Scott T / Faulkner, Guy

    Frontiers in public health

    2022  Volume 10, Page(s) 889987

    Abstract: ... of this study was to examine the association between different types of physical activity [i.e., non-competitive ... physical activity (MVPA) per day] and substance use (i.e., current smoking, e-cigarette, cannabis, binge drinking ...

    Abstract Physical activity may play a role in promoting or preventing substance use among youth. The purpose of this study was to examine the association between different types of physical activity [i.e., non-competitive school sport, competitive school sport, outside of school sport and minutes of moderate to vigorous physical activity (MVPA) per day] and substance use (i.e., current smoking, e-cigarette, cannabis, binge drinking) among Canadian youth. Interaction effects between physical activity and school connectedness were also examined. Using data from the COMPASS study (2018-19;
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Electronic Nicotine Delivery Systems ; Binge Drinking/epidemiology ; Canada/epidemiology ; Schools ; Exercise ; Substance-Related Disorders/epidemiology
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.889987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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