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Article: Correction: Kim, Young-Gun; Jeon, Ja Young; Kim, Hae Jin; Kim, Dae Jung; Lee, Kwan-Woo; Moon, So Young; Han, Seung Jin. Risk of Dementia in Older Patients with Type 2 Diabetes on Dipeptidyl-Peptidase IV Inhibitors versus Sulfonylureas: A Real-World Population-Based Cohort Study.

Kim, Young-Gun / Jeon, Ja Young / Kim, Hae Jin / Kim, Dae Jung / Lee, Kwan-Woo / Moon, So Young / Han, Seung Jin

2019 Volume 8, Issue 3

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2019-03-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8030389
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Article ; Online: Age-Specific Association Between Handgrip Strength and Nutritional Quality in Korean Men: A Nationwide Cross-Sectional Study.

Shin, Woo-Young / Kim, Jung-Ha

American journal of men's health

2022 Volume 15, Issue 6, Page(s) 15579883211063339

Abstract: This study aimed to determine the potential association between handgrip strength and nutritional quality in Korean men aged ≥20 years using data from the Korea National Health and Nutrition Examination Survey 2016 to 2018. This population-based cross- ... ...

Abstract	This study aimed to determine the potential association between handgrip strength and nutritional quality in Korean men aged ≥20 years using data from the Korea National Health and Nutrition Examination Survey 2016 to 2018. This population-based cross-sectional study included 5,748 men aged ≥20 years. A dietary intake survey was performed using the 24-hr dietary recall method. Nutritional quality was examined using the Index of Nutritional Quality (INQ) score. A high INQ score reflected poor nutritional quality, with insufficient intake of many nutrients. Multivariate linear regression was used to determine the association between handgrip strength and INQ scores after adjusting for other covariates. The intake of carbohydrates, fiber, calcium, and vitamins B2 and C was significantly positively associated with a higher quartile for handgrip strength for those aged ≥65 years (all
MeSH term(s)	Age Factors ; Aged ; Cross-Sectional Studies ; Hand Strength ; Humans ; Male ; Nutrition Surveys ; Nutritive Value ; Republic of Korea
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883211063339
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Article ; Online: Therapeutic maintenance effect of finasteride 1 mg every other month regimen in androgenetic alopecia and study on the difference in response to finasteride treatment: A prospective cohort study.

Kim, Ki-Hun / Kwon, Soon-Hyo / Sim, Woo-Young / Lew, Bark-Lynn

The Journal of dermatology

2024 Volume 51, Issue 4, Page(s) 552–557

Abstract: Finasteride is commonly used for androgenetic alopecia (AGA) treatment. The aim of this study was to assess the therapeutic maintenance effect of a finasteride every other month (EOM) regimen and analyze clinical and laboratory differences in patients ... ...

Abstract	Finasteride is commonly used for androgenetic alopecia (AGA) treatment. The aim of this study was to assess the therapeutic maintenance effect of a finasteride every other month (EOM) regimen and analyze clinical and laboratory differences in patients with AGA according to their treatment response. One hundred males with AGA who received finasteride 1 mg daily treatment for a year were enrolled in the study. At 1 year follow-up, treatment responses of patients who completed the visit schedule were assessed using five scales. The patients were assigned to good or bad response groups according to their assessment. Further, they were randomly divided into two groups (daily vs. EOM) and treated with finasteride (1 mg) for 1 more year. At 2 years follow-up, treatment efficacy was assessed. At 1-year follow-up, 36 patients completed the schedule, including eight and three patients in the good and bad response groups, respectively. At the 2-year follow-up, 23 patients completed the schedule, with nine in the daily group and 14 in the EOM group. Changes in global photographic assessment in the second year were 1.33 and 1.29 for the daily and EOM groups, respectively. The daily group showed an elevated hair density and lower concentration of dihydrotestosterone (DHT) and the DHT to testosterone ratio (DHT/T). However, the EOM group showed decreased hair density and elevated DHT and DHT/T. Following treatment response assessment after 1 year of treatment, the good response group showed early onset which was associated with maternal AGA. Analysis of serum androgen hormone magnitude of DHT reduction was much greater (54.4% vs. 44.4%). DHT/T was higher in the bad response group (1.98 vs. 2.33). We concluded that the finasteride EOM regimen showed similar maintenance effects to the daily regimen.
MeSH term(s)	Male ; Humans ; Finasteride/therapeutic use ; Prospective Studies ; Alopecia/chemically induced ; Hair ; Dihydrotestosterone/pharmacology ; Dihydrotestosterone/therapeutic use ; 5-alpha Reductase Inhibitors/therapeutic use
Chemical Substances	Finasteride (57GNO57U7G) ; Dihydrotestosterone (08J2K08A3Y) ; 5-alpha Reductase Inhibitors
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.17120
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Article ; Online: The role and medical prospects of long non-coding RNAs in cardiovascular disease.

