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  1. Book ; Thesis: Untersuchungen zu den pathophysiologischen Grundlagen der fibrinolytischen Therapie intrazerebraler Blutungen

    Thiex, Ruth

    2005  

    Author's details vorgelegt von Ruth Thiex
    Language German
    Size V, 101 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Habil.-Schr., 2005
    HBZ-ID HT014686042
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 1365 order to use in reading room Magazin

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  2. Book ; Thesis: Zur Differenzierung demyelinisierender Neuropathien mittels Polymerase-Kettenreaktion (PCR) des Genbereichs für das periphere Markscheidenprotein-22 an Paraffin-eingebetteten Suralnervenbiopsien

    Thiex, Ruth

    1999  

    Author's details vorgelegt von Ruth Thiex
    Language German
    Size 50 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 1999
    HBZ-ID HT010828069
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 D 1458 order for loan Magazin

    Order via subito

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  3. Article: Diagnosing spinal cord ischemia: Are we doing enough catheter angiography?

    Young, Robert J / Huang, Jason H / Thiex, Ruth

    Neurology. Clinical practice

    2020  Volume 10, Issue 6, Page(s) 469–470

    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Future perspectives on the fibrinolytic therapy of intracerebral hemorrhages.

    Thiex, Ruth

    Central nervous system agents in medicinal chemistry

    2011  Volume 11, Issue 2, Page(s) 150–156

    Abstract: Intracerebral hemorrhage (ICH) is associated with a high mortality and severe disability. Whereas a classical open craniotomy for hematoma removal may further traumatize brain tissue, minimally invasive surgery combines benefits of surgical clot removal ... ...

    Abstract Intracerebral hemorrhage (ICH) is associated with a high mortality and severe disability. Whereas a classical open craniotomy for hematoma removal may further traumatize brain tissue, minimally invasive surgery combines benefits of surgical clot removal with limited tissue damage and shorter surgery duration. Evacuation is often hampered by clot retraction, thus, advocating clot liquefaction to facilitate complete evacuation. The use of urokinase or recombinant tissue plasminogen activator (rtPA) alone and in combination with neuroprotective drugs in experimental studies and clinical trials is reviewed with respect to efficacy in hematoma reduction and effects on secondary brain injury. Whereas rtPA promotes delayed edema formation and inflammation after local fibrinolysis, desmoteplase (DSPA), a highly fibrin-selective plasminogen activator derived from vampire bat saliva, combines high fibrinolytic potential with lack of excitotoxicity, thus representing a novel, promising candidate for fibrinolytic therapy of ICH.
    MeSH term(s) Animals ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/pathology ; Cerebral Hemorrhage/physiopathology ; Fibrinolytic Agents/therapeutic use ; Hematoma/drug therapy ; Hematoma/pathology ; Hematoma/surgery ; Humans ; Thrombolytic Therapy/methods ; Thrombolytic Therapy/trends ; Tissue Plasminogen Activator/therapeutic use ; Urokinase-Type Plasminogen Activator/therapeutic use
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2011-04-22
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2227560-5
    ISSN 1875-6166 ; 1871-5249
    ISSN (online) 1875-6166
    ISSN 1871-5249
    DOI 10.2174/187152411796011367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Untersuchungen zu den pathophysiologischen Grundlagen der fibrinolytischen Therapie intrazerebraler Blutungen

    Thiex, Ruth

    2005  

    Author's details vorgelegt von Ruth Thiex
    Language German
    Size V, 101 Bl., Ill., 30 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Habil--Aachen, 2005
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  6. Article ; Online: Brain edema after intracerebral hemorrhage: mechanisms, treatment options, management strategies, and operative indications.

    Thiex, Ruth / Tsirka, Stella E

    Neurosurgical focus

    2007  Volume 22, Issue 5, Page(s) E6

    Abstract: Primary intracerebral hemorrhage (ICH) is associated with a high mortality rate and severe morbidity. The treatment of choice is still controversial, given that data from several clinical trials have not provided convincing evidence to support the ... ...

