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  1. Article: Malignant transformation of tailgut cyst to squamous cell carcinoma, a rare case with poor outcome.

    Moshtaghian, Mahsa / Shahsiah, Reza / Jafari, Fatemeh / Aghili, Mahdi

    Clinical case reports

    2023  Volume 11, Issue 2, Page(s) e6893

    Abstract: Tailgut cyst, a type of retro-rectal cyst, is a rare condition requiring evaluation for malignant transformation. We report a case of squamous cell carcinoma arising in the retro-rectal cyst, in a 51-year-old female who underwent incomplete resection of ... ...

    Abstract Tailgut cyst, a type of retro-rectal cyst, is a rare condition requiring evaluation for malignant transformation. We report a case of squamous cell carcinoma arising in the retro-rectal cyst, in a 51-year-old female who underwent incomplete resection of the cyst and chemo-radiotherapy, subsequently became locally recurred and metastatic.
    Language English
    Publishing date 2023-02-05
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endocervical adenocarcinoma implantation in episiotomy scar: a case report and  review of the literature.

    Yarandi, Fariba / Aghili, Mahdi / Ramhormozian, Sara / Shirali, Elham

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 100

    Abstract: Background: Cervical cancer is a rare malignancy in the 1st months of pregnancy. Implantation of this cancer in an episiotomy scar is a condition that is rarely reported.: Case presentation: We reviewed the literature on this condition and reported a ...

    Abstract Background: Cervical cancer is a rare malignancy in the 1st months of pregnancy. Implantation of this cancer in an episiotomy scar is a condition that is rarely reported.
    Case presentation: We reviewed the literature on this condition and reported a 38 year-old Persian patient who had been diagnosed with cervical cancer, clinically stage IB1, 5 months after a term vaginal delivery. She underwent transabdominal radical hysterectomy with ovarian preservation. Two months later she presented with a mass-like lesion in the episiotomy scar which was proved to be of cervical adenocarcinoma origin after biopsy. The patient was scheduled for chemotherapy with interstitial brachytherapy, an alternative to wide local resection, with successful long-term disease-free survival.
    Conclusion: Implantation of adenocarcinoma in an episiotomy scar is a rare occurrence in patients with a history of cervical cancer and previous vaginal delivery near the time of diagnosis which requires extensive local excision as a primary treatment when feasible. The proximity of the lesion to the anus can lead to major complications of extensive surgery. Alternative chemoradiation combined with interstitial brachytherapy can be successful in eliminating cancer recurrence without compromising the functional outcome.
    MeSH term(s) Female ; Pregnancy ; Humans ; Adult ; Uterine Cervical Neoplasms/radiotherapy ; Episiotomy/adverse effects ; Cicatrix ; Neoplasm Recurrence, Local ; Adenocarcinoma/therapy
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03786-4
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  3. Article ; Online: Malignant transformation of tailgut cyst to squamous cell carcinoma, a rare case with poor outcome

    Mahsa Moshtaghian / Reza Shahsiah / Fatemeh Jafari / Mahdi Aghili

    Clinical Case Reports, Vol 11, Iss 2, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Tailgut cyst, a type of retro‐rectal cyst, is a rare condition requiring evaluation for malignant transformation. We report a case of squamous cell carcinoma arising in the retro‐rectal cyst, in a 51‐year‐old female who underwent incomplete ... ...

    Abstract Abstract Tailgut cyst, a type of retro‐rectal cyst, is a rare condition requiring evaluation for malignant transformation. We report a case of squamous cell carcinoma arising in the retro‐rectal cyst, in a 51‐year‐old female who underwent incomplete resection of the cyst and chemo‐radiotherapy, subsequently became locally recurred and metastatic.
    Keywords malignant ; SCC ; tailgut cyst ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells.

