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Article ; Online: Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton.

Rodríguez-Güell, Elisabeth / Agustí, Gemma / Corominas, Mercè / Cardona, Pere-Joan / Luquin, Marina / Julián, Esther

2008 Volume 15, Issue 5, Page(s) 893–896

Abstract: ... from both non-TB and TB M. vaccae-treated mice. ...

Abstract	Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.
MeSH term(s)	Adoptive Transfer ; Animals ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Cell Wall Skeleton/administration & dosage ; Cell Wall Skeleton/immunology ; Interferon-gamma/biosynthesis ; Mice ; Mycobacterium/chemistry ; Mycobacterium/immunology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/therapy
Chemical Substances	Bacterial Vaccines ; Cell Wall Skeleton ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2008-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2221082-9
ISSN	1556-679X ; 1556-6811
ISSN (online)	1556-679X
ISSN	1556-6811
DOI	10.1128/CVI.00477-07
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Book: Epistolari Joan Coromines & Josep M. Batista i Roca, Joan Triadú, Albert Manent i Max Cahner

Corominas, Joan / Batista i Roca, Josep M / Ferrer, Josep / Triadú i Font, Joan

(Textos i estudis / Fundació Pere Coromines ; 14)

2009

Title variant	Sammlung
Author's details	a cura de Josep Ferrer, Joan Pujadas; pròleg de Carles Duarte
Series title	Textos i estudis / Fundació Pere Coromines ; 14
Language	Catalan
Size	559 p, 21 cm
Edition	1. ed
Publisher	Fundació Pere Coromines
Publishing place	Barcelona
Document type	Book
Note	Includes bibliographical references ; Letters, partly publ. for the first time, by and to J. Corominas ; Text in Catalan
ISBN	9788472567672 ; 8472567672
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.

Esteban-Collado, José / Corominas, Montserrat / Serras, Florenci

Development (Cambridge, England)

2021 Volume 148, Issue 8

Abstract: Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as early signals that are sensed by the MAP3 kinase Ask1, which in turn activates by phosphorylation the MAP kinases p38 and JNK. ... ...

Abstract	Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as early signals that are sensed by the MAP3 kinase Ask1, which in turn activates by phosphorylation the MAP kinases p38 and JNK. The sustained or high activation of these kinases can result in apoptosis, whereas short or low activation can promote regeneration. Using the Ask1-dependent regeneration program, we demonstrate in Drosophila wing that PI3K/Akt signaling is necessary for Ask1 to activate p38, but not JNK. In addition, nutrient restriction or mutations that target Ser83 of the Drosophila Ask1 protein, a PI3K/Akt-sensitive residue, block regeneration. However, these effects can be reversed by the ectopic activation of p38, but not of JNK. Our results demonstrate that Ask1 controls the activation of p38 through Ser83, and that the phosphorylation of p38 during regeneration is nutrient sensitive. This mechanism is important for discriminating between p38 and JNK in the cells involved in tissue repair and regenerative growth.
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.197087
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Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 91: Show issues

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Article: Seamless integration of sewer system topology and tree location data: An algorithm to diagnose the potential impact of tree roots on pipes and propose rearrangement solutions.

Martínez, David / Bergillos, Sergi / Corominas, Lluís / Comas-Cufí, Marc / Calle, Eusebi

Heliyon

2023 Volume 10, Issue 1, Page(s) e23382

Abstract: Wastewater networks are subject to several threats leading to wastewater leakages and public health hazards. External elements such as natural factors and human activities are common causes of wastewater leakages and require more in-depth analysis. ... ...

Abstract	Wastewater networks are subject to several threats leading to wastewater leakages and public health hazards. External elements such as natural factors and human activities are common causes of wastewater leakages and require more in-depth analysis. Prevention and rehabilitation work is essential to secure wastewater networks and avoid pipe failures. This work presents a new algorithm that allows for the seamless integration of sewer topology and tree location data to diagnose the potential impact of tree roots on pipes. The algorithm also proposes tree rearrangement options that balance the cost of tree rearrangement with the cost of pipe repair. The paper also showcases a real-world case study in the city of Girona to evaluate the performance of the presented algorithms for a specific case focusing on tree roots as a natural factor. Results show that it is possible to optimally rearrange a number of the trees with the greatest impact, significantly minimizing pipe failures and wastewater leakages (82% risk reduction with only rearranging a 12% of the most impactful trees). The rearrangement solution not only protects the environment and prevents public health hazards, but also achieves a positive economic payback during the operational period of the pipes, saving up to 1.33M€ for a tree rearrangement of 7%. The presented methodology is applicable to other natural or human factors.
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23382
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: N-Nitrosamines and their precursors in wastewater effluents from selected industries in Spain.

