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Article ; Online: Distal spread and tumor regression patterns following preoperative chemoradiotherapy in rectal cancer patients

Özer, İlter / Zengin, Neslihan İnci / Çaycı, Hacı Murat / Yüksel, Adem / Dalgıç, Tahsin / Ulaş, Murat / Bostancı, Erdal Birol / Akoğlu, Musa

Turkish journal of medical sciences

2021 Volume 51, Issue 6, Page(s) 2978–2985

Abstract: Background/aim/aim: This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation.: Materials and methods: Specimens from 56 patients who underwent radical resection ... ...

Abstract	Background/aim/aim: This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation. Materials and methods: Specimens from 56 patients who underwent radical resection after preoperative chemoradiation for rectal cancer were examined. The regression pattern (total, fragmented) of the tumor was recorded. DIS status was evaluated by creating sections 0.2 to 0.3 cm thick. Results: A single macroscopic residual area was detected in all specimens. In 10 patients (17.8 %), pathologically complete responses were identified, and DIS was detected in 33 patients (58.9%). The average DIS distance was 0.56± 0.3 cm (range 0.2 – 1.8 cm); the spread was < 1 cm in 87.9% of the patients (29/33). The overall survival rates for 5 and 7 years were 76.8% and 73.2%, respectively. The survival rates between patients with and without DIS were not statistically different (94.6± 5.5 vs. 75.1 ± 10.2 months, respectively). In all of the patients, tumor regression pattern was total shrinkage of the tumor. Conclusion: A sufficient distal resection margin for rectal cancer after preoperative chemoradiation is 1 cm in the vast majority of cases. However, DIS may exceed 1 cm in a small proportion of patients.
MeSH term(s)	Adult ; Aged ; Chemoradiotherapy/methods ; Female ; Humans ; Male ; Margins of Excision ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Survival Rate
Language	English
Publishing date	2021-12-13
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2007-102
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Zs.A 3242: Show issues

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Article ; Online: Pancreaticobiliary maljunction in Turkish patients: a multicenter case series.

Parlak, Erkan / Köksal, Aydın Şeref / Eminler, Ahmet Tarık / Çiçek, Bahattin / Dişibeyaz, Selçuk / Bostancı, Erdal Birol / Akoğlu, Musa / Şahin, Burhan

Surgical endoscopy

2021 Volume 36, Issue 3, Page(s) 2042–2051

Abstract: Background and aims: Pancreaticobiliary maljunction (PBM) is a malformation in which the pancreatic and bile ducts join outside the duodenal wall. It is associated with various biliary and pancreatic diseases. In addition, patients with PBM carry a ... ...

Abstract	Background and aims: Pancreaticobiliary maljunction (PBM) is a malformation in which the pancreatic and bile ducts join outside the duodenal wall. It is associated with various biliary and pancreatic diseases. In addition, patients with PBM carry a substantial lifetime risk of developing biliary or gallbladder carcinoma. We aimed to present a multicenter case series of PBM from Turkey. Methods: This study was conducted in adult and pediatric PBM patients who were referred to three tertiary reference centers of Turkey for endoscopic retrograde cholangiopancreatography (ERCP) between July 2007 and May 2020. The clinical presentations, types of PBM, ERCP findings, surgical histories, and the postoperative courses, including the development of biliary malignancies, were retrospectively reviewed. Results: The study group included 47 (31 adult and 16 children) patients. Type D PBM was more frequent (13/41: 27.7%) than that reported in Eastern studies. Type A PBM was more common in the adults (51.6% vs. 12.5%, p < 0.05), whereas type C was more common in pediatric patients (31.3% vs. 13.2%, p < 0.05). Although fusiform anatomy was predominant in both of the groups, cystic dilatation was more common (25.8% vs. 12.5%) in adults and the common bile duct diameter was greater [22 mm (range 11-58) vs. 12 mm (range 5-33)] in adult patients compared to pediatric patients. Resective surgeries were more frequently done in pediatric patients (73.3% vs. 53.6%), whereas cholecystectomy was more frequently performed in adult patients (21.4% vs. 6.7%). Conclusion: Although our findings were compatible with Eastern studies, type D PBM (associated with pancreas divisum) was more frequent in our study population.
MeSH term(s)	Adult ; Bile Ducts/surgery ; Child ; Cholangiopancreatography, Endoscopic Retrograde ; Humans ; Pancreatic Ducts/surgery ; Pancreaticobiliary Maljunction ; Retrospective Studies ; Turkey/epidemiology
Language	English
Publishing date	2021-04-12
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08490-2
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Article: Dual mesh repair for a large diaphragmatic hernia defect: An unusual case report.