    Varnamkhasti, Tahereh Jalali / Jafarzadeh, Meisam / Sadeghizadeh, Majid / Aghili, Mahdi

    Pharmacological reports : PR

    2022  Volume 74, Issue 4, Page(s) 769

    Language English
    Publishing date 2022-07-24
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1007/s43440-022-00392-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
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  5. Article: Role of Oxaliplatin in the Neoadjuvant Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer: a Review of Evidence.

    Nazari, Reza / Piozzi, Guglielmo Niccolò / Ghalehtaki, Reza / Ahmadi-Tafti, Seyed Mohsen / Behboudi, Behnam / Mousavi Darzikolaee, Nima / Aghili, Mahdi / Gambacorta, Maria Antonietta

    Clinical Medicine Insights. Oncology

    2024  Volume 18, Page(s) 11795549241236409

    Abstract: The treatment of locally advanced rectal cancer (LARC) is a challenging situation for radiation oncologists and colorectal surgeons. Most current approaches recommend neoadjuvant fluorouracil or capecitabine-based chemoradiotherapy followed by surgery as ...

    Abstract The treatment of locally advanced rectal cancer (LARC) is a challenging situation for radiation oncologists and colorectal surgeons. Most current approaches recommend neoadjuvant fluorouracil or capecitabine-based chemoradiotherapy followed by surgery as a standard of care. Intensification of concurrent chemotherapy by adding oxaliplatin to fluorouracil or capecitabine backbone to get better outcomes is the matter that has remained unresolved. In this review, we searched Medline and Google Scholar databases and selected 28 prospective phase II and III clinical trials that addressed this question. We discussed the potential advantages and drawbacks of incorporating oxaliplatin into concurrent chemoradiation therapy. We tried to define whether adding oxaliplatin to concurrent chemoradiation with excellent performance and high-risk features benefits some subpopulations. The available literature suggests that by adding oxaliplatin there are some benefits in enhancing response to neoadjuvant chemoradiotherapy, however, without any translated improvements in long-term outcomes including overall and disease-free survival.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2577877-8
    ISSN 1179-5549
    ISSN 1179-5549
    DOI 10.1177/11795549241236409
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  6. Article: Complication and response assessment of high-dose-rate endorectal brachytherapy boost in neo-adjuvant chemoradiotherapy of locally advanced rectal cancer with long-term outcomes.

    Saeedian, Arefeh / Lashkari, Marzieh / Ghalehtaki, Reza / Taherioun, Maryam / Razmkhah, Mahdieh / Kazemian, Ali / Aghili, Mahdi

    Journal of contemporary brachytherapy

    2023  Volume 15, Issue 2, Page(s) 117–122

    Abstract: Purpose: To identify efficacy, complication, and pathologic response of high-dose-rate endorectal brachytherapy (HDR-BRT) boost in neo-adjuvant chemoradiotherapy (nCRT) of locally advanced rectal cancer.: Material and methods: Forty-four patients who ...

    Abstract Purpose: To identify efficacy, complication, and pathologic response of high-dose-rate endorectal brachytherapy (HDR-BRT) boost in neo-adjuvant chemoradiotherapy (nCRT) of locally advanced rectal cancer.
    Material and methods: Forty-four patients who met eligibility criteria were included in this non-randomized comparative study. Control group was recruited retrospectively. nCRT (50.40 Gy/28 fr. plus capecitabine 825 mg/m
    Results: From 44 patients in the case and control groups, pCR was 11 (50%) and 8 (36.4%), respectively (
    Conclusions: Treatment schedule was well-tolerated, and neo-adjuvant HDR-BRT could achieve better T down-staging as a boost comparing with nCRT, without significant complication. However, the optimal dose and fractions in the context of HDR-BRT boost needs further studies.
    Language English
    Publishing date 2023-04-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2627721-9
    ISSN 2081-2841 ; 1689-832X
    ISSN (online) 2081-2841
    ISSN 1689-832X
    DOI 10.5114/jcb.2023.127051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-term disease-free survival following salvage brachytherapy for recurrent pediatric rhabdomyosarcoma: Two case reports and review of relevant literature.

