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Article ; Online: Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight?

Ghahestani, Seyed-Mohammad / Mahmoudi, Javad / Hajebrahimi, Sakineh / Sioofy-Khojine, Amir-Babak / Salehi-Pourmehr, Hanieh / Sadeghi-Ghyassi, Fatemeh / Mostafaei, Hadi

Iranian journal of allergy, asthma, and immunology

2020 Volume 19, Issue S1, Page(s) 13–17

Abstract: The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which ...

Abstract	The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which is a profoundly active peptide, into Ang 1-7 with quite a balancing barbell function. It is emphasized that the direct target of the virus is ACE2 underlining the obvious difference with ACE. Nevertheless, we hypothesized that a back load build up effect on Ang II may usurp the ACE capacity and subsequently leave the bradykinin system unabated. We think there are clinical clues for dry cough and the presumed aggravating role of ACE inhibitors like captopril on the disease process. Thereby, we speculated that inhibition of bradykinin synthesis and/or blockade of bradykinin B2 receptor using Aprotinin/ecallantide and Icatibant, respectively, may hold therapeutic promise in severe cases and these molecules can be advanced to clinical trials.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; Bradykinin/metabolism ; Bradykinin B2 Receptor Antagonists/pharmacology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Receptors, Bradykinin/drug effects ; Receptors, Bradykinin/metabolism ; SARS-CoV-2 ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	Bradykinin B2 Receptor Antagonists ; Receptors, Bradykinin ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Bradykinin (S8TIM42R2W)
Keywords	covid19
Language	English
Publishing date	2020-05-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2488724-9
ISSN	1735-5249 ; 1735-1502
ISSN (online)	1735-5249
ISSN	1735-1502
DOI	10.18502/ijaai.v19i(s1.r1).2850
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Article ; Online: Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios

Seyed-Mohammad Ghahestani / Javad Mahmoudi / Sakineh Hajebrahimi / Amir-Babak Sioofy-Khojine / Hanieh Salehi-Pourmehr / Fatemeh Sadeghi-Ghyassi / Hadi Mostafaei

Iranian Journal of Allergy, Asthma and Immunology, Vol 19, Iss S

Is Bradykinin Sneaking out of Our Sight?

2020 Volume 1

Abstract	The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which is a profoundly active peptide, into Ang 1-7 with quite a balancing barbell function. It is emphasized that the direct target of the virus is ACE2 underlining the obvious difference with ACE. Nevertheless, we hypothesized that a back load build up effect on Ang II may usurp the ACE capacity and subsequently leave the bradykinin system unabated. We think there are clinical clues for dry cough and the presumed aggravating role of ACE inhibitors like captopril on the disease process. Thereby, we speculated that inhibition of bradykinin synthesis and/or blockade of bradykinin B2 receptor using Aprotinin/ecallantide and Icatibant, respectively, may hold therapeutic promise in severe cases and these molecules can be advanced to clinical trials.
Keywords	Aprotinin ; Angiotensin-converting enzyme 2 ; Bradykinin ; Icatibant ; SARS-CoV-2 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Post-syncope trauma should be considered in COVID-19 patients

Fatemeh Ghanbarpour / Seyed Mohammad Ghahestani / Rayka Sharifian

Men's Health Journal, Vol 4, Iss 1, Pp e11-e

2020 Volume 11

Abstract: In December 2019, a new form of respiratory infection associated with coronavirus appeared in Wuhan, China. As of today, COVID-19 has spread all around the world. There have been 9.24 million confirmed cases and 477,000 deaths globally. Fever, cough, and ...