Ercan, Metin / Aziret, Mehmet / Karaman, Kerem / Bostancı, Birol / Akoğlu, Musa

International journal of surgery case reports

2016 Volume 28, Page(s) 266–269

Abstract: Introduction: Diaphragmatic hernia secondary to traumatic rupture is a rare entity which can occur after stab wound injuries or blunt abdominal traumas. We aimed to report successfully management of dual mesh repair for a large diaphragmatic defect.: ... ...

Abstract	Introduction: Diaphragmatic hernia secondary to traumatic rupture is a rare entity which can occur after stab wound injuries or blunt abdominal traumas. We aimed to report successfully management of dual mesh repair for a large diaphragmatic defect. Case report: A 66-year-old male was admitted with a right sided diaphragmatic hernia which occurred ten years ago due to a traffic accident. He had abdominal pain with worsened breath. Chest X-ray showed an elevated right diaphragm. Further, thoraco-abdominal computerized tomography detected herniation a part of the liver, gallbladder, stomach, and omentum to the right hemi-thorax. It was decided to diaphragmatic hernia repair. After an extended right subcostal laparotomy, a giant right sided diaphragmatic defect measuring 25×15cm was found in which the liver, gallbladder, stomach and omentum were herniated. The abdominal organs were reducted to their normal anatomic position and a dual mesh graft was laid to close the diaphragmatic defect. Patients' postoperative course was uneventful. Discussion: Diaphragmatic hernia secondary to trauma is more common on the left side of the diaphragm (left/right=3/1). A right sided diaphragmatic hernia including liver, stomach, gallbladder and omentum is extremely rare. The main treatment of diaphragmatic hernias is primary repair after reduction of the herniated organs to their anatomical position. However, in the existence of a large hernia defect where primary repair is not possible, a dual mesh should be considered. Conclusion: A dual mesh repair can be used successfully in extensive large diaphragmatic hernia defects when primary closure could not be achieved.
Language	English
Publishing date	2016-10-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2016.10.015
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Article: Laparoscopic sleeve gastrectomy on a morbidly obese patient with situs inversus totalis: A case study and systematic review of the literature.

Aziret, Mehmet / Karaman, Kerem / Ercan, Metin / Bostancı, Erdal Birol / Akoğlu, Musa

Obesity research & clinical practice

2017 Volume 11, Issue 5S1, Page(s) 144–151

Abstract: Introduction: Situs inversus totalis (SIT) is a condition where the internal organs or organ systems are located contra-laterally to the norm, forming a mirror image. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure that has ... ...

Abstract	Introduction: Situs inversus totalis (SIT) is a condition where the internal organs or organ systems are located contra-laterally to the norm, forming a mirror image. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure that has become more common over the last two decades. We report on a morbidly obese patient with SIT who underwent a successful LSG. Case report: A 54-year-old female morbidly obese patient (136k; 167cm; body mass index (BMI): 48kg/m Discussion: SIT is a rare congenital condition, occurring in 1/10,000 to 1/50,000 live births. Organ function is generally normal, although it may sometimes be accompanied by respiratory or cardiovascular anomalies. Although undertaking LSG on morbidly obese patients with SIT may seem a daunting proposition at first, experienced laparoscopic surgeons can manage this operation with success. Conclusion: Although SIT is a rare congenital condition, LSG can be performed safely and effectively.
Keywords	covid19
Language	English
Publishing date	2017-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2016.12.003
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Article ; Online: Changing Trends in Gastric Cancer Surgery.

Özer, İlter / Bostancı, Erdal Birol / Ulaş, Murat / Özoğul, Yusuf / Akoğlu, Musa

Balkan medical journal

2017 Volume 34, Issue 1, Page(s) 10–20

Abstract: Gastric cancer is one of the most common causes of cancer-related death. It requires multimodal treatment and surgery is the most effective treatment modality. Radical surgery includes total or subtotal gastrectomy with lymph node dissection. The extent ... ...

