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  1. Article ; Online: HIF2 Inhibition for von-Hippel Lindau Associated Kidney Cancer: Will Urology Lead or Follow?

    Shuch, Brian

    Urologic oncology

    2021  Volume 39, Issue 5, Page(s) 277–280

    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/physiology ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/etiology ; Urology ; von Hippel-Lindau Disease/complications ; von Hippel-Lindau Disease/drug therapy
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2021.01.018
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    Zs.A 4817: Show issues Location:
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  2. Article ; Online: [

    Unterrainer, Lena M / Sisk, Anthony E / Czernin, Johannes / Shuch, Brian M / Calais, Jeremie / Hotta, Masatoshi

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 10, Page(s) 1660–1661

    MeSH term(s) Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Humans
    Chemical Substances FAPI-46 ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.265640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  3. Article ; Online: Advances in the Characterization of Clear Cell Papillary Renal Cell Carcinoma: Identifying the Sheep in Wolf's Clothing.

    Filippou, Pauline / Shuch, Brian / Psutka, Sarah P

    European urology

    2021  Volume 79, Issue 4, Page(s) 478–479

    MeSH term(s) Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.01.023
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  4. Article ; Online: Reply to Alexa R. Meyer, Steven P. Rowe, and Nirmish Singla's Letter to the Editor re: Patrick D. McGillivray, Daiki Ueno, Aydin Pooli, et al. Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression (ONEX) Classifier. Eur Urol 2021;79:107-11. Integrating

    Shuch, Brian / Raman, Steven / Calais, Jeremie

    European urology

    2021  Volume 80, Issue 1, Page(s) e22–e23

    MeSH term(s) Carcinoma, Renal Cell/genetics ; Gene Expression ; Humans ; Kidney Neoplasms/genetics ; Risk Assessment ; Technetium Tc 99m Sestamibi
    Chemical Substances Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.04.018
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    Zs.MO 294: Show issues

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  5. Article ; Online: Genetic Testing in Kidney Cancer Patients: Who, When, and How?

    Lui, Sandy T / Shuch, Brian

    European urology focus

    2019  Volume 5, Issue 6, Page(s) 973–976

    Abstract: There are more than a dozen recognized hereditary forms of kidney cancer. While classic syndromic forms are readily recognizable, more recently described conditions are subtler because of lower penetrance. Adequate counseling and implementation of risk ... ...

    Abstract There are more than a dozen recognized hereditary forms of kidney cancer. While classic syndromic forms are readily recognizable, more recently described conditions are subtler because of lower penetrance. Adequate counseling and implementation of risk assessment before or after management are important aspects of clinical care. Germline testing to assess hereditary risk has rapidly evolved thanks to multigene panel testing, which can be performed quickly and at relatively low cost. This review discusses what is known about germline risk assessment, namely which individuals should be tested and when and how, and covers many of the uncertainties around this process. PATIENT SUMMARY: More than a dozen genes have been linked to predisposition to kidney cancer. We review genetic testing in terms of who should be tested and when and how the testing should be carried out. Results from genetic tests can help in tailoring screening and surgical management and in selecting the most suitable chemotherapy.
    MeSH term(s) Adult ; Carcinoma, Renal Cell/surgery ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Germ-Line Mutation/genetics ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Mass Screening/methods ; Middle Aged ; Pedigree ; Risk Assessment
    Language English
    Publishing date 2019-10-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2019.09.005
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  6. Article ; Online: Sequencing of Renal Mass Biopsy and Ablation: Results from the National Cancer Database.

    Uhlig, Annemarie / Lenis, Andrew / Wang, Xiaoyan / Shuch, Brian

    Urology practice

    2021  Volume 8, Issue 5, Page(s) 555–564

    Abstract: Introduction: We assessed current utilization and sequencing of renal mass biopsy (RMB) and thermal ablation for renal cell carcinoma (RCC) patients in the United States.: Methods: The 2004-2014 National Cancer Database was queried for adult patients ...

    Abstract Introduction: We assessed current utilization and sequencing of renal mass biopsy (RMB) and thermal ablation for renal cell carcinoma (RCC) patients in the United States.
    Methods: The 2004-2014 National Cancer Database was queried for adult patients with histopathologically diagnosed American Joint Committee on Cancer stage I RCC ≤5 cm undergoing RMB and thermal ablation. RMB sequencing was stratified into "staged RMB" (separate sessions for RMB/ablation) or "concomitant RMB" (same date RMB/ablation). Demographics, cancer variables and time trends were compared. Univariate and multivariable logistic regression identified predictors of concomitant RMB, and evaluated their impact on inpatient hospital stay and 30-day unplanned readmissions.
    Results: A total of 6,323 patients were included, of whom 2,913 (46.1%) underwent staged RMB and 3,410 (53.9%) underwent concomitant RMB. Concomitant RMB was more frequently performed until 2012, and staged RMB thereafter (trend p <0.001). In multivariable logistic regression models, private insurance, clear cell RCC, right-sided disease and smaller tumor diameter demonstrated higher probability of concomitant RMB. Furthermore, geographical differences across the United States were evident (concomitant RMB West/South Central region 64.6% versus New England 29.3%, multivariable p <0.05). Concomitant RMB was associated with greater odds of inpatient hospital stay (multivariable OR=1.42, 95% CI=1. 27-1. 60; p <0.001) and 30-day unplanned hospital readmissions (OR=1.55, 95% CI=1.07-2.27; p=0.022).
    Conclusions: Staged RMB is more frequently performed in more recent years and is associated with lower odds of inpatient hospital stay and unplanned readmissions within 30 days. These potential benefits, combined with the potential to limit ablation of benign tumors, need to be weighed against additional health care costs and inconvenience associated with 2 interventions.
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000241
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  7. Article ; Online: Inherited kidney cancer syndromes.