Farré, Maria José / Insa, Sara / Gernjak, Wolfgang / Corominas, Lluís / Čelić, Mira / Acuña, Vicenç

Journal of hazardous materials

2023 Volume 451, Page(s) 131159

Abstract: N-nitrosamines (NAs), and N-nitrosodimethylamine (NDMA) in particular, are hazardous disinfection byproducts (DBPs) relevant when wastewater impacts drinking water sources and, in water reuse practices. Our study investigates the concentrations of NDMA ... ...

Abstract	N-nitrosamines (NAs), and N-nitrosodimethylamine (NDMA) in particular, are hazardous disinfection byproducts (DBPs) relevant when wastewater impacts drinking water sources and, in water reuse practices. Our study investigates the concentrations of NDMA and five additional NAs and their precursors in industrial wastewater effluents. Aiming to identify potential differences between industrial typologies, wastewaters from 38 industries belonging to 11 types of the UN International Standard Industrial Classification of All Economic Activities system (ISIC) were analysed. Results show that the presence of most NAs and their precursors cannot be linked to a specific industry type as these were in general very different within the classes. Nevertheless, N-nitrosomethylethylamine (NMEA) and N-nitrosopiperidine (NPIP) as well as precursors for N-nitrosodiethylamine (NDEA), NPIP and N-nitrosodibuthylamine (NDBA) could be rank with different concentrations between ISIC classes (p-value < 0.05). Specific industrial wastewater with notable high concentrations of NAs and their precursors were identified too. The effluents with the highest concentration of NDMA belong to the ISIC C2011 class (Manufacture of basic chemical), while the effluents with the highest concentration of NDMA precursors were from the ISIC C1511 class (Tanning and dressing of leather; dressing and dyeing of fur). Other relevant NAs found were NDEA in ISIC class B0810 (Quarrying of stone, sand, and clay) and ISIC class C2029 (Manufacture of other chemical products).
Language	English
Publishing date	2023-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131159
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chromatin status is key for regeneration.

Forcales, Sonia V / Corominas, Montserrat

Seminars in cell & developmental biology

2019 Volume 97, Page(s) 1–2

MeSH term(s)	Chromatin/metabolism ; Humans ; Regeneration/drug effects
Chemical Substances	Chromatin
Language	English
Publishing date	2019-06-18
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2019.06.002
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Zs.A 2918: Show issues

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Article ; Online: The first two years of the use of low titer group O whole blood during French Military overseas operations: A retrospective study.

Riff, Jean-Clément / Duranteau, Olivier / Ausset, Sylvain / Pasquier, Pierre / Fleuriot, Estelle / Corominas, Vanina / Boutonnet, Mathieu

Transfusion

2024

Abstract: Background: On the battlefield, hemorrhage is the main cause of potentially preventable death. To reduce mortality due to hemorrhagic injuries, the French Military Medical Service (FMMS) has deployed low titer group O whole blood (LTOWB) since June 2021 ...

Abstract	Background: On the battlefield, hemorrhage is the main cause of potentially preventable death. To reduce mortality due to hemorrhagic injuries, the French Military Medical Service (FMMS) has deployed low titer group O whole blood (LTOWB) since June 2021 during operation BARKHANE in the Sahel-Saharan strip. Questions persist regarding the circumstances under which the FMMS employs LTOWB during overseas operations. Study design: We performed a retrospective analysis of all LTOWB transfused by the FMMS during overseas operations in the Sahel-Saharan strip between June 1, 2021, and June 1, 2023. Information was collected from battlefield forward transfusion sheets. Results: Over the 2-year study period, 40 units of LTOWB were transfused into 25 patients. Of the 25 patients, 18 were combat casualties and seven were transfused for non-trauma surgery. Of the 40 units of LTOWB transfused, 22 were provided during Role 2 care, 11 during tactical medical evacuation (MEDEVAC), and seven in light and mobile surgical units. Among combat casualties, LTOWB was the first blood product transfused in 13 patients. In combat casualties, 6 h post-trauma, the median ratio of plasma: red blood cells (RBCs) was 1.5, and the median equivalent platelet concentrate (PC) transfused was 0.17. No immediate adverse events related to LTOWB transfusion were reported. Conclusion: LTOWB is transfused by the FMMS during overseas operations from the tactical MEDEVAC until Role 2 care. Deployment of LTOWB by the FMMS enables an early high-ratio plasma/RBC transfusion and an early platelet transfusion for combat casualties.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.17776
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Zs.A 284: Show issues

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Article: Identification of GB3 as a Novel Biomarker of Tumor-Derived Vasculature in Neuroblastoma Using a Stiffness-Based Model.

Villasante, Aranzazu / Corominas, Josep / Alcon, Clara / Garcia-Lizarribar, Andrea / Mora, Jaume / Lopez-Fanarraga, Monica / Samitier, Josep

Cancers

2024 Volume 16, Issue 5

Abstract: Neuroblastoma (NB) is a childhood cancer in sympathetic nervous system cells. NB exhibits cellular heterogeneity, with adrenergic and mesenchymal states displaying distinct tumorigenic potentials. NB is highly vascularized, and blood vessels can form ... ...