Abstract	Gastric cancer is one of the most common causes of cancer-related death. It requires multimodal treatment and surgery is the most effective treatment modality. Radical surgery includes total or subtotal gastrectomy with lymph node dissection. The extent of lymphadenectomy still remains controversial. Eastern surgeons have performed D2 or more extended lymphadenectomy while their Western colleagues have performed more limited lymph node dissection. However, the trend has been changing in favour of D2 lymph node dissection in both hemispheres. Currently, D2 is the recommended type of lymphadenectomy in experienced centres in the west. In Japan, D2 lymph node dissection is the standard surgical approach. More extensive lymphadenectomy than D2 has not been found to be associated with improved survival and generally is not performed. Bursectomy and splenectomy are additional controversial issues in surgical performance, and trends regarding them will be discussed. The performance of bursectomy is controversial and there is no clear evidence of its clinical benefit. However, a trend toward better survival in patients with serosal invasion has been reported. Routine splenectomy as a part of lymph node dissection has largely been abandoned, although splenectomy is recommended in selected cases. Minimally invasive surgery has gained wide popularity and indications for minimally invasive procedures have been expanding due to increasing experience and improving technology. Neoadjuvant therapy has been shown to have beneficial effects and seems necessary to provide a survival benefit. Diagnostic laparoscopy should be kept in mind prior to treatment.
MeSH term(s)	Bursa, Synovial/surgery ; Digestive System Surgical Procedures/trends ; Endoscopy/methods ; Endoscopy/trends ; Gastrectomy/methods ; Gastrectomy/trends ; Humans ; Laparoscopy/methods ; Laparoscopy/trends ; Lymph Node Excision/methods ; Lymph Node Excision/trends ; Robotic Surgical Procedures/methods ; Splenectomy/methods ; Splenectomy/trends ; Stomach Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2017-01-05
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3123
ISSN (online)	2146-3131
ISSN	2146-3123
DOI	10.4274/balkanmedj.2015.1461
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Article: The effect on morbidity of the use of prophylactic abdominal drain following elective laparoscopic cholecystectomy.

Bostanci, Mustafa Taner / Saydam, Mehmet / Kosmaz, Koray / Tastan, Baki / Bostanci, Erdal Birol / Akoglu, Musa

Pakistan journal of medical sciences

2019 Volume 35, Issue 5, Page(s) 1306–1311

Abstract: Background and objective: To evaluate the clinical role of the routine use of a drain in an elective laparoscopic cholecystectomy operation applied to patients with symptomatic cholelithiasis not showing acute inflammation.: Method: Following ... ...

Abstract	Background and objective: To evaluate the clinical role of the routine use of a drain in an elective laparoscopic cholecystectomy operation applied to patients with symptomatic cholelithiasis not showing acute inflammation. Method: Following laparoscopic removal of the gallbladder, patients were separated into two groups of 30 each, either with subhepatic drain placement or without. The presence of subhepatic fluid collection was evaluated with transabdominal ultrasonography (USG) at 24 hours postoperatively and on the 7th day. The other parameters evaluated were postoperative morbidity, shoulder and abdominal pain. Results: No statistically significant difference was found between the two groups in respect of demographic characteristics and operative details. The median pain score was determined to be statistically significantly higher in the group with a drain applied compared to the group without a drain (p=0.007). In the comparison between the groups of fluid collection on USG at 24 hours and shoulder pain persisting until the 7th day, although seen less in the group with no drain applied, no statistically significant difference was determined (p=0.065, p=0.159). In the examinations made on the 7th day, no hematoma or significant fluid collection was determined on USG and no wound infection was observed in any patient of either group. Conclusion: The routine application of prophylactic subhepatic drain in laparoscopic cholecystectomy procedure did not show any benefit to the patient.
Language	English
Publishing date	2019-08-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.35.5.291
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Zs.A 3948: Show issues

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Article ; Online: Three-Port, Two Located on the Pfannenstiel Line, Laparoscopic Cholecystectomy Comparison with Traditional Laparoscopic Cholecystectomy.