    Ball, Mark W / Shuch, Brian M

    Current opinion in urology

    2019  Volume 29, Issue 4, Page(s) 334–343

    Abstract: Purpose of review: To describe current paradigms for genetic testing, screening, and treatment of patients with inherited kidney cancer syndromes.: Recent findings: We describe various new aspects of hereditary kidney cancer. Recent data now support ... ...

    Abstract Purpose of review: To describe current paradigms for genetic testing, screening, and treatment of patients with inherited kidney cancer syndromes.
    Recent findings: We describe various new aspects of hereditary kidney cancer. Recent data now support that hereditary kidney cancer may account for 5-8% of kidney cancers diagnosed. Methods of testing have evolved including the introduction of multigene next-generation sequencing panels. We continue to learn more about the natural history and management of classic hereditary cancer syndromes. New emerging conditions with lower kidney cancer penetrance have been recognized adding the growing list of syndromes associated with kidney cancer development. The surgical management strategies of enucleation remain however systemic therapy options are being explored both for localized and advanced settings.
    Summary: Genetic predisposition to kidney cancer is likely more common than once thought. Knowledge of clinical manifestation and genetic testing strategies are needed to properly identify and treat patient and their families.
    MeSH term(s) Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; Genetic Predisposition to Disease/genetics ; Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/therapy ; Mass Screening ; Neoplastic Syndromes, Hereditary/diagnosis ; Neoplastic Syndromes, Hereditary/genetics ; Neoplastic Syndromes, Hereditary/therapy
    Language English
    Publishing date 2019-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000000646
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    Zs.A 3345: Show issues Location:
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  8. Article ; Online: Genetic Predisposition to Renal Cell Carcinoma: Implications for Counseling, Testing, Screening, and Management.

    Shuch, Brian / Zhang, Jin

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  , Page(s) JCO2018792523

    Abstract: In many individuals with renal cell carcinoma (RCC), a hereditary cause may have contributed to cancer development. Various risk factors can be suggestive of a genetic contribution, including early disease onset, multifocal or bilateral tumors, family ... ...

    Abstract In many individuals with renal cell carcinoma (RCC), a hereditary cause may have contributed to cancer development. Various risk factors can be suggestive of a genetic contribution, including early disease onset, multifocal or bilateral tumors, family history of RCC, and personal/family history of other benign or malignant tumors. Genetic counseling and understanding of the entire family tree are the first steps in evaluation and will determine if the patient should proceed with testing. Methods of testing have changed to next-generation sequencing, which allows multiple genes to be evaluated together. The results of testing have significant implications for the individual and his or her family members. Screening of the kidney and at-risk organs ensues, with most algorithms focused on early diagnosis and intervention to limit morbidity and mortality of disease manifestations. A comprehensive clinical program that can offer multidisciplinary care is useful for several complex cancer syndromes. Management of localized and advanced hereditary kidney cancers may differ from the sporadic forms of RCC. Knowledge of the genetics can have significant management implications and if necessary genetic evaluation can be expedited to allow treatment decisions.
    Language English
    Publishing date 2018-10-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2018.79.2523
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    Zs.MO 650: Show issues

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  9. Article ; Online: Adjuvant Therapy for Localized High-Risk Renal Cell Carcinoma.

    Wood, Erika / Donin, Nicholas / Shuch, Brian

    The Urologic clinics of North America

    2020  Volume 47, Issue 3, Page(s) 345–358

    Abstract: This article reviews the use of adjuvant therapies for prevention of recurrence following resection of clinically localized renal cell carcinoma (RCC). Clinical trials evaluating adjuvant therapy for RCC have focused primarily on the use of tyrosine ... ...

    Abstract This article reviews the use of adjuvant therapies for prevention of recurrence following resection of clinically localized renal cell carcinoma (RCC). Clinical trials evaluating adjuvant therapy for RCC have focused primarily on the use of tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors, which had improved outcome in patients with metastatic disease. However, all but 1 trial found no difference in disease-free survival in the adjuvant setting and none improved overall survival.
    MeSH term(s) Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/therapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Immunotherapy ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Molecular Targeted Therapy ; Nephrectomy
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 192293-2
    ISSN 1558-318X ; 0094-0143
    ISSN (online) 1558-318X
    ISSN 0094-0143
    DOI 10.1016/j.ucl.2020.04.007
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    Se 269: Show issues Location:
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  10. Article ; Online: Papillary renal cell carcinoma: Review.

    Mendhiratta, Neil / Muraki, Peter / Sisk, Anthony E / Shuch, Brian

    Urologic oncology

    2021  Volume 39, Issue 6, Page(s) 327–337

    Abstract: Kidney cancer is the 13th most common malignancy globally, and the incidence is rising. Papillary renal cell carcinoma is the second most common subtype, comprising 10-15% of renal cell carcinomas. Though the histologic features of this subtype were ... ...

    Abstract Kidney cancer is the 13th most common malignancy globally, and the incidence is rising. Papillary renal cell carcinoma is the second most common subtype, comprising 10-15% of renal cell carcinomas. Though the histologic features of this subtype were initially described in the 1990's, our understanding of the genetic and molecular characteristics of this disease have rapidly evolved over the past decade. In this review, we summarize the contemporary understanding of the clinical, morphologic, radiographic, and genetic characteristics of papillary renal cell carcinoma, as well as clinical considerations, current options for management, and prognosis.
    MeSH term(s) Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/therapy ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/therapy
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2021.04.013
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