Kim, Najung / Chung, Woo-Young / Cho, Je-Yoel

Heart failure reviews

2023 Volume 28, Issue 6, Page(s) 1437–1453

Abstract: Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated ... ...

Abstract	Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated cardiomyopathy, myocardial infarction, heart fibrosis, and genetic and developmental heart defects such as heart valve deformities. Damaged or defective heart tissue has limited regenerative capacity and results in a loss of functioning myocardium. Advances in transcriptomic profiling technology have revealed that long noncoding RNA (lncRNA) is transcribed from what was once considered "junk DNA." It has since been discovered that lncRNAs play a critical role in the pathogenesis of various CVDs and in myocardial regeneration. This review will explore how lncRNAs impact various forms of CVD as well as those involved in cardiomyocyte regeneration. Further, we discuss the potential of lncRNAs as a therapeutic modality for treating CVD.
MeSH term(s)	Humans ; Cardiovascular Diseases/genetics ; RNA, Long Noncoding/genetics ; Myocardium/pathology ; Cardiomegaly/genetics ; Myocytes, Cardiac/pathology
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1336499-6
ISSN	1573-7322 ; 1382-4147
ISSN (online)	1573-7322
ISSN	1382-4147
DOI	10.1007/s10741-023-10342-1
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Article ; Online: Real-World Safety and Effectiveness of Controlled-Release Cilostazol in Patients with Symptomatic Peripheral Artery Disease.

Shin, Woo-Young / Lee, Hye Jun / Kim, Jung-Ha

Clinical drug investigation

2023 Volume 43, Issue 9, Page(s) 729–738

Abstract: Background: Cilostazol is the only first-line medication for treating intermittent claudication, and the controlled-release (CR) formulation is associated with a lower prevalence of adverse events (AEs).: Objective: The objective of the study was to ... ...

Abstract	Background: Cilostazol is the only first-line medication for treating intermittent claudication, and the controlled-release (CR) formulation is associated with a lower prevalence of adverse events (AEs). Objective: The objective of the study was to assess the safety and effectiveness of cilostazol CR in patients with symptomatic peripheral artery disease (PAD). Methods: In this multicentre (113 sites), open-label, prospective observational study, we evaluated the real-world safety and effectiveness of cilostazol CR 200 mg once daily in patients with symptomatic PAD treated in routine clinical settings. The primary endpoint was the incidence and severity of AEs, and their causal relationship with cilostazol CR. The secondary endpoint was the effectiveness of the drug, as assessed by each patient's physician, for improving intermittent claudication. Results: Among 2063 participants who received cilostazol CR for a mean duration of 88.6 days, 99 (4.80 %) experienced adverse drug reactions (ADRs), although no unexpected adverse reactions were observed. There was no significant difference in the incidence of ADRs according to patient demographics and comorbidities (all p > 0.05). The treatment was 'effective' in 1600 patients (78.93 %), although effectiveness significantly differed according to the patients' sex and the presence of comorbidities, including diabetes mellitus, hypertension, and coronary artery disease (all p < 0.01). Conclusions: This study demonstrated the tolerability and effectiveness of cilostazol CR treatment in patients with symptomatic PAD.
MeSH term(s)	Humans ; Cilostazol/adverse effects ; Intermittent Claudication/drug therapy ; Delayed-Action Preparations/adverse effects ; Peripheral Arterial Disease/drug therapy ; Peripheral Arterial Disease/epidemiology ; Coronary Artery Disease ; Drug-Related Side Effects and Adverse Reactions
Chemical Substances	Cilostazol (N7Z035406B) ; Delayed-Action Preparations
Language	English
Publishing date	2023-08-31
Publishing country	New Zealand
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01302-6
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Article ; Online: Prognostic value of reactive hyperemia index using peripheral artery tonometry in patients with heart failure.

Kim, Hack-Lyoung / Lim, Woo-Hyun / Seo, Jae-Bin / Chung, Woo-Young

Scientific reports

2023 Volume 13, Issue 1, Page(s) 125

Abstract: Given the high prevalence and poor prognosis of heart failure (HF), finding prognostic factors for patients with HF is crucial. This study investigated the prognostic value of reactive hyperemia index (RHI), a measure of endothelial function, in HF. A ... ...