Abstract	In December 2019, a new form of respiratory infection associated with coronavirus appeared in Wuhan, China. As of today, COVID-19 has spread all around the world. There have been 9.24 million confirmed cases and 477,000 deaths globally. Fever, cough, and coexistence chest or back pain are some of the most reported symptoms of COVID-19. Although syncope is not a primary symptoms, we see patients passing out in the street after coronavirus pandemic. Up to now, syncope due to COVID-19 has only been reported by CHANTAL and coauthor in a 79 year-old patient. (1) There is no available data on syncope in COVID-19 patients. This is while some patients have been referred to us purely for their symptoms of fainting. Etiology of fainting in COVID-19 may be the product of orthostatic hypotension and vasovagal syncope due to dehydration. Increasing pressure in thoracic cavity during sequential cough may induce “cough syncope”
Keywords	Medicine ; R
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Shahid Beheshti University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Effect of Laser Acupuncture on Semen Parameters in Infertile Men With Oligospermia: A Randomized Clinical Trial.

Allameh, Farzad / Razzaghi, Mohammadreza / Hosseini, Sedighe / Barati, Maryam / Razzaghi, Zahra / Salehi, Safa / Ghahestani, Seyed Mohammad / Shahabi, Vahid

Journal of lasers in medical sciences

2021 Volume 12, Page(s) e84

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-12-27
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2658681-2
ISSN	2228-6721 ; 2008-9783
ISSN (online)	2228-6721
ISSN	2008-9783
DOI	10.34172/jlms.2021.84
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Article ; Online: Post-syncope trauma should be considered in COVID-19 patients

Ghanbarpour, Fatemeh / Ghahestani, Seyed Mohammad / Sharifian, Rayka

Men's Health Journal; Vol. 4 No.; e11 ; 2645-3614

2020 Volume 1

Abstract: In December 2019, a new form of respiratory infection associated with coronavirus appearedinWuhan,China. As of today, COVID-19 has spread all around the world. There have been 9.24 million confirmed cases and 477,000 deaths globally. Fever, cough, and ... ...

Abstract	In December 2019, a new form of respiratory infection associated with coronavirus appearedinWuhan,China. As of today, COVID-19 has spread all around the world. There have been 9.24 million confirmed cases and 477,000 deaths globally. Fever, cough, and coexistence chest or back pain are some of the most reported symptoms of COVID-19. Although syncope is not a primary symptoms, we see patients passing out in the street after coronavirus pandemic. Up to now, syncope due to COVID-19 has only been reported by CHANTAL and coauthor in a 79 year-old patient. (1) There is no available data on syncope in COVID-19 patients. This is while some patients have been referred to us purely for their symptoms of fainting. Etiology of fainting in COVID-19 may be the product of orthostatic hypotension and vasovagal syncope due to dehydration. Increasing pressure in thoracic cavity during sequential cough may induce “cough syncope”
Keywords	covid19
Language	English
Publishing date	2020-08-02
Publisher	SBMU Journals
Publishing country	ir
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight?

Ghahestani, Seyed-Mohammad / Mahmoudi, Javad / Hajebrahimi, Sakineh / Sioofy-Khojine, Amir-Babak / Salehi-Pourmehr, Hanieh / Sadeghi-Ghyassi, Fatemeh / Mostafaei, Hadi

Iran J Allergy Asthma Immunol

Abstract	The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which is a profoundly active peptide, into Ang 1-7 with quite a balancing barbell function. It is emphasized that the direct target of the virus is ACE2 underlining the obvious difference with ACE. Nevertheless, we hypothesized that a back load build up effect on Ang II may usurp the ACE capacity and subsequently leave the bradykinin system unabated. We think there are clinical clues for dry cough and the presumed aggravating role of ACE inhibitors like captopril on the disease process. Thereby, we speculated that inhibition of bradykinin synthesis and/or blockade of bradykinin B2 receptor using Aprotinin/ecallantide and Icatibant, respectively, may hold therapeutic promise in severe cases and these molecules can be advanced to clinical trials.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #598032
Database	COVID19

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Article ; Online: The Inflammatory and Fibrotic Patterns of Hepatic Stellate Cells Following Coagulation Factors (VII or X)-Shielded Adenovirus Infection.