    Abstract Primary intracerebral hemorrhage (ICH) is associated with a high mortality rate and severe morbidity. The treatment of choice is still controversial, given that data from several clinical trials have not provided convincing evidence to support the efficacy of surgical clot removal. Favoring early clot removal is evidence that the limited release of specific neurotoxins associated with the breakdown products of hemoglobin underlies secondary brain injury. Attention has therefore shifted to perilesional brain injury, especially brain edema, as a potential target for therapeutic intervention in patients with ICH. In this review the authors address current understanding of the causes of edema formation following ICH and the treatment options, which are mostly supportive in nature.
    MeSH term(s) Animals ; Blood-Brain Barrier/physiology ; Brain Edema/etiology ; Brain Edema/pathology ; Brain Edema/therapy ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/therapy ; Humans ; Time Factors
    Language English
    Publishing date 2007-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/foc.2007.22.5.7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Basilar megadolicho trunk causing obstructive hydrocephalus at the foramina of Monro.

    Thiex, Ruth / Mull, Michael

    Surgical neurology

    2006  Volume 65, Issue 2, Page(s) 199–201

    Abstract: We report on a 54-year-old man with megadolicho basilar artery presenting with acute signs of raised intracranial pressure due to a compromise of cerebrospinal fluid (CSF) flow at the level of the foramina of Monro by the basilar apex extending more than ...

    Abstract We report on a 54-year-old man with megadolicho basilar artery presenting with acute signs of raised intracranial pressure due to a compromise of cerebrospinal fluid (CSF) flow at the level of the foramina of Monro by the basilar apex extending more than 3 cm cranially to the dorsum sellae. The diagnosis was confirmed on computed tomographic angiography and emergent CSF drainage relieved symptoms immediately.
    MeSH term(s) Basilar Artery/diagnostic imaging ; Basilar Artery/pathology ; Cerebral Ventricles ; Cerebrospinal Fluid Shunts ; Humans ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/pathology ; Hydrocephalus/therapy ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/pathology ; Intracranial Hypertension/therapy ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 221938-4
    ISSN 1879-3339 ; 0090-3019
    ISSN (online) 1879-3339
    ISSN 0090-3019
    DOI 10.1016/j.surneu.2005.04.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  8. Book ; Thesis: Zur Differenzierung demyelinisierender Neuropathien mittels Polymerase-Kettenreaktion (PCR) des Genbereichs für das periphere Markscheidenprotein-22 an Paraffin-eingebetteten Suralnervenbiopsien

    Thiex, Ruth

    1999  

    Author's details vorgelegt von Ruth Thiex
    Language German
    Size 50 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 1999
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Transvenous approach to carotid-cavernous fistula via facial vein cut down.

    Thiex, Ruth / Gross, Bradley A / Gupta, Rishi / Wyers, Mark C / Frerichs, Kai U / Thomas, Ajith J

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2014  Volume 21, Issue 7, Page(s) 1238–1240

    Abstract: Endovascular access to carotid-cavernous sinus fistulae (CCF) can be obtained through a transfemoral approach to the inferior petrosal sinus (IPS) or superior ophthalmic vein (SOV). If the transfemoral approach cannot be utilized, direct surgical ... ...

    Abstract Endovascular access to carotid-cavernous sinus fistulae (CCF) can be obtained through a transfemoral approach to the inferior petrosal sinus (IPS) or superior ophthalmic vein (SOV). If the transfemoral approach cannot be utilized, direct surgical exposure of the SOV can provide access to the CCF. The authors present an alternate approach to a CCF in a 66-year-old woman in whom the IPS was thrombosed and the facial vein so tortuous at its origin that it could not be passed with a wire. The facial vein was exposed surgically at the angle of the mandible after percutaneous attempts failed. After localization of the anterior facial vein with ultrasound, a 1 cm skin incision was made over the margin of the mandible. The dissected vein was cannulated using a micropuncture technique and a 0.018 inch wire. A four French short access sheath was inserted and sutured to the vein. Subsequent venogram allowed navigation of an SL-10 microcatheter over a Synchro soft microwire (both Boston Scientific, Natick, MA, USA) via the SOV into the cavernous sinus, and coil embolization was performed with angiographic cure of the fistula. No complications were encountered and the cosmetic result of the small incision of the mandibular region was excellent and less conspicuous than it would have been on the eyelid. This technical note illustrates that facial vein cut down is an attractive and safe alternate approach to endovascular management of CCF via a transvenous route in patients with a focally narrowed and tortuous IPS and common facial vein.
    MeSH term(s) Aged ; Carotid-Cavernous Sinus Fistula/surgery ; Coronary Angiography ; Embolization, Therapeutic/instrumentation ; Embolization, Therapeutic/methods ; Female ; Humans ; Jugular Veins/surgery
    Language English
    Publishing date 2014-07
    Publishing country Scotland
    Document type Case Reports ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2013.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The role of preoperative transarterial embolization in spinal tumors. A large single-center experience.