    Aghili, Mahdi / Kolahdouzan, Kasra / Shabani, Mahya / Jafari, Fatemeh / Jaberi, Ramin

    Brachytherapy

    2022  Volume 21, Issue 4, Page(s) 494–500

    Abstract: Purpose: Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma, mostly involving the genitourinary (GU) tract, head and neck, and extremities. This study reports the long-term outcome of two infants with recurrent GU-RMS who underwent ... ...

    Abstract Purpose: Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma, mostly involving the genitourinary (GU) tract, head and neck, and extremities. This study reports the long-term outcome of two infants with recurrent GU-RMS who underwent combination therapy with chemotherapy (ChT) and salvage brachytherapy (BT).
    Methods and materials: An 18-month-old girl with vaginal bleeding and a 7-month-old boy with urinary retention presented with a diagnosis of vaginal, and bladder/prostate embryonal RMS, respectively. Surgical resection and ChT were done for both patients. However, both developed local recurrences after one year and subsequently, underwent second-line ChT and salvage interstitial high dose rate BT.
    Results: The clinical target volumes for the first and second patients were treated to a totaldose of 32 Gy in 10 fractions and 35 Gy in 10 fractions, respectively, with two fractions delivered per day with a 6-h interval between fractions. After 9 years of follow-up, both patients are alive with natural growth and no late complication or evidence of recurrence.
    Conclusions: Our report shows that BT (for patients with no prior history of irradiation) could result in long-term disease-free survival in well-selected pediatric patients with recurrent GU embryonal RMS without inflicting expected adverse effects of external beam radiotherapy.
    MeSH term(s) Brachytherapy/methods ; Child ; Disease-Free Survival ; Female ; Humans ; Infant ; Male ; Neoplasm Recurrence, Local/etiology ; Rhabdomyosarcoma/radiotherapy ; Rhabdomyosarcoma, Embryonal ; Salvage Therapy/methods
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2098608-7
    ISSN 1873-1449 ; 1538-4721
    ISSN (online) 1873-1449
    ISSN 1538-4721
    DOI 10.1016/j.brachy.2022.03.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6116: Show issues Location:
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  8. Article: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells.

    Varnamkhasti, Tahereh Jalali / Jafarzadeh, Meisam / Sadeghizadeh, Majid / Aghili, Mahdi

    Pharmacological reports : PR

    2022  Volume 74, Issue 4, Page(s) 718–735

    Abstract: Background: Curcumin was found to possess numerous pharmacological activities in clinical research, however, its biological effects together with radiation are yet to be addressed. The present study investigated whether the combined treatment of ... ...

    Abstract Background: Curcumin was found to possess numerous pharmacological activities in clinical research, however, its biological effects together with radiation are yet to be addressed. The present study investigated whether the combined treatment of dendrosomal nanoformulation of curcumin (DNC) and gamma radiation can enhance the radiosensitivity of U87MG and MDA-MB-231 cell lines.
    Methods: U87MG and MDA-MB-231 cell lines were exposed to 2 Gray (Gy) and 10 μM DNC determined by MTT assay, then subjected to clonogenic assay, cell cycle assay, and flow cytometric apoptosis analysis. Acridine Orange/Ethidium Bromide (AO/EB) and 4',6-diamidino-2-phenylindole dihydrochloride (DAPI) stained cells were used to study morphologic changes. The expression evaluation of putative cell cycle genes, i.e., P53, P21, CCND1, and CCNB1 was carried out by RT-qPCR.
    Results: Our findings indicated that the combined treatment with DNC and radiation might cooperatively augment the efficacy of ionizing radiation in the cancer cells and notably decrease the survival and viability of the cells in a time- and concentration-dependent manner. In addition to a synergistic effect deducted by sensitizer enhancement ratio (SER) assessment, co-treatment resulted in greater apoptotic cells than the individual treatments. Further experiments then indicated that DNC could effectively induce G2/M phase cell cycle arrest and apoptosis following irradiation. Conformably, there was a decrement of CCND1 and CCNB1 expression, and an increment of P53, P21 expression.
    Conclusions: The data implied that DNC as a radiosensitizer can enhance the lethal effect of ionizing radiation on cancer cells which could be a promising adjuvant therapy in clinical treatments.
    MeSH term(s) Apoptosis ; Cell Cycle ; Cell Line, Tumor ; Curcumin/pharmacology ; Neoplasms ; Radiation-Sensitizing Agents/pharmacology ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Radiation-Sensitizing Agents ; Tumor Suppressor Protein p53 ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2022-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1007/s43440-022-00383-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
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  9. Article: First report of tinea corporis caused by Trichophyton quinckeanum in Iran and its antifungal susceptibility profile.