Abstract	Given the high prevalence and poor prognosis of heart failure (HF), finding prognostic factors for patients with HF is crucial. This study investigated the prognostic value of reactive hyperemia index (RHI), a measure of endothelial function, in HF. A total of 90 HF patients (mean age, 63.7 ± 13.2 years; female, 25.6%) with a history of hospitalization for HF treatment were prospectively enrolled. RHI was measured using digital arterial tonometry in a stable condition. Clinical events, including all-cause death and HF admission, were assessed. During the median follow-up of 3.66 years (interquartile range, 0.91-4.94 years), 26 clinical events (28.9%) occurred. Although there were no significant differences in risk factors and laboratory findings according to the occurrence of clinical events, the RHI value was significantly lower in patients with clinical events than in those without (1.21 ± 0.34 vs. 1.68 ± 0.48; P < 0.001). Kaplan-Meier survival analysis showed that a lower RHI value (< 1.48) was associated with a significantly higher incidence rate of clinical events (log-rank P < 0.001). In multivariable cox regression analysis, a low RHI value (< 1.48) was associated with an increased risk of clinical events (hazard ratio, 14.09; 95% confidence interval, 3.61-54.99; P < 0.001) even after controlling for potential confounders. Our study showed that reduced RHI was associated with an increased risk of adverse clinical outcomes in HF. This suggests that endothelial dysfunction may be an important prognostic marker in patients with HF.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Prognosis ; Hyperemia ; Endothelium, Vascular ; Heart Failure/diagnosis ; Risk Factors ; Arteries ; Manometry
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-27454-1
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Article: Therapeutic targeting of lipid synthesis metabolism for selective elimination of cancer stem cells.

Kim, Woo-Young

Archives of pharmacal research

2018 Volume 42, Issue 1, Page(s) 25–39

Abstract: Cancer stem cells (CSCs) are believed to have an essential role in tumor resistance and metastasis; however, no therapeutic strategy for the selective elimination of CSCs has been established. Recently, several studies have shown that the metabolic ... ...

Abstract	Cancer stem cells (CSCs) are believed to have an essential role in tumor resistance and metastasis; however, no therapeutic strategy for the selective elimination of CSCs has been established. Recently, several studies have shown that the metabolic regulation for ATP synthesis and biological building block generation in CSCs are different from that in bulk cancer cells and rather similar to that in normal tissue stem cells. To take advantage of this difference for CSC elimination therapy, many studies have tested the effect of blocking these metabolism. Two specific processes for lipid biosynthesis, i.e., fatty acid unsaturation and cholesterol biosynthesis, have been shown to be very effective and selective for CSC targets. In this review, lipid metabolism specific to CSCs are summarized. In addition, how monounsaturated fatty acid and cholesterol synthesis may contribute to CSC maintenance are discussed. Specifically, the molecular mechanism required for lipid synthesis and essential for stem cell biology is highlighted. The limit and preview of the lipid metabolism targeting for CSCs are also discussed.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Drug Delivery Systems/methods ; Humans ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Lipogenesis/drug effects ; Lipogenesis/physiology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2018-12-08
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-018-1098-z
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Article: Characterization of Spray Modes and Factors Affecting the Ionization Efficiency of Paper Spray Ionization.

Nguyen, Thi Minh Hoa / Song, Woo-Young / Kim, Tae-Young

Frontiers in chemistry

2022 Volume 10, Page(s) 864184

Abstract: In this study, we systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI), such as electric field, solvent supply rate, and paper thickness and hydrophobicity. The observed paper spray plume was classified ...

Abstract	In this study, we systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI), such as electric field, solvent supply rate, and paper thickness and hydrophobicity. The observed paper spray plume was classified into three modes: single cone-jet, multi-jet, and rim-jet modes. With the increase in the spraying voltage, the spray plume appeared in order of single cone-jet, multi-jet, and rim-jet modes. The rim-jet mode exhibited the lowest standard deviation and high ionization efficiency among the three spray modes. The main parameter determining the spray mode was the charge density of the droplets generated by paper spray, which depends on the electric field and solvent supply rate. A thicker paper reduced the electric repulsion between the jets and lowered the threshold voltage to reach the rim-jet mode. Lowering the solvent supply rate caused mode transitions from the single cone-jet to the rim-jet, possibly due to the increased droplet charge density. The hydrophobic modification on a paper substrate led to a different ionization mechanism or electrostatic spray ionization at low applied voltages.
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.864184
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Article ; Online: Poor diet quality is associated with self-reported knee pain in community-dwelling women aged 50 years and older.