Akoglu, Musa / Bostanci, Erdal Birol / Colakoglu, Muhammet Kadri / Aksoy, Erol

The American surgeon

2017 Volume 83, Issue 3, Page(s) 260–264

Abstract: Laparoscopic cholecystectomy (LC) is seen as a gateway to minimally invasive surgery. We defined a new three-port technique with different port sites and compared the postoperative results with traditional four-port LC procedure in a case-match study. ... ...

Abstract	Laparoscopic cholecystectomy (LC) is seen as a gateway to minimally invasive surgery. We defined a new three-port technique with different port sites and compared the postoperative results with traditional four-port LC procedure in a case-match study. Between June 2012 and May 2013, 104 consecutive patients underwent three-port LC by same experienced surgeon. In the same center, 2963 consecutive patients underwent four-port LC, and of these 2963 patients, a matched group of 104 patients was selected. Data included patient age, gender, body mass index, American Society of Anesthesiologists score, history of abdominal operations, intraoperative data about operating time and conversion to open surgery, and postoperative data about length of hospital stay and postoperative complications were recorded prospectively. We concluded that our new three-port technique with different port sites is as feasible and safe as traditional four-port technique.
MeSH term(s)	Adult ; Age Factors ; Cholecystectomy, Laparoscopic/methods ; Conversion to Open Surgery ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Operative Time ; Postoperative Complications/epidemiology ; Treatment Outcome
Language	English
Publishing date	2017-03-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Uk I Zs.106: Show issues

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Article: Detection of HPV DNA in Esophageal Lesions: a Cross-Sectional Study.

Dinc, Bedia / Altay-Kocak, Aylin / Aydog, Gulden / Kuran, Sedef / Akoglu, Musa / Ozkan, Secil / Bozdayi, Gulendam

Clinical laboratory

2020 Volume 66, Issue 3

Abstract: Background: Several studies have documented human papillomavirus (HPV) in extra-cervical tumors. We aimed to detect HPV type 16 and HPV other than type 16 (OT-16) DNA in esophageal papilloma and esophagus squamous cell carcinoma (ESCC) samples and to ... ...

Abstract	Background: Several studies have documented human papillomavirus (HPV) in extra-cervical tumors. We aimed to detect HPV type 16 and HPV other than type 16 (OT-16) DNA in esophageal papilloma and esophagus squamous cell carcinoma (ESCC) samples and to compare clinicopathological features of HPV positive and negative patients. Methods: Materials were obtained from a tertiary care public hospital and studied in an university hospital for this cross-sectional study. Seventy-six tissue samples (50 papilloma and 26 ESCC) were included. After deparaffinization by xylene and DNA extraction by phenol chloroform-isoamyl-alcohol, 76 samples were studied with a G6PDH control kit. Forty-four papilloma and 21 ESCC samples with enough tissues were studied for HPV DNA. HPV OT-16 DNA and HPV type 16 were detected by real time-polymerase chain reaction. Results: Twelve (27.3%) and one (2.3%) of the papilloma samples were HPV type 16 and other than type 16 positive, respectively. Eleven (52.4%) and one (4.8%) of ESCC samples were HPV type 16 and mixed type positive, respectively. Conclusions: We suggest that HPV infection is common in esophageal papilloma and ESCC. Due to the wellknown association of HPV with premalignant and malignant conditions, follow-up of these patients accompanied by HPV should be implemented.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; DNA, Viral/analysis ; DNA, Viral/isolation & purification ; Esophageal Neoplasms/epidemiology ; Esophageal Neoplasms/virology ; Esophageal Squamous Cell Carcinoma/epidemiology ; Esophageal Squamous Cell Carcinoma/virology ; Female ; Human papillomavirus 16/genetics ; Humans ; Male ; Middle Aged ; Papillomaviridae/genetics ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/virology ; Retrospective Studies ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2020-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2019.190506
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Ud II Zs.170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pancreatic stump closure using only stapler is associated with high postoperative fistula rate after minimal invasive surgery.