Abstract	Neuroblastoma (NB) is a childhood cancer in sympathetic nervous system cells. NB exhibits cellular heterogeneity, with adrenergic and mesenchymal states displaying distinct tumorigenic potentials. NB is highly vascularized, and blood vessels can form through various mechanisms, including endothelial transdifferentiation, leading to the development of tumor-derived endothelial cells (TECs) associated with chemoresistance. We lack specific biomarkers for TECs. Therefore, identifying new TEC biomarkers is vital for effective NB therapies. A stiffness-based platform simulating human arterial and venous stiffness was developed to study NB TECs in vitro. Adrenergic cells cultured on arterial-like stiffness transdifferentiated into TECs, while mesenchymal state cells did not. The TECs derived from adrenergic cells served as a model to explore new biomarkers, with a particular focus on GB3, a glycosphingolipid receptor implicated in angiogenesis, metastasis, and drug resistance. Notably, the TECs unequivocally expressed GB3, validating its novelty as a marker. To explore targeted therapeutic interventions, nanoparticles functionalized with the non-toxic subunit B of the Shiga toxin were generated, because they demonstrated a robust affinity for GB3-positive cells. Our results demonstrate the value of the stiffness-based platform as a predictive tool for assessing NB aggressiveness, the discovery of new biomarkers, and the evaluation of the effectiveness of targeted therapeutic strategies.
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16051060
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Article ; Online: Reacciones cruzadas entre factor reumatoide e IgM SARS-CoV-2.

Vinyé Bausà, Marta / Bausà Peris, Rosa / Corominas, Hèctor

Medicina clinica

2020 Volume 155, Issue 9, Page(s) 417–418

Title translation	Cross-reactions between rheumatoid factor and IgM SARS-CoV-2.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Immunoglobulin M ; Pandemics ; Pneumonia, Viral ; Rheumatoid Factor ; SARS-CoV-2
Chemical Substances	Immunoglobulin M ; Rheumatoid Factor (9009-79-4)
Keywords	covid19
Language	Spanish
Publishing date	2020-07-28
Publishing country	Spain
Document type	Letter ; Comment
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2020.07.008
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Ua VI Zs.279: Show issues

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Article ; Online: Zooming in to the neighborhood level: A year-long wastewater-based epidemiology monitoring campaign for COVID-19 in small intraurban catchments.

Zammit, Ian / Badia, Sergi / Mejías-Molina, Cristina / Rusiñol, Marta / Bofill-Mas, Sílvia / Borrego, Carles M / Corominas, Lluís

The Science of the total environment

2023 Volume 907, Page(s) 167811

Abstract: In recent years, wastewater-based epidemiology (WBE) has emerged as a valuable and cost-effective tool for monitoring the prevalence of COVID-19. Large-scale monitoring efforts have been implemented in numerous countries, primarily focusing on sampling ... ...

Abstract	In recent years, wastewater-based epidemiology (WBE) has emerged as a valuable and cost-effective tool for monitoring the prevalence of COVID-19. Large-scale monitoring efforts have been implemented in numerous countries, primarily focusing on sampling at the entrance of wastewater treatment plants (WWTPs) to cover a large population. However, sampling at a finer spatial scale, such as at the neighborhood level (NGBs), pose new challenges, including the absence of composite sampling infrastructure and increased uncertainty due to the dynamics of small catchments. This study aims to investigate the feasibility and accuracy of WBE when deployed at the neighborhood level (sampling in sewers) compared to the city level (sampling at the entrance of a WWTP). To achieve this, we deployed specific WBE sampling stations at the intraurban scale within three NGBs in Barcelona, Spain. The study period covers the 5th and the 6th waves of COVID-19 in Spain, spanning from March 2021 to March 2022, along with the WWTP downstream from the NGBs. The results showed a strong correlation between the dynamics of COVID-19 clinical cases and wastewater SARS-CoV-2 loads at both the NGB and city levels. Notably, during the 5th wave, which was dominated by the Delta SARS-CoV-2 variant, wastewater loads were higher than during the 6th wave (Omicron variant), despite a lower number of clinical cases recorded during the 5th wave. The correlations between wastewater loads and clinical cases at the NGB level were stronger than at the WWTP level. However, the early warning potential varied across neighborhoods and waves, with some cases showing a one-week early warning and others lacking any significant early warning signal. Interestingly, the prevalence of COVID-19 did not exhibit major differences among NGBs with different socioeconomic statuses.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Wastewater ; Wastewater-Based Epidemiological Monitoring
Chemical Substances	Wastewater
Language	English
Publishing date	2023-10-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167811
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Zs.A 949: Show issues

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