Shin, Woo-Young / Kim, Jung-Ha

PloS one

2021 Volume 16, Issue 2, Page(s) e0245630

Abstract: In the current study, we aimed to examine the association between knee pain and diet quality in women aged ≥ 50 years using data from the Korea National Health and Nutrition Examination Survey. This was a population-based, cross-sectional study. Diet ... ...

Abstract	In the current study, we aimed to examine the association between knee pain and diet quality in women aged ≥ 50 years using data from the Korea National Health and Nutrition Examination Survey. This was a population-based, cross-sectional study. Diet quality was assessed using the Diet Quality Index-International (DQI-I), and knee pain and osteoarthritis were self-reported. A multivariate logistic regression model was used to adjust for age, body mass index, household income, marital status, education, occupation, smoking status, hazardous alcohol use, regular physical activity, menopause, and chronic diseases, including hypertension, diabetes, dyslipidemia, osteoarthritis, and depression. A total of 3,881 women were included in this study, and the prevalence of knee pain was 25.4%. The intakes of total energy, protein, and fat were lower in women with knee pain than in those without (all P < 0.01), while the carbohydrate intake was higher (P = 0.01). No significant differences were noted in the scores for variety, overall balance, and moderation components, except for the item of total fat intake, between the DQI-I scores for women with and without knee pain, after adjusting for age. Women without knee pain showed higher scores in several items of the adequacy component (P < 0.05) than did women with knee pain. The total DQI-I scores were lower in women with knee pain than in women without knee pain, after adjusting for covariates, including osteoarthritis (OR = 0.985, 95% CI = 0.973-0.997, P = 0.01). Knee pain independent of osteoarthritis was associated with poor diet quality in community-dwelling women aged ≥ 50 years.
MeSH term(s)	Aged ; Aged, 80 and over ; Comorbidity ; Cross-Sectional Studies ; Diet/methods ; Female ; Humans ; Independent Living ; Knee/physiopathology ; Knee Joint/physiopathology ; Middle Aged ; Musculoskeletal Pain/epidemiology ; Nutrition Surveys ; Osteoarthritis, Knee/epidemiology ; Prevalence ; Republic of Korea/epidemiology ; Self Report
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0245630
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Article ; Online: Improving liquid chromatography-mass spectrometry sensitivity for characterization of lignin oligomers and phenolic compounds using acetic acid as a mobile phase additive.

Song, Woo-Young / Park, Hyejin / Kim, Tae-Young

Journal of chromatography. A

2022 Volume 1685, Page(s) 463598

Abstract: Characterization of complex lignin degradation products by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) requires a high sensitivity, which can be improved by use of optimized mobile phase additive. In this study, ... ...

Abstract	Characterization of complex lignin degradation products by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) requires a high sensitivity, which can be improved by use of optimized mobile phase additive. In this study, chromatographic separation and ionization efficiency for LC-MS analysis of lignin oligomers and lignin-derived phenolic compounds were compared among six different mobile phase additives. We found that acetic acid exhibits analytical performance superior to the other mobile phase additives for characterization of lignin degradation products by LC-(-)-ESI-MS/MS. The retention of phenolic compounds (PCs) containing carboxylic group was improved by using acidic additives instead of their ammonium salts. The use of acetic acid as an LC mobile phase additive enhanced the ionization efficiency of PCs in (-)-ESI-MS about 2 to 4 times higher than the other additives. The improved MS sensitivity with acetic acid yielded a higher coverage of fragment ions in LC-MS/MS analysis, leading to identification of four additional synthetic G-type lignin oligomers (LOs) than ammonium acetate. A similar degree of sensitivity enhancement was also demonstrated for degradation products from rice straw lignin using acetic acid additive over the others. The increased chromatographic retention and enhanced sensitivity of PCs and LOs provided by the use of acetic acid as an LC-(-)-ESI-MS mobile phase additive will facilitate structural analysis of lignin degradation products without relying on additional instrumentation.
MeSH term(s)	Chromatography, Liquid/methods ; Spectrometry, Mass, Electrospray Ionization/methods ; Tandem Mass Spectrometry/methods ; Lignin ; Acetic Acid/chemistry ; Phenols
Chemical Substances	Lignin (9005-53-2) ; Acetic Acid (Q40Q9N063P) ; Phenols
Language	English
Publishing date	2022-10-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2022.463598
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