    Aghili, Seyed Reza / Alehashemi, Raheleh / Abastabar, Mahdi / Niknejad, Farhad / Haghani, Iman / Livani, Fatemeh / Kashiri, Amineh / Javidnia, Javad / Nosratabadi, Mohsen

    Current medical mycology

    2023  Volume 8, Issue 4, Page(s) 37–41

    Abstract: Background and purpose: Trichophyton quinckeanum: Case report: This study aimed to report a case of tinea corporis caused by : Conclusion: It can be said ... ...

    Abstract Background and purpose: Trichophyton quinckeanum
    Case report: This study aimed to report a case of tinea corporis caused by
    Conclusion: It can be said that
    Language English
    Publishing date 2023-09-09
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 3015705-5
    ISSN 2423-3420 ; 2423-3439
    ISSN (online) 2423-3420
    ISSN 2423-3439
    DOI 10.32598/CMM.2023.1344
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  10. Article ; Online: Safety and efficacy of salvage high-dose rate brachytherapy for prostate-bed recurrences following radical prostatectomy and external beam radiotherapy.

    Aghili, Mahdi / Jafari, Fatemeh / Yamrali, Maisa / Jaberi, Ramin / Cuccia, Francesco

    International urology and nephrology

    2022  Volume 54, Issue 5, Page(s) 1031–1037

    Abstract: Purpose: This retrospective study aims to evaluate the efficacy and safety of salvage HDR brachytherapy in second local recurrences of prostate cancer after applying radical prostatectomy (RP) and post-operative external beam radiotherapy (EBRT).: ... ...

    Abstract Purpose: This retrospective study aims to evaluate the efficacy and safety of salvage HDR brachytherapy in second local recurrences of prostate cancer after applying radical prostatectomy (RP) and post-operative external beam radiotherapy (EBRT).
    Materials and methodology: Fifteen patients with locally recurrent prostate cancer after RP and EBRT were salvaged with HDR brachytherapy. Patients had no nodal or distant metastasis evidence on imaging findings, including whole body bone scan, CT scan, and MRI or PSMA PET scan. HDR brachytherapy was applied with 36 Gy in four fractions, in two implantations with 1 week apart. We followed the patients for a control visit every 3 months for 2 years, and every 6 months thereafter.
    Results: Fifteen patients with the mean age of 64 years (ranged 51-79) underwent salvage HDR brachytherapy. The mean baseline level of PSA was calculated 2.26 ng/ml (ranged from 0.21 to 9, SD = 2.33), which has been significantly decreased in all patients. Hence, two of our patients experienced a biochemical failure during the follow-up period. Our results showed that 86.6% (n = 13) of patients had never experienced a significant increment in PSA level after a median follow-up of 48 months (ranging from 12 to 132 months). Besides, salvage HDR brachytherapy did not induce any significant side effects such as acute or late rectal complications, despite causing urinary complication.
    Conclusions: HDR brachytherapy could be considered as a treatment in well-selected patients with the second recurrence in their prostatic bed after the former EBRT allowing for dose escalating to the second nodular recurrence.
    MeSH term(s) Aged ; Brachytherapy/adverse effects ; Brachytherapy/methods ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Radiotherapy Dosage ; Retrospective Studies ; Salvage Therapy/adverse effects
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-03-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-022-03155-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 733: Show issues Location:
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