Yüksel, Adem / Bostancı, Erdal Birol / Çolakoğlu, Muhammet Kadri / Ulaş, Murat / Özer, İlter / Karaman, Kerem / Akoğlu, Musa

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2018 Volume 29, Issue 2, Page(s) XXXX

Abstract: Background/aims: Postoperative pancreatic fistula (POPF) is the most common cause of morbidity and mortality after distal pancreatectomy (DP). The aim of the present study is to determine the risk factors that can lead to POPF.: Materials and methods!# ...

Abstract	Background/aims: Postoperative pancreatic fistula (POPF) is the most common cause of morbidity and mortality after distal pancreatectomy (DP). The aim of the present study is to determine the risk factors that can lead to POPF. Materials and methods: The study was conducted between January 2008 and December 2012. A total of 96 patients who underwent DP were retrospectively analyzed. Results: Overall, 24 patients (25%) underwent laparoscopic distal pancreatectomy (LDP) and 72 patients (75%) open surgery. The overall morbidity rate was 51% (49/96). POPF (32/96, 33.3%) was the most common postoperative complication. Grade B fistula (18/32, 56.2%) was the most common fistula type according to the International Study Group on Pancreatic Fistula definition. POPF rate was significantly higher in the minimally invasive surgery group (50%, p=0.046). POPF rate was 58.6% (17/29) in patients whose pancreatic stump closure was performed with only stapler, whereas POPF rate was 3.6% (1/28) in the group where the stump was closed with stapler plus oversewing sutures. Both minimally invasive surgery (OR: 0.286, 95% CI: 0.106-0.776, p=0.014) and intraoperative blood transfusion (OR: 4.210, 95% CI: 1.155-15.354, p=0.029) were detected as independent risk factors for POPF in multi-variety analysis. Conclusion: LDP is associated with a higher risk of POPF when stump closure is performed with only staplers. Intraoperative blood transfusion is another risk factor for POPF. On the other hand, oversewing sutures to the stapler line reduces the risk of POPF.
MeSH term(s)	Adult ; Aged ; Blood Transfusion/methods ; Female ; Humans ; Intraoperative Care/adverse effects ; Intraoperative Care/methods ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Male ; Middle Aged ; Pancreas/surgery ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreatic Fistula/etiology ; Pancreatic Fistula/mortality ; Postoperative Complications/etiology ; Postoperative Complications/mortality ; Retrospective Studies ; Risk Factors ; Surgical Stapling/adverse effects
Language	English
Publishing date	2018-05-15
Publishing country	Turkey
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2018.17567
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Article ; Online: Changing Trends in Gastric Cancer Surgery

İlter Özer / Erdal Birol Bostancı / Murat Ulaş / Yusuf Özoğul / Musa Akoğlu

Balkan Medical Journal, Vol 34, Iss 1, Pp 10-

2017 Volume 20

Abstract	Gastric cancer is one of the most common causes of cancer-related death. It requires multimodal treatment and surgery is the most effective treatment modality. Radical surgery includes total or subtotal gastrectomy with lymph node dissection. The extent of lymphadenectomy still remains controversial. Eastern surgeons have performed D2 or more extended lymphadenectomy while their Western colleagues have performed more limited lymph node dissection. However, the trend has been changing in favour of D2 lymph node dissection in both hemispheres. Currently, D2 is the recommended type of lymphadenectomy in experienced centres in the west. In Japan, D2 lymph node dissection is the standard surgical approach. More extensive lymphadenectomy than D2 has not been found to be associated with improved survival and generally is not performed. Bursectomy and splenectomy are additional controversial issues in surgical performance, and trends regarding them will be discussed. The performance of bursectomy is controversial and there is no clear evidence of its clinical benefit. However, a trend toward better survival in patients with serosal invasion has been reported. Routine splenectomy as a part of lymph node dissection has largely been abandoned, although splenectomy is recommended in selected cases. Minimally invasive surgery has gained wide popularity and indications for minimally invasive procedures have been expanding due to increasing experience and improving technology. Neoadjuvant therapy has been shown to have beneficial effects and seems necessary to provide a survival benefit. Diagnostic laparoscopy should be kept in mind prior to treatment
Keywords	Gastric cancer ; lymph node dissection ; bursectomy ; splenectomy ; minimally invasive surgery ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	Galenos Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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