Shiri, Alireza / Sarvari, Jamal / Firoozi Ghahestani, Saeed / Gholijani, Nasser / Tamaddon, Ali Mohammad / Rastegari, Mahroo / Moattari, Afagh / Hosseini, Seyed Younes

Current microbiology

2021 Volume 78, Issue 2, Page(s) 718–726

Abstract: The role of coagulation factors on the inflammatory effect of adenovirus (Ad) is an unresolved question that was considered herein. Adenovirus-36(Ad36) and adenovector-5-GFP(Ad5-GFP) were prepared; then, they were loaded with VII or FX factors. The size/ ... ...

Abstract	The role of coagulation factors on the inflammatory effect of adenovirus (Ad) is an unresolved question that was considered herein. Adenovirus-36(Ad36) and adenovector-5-GFP(Ad5-GFP) were prepared; then, they were loaded with VII or FX factors. The size/charge parameters and transduction efficiency were evaluated using fluorescent microscopy and Zetasizer, respectively. The Ad36-coagulation factor complexes were added on the stellate cells, LX-2. Thereafter, the expression levels of inflammatory and fibrotic genes including PKR, IL-1β, TNF-α, TIMP-1, collagen, and TGF-β were measured by qPCR and ELISA assays. The loading of FVII or FX factors not only increased the size/charge of Ad5-GFP but also enhanced the transduction rate up to 60% and 75%, respectively, compared to the controls (45%). The PKR expression analysis showed an upregulation following treatment with all Ad36 forms (P = 0.0152). The IL-1β and TNF-α cytokines analyses demonstrated that the Ad36-FVII complex elicited the highest inflammatory response (P = 0.05). Similarly, the fibrosis-related expression analysis revealed a more inductive role of FVII when loaded on Ad36, compared to the FX factor. The findings suggested that adenovirus elicited the innate inflammatory and activation state in the hepatic stellate cell. In addition, adenovirus shielded by FVII exhibited more innate inflammation as well as activation of the stellate cells than the FX-loaded virus.
MeSH term(s)	Adenoviridae Infections ; Blood Coagulation Factors/genetics ; Cytokines/genetics ; Fibrosis ; Hepatic Stellate Cells ; Humans
Chemical Substances	Blood Coagulation Factors ; Cytokines
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02297-5
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Article ; Online: Iranian Urology Association Coronavirus Disease 2019 (COVID-19) Taskforce Pamphlet (IUA-CTP) Recommended Practice based on National Epidemiologic Analysis.

Ghahestani, Seyed Mohammad / Bonakdar Hashemi, Milad / Yousefzadeh Kandevani, Naser / Borumandnia, Nasrin / Dadpour, Mehdi / Sharifiaghdas, Farzaneh

Urology journal

2020 Volume 17, Issue 5, Page(s) 543–547

Abstract: Since the emergence of Covid19 epidemics different guidelines and protocols have been published by Urology associations. Most of these recommendations have focused on the aptitude of any disease or condition for postponement. With the evolution of the ... ...

Abstract	Since the emergence of Covid19 epidemics different guidelines and protocols have been published by Urology associations. Most of these recommendations have focused on the aptitude of any disease or condition for postponement. With the evolution of the outbreak, it is clear that postponement of procedures is not the policy we can rely on exclusively. We must know where do we stand? Where are we going in our country? How useful our recommendations have been for urology practitioners? We try to draw a clearer although-to some extent- conjectural picture and to adjust our protocols to this picture of outbreak evolution. Assuming that anything in this predicament is subject to unexpected changes. For these goals, we raise these arguments in three sections. First, where do we stand and where are we going? Explaining the present situation and best available statistics of the disease, the velocity the disease is spreading and our approximate predicted date its subsidence or partial remission. In a web form survey, we tried to evaluate that in the absence of a clear picture of outbreak progress in a specific area, how useful experts' points of view will be for the urologists working in non-referral centers especially in relevance to equivocal and challenging cases. Will there be any significant difference at all? In the third section, we try to give the plot to guide scheduling or postponing procedures in any given are according to the level of involvement. Here we considered both the characteristics of the special urology condition and also the situation and progress of the outbreak in that area.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Humans ; Iran/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Practice Guidelines as Topic ; SARS-CoV-2 ; Surveys and Questionnaires ; Urologic Diseases/epidemiology ; Urologic Diseases/surgery ; Urologic Surgical Procedures/standards
Keywords	covid19
Language	English
Publishing date	2020-08-09
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v16i7.6372
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Article ; Online: Palliative treatment of intractable hematuria in context of advanced bladder cancer: a systematic review.

