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  1. Book: The neurobiological basis of suicide

    Dwivedi, Yogesh

    (Frontiers in neuroscience)

    2012  

    Author's details ed. by Yogesh Dwivedi
    Series title Frontiers in neuroscience
    Keywords Suicide / psychology ; Adrenergic Neurons / physiology ; Serotonin / physiology
    Language English
    Size XXV, 454 S., [1] Bl. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017052126
    ISBN 978-1-4398-3881-5 ; 9781439838822 ; 1-4398-3881-X ; 1439838828
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3092 order for loan Magazin

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  2. Book ; Online: Neuroinflammation and Cognition

    Kumar, Ashok / K Ormerod, Brandi / Dwivedi, Yogesh / W Streit, Jakob

    2019  

    Keywords Science: general issues ; Neurosciences ; Aging ; Cognitive Function ; Hippocampus ; Synaptic Function ; Calcium ; Oxidative Stress ; Neuroinflammation ; LPS ; Microglia ; systemic inflammation
    Size 1 electronic resource (191 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231223
    ISBN 9782889457601 ; 2889457605
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Cell-Type-Specific Transcriptomic Analysis in the Dorsolateral Prefrontal Cortex Reveals Distinct Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder.

    Dwivedi, Yogesh

    The American journal of psychiatry

    2020  Volume 177, Issue 12, Page(s) 1107–1109

    MeSH term(s) Bipolar Disorder/genetics ; Gene Expression Profiling ; Humans ; Prefrontal Cortex ; Schizophrenia/genetics ; Transcriptome/genetics
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2020.20101455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Psychological fear and anxiety caused by COVID-19

    Yogesh, Dwivedi

    Insights from Twitter analytics

    2020  

    Keywords covid19
    Publisher Elsevier BV
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: An insight into the sprawling microverse of microRNAs in depression pathophysiology and treatment response.

    Roy, Bhaskar / Dwivedi, Yogesh

    Neuroscience and biobehavioral reviews

    2023  Volume 146, Page(s) 105040

    Abstract: Stress-related neuropathologies are pivotal in developing major depressive disorder (MDD) and are often governed by gene-regulatory changes. Being a stress-responsive gene-regulatory factor, microRNAs (miRNAs) have tremendous biomolecular potential to ... ...

    Abstract Stress-related neuropathologies are pivotal in developing major depressive disorder (MDD) and are often governed by gene-regulatory changes. Being a stress-responsive gene-regulatory factor, microRNAs (miRNAs) have tremendous biomolecular potential to define an altered gene-regulatory landscape in the MDD brain. MiRNAs' regulatory roles in the MDD brain are closely aligned with changes in plasticity, neurogenesis, and stress-axis functions. MiRNAs act at the epigenetic interface between stress-induced environmental stimuli and cellular pathologies by triggering large-scale gene expression changes in a highly coordinated fashion. The parallel changes in peripheral circulation may provide an excellent opportunity for miRNA to devise more effective treatment strategies and help explore their potential as biomarkers in treatment response. This review discusses the role of miRNAs as epigenetic modifiers in the etiopathogenesis of MDD. Concurrently, key research is highlighted to show the progress in using miRNAs as predictive biomarkers for treatment response.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Depressive Disorder, Major/genetics ; Depression ; Brain/metabolism ; Biomarkers
    Chemical Substances MicroRNAs ; Biomarkers
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Genomics in Treatment Development.

    Dwivedi, Yogesh / Shelton, Richard C

    Advances in neurobiology

    2023  Volume 30, Page(s) 363–385

    Abstract: The Human Genome Project mapped the 3 billion base pairs in the human genome, which ushered in a new generation of genomically focused treatment development. While this has been very successful in other areas, neuroscience has been largely devoid of such ...

    Abstract The Human Genome Project mapped the 3 billion base pairs in the human genome, which ushered in a new generation of genomically focused treatment development. While this has been very successful in other areas, neuroscience has been largely devoid of such developments. This is in large part because there are very few neurological or mental health conditions that are related to single-gene variants. While developments in pharmacogenomics have been somewhat successful, the use of genetic information in practice has to do with drug metabolism and adverse reactions. Studies of drug metabolism related to genetic variations are an important part of drug development. However, outside of cancer biology, the actual translation of genomic information into novel therapies has been limited. Epigenetics, which relates in part to the effects of the environment on DNA, is a promising newer area of relevance to CNS disorders. The environment can induce chemical modifications of DNA (e.g., cytosine methylation), which can be induced by the environment and may represent either shorter- or longer-term changes. Given the importance of environmental influences on CNS disorders, epigenetics may identify important treatment targets in the future.
    MeSH term(s) Humans ; Genomics ; Epigenesis, Genetic ; DNA Methylation
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2190-5215
    ISSN 2190-5215
    DOI 10.1007/978-3-031-21054-9_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: microRNA-124: a putative therapeutic target and biomarker for major depression.

    Dwivedi, Yogesh

    Expert opinion on therapeutic targets

    2017  Volume 21, Issue 7, Page(s) 653–656

    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2017.1328501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MicroRNAs in depression and suicide: Recent insights and future perspectives.

    Dwivedi, Yogesh

    Journal of affective disorders

    2018  Volume 240, Page(s) 146–154

    Abstract: Suicide is a major public health concern. A significant proportion of depressed individuals show suicidal ideation. The currently available medications are not optimal and a large number of depressed/suicidal patients do not respond to these medications. ...

    Abstract Suicide is a major public health concern. A significant proportion of depressed individuals show suicidal ideation. The currently available medications are not optimal and a large number of depressed/suicidal patients do not respond to these medications. Thus, there is an urgent need to fully understand the neurobiological mechanisms associated with depression and suicidal behavior and to find novel targets for therapeutic interventions. In this regard, microRNAs (miRNAs), member of small non-coding RNA family, have emerged as an invaluable tool not only to understand disease pathogenesis but also to precisely pinpoint the targets that can be developed as drugs. In this review, these aspects have been discussed in a comprehensive and critical manner.
    MeSH term(s) Depression/drug therapy ; Depression/genetics ; Humans ; MicroRNAs/genetics ; Molecular Targeted Therapy/methods ; Suicidal Ideation
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2018-07-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2018.07.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1485: Show issues Location:
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  9. Article ; Online: Dissecting early life stress-induced adolescent depression through epigenomic approach.

    Ochi, Shinichiro / Dwivedi, Yogesh

    Molecular psychiatry

    2022  Volume 28, Issue 1, Page(s) 141–153

    Abstract: Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to ... ...

    Abstract Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.
    MeSH term(s) Adult ; Humans ; Adolescent ; Child ; Depression/genetics ; Epigenomics ; Adverse Childhood Experiences ; Mental Disorders/genetics ; MicroRNAs/genetics ; Stress, Psychological/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01907-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Online User Behavior and User-Generated Content.

    Saura, Jose Ramon / Dwivedi, Yogesh K / Palacios-Marqués, Daniel

    Frontiers in psychology

    2022  Volume 13, Page(s) 895467

    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.895467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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