    Thiex, Ruth / Harris, Mitchel B / Sides, Corey / Bono, Christopher M / Frerichs, Kai U

    The spine journal : official journal of the North American Spine Society

    2013  Volume 13, Issue 2, Page(s) 141–149

    Abstract: Background context: Patients with spinal tumors are often referred for preoperative angiography and embolization before surgical resection to minimize intraoperative bleeding.: Purpose: The purpose of the present study was to investigate the ... ...

    Abstract Background context: Patients with spinal tumors are often referred for preoperative angiography and embolization before surgical resection to minimize intraoperative bleeding.
    Purpose: The purpose of the present study was to investigate the angiographic appearance of a variety of spinal tumors, assess the safety and efficacy of preoperative embolization in relation to the amount of intraoperative blood loss, and correlate intraoperative tumor histology with the degree of gadolinium enhancement on spinal magnetic resonance imaging (MRI) and tumor vascularity visualized during angiography.
    Study design/setting: Retrospective and single-institution cohort study.
    Patient sample: One hundred four patients with spinal tumors referred for preoperative embolization.
    Outcome measures: Effectiveness of preoperative embolization in relation to intraoperative blood loss and number of transfused packed red blood cell units in perioperative period (72 hours).
    Methods: From 2000 to 2009, 104 patients with spinal tumors underwent 114 spinal angiographies with the intent to embolize feeder vessels before surgery. The effectiveness of embolization was compared with the documented intraoperative blood loss. Angiographic tumor vascularity was graded from 0 (avascular) to 3 (highly vascular). Ninety-four patients had a pre- and post-gadolinium-enhanced MRI of the spine before transarterial embolization. Magnetic resonance imaging vascular enhancement was classified as Grade 3 (avid contrast enhancement), Grade 2 (moderate), or Grade 1 (mild).
    Results: Transarterial tumor embolization was angiographically complete in 63 (66%) and partial in 33 procedures (34%). In 18 cases, the target was not deemed suitable for embolization. A limited statistical analysis did not reveal a statistical difference in documented intraoperative blood loss between patients with complete versus partial embolization for the entire cohort or when stratified into renal cell carcinoma (RCC; p=.64), multiple myeloma (p=.28), malignant (p=.17) and benign tumor groups (p=.26). There were no clinical complications associated with embolization. There was poor correlation between MRI enhancement and angiographic vascularity.
    Conclusions: Preoperative embolization was angiographically effective in most cases. Avid gadolinium enhancement (Grade 3) on MRI was not predictive of hypervascularity on angiography. Furthermore, hypervascularity was not restricted to classically vascular tumors, such as RCC, as it was noted in some patients with breast and prostate cancer. However, with the available numbers, the quality of preoperative embolization did not significantly affect intraoperative blood loss. A future prospective randomized controlled study may be warranted to better characterize the benefits of preoperative embolization for spinal tumors.
    MeSH term(s) Adult ; Aged ; Blood Loss, Surgical/prevention & control ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Breast Neoplasms/therapy ; Carcinoma, Renal Cell/secondary ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/therapy ; Embolization, Therapeutic/methods ; Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Kidney Neoplasms/therapy ; Male ; Middle Aged ; Multiple Myeloma/secondary ; Multiple Myeloma/surgery ; Multiple Myeloma/therapy ; Preoperative Care ; Preoperative Period ; Retrospective Studies ; Spinal Neoplasms/secondary ; Spinal Neoplasms/surgery ; Spinal Neoplasms/therapy ; Treatment Outcome
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2012.10.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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