Ghahestani, Seyed Mohammad / Shakhssalim, Nasser

Urology journal

2009 Volume 6, Issue 3, Page(s) 149–156

Abstract: Introduction: In a patient with bladder urothelial cancer that is not suitable for or does not choose curative treatment, intractable hematuria is a disastrous condition. In this article, we tried to review the literature and extract a stepwise approach ...

Abstract	Introduction: In a patient with bladder urothelial cancer that is not suitable for or does not choose curative treatment, intractable hematuria is a disastrous condition. In this article, we tried to review the literature and extract a stepwise approach for palliative treatment of hematuria in these patients. Materials and methods: The MEDLINE was searched with the help of the Medical Subject Headings system using different combinations of terms urinary bladder neoplasm, hematuria, carboprost, cyclophosphamide, cystitis, alum, and hyperbaric oxygenation. The articles were separately reviewed by the two authors and verified by each other. Eventually, a decision tree was developed for management of gross hematuria in patients with bladder cancer. Results: Although, there was not any reported randomized controlled trial or prospectively designed study, the available case series were rather expressive to draw out a logical approach. Formalin has a grave adverse effect profile and recommended only in special circumstances. For management of each case of gross hematuria in bladder cancer, the etiology of bleeding is the most important determinant. Conclusion: Hematuria in the context of advanced bladder neoplasms can now be effectively treated with fewer side effects using all available modalities in a logical holistic approach. We proposed a decision tree for management of hematuria in this context. However, regarding lack of well-designed trials, a treatment method should be based on individualized scenarios and clinical experience, bringing into account the patient's preferences.
MeSH term(s)	Hematuria/etiology ; Hematuria/therapy ; Humans ; Neoplasm Staging ; Palliative Care ; Treatment Failure ; Urinary Bladder Neoplasms/complications ; Urinary Bladder Neoplasms/pathology
Language	English
Publishing date	2009
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
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Article: Iranian Urology Association Coronavirus Disease 2019 (COVID-19) Taskforce Pamphlet (IUA-CTP) Recommended Practice based on National Epidemiologic Analysis

Ghahestani, Seyed Mohammad / Bonakdar Hashemi, Milad / Yousefzadeh Kandevani, Naser / Borumandnia, Nasrin / Dadpour, Mehdi / Sharifiaghdas, Farzaneh

Urol J

Abstract	Since the emergence of Covid19 epidemics different guidelines and protocols have been published by Urology associations. Most of these recommendations have focused on the aptitude of any disease or condition for postponement. With the evolution of the outbreak, it is clear that postponement of procedures is not the policy we can rely on exclusively. We must know where do we stand? Where are we going in our country? How useful our recommendations have been for urology practitioners? We try to draw a clearer although-to some extent- conjectural picture and to adjust our protocols to this picture of outbreak evolution. Assuming that anything in this predicament is subject to unexpected changes. For these goals, we raise these arguments in three sections. First, where do we stand and where are we going? Explaining the present situation and best available statistics of the disease, the velocity the disease is spreading and our approximate predicted date its subsidence or partial remission. In a web form survey, we tried to evaluate that in the absence of a clear picture of outbreak progress in a specific area, how useful experts' points of view will be for the urologists working in non-referral centers especially in relevance to equivocal and challenging cases. Will there be any significant difference at all? In the third section, we try to give the plot to guide scheduling or postponing procedures in any given are according to the level of involvement. Here we considered both the characteristics of the special urology condition and also the situation and progress of the outbreak in that area.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #717841
Database